Clinical trials: Acute Respiratory Failure
ARDS, COVID19
Evaluation of Airway Pressure Release Ventilation in COVID-19 ARDS
The 2020 pandemic of the coronavirus (SARS-CoV2) has lead to an increase in ARDS cases requiring invasive mechanical ventilation in the ICU (Intensive Care Unit).
- Trial name
- APRV-COVID19 (NCT04386369)
- Testing
- Airway pressure release ventilation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Central Hospital, Nancy, France
Sepsis, Cardiac Arrest
Thigh Muscle Mass and Muscle Wasting in Patients in the Emergency Department
The goal of this observational study is to evaluate whether thigh muscle mass and muscle wasting are associated with mortality in patients who visit the emergency department.
- Conditions
- Sepsis, Cardiac Arrest, Acute Respiratory Failure, Patients Who Visit Emergency Department
- Trial name
- NCT05978154
- Testing
- Thigh muscle mass and muscle wasting (exposure)
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Korea University Ansan Hospital
Acute Respiratory Failure
METEOR Think NIV Pilot
This study will pilot test three strategies designed to speed implementation of preventive post-extubation noninvasive ventilation (NIV): one control strategy (traditional online continuing medical education) and two novel…
- Trial name
- NCT04052542
- Testing
- Traditional online continuing education, Interprofessional education, Just-in-time education
- Where
- United States
- Volunteers
- 1,328 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Disease
Chronic Obstructive Pulmonary Disease (COPD) in Patients Hospitalized for Acute Decompensated Heart Failure.
The presence of chronic obstructive pulmonary disease (COPD) would confer increased in-hospital mortality and length of hospital stay in patients with acute decompensated heart failure Assess the (1) prevalence of COPD in…
- Trial name
- COPD (NCT02340702)
- Testing
- COPD
- Sponsor
- Mayo Clinic
Community Acquired Pneumonia., Acute Hypoxemic Respiratory Failure
Efects of Noninvasive Mechanical Ventilation and Conventional Mechanical Ventilation in Patients With Severe Comunity Pneumonia
The purpose of this study is to determine whether the noninvasive ventilation is more effective in the treatment of severe comunity acquired pneumonia in comparison with the conventional mechanical ventilation with orotracheal…
- Trial name
- NIMV AND SCAP (NCT00523497)
- Testing
- Non invasive mechanical ventilation
- Where
- Argentina
- Sponsor
- Hospital Privado del Sur
Acute Respiratory Failure, Extracorporeal Membrane Oxygenation Complication
Fixed Low-dose Heparin Versus Standard Adjusted-dose Heparin Infusion in Adults Receiving Venovenous ECMO With a Heparin Bonded Circuit.
Heparin is a blood thinner used to prevent blood clots in patients on a form of life-support called ECMO. Heparin can cause bleeding - the most common complication of ECMO.
- Conditions
- Acute Respiratory Failure, Extracorporeal Membrane Oxygenation Complication, Bleeding
- Trial name
- NCT02966080
- Testing
- HEP-IV
- Where
- United States
- Sponsor
- University of Arizona
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Acute Respiratory Failure, Critical Illness
Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients
Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood.
- Trial name
- NCT06189924
- Testing
- Proteomic analysis of exhaled breath condensate
- Where
- 2 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Acute Respiratory Failure, Pneumonia
Predicting Success of HFNC: The Utility of the ROX Index
The purpose of the study was to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation in pneumonia patients with acute respiratory failure treated with High Flow…
- Trial name
- NCT02834325
- Testing
- mechanical ventilation
- Volunteers
- 201 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Respiratory Failure, Community-Acquired Pneumonia
Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia
This is a prospective, multicenter, interventional cohort study aimed at constructing a high-quality, dynamic multimodal database for patients with acute respiratory failure caused by community-acquired pneumonia (CAP-ARF).
