Clinical trials: Acute Respiratory Infection
Acute Respiratory Failure, COVID-19
REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
The worldwide COVID-19 pandemic has led to a dramatic increase in the number of patients hospitalized in intensive care units for an acute respiratory failure in all countries.
- Conditions
- Acute Respiratory Failure, COVID-19, Trauma, Stroke
- Trial name
- REHSCU (NCT04611425)
- Testing
- Remimazolam
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Covid19
Study of a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Virus-like Particle (VLP) Vaccine
This is a randomized, parallel dose assigned, double blind, multi center, Phase II study assessing the efficacy, safety, and immunogenicity of VLP vaccine (Authentic and Alpha variants) in adults between 18 and 59 years who are…
- Trial name
- COVID-19 (NCT04962893)
- Testing
- SARS-CoV-2 VLP Vaccine-Wuhan, SARS-CoV-2 VLP Vaccine-Alpha (British) variant, SARS-CoV-2 VLP Vaccine-Wuhan+Alpha variant
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Ihsan GURSEL, PhD, Prof.
Symptoms of Acute Bronchitis Accompanied by Coughing
Prospan® Hustenzäpfchen - Investigation on Efficacy and Tolerability in Children
The aims of this study are Demonstrating superior efficacy of Prospan® Hustenzäpfchen compared to Placebo in children suffering from acute bronchitis accompanied by coughing Characterisation of safety and tolerability of Prospan®…
- Trial name
- NCT01127048
- Testing
- Suppositories containing Ivy leaves dry extract
- Where
- Germany
- Volunteers
- 1,400 people
- Sponsor
- Engelhard Arzneimittel GmbH & Co.KG
SARS-CoV Infection, Seroprevalence
COVID-19 Sero-prevalence Health Care Workers Kinshasa
This is a cohort study, in which the investigators will follow-up 650 health care workers (HCW) and a selection of their households (of COVID positive and COVID negative HCW) at baseline and in three follow-up surveys, with 4 to…
- Trial name
- PRESTACOV (NCT04699058)
- Testing
- COVID-antibody test
- Where
- Democratic Republic of the Congo
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Covid19, ARDS, Human
MSC-based Therapy in COVID-19-associated Acute Respiratory Distress Syndrome
Considering the potential of mesenchymal stromal cells (MSCs) in the treatment of lung injuries by COVID-19, this pilot clinical trial evaluates the safety and potential efficacy of the cell therapy, administered intravenously…
- Trial name
- NCT04525378
- Testing
- Mesenchymal stromal cell-based therapy
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- D'Or Institute for Research and Education
Neurocognitive Disorders, Cognitive Dysfunction
A Pilot Randomized Controlled Trial: CoINTEGRATE
The purpose of this study is to examine the feasibility of comprehensive multimodal individually tailored Cognitive Behavioral Therapy (CBT), Cognitive Rehabilitation Therapy (CRT), and modifiable lifestyle sessions.
- Conditions
- Neurocognitive Disorders, Cognitive Dysfunction, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- CoINTEGRATE (NCT05732285)
- Testing
- CRT, CBT, Modifiable lifestyle factors
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Acute Respiratory Distress Syndrome
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
Acute Respiratory Distress Syndrome (ARDS) causes the lungs to fail due to the collection of fluid in the lungs (pulmonary oedema).
- Trial name
- REALIST (NCT03042143)
- Testing
- Human umbilical cord derived CD362 enriched MSCs
- Where
- United Kingdom
- Volunteers
- 129 people
- Sponsor
- Belfast Health and Social Care Trust
Chronic Obstructive Pulmonary Disease (COPD)
Examine the Impact of Early Education on COPD Management
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease primarily caused by smoking. COPD creates a tremendous burden to the healthcare system, as disease exacerbations result in frequent, prolonged…
- Trial name
- NCT02398643
- Testing
- Pulmonary Education (PE), Usual Care
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Alberta
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
COVID, Sars-CoV2
Prospective Registry of Corona Virus Disease 2019 (Covid-19) Patients With Neuromuscular Involvement
Prospective registry for multimodal assessment of neuromuscular pathology associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, enrolling consecutive patients with corona virus disease 2019…
- Conditions
- COVID, Sars-CoV2, Corona Virus Infection, Myositis
- Trial name
- NCT04367350
- Testing
- laboratory biomarkers, muscle ultrasound
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Tuebingen
Sinusitis
Application of Ectoin® Rhinitis Nasal Spray in Patients With Acute Rhinosinusitis
This is a comparative, open label, parallel group, non interventional study to further demonstrate the effectiveness and tolerability of Ectoin® Rhinitis Nasal Spray.
- Trial name
- SNS01 (NCT01684540)
- Testing
- Medical Device, Drug-like, Sinupret forte
- Where
- 6 sites in Germany
- Volunteers
- 66 people
- Sponsor
- Bitop AG
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
COVID-19, Endothelial Dysfunction
The Glycocalyx in COVID-19 Patients. A Pilot Study
The damage of the endothelial glycocalyx is based on microvascular endothelial dysfunction and typical for critical clinical conditions like sepsis, trauma, bleeding, shock, as well as ARDS.
- Conditions
- COVID-19, Endothelial Dysfunction, Coagulation Disorder
- Trial name
- Glycovid-19 (NCT05137249)
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Coronavirus, Covid19
COVID-19: A Study to Evaluate Safety, Reactogenicity and Immunogenicity of the SARS-CoV-2 mRNA Vaccine CVnCoV in Adults With Co-morbidities
The primary objectives of this study are to evaluate the safety and reactogenicity profile after 1 and 2 dose administrations of investigational SARS-CoV-2 mRNA vaccine CVnCoV, and to evaluate the humoral immune responses 14 days…
- Conditions
- Coronavirus, Covid19, SARS-CoV-2, Severe Acute Respiratory Syndrome
- Trial name
- NCT04860258
- Testing
- CVnCoV Vaccine
- Where
- 4 sites in Belgium
- Volunteers
- 129 people
- Sponsor
- CureVac
Respiratory Tract Infections, Urinary Tract Infections in Children
PHase IV Clinical Trial of Ceftriaxone Sodium and Sulbactam Sodium for Injection (CRO-SBT)
To evaluate the safety and efficacy of treatment of children with acute bacterial infection disease with Ceftriaxone Sodium and Sulbactam Sodium for Injection in the condition of widely used, and provide the basis of adjusting…
- Trial name
- CRO-SBT (NCT04066621)
- Testing
- Ceftriaxone Sodium and Sulbactam Sodium for Injection
- Volunteers
- 30 people
- Sponsor
- Xiangbei Welman Pharmaceutical Co., Ltd
Viral Bronchiolitis
Intravenous Fluids Versus Naso/Orogastric-tube Feeding in Hospitalized Infants With Bronchiolitis
Oro- or nasogastric tube feeding is safe and may be more physiologic than intravenous (IV) fluids in hospitalized infants with acute viral bronchiolitis.
- Trial name
- NCT01189149
- Testing
- IV fluids, Naso/oro gastric tube feedings
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Bnai Zion Medical Center
Non-Small Cell Lung Cancer, Metastatic Melanoma
A Study to Investigate 14C-bemcentinib in Healthy Male Subjects
The aims of this Study were to determine: How much of the Study Drug (bemcentinib) ends up in urine and faeces How much of the Study Drug and its breakdown products get into the bloodstream The breakdown products (metabolites) of…
- Conditions
- Non-Small Cell Lung Cancer, Metastatic Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndromes
- Trial name
- 8479217 (NCT06469138)
- Testing
- Bemcentinib
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- BerGenBio ASA
Pulmonary Disease, Chronic Obstructive
Sputum Colour Charts to Guide Antibiotic Self-treatment of Acute Exacerbation of COPD (Colour COPD)
The primary objective of this study is to determine if a sputum colour chart can aid patient self-management of COPD exacerbations, such that use of the chart is non-inferior to usual care with respect to hospital admissions.
- Trial name
- NCT04705233
- Testing
- sputum colour chart
- Where
- United Kingdom
- Volunteers
- 2,954 people
- Sponsor
- University of Birmingham
COVID19, ARDS
Follow-up of Critical COVID-19 Patients
The study will follow COVID-19 patients who required intensive care after 3-6 months and one year after discharge from the ICU with functional level as well as organ function to assess recovery after COVID-19.
- Conditions
- COVID19, ARDS, AKI, Circulatory Failure
- Trial name
- FUP-COVID (NCT04474249)
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University
Acute Respiratory Distress Syndrome
Immune Alveolar Alterations During Pneumonia-Associated Acute Respiratory Distress Syndrome
Sepsis is a dysregulated host response to severe life-threatening infections, leading to organ failure and death in up to 40% of patients with septic shock.
- Trial name
- PICARD2 (NCT03971006)
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris