Clinical trials: Acute Respiratory Failure
Acute Respiratory Failure, Coma
EASiVENT Study Comparing INTELLiVENT-ASV vs Non Automated Ventilation in Adult ICU Patients
The purpose of the study is to assess the safety and efficacy of INTELLiVENT-ASV (Adaptive Support Ventilation) in adult ICU patients comparing to non automated ventilation.
- Conditions
- Acute Respiratory Failure, Coma, Acute Respiratory Distress Syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT04400643
- Testing
- INTELLiVENT-ASV, Non-automated ventilation
- Where
- Portugal
- Volunteers
- 62 people
- Sponsor
- Hamilton Medical AG
Hypercapnic Respiratory Failure, COPD
Feasibility Study of the Hemolung Respiratory Assist System
The purpose of this study is to evaluate the safety and efficacy of the Hemolung Respiratory Assist System in patients with hypercapnic respiratory failure associated with acute exacerbation of chronic obstructive pulmonary…
- Trial name
- NCT00987740
- Testing
- Hemolung Respiratory Assist System
- Where
- India
- Volunteers
- 2 people
- Sponsor
- Alung Technologies
Acute Hypoxemic Respiratory Failure
Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study
About 65,000 Canadians develop acute respiratory failure requiring breathing machines (ventilators) to give oxygen to their lungs. Unfortunately, up to 50% of these individuals will not survive their illness.
- Trial name
- AiCLOSE (NCT05196074)
- Testing
- Acute hypoxemic respiratory failure patients on VV-ECMO
- Where
- Canada
- Volunteers
- 299 people
- Sponsor
- Lorenzo delSorbo
COVID-19, Pneumonia
Study to Assess Efficacy and Safety Relative to Standard of Care in Patients With COVID-19 Pneumonia
To assess the clinical efficacy of ANG-3777 relative to the standard of care in reducing the severity and progression of pulmonary and renal dysfunction and mortality in adult patients hospitalized with COVID-19 pneumonia
- Trial name
- NCT04459676
- Testing
- Standard of Care (SOC) + ANG-3777
- Where
- 10 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Angion Biomedica Corp
Acute Respiratory Failure, Lung Diseases
Extracorporeal Support for Respiratory Insufficiency (ECMO)
To evaluate indications for the use and efficacy of extracorporeal membrane oxygenators (ECMO's) for the support of patients with potentially reversible acute respiratory failure.
- Trial name
- NCT00000562
- Testing
- extracorporeal membrane oxygenation
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COVID-19
ABX464 in Treating Inflammation and Preventing Acute Respiratory Failure in Patients With COVID-19
A phase 2/3, randomized, double blind, placebo-controlled study to evaluate the efficacy and the safety of ABX464 in treating inflammation and preventing acute respiratory failure in patients aged ≥65 and patients aged ≥18 with…
- Trial name
- Mir-Age (NCT04393038)
- Testing
- ABX464
- Where
- 30 sites in Belgium, Brazil and 6 more
- Volunteers
- 509 people
- Sponsor
- Abivax S.A.
Vibration, Respiratory Complications
The Course of Acute Respiratory Failure in Geriatric Patients With Hip Fracture Using Different Modes of a Vibroacoustic Device for the Lungs
A medical professional trained in the procedure and use of the device will conduct the vibroacoustic therapy session. He will also take blood samples.
- Trial name
- NCT07517497
- Testing
- Vibrolung
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Astana Medical University
Rib Fracture Multiple, Pain, Chest
RIB PAIN (Rib Fractures Treated With Parental Analgesia With Infused LidocaiNe)
Traumatic rib fractures (RF) are a relatively common occurrence in patients of all ages, with a 10% incidence in all trauma patients and are associated with significant morbidity and mortality.
- Conditions
- Rib Fracture Multiple, Pain, Chest, Pain, Acute, Respiratory Failure
- Trial name
- RIB PAIN (NCT03770208)
- Testing
- Intervention: Lidocaine
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Western University, Canada
Acute Hypoxemic Respiratory Failure, Hypoxemia
Evaluation of the FreeO2 System for Oxygen Weaning After Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure (AHRF) is a common condition associated with substantial morbidity, mortality, and healthcare resource utilization.
- Trial name
- EVOLUERA (NCT07794124)
- Testing
- FreeO2 automated oxygen titration system, Standard oxygen weaning
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Heart Failure, Obstructive Sleep Apnea
The Role of Sleep Apnea in the Acute Exacerbation of Heart Failure
This study will evaluate whether treating sleep apnea while in the hospital would help heart failure, and assist recovery from the worsening of the heart function more than the current clinical standard of waiting for treatment…
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Heart Failure, Congestive
- Trial name
- NCT00679549
- Testing
- CPAP Therapy
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Ohio State University
Acute Respiratory Diseases
Voice, Dyspnea and Acute Respiratory Failure
Breathing is an automatic vital function that has the peculiarity of being controllable voluntary for actions other than breathing.
- Trial name
- LocuPnée-H (NCT05340933)
- Testing
- Voice registration
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Failure
Non-Positive Pressure Ventilation in Hypoxemic Patients
The study is aimed to assess the possible benefit of non-positive pressure mechanical support in front of conventional ventilation in patients admitted to the intensive care unit (ICU) because of pure hypoxemic respiratory…
- Trial name
- NCT00925860
- Testing
- non positive pressure mechanical ventilatory support
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Hospital Provincial de Castellon
Intensive Care Unit Syndrome, Hypercapnia
Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study
Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg.
- Conditions
- Intensive Care Unit Syndrome, Hypercapnia, Acute Respiratory Failure
- Trial name
- YETI (NCT04304339)
- Testing
- Hypercapnic respiratory failure
- Where
- 3 sites in France
- Volunteers
- 862 people
- Sponsor
- French Society for Intensive Care
Chronic Obstructive Pulmonary Disease
Home Mechanical Ventilation vs Home Oxygen Therapy in COPD
This study is designed to investigate the effect of home mechanical ventilation (HMV) in patients with severe chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00990132
- Testing
- Home mechanical ventilation, Long term oxygen therapy
- Where
- 7 sites in United Kingdom
- Volunteers
- 116 people
- Sponsor
- Patrick Murphy
COPD Exacerbation, Respiratory Failure
Predictability of Echographic Excursion of the Diaphragm for Intubation in COPD- Patients With Acute Respiratory Failure in ED
The investigators seek to evaluate if the ultra-sound measure of the diaphragm expansion is predictive of admission into an ICU and/or intubation for patients with COPD.
- Trial name
- PREEDICT-ED (NCT04591509)
- Where
- 3 sites in France
- Volunteers
- 390 people
- Sponsor
- European Georges Pompidou Hospital
Shortness of Breath, Acute Exacerbation
NT-proBNP for Evaluation of the Dyspneic Patient in the Emergency Room and the Medical Ward
The proposed study intends to evaluate the impact of the NT-proBNP assay on the diagnosis of heart failure in patients with dyspnea of unknown etiology presenting to the emergency room and admitted to the medical wards.
- Trial name
- NCT00271128
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Hillel Yaffe Medical Center
COVID-19, Coronavirus Disease 2019
Tigerase® Efficacy and Safety as Part of Complex Therapy in Patients With COVID-19
It is a multicenter, open-label, randomized, parallel-group study of the efficacy and safety of Tigerase® (GENERIUM JSC, Russia) with standard therapy versus standard therapy in patients with COVID-19.
- Trial name
- NCT04459325
- Testing
- Tigerase® and best available care, Best available care
- Where
- 6 sites in Russia
- Volunteers
- 100 people
- Sponsor
- AO GENERIUM
Acute Hypercapnic Respiratory Failure
Under the Nose Face Mask to Prevent Facial Pressure Ulcers During NIV for Acute Hypercapnic Respiratory Failure (AHRF)
Noninvasive ventilation (NIV) is essential to treat acute hypercapnic respiratory failure. However, facial pressure ulcers appearing during facemask-delivered noninvasive ventilation are a source of NIV failure by interface…
- Trial name
- UNDER PRESSURE (NCT04102735)
- Testing
- Under-the-nose facemask, Over-the-nose facemask
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier Arras
Acute Respiratory Failure, Mechanical Ventilation Complication
Assessing Ventilator Safety in Patients on Pressure-Support Ventilation
ASOP is a prospective cohort study comparing three methods for assessing risk of self-induced lung injury in patients with acute respiratory failure being managed with pressure-support ventilation.
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- ASOP (NCT05125952)
- Testing
- Viasys Avea Ventilator, Philips Respironics NM3 device, Servo U ventilator
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Lung Neoplasms, Respiratory Failure
Clearance Of Mucus In Stents (COMIS)
The goal of this clinical research study is to compare the effects of sodium bicarbonate to normal saline when used for clearing mucus blockage in patients with airway stents.
- Conditions
- Lung Neoplasms, Respiratory Failure, Pneumonia, Acute Coronary Syndromes
- Trial name
- NCT01370278
- Testing
- Normal Saline, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center