- Trial name
- NCT07357935
- Testing
- Methylprednisolone
- Volunteers
- 500 people
- Sponsor
- Qingyuan Zhan
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
COPD Exacerbation
Oral Prednisolone in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Evaluation of systematic administration of oral prednisolone (1mg/Kg/day) as an add on therapy in Chronic Obstructive Pulmonary Disease (COPD) patients admitted to intensive care unit (ICU) for severe exacerbation of COPD.
- Trial name
- NCT01353235
- Testing
- Prednisolone, usual care
- Where
- Tunisia
- Volunteers
- 317 people
- Sponsor
- Fekri Abroug
COPD, COPD Exacerbation Acute
The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a treatable but debilitating medical condition associated with persistent symptoms and chronic airflow obstruction.
- Conditions
- COPD, COPD Exacerbation Acute, Comorbid Chronic Lung Disease on Heart Failure, Mortality
- Trial name
- ICoRe (NCT06652776)
- Testing
- Pharmacological treatment
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milan
Acute Respiratory Failure
High Flow During Weaning From Mechanical Ventilation
Detection and relief of dyspnea in mechanically ventilated patients is a priority. Optimization of mechanical ventilation settings is unfortunately often insufficient to relieve dyspnea in patients entering the weaning process.
- Trial name
- FLOWEAN (NCT05577221)
- Testing
- High Flow Nasal Air
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome
Study to Find the Highest Safe Dose of Soluble Guanylate Cyclase (sGC) Activator, BAY 1211163 Administered as Multiple Doses by Inhalation to Patients Who Cannot Breathe by Their Own and Suffer From a Type of Lung Failure That Causes Fluid to Build up in the Lungs Making Breathing Difficult (ARDS)
With this study researchers want to find the highest safe dose of the soluble Guanylate Cyclase (sGC) Activator, BAY 1211163 and how safe and well the study drug works.
- Trial name
- NCT04609943
- Testing
- BAY1211163
- Where
- 4 sites in Germany
- Volunteers
- 16 people
- Sponsor
- Bayer
Euthyroid Sick Syndrome, Obesity Hypoventilation Syndrome (OHS)
Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome
The goal of this observational study is to learn about the frequency and clinical impact of Euthyroid Sick Syndrome (ESS) in patients with Obesity Hypoventilation Syndrome (OHS) who are admitted to the intensive care unit (ICU)…
- Trial name
- NCT06983418
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Mansoura University
Dyspnea,, Acute Heart Failure Syndrome
Fluid Status of Outpatients With Dyspnea
The purpose of this study is to determine the distribution of lung fluid status as reported by the IMED-4 system in patients presenting to the emergency department or urgent care facility with shortness of breath.
- Conditions
- Dyspnea,, Acute Heart Failure Syndrome, Pulmonary Congestion
- Trial name
- FLOOD (NCT02111525)
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Intersection Medical, Inc.
Chronic Obstructive Pulmonary Disease
Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa
Acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a major source of morbidity and mortality for patients and cost to the society.
- Trial name
- MORPHEUS I/IIa (NCT04427826)
- Testing
- Morphine hydrochloride
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Grenoble
Critical Illness, Sepsis
Implementation of a Web Based Real Time Clinical Decision Support Tool.
In the developed world critical illness is routinely treated in an intensive care unit (ICU) by highly specialized physicians, nurses and support staff.
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, Shock
- Trial name
- CERTAINp (NCT02398981)
- Testing
- Clinical decision support tool
- Where
- 10 sites in China, Croatia and 4 more
- Volunteers
- 962 people
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease Exacerbation, Obstructive Sleep Apnea Exacerbation
Non-invasive Ventilation or CPAP in OSA-COPD Following Admission for an Acute Hypercapnic Respiratory Failure
Chronic obstructive pulmonary disease (COPD) is a major public health problem with 212.3 million prevalent cases of COPD worldwide and 3.3 million deaths related to COPD in 2019.
- Trial name
- NCT07047092
- Testing
- Non-invasive Ventilation (NIV), Continous Positive Airway Pressure (CPAP)
- Where
- France
- Volunteers
- 386 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris