Clinical trials: Acute Stroke, open to volunteers
Stroke, Acute Ischemic Stroke
Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer
The primary hypothesis being tested in this trial is that ischemic stroke patients with active cancer will have improved clinical outcomes when given intravenous thrombolysis compared to standard care.
- Trial name
- NCT06841965
- Testing
- Intravenous thrombolysis
- Volunteers
- 280 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Acute Ischemic Stroke
Intravenous Thrombosis and Patients with Prior Ischemic Stroke Within 3 Months
The primary hypothesis being tested in this trial is that ischemic stroke patients with prior ischemic stroke within 3 months will have improved clinical outcomes when given intravenous thrombolysis compared to standard care.
- Trial name
- NCT06841978
- Testing
- Intravenous Thrombolysis
- Volunteers
- 306 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Acute, Intracerebral Hemorrhage
The Akershus Study of Ischemic Stroke and Thrombolysis -1
This observational study comprises consecutively patients with cerebrovascular diseases admitted to the Stroke Unit at Akershus University Hospital in Norway.
- Conditions
- Stroke, Acute, Intracerebral Hemorrhage, Stroke, Ischemic, TIA
- Trial name
- ASIST-1 (NCT05378490)
- Where
- Norway
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Akershus
Stroke, Acute, Stroke, Ischemic
Effects of Atalante Exoskeleton on Gait Recovery in Non- or Poorly Ambulatory Patients With Hemiparesis in the Acute/Subacute Phase (Month 1 to 4)
The present clinical investigation - EarlyExo, is an interventional, international, multicentric, prospective, single-blinded randomized controlled trial.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke, Subacute, Stroke Hemorrhagic
- Trial name
- EarlyExo (NCT06107010)
- Testing
- Use of the Atalante exoskeleton
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 66 people
- Sponsor
- Wandercraft
Stroke Acute
Adjuvant Cerebroprotection Using Normobaric Hyperoxia in Pre-hospital Patients with Suspected Stroke
The primary objective of this study is to determine the efficacy and safety of inhaled normobaric hyperoxia therapy (NBO) beginning in the pre-hospital setting in patients with suspected acute cerebral ischemia (ACI) due to large…
- Trial name
- AN-O2-EMS (NCT06801457)
- Testing
- NBO, Control
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Capital Medical University
Stroke, Acute Ischemic, Blood-Brain Barrier
The Efficacy and Safety of Y-3 Intracalvariosseous Injection Versus Intravenous Injection in the Treatment of Acute Large Hemispheric Infarction
A pilot study confirmed the feasibility and safety of neuroprotectant Y-3 intracalvariosseous(ICO) injection in patients with malignant middle cerebral artery infarction (mMCAI), showing a trend in improving 90-day functional…
- Trial name
- SOLUTION-2 (NCT06374667)
- Testing
- Y-3 ICO injection, Y-3 intravenous injection, Conventional treatment
- Where
- 6 sites in China
- Volunteers
- 134 people
- Sponsor
- yilong Wang
Acute Ischemic Stroke, Large Vessel Occlusion
Acute Ischemic Stroke EndoVascular Therapy: a Multicenter REGISTRY Study
A Multicenter Registry of Endovascular Treatment for Acute Ischemic Stroke.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Thrombosis
- Trial name
- NCT05864638
- Testing
- Endovascular treatment
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Changhai Hospital
Acute Ischemic Stroke
Plaque Imaging in Routine Care to Detect Intraplaque Hemorrhage
The aim of this study is to investigate the association between intraplaque hemorrhage (IPH) detected by non-contrast magnetic resonance imaging (MRI) of the carotid artery in routine clinical practice and ipsilateral acute…
- Trial name
- PARADE (NCT06749106)
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Acute Ischemic Stroke, Large Vessel Occlusion
Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment
The goal of this clinical trial is to learn if semaglutide works to treat acute ischemic stroke (AIS). It will also learn about the safety of semaglutide in AIS.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Neuroprotective Drugs, Endovascular Treatment
- Trial name
- GALLOP2 (NCT06788626)
- Testing
- Semaglutide 0.5 mg, Standard medical treatment
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Wei Hu
Acute Ischemic Stroke
CompARing Between CO2 Phenylephrine and Phenylephrine Only Treatment in Patients With proGrEssing Cerebral infarctioN
Progressing stroke is associated poor functional outcome and neurological deficit. Currently, no treatment for progressing stroke is recommended on the guideline. Carbogen is a mixture of 5% CO2 with 95% O2.
