Clinical trials: Acute Stroke
Acute Cerebrovascular Accident, Cerebral Edema
Histamine Glutamate Antagonism in Stroke
Stroke is the 4th leading cause of death in United States with an estimated 1 death every 4 minutes. On average, someone suffers from stroke in United States every 40th second. Stroke recurs in 1 out of 4 stroke patients.
- Trial name
- NCT02142712
- Testing
- Diphenhydramine, Pantoprazole, Famotidine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Ischemic Stroke, Acute Stroke
The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System
The trial is designed to assess the safety and efficacy of using the Zoom Reperfusion System in subjects diagnosed with acute ischemic stroke and undergoing a thrombectomy procedure within 8 hours of last known well.
- Trial name
- NCT04129125
- Testing
- Zoom Reperfusion System
- Where
- 28 sites in United States
- Volunteers
- 328 people
- Sponsor
- Imperative Care, Inc.
Stroke
Stroke Team Remote Evaluation Using a Digital Observation Camera
The purpose of this trial is to determine if an experimental remote video camera system is an effective way for a stroke specialist to evaluate stroke patients from a distant site.
- Trial name
- STRokE DOC (NCT00283868)
- Where
- 4 sites in United States
- Volunteers
- 234 people
- Sponsor
- University of California, San Diego
Acute Coronary Syndrome
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome
This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death…
- Trial name
- AEGIS-II (NCT03473223)
- Testing
- Apolipoprotein A-I [human] (apoA-I)
- Where
- 903 sites in United States, Argentina and 47 more
- Volunteers
- 18,226 people
- Sponsor
- CSL Behring
Feeding Tube
Self-Propelled Versus Standard Percutaneous Endoscopic Gastrojejunostomy(PEG-J); RCT
Our main hypothesis is that self-propelled Percutaneous Endoscopic Gastrojejunostomy tube (PEG-J) that has a balloon on it's tip is associated with lower J-tube retrograde migration rate, and lower rates of short- and long-term…
- Trial name
- NCT01892267
- Testing
- PEG-J placement
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Stroke, Acute, Hyperglycemia
Pioglitazone Treatment for Hyperglycemic Acute Ischemic Stroke
Study objective is to determine whether Pioglitazone (PGZ) can improve clinical outcomes in hyperglycemic acute ischemic stroke (IS).
- Conditions
- Stroke, Acute, Hyperglycemia, Diabetes
- Trial name
- NCT04123067
- Testing
- Pioglitazone 45 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Milton S. Hershey Medical Center
Stroke, Ischemic
Neuroprotection in Acute Ischemic Stroke
This is a pilot randomized control trial (RCT) to explore the possible beneficial effect of a novel combination therapy consisting of molecular hydrogen H2 plus minocycline ("H2M"), on neurological recovery after acute ischemic…
- Trial name
- H2M (NCT03320018)
- Testing
- Hydrogen, Minocycline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stony Brook University
Acute Ischemic Stroke
Multi-arm Optimization of Stroke Thrombolysis
The primary efficacy objective of the MOST trial is to determine if argatroban (100µg/kg bolus followed by 3µg/kg per minute for 12 hours) or eptifibatide (135µg/kg bolus followed by 0.75µg/kg/min infusion for two hours) results…
- Trial name
- MOST (NCT03735979)
- Testing
- Argatroban, Eptifibatide
- Where
- 61 sites in United States
- Volunteers
- 514 people
- Sponsor
- Washington University School of Medicine
Stroke, Acute
Efficacy and Safety of Trans Sodium Crocetinate (TSC) for Treatment of Suspected Stroke
This study will assess the potential efficacy and safety of TSC as early treatment for both ischemic and hemorrhagic stroke when administered while subject is in ambulance being transported to hospital.
- Trial name
- PHAST-TSC (NCT03763929)
- Testing
- Trans-Sodium Crocetinate
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Diffusion Pharmaceuticals Inc
Acute Ischemic Stroke, Biofeedback
Effects of Biofeedback in Patients With Acute Cerebral Infarction
The major aim of this study is to investigate the effects of biofeedback assisted abdominal breathing training on improving the psychological and physiological distress in patients with ACI.
- Conditions
- Acute Ischemic Stroke, Biofeedback, Autonomic Dysfunction, Cognitive Function, Psychological Distress
- Trial name
- NCT03516227
- Testing
- heart rate variability biofeedback
- Volunteers
- 40 people
- Sponsor
- National Defense Medical Center, Taiwan
Ischemic Stroke
Comparative Effectiveness of Rehabilitation Services for Survivors of Acute Ischemic Stroke
Retrospective analysis of Get With the Guidelines-Stroke data linked with Medicare claims and the AVAIL longitudinal data sets to assess patterns, predictors, and outcomes associated with the use of rehabilitation services…
- Trial name
- NCT02284165
- Testing
- retrospective analysis
- Where
- United States
- Volunteers
- 164,246 people
- Sponsor
- Duke University
Stroke, Acute
Harmony Scapulohumeral Rhythm (SHR) Reliability and Efficacy Study
The purpose of this study is to assess the safety, reliability, and efficacy of the use of the Harmony Scapulohumeral Rhythm (SHR) upper extremity robotic rehabilitation system for persons with impaired functional use of one or…
- Trial name
- NCT05251077
- Testing
- Harmony SHR, Traditional Occupational Therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Shirley Ryan AbilityLab
Acute Ischemic Stroke
SELECT2: A Randomized Controlled Trial to Optimize Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke
SELECT 2 evaluates the efficacy and safety of endovascular thrombectomy compared to medical management alone in acute ischemic stroke patients due to a large vessel occlusion in the distal ICA and MCA M1 who have large core on…
- Trial name
- SELECT2 (NCT03876457)
- Testing
- Endovascular Thrombectomy, Medical Management
- Where
- 31 sites in United States, Australia and 4 more
- Volunteers
- 352 people
- Sponsor
- University Hospitals Cleveland Medical Center
Stroke, Acute Stroke
Inflammation and Post-Stroke Depression
This study is being done to see if there is a relationship between stroke, post-stroke depression, and measures of inflammatory and/or stress compounds in the blood.
- Trial name
- NCT02368145
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Alexander Kusnecov, Ph.D.
Intracerebral Hemorrhage, Stroke
The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial
The purpose of this academic lead study is to determine if a treatment strategy of early intensive blood pressure (BP) lowering compared to conservative BP lowering policy in patients with elevated blood pressure within 6 hours…
- Conditions
- Intracerebral Hemorrhage, Stroke, Hypertension
- Trial name
- INTERACT2 (NCT00716079)
- Testing
- Blood pressure management policies
- Where
- 62 sites in United States, Argentina and 17 more
- Volunteers
- 2,839 people
- Sponsor
- The George Institute
Acute Stroke, Brain Ischemia
The Capillary Index Score Trial
This study seeks to investigate the capillary index score (CIS) to further improve patient selection of endovascular treatment (EVT) in acute ischemic stroke (AIS).
- Conditions
- Acute Stroke, Brain Ischemia, Ischemic Stroke
- Trial name
- NCT02618031
- Testing
- Endovascular Treatment (EVT)
- Where
- 6 sites in United States
- Volunteers
- 57 people
- Sponsor
- Firas Al-Ali
Stroke, Ischemic
A Study of the Use of the Q Aspiration Catheter to Remove Clot in Stroke Patients
The purpose of this study is to collect real-world safety and performance data on the MIVI Neuroscience, Inc. Q Aspiration Catheter for use in the removal of fresh, soft emboli and thrombi in the neurovascular system during acute…
- Trial name
- TAPAS (NCT04089917)
- Testing
- Q Aspiration Catheter
- Where
- 4 sites in Spain
- Volunteers
- 45 people
- Sponsor
- MIVI Neuroscience, Inc.
Cerebrovascular Accident
EARLY 3-months Aggrenox Treatment Started Within 24 Hrs of Ischemic Stroke Onset vs. After One Week 100 mg ASA
German stroke units are hesitating to use Aggrenox for secondary ischaemic stroke / transient ischaemic attack (TIA) prevention in a sub-acute treatment setting.
- Trial name
- NCT00562588
- Testing
- Aggrenox bid (ASA 25mg/Dipyridamole ER 200mg), ASA 100 mg qd
- Where
- Germany
- Volunteers
- 551 people
- Sponsor
- Boehringer Ingelheim
Arterial Ischemic Stroke
A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)
The primary study objective is to assess the safety of afamelanotide while the secondary objective is to assess whether the therapy affects the size of the penumbra, by increasing blood flow, restoring oxygen supply to the brain…
- Trial name
- NCT04962503
- Testing
- Afamelanotide
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Acute Ischemic Stroke, Transient Ischemic Attack (TIA)
A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel
The purpose of this clinical study is to determine whether the addition of an oral Factor XIa Inhibitor to Aspirin and Clopidogrel is more effective than standard therapy in secondary stroke prevention.
- Trial name
- AXIOMATIC-SSP (NCT03766581)
- Testing
- BMS-986177, Clopidogrel, Aspirin
- Where
- 424 sites in United States, Argentina and 27 more
- Volunteers
- 2,366 people
- Sponsor
- Bristol-Myers Squibb