- Trial name
- NCT06770426
- Testing
- carbogen with or without phenyleprhine, phenylephrine
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke AIS
Palmitoylethanolamide and Luteolin in Patients with Acute Ischemic Stroke
Acute ischemic stroke is caused by reduced blood supply to the brain associated with neuroinflammation. This mechanism contributes to acute neuronal death and persists even after reopening of the closed vessel, with consequent…
- Trial name
- NCT06777680
- Testing
- co-ultramicronized Palmitoylethanolamide + Luteolin (770 mg), Thrombectomy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Ospedali Riuniti Trieste
Stroke, Stroke, Acute
Data Collection of Patients Admitted to the Stroke Unit
The purpose of this prospective observational study is to create a database in which data will be collected from every patient admitted to the Stroke unit and who has explicitly given his or her informed consent for this data…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- PRODA-STROKE (NCT04956185)
- Where
- Belgium
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Ghent
Stroke, Acute, Stroke, Ischemic
Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine
PRESSURE is a multicenter, prospective, randomized, open, blinded end-point assessed (PROBE) trial, that aims to evaluate the efficacy and safety of drug-induced hypertension using peripheral dilute norepinephrine, in patients…
- Trial name
- PRESSURE (NCT06059144)
- Testing
- Peripheral intravenous norepinephrine
- Where
- France
- Volunteers
- 358 people
- Sponsor
- University Hospital, Bordeaux
Acute Ischemic Stroke
Intra-arterial Hypothermic Magnesium Sulfate Infusion in Combination with Endovascular Thrombectomy in Acute Ischemic Stroke
The primary objective of this study is to estimate the safety of intra-arterial hypothermic magnesium sulfate infusion after endovascular thrombectomy in patients with acute ischemic stroke
- Trial name
- Hypo-Mag (NCT06760195)
- Testing
- Intra-arterial hypothermic magnesium sulfate infusion, Endovascular thrombectomy, Intravenous thrombolysis
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Capital Medical University
Stroke, Stroke Acute
Research on the Effectiveness of Neurorehabilitation After Stroke
This clinical trial aims to investigate the effectiveness of a novel neurorehabilitation technology for treating stroke in adults.
- Conditions
- Stroke, Stroke Acute, Stroke with Hemiparesis, Stroke, Acute
- Trial name
- NCT06753006
- Testing
- Neurorehabilitation simulator, Standard course
- Where
- Russia
- Volunteers
- 44 people
- Sponsor
- Neurotechnika
Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease
Testing of a System for Remote Ischemic Conditioning in Cerebral Small Vessel Disease and Pre-hospital Stroke Care
This early phase trial will address the following key objectives: 1. Completion of initial safety and tolerability testing of our viable prototype for remote ischemic conditioning (RIC) with patients with (a) CSVD and (b) acute…
- Conditions
- Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease, Ischemic Stroke, Vascular Cognitive Impairment
- Trial name
- TRIC-SVD (NCT05967728)
- Testing
- Remote ischemic conditioning (RIC) progammable device
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Acute Ischemic Stroke
Study on Hibernation-like Therapy Based on Mechanical Thrombectomy
The goal of this clinical trial is to learn whether chlorpromazine and promethazine（C+P）is safe in Acute Ischemic Stroke（AIS) patients and determine the maximum dosage.
- Trial name
- CHILL-1 (NCT06663631)
- Testing
- chlorpromazine and promethazine, endovascular thrombectomy, rt-PA
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke, Endovascular Thrombectomy
A Multicenter, Randomized Controlled Clinical Investigation to Evaluate the Safety and Effectiveness of the Super-Bore 8/7F Aspiration Catheters in the Treatment of Acute Intracranial Large Vessel Occlusion
To Evaluate the Safety and Efficacy of the Super-Bore 8/7F Thrombosis Aspiration Catheter in the Treatment of Acute Intracranial Large Vessel Occlusion.
- Trial name
- NCT06559475
- Testing
- Super-Bore Thrombosis Aspiration Catheter treatment group, Conventional thrombectomy device treatment group
- Where
- China
- Volunteers
- 360 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Stroke, Stroke Acute
Accelerating Referral for Thrombectomy in Acute Stroke Patients Using an Artificial Intelligence-based Software
The goal of this clinical trial is to learn if an AI-based imaging software, Methinks Stroke Suite, can reduce the time to transfer stroke patients who need thrombectomy from local stroke centers to specialized centers.
- Conditions
- Stroke, Stroke Acute, Ischemic Stroke, Acute, Thrombectomy
- Trial name
- CATalyze-AI (NCT06741332)
- Testing
- Methinks software, Normal CT scans evaluation
- Where
- 2 sites in Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Large Vessel Occlusion, Stroke Acute
Rescue Stenting and Intravenous Thrombolysis In Patients With Large Vessel Ischemic Stroke
Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are the standard of care for treating selected patients with acute large-vessel occlusion stroke (LVOS).
- Conditions
- Large Vessel Occlusion, Stroke Acute, Thrombolysis, Rescue Stenting
- Trial name
- STARS (NCT06727006)
- Where
- 7 sites in Italy
- Volunteers
- 400 people
- Sponsor
- ASST Santi Paolo e Carlo