Clinical trials: Acute Upper Gastrointestinal Bleeding
Gastrointestinal Hemorrhage
Bipolar Hemostatic Forceps Versus Standard Therapy in Acute Non-variceal Upper GI Bleeding
Bipolar hemostatic forceps will be tested against standard therapy in active, non-variceal, upper gastrointestinal bleeding by a prospective, randomized trial
- Trial name
- BeBop (NCT05353062)
- Testing
- Hemostatic therapy, Endoscopic therapy with hemoclip +/- injection of epinephrine solution
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Non-variceal Upper Gastrointestinal Bleeding
Keverprazan vs Pantoprazole for the Treatment of ANVUGIB
Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is a common medical emergency requiring hospitalization. The cornerstone of ANVUGIB management is effective gastric acid suppression.
- Trial name
- NCT07776730
- Testing
- Pantoprazole, Keverprazan
- Where
- China
- Volunteers
- 908 people
- Sponsor
- General Hospital of Shenyang Military Region
Acute Myocardial Infarction
Evaluation of C13 Breath Test for Upper Gastrointestinal Bleeding in Patients Who Need Double Antiplatelet After PCI
Hp infection is closely related to upper gastrointestinal bleeding in patients who need dual-antiplatelet after PCI. Taking anti-Hp treatment has the effect of reducing bleeding risk.
- Trial name
- NCT04012801
- Testing
- C13 breath test
- Volunteers
- 1,500 people
- Sponsor
- Chongqing Medical University
Acute Gastrointestinal Bleeding
Safety and Efficacy of Prophylactic Arterial Embolization in the Treatment of Angiography-negative Acute Upper Gastrointestinal Bleeding
Guided by clinical problems, this study focused on the problems encountered in clinical practice, with the interventional treatment of emergency gastrointestinal bleeding as the breakthrough point, and focused on the dilemma of…
- Trial name
- NCT05550649
- Testing
- embolization
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Acute Upper Gastrointestinal Bleeding, Capsule Endoscopes
Detachable String Magnetically Controlled Capsule Endoscopy for Patients with AUGIB
Use CE for pre-examination of patients with AUGIB symptoms in emergency centers may reduce the need for emergency electronic gastroscopy and have certain advantages in clinical work.
- Trial name
- NCT06725056
- Testing
- DS-MCE and EGD examinations
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Coronary Artery Disease, Percutaneous Coronary Intervention
Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy
The primary aim of this study is to evaluate the efficacy and safety of novel P-CAB (tegoprazan 50 mg once daily) as compared with standard PPI (rabeprazole 20 mg once daily) for protection of GI events in patients with known…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- PROTECT-HBR (NCT04416581)
- Testing
- PPI, P-CAB 50
- Where
- 45 sites in South Korea
- Volunteers
- 3,320 people
- Sponsor
- Duk-Woo Park, MD
Upper Digestive Bleeding, Cirrhosis
Efficacity and Safety of Tranexamic Acid in Cirrhotic Patients Presenting With Acute Upper Gastrointestinal Bleeding
Upper digestive bleeding. Upper gastrointestinal haemorrhage is a common cause of decompensated cirrhosis and is associated with a high mortality rate among cirrhotic patients.
- Trial name
- EXARHOSE (NCT03023189)
- Testing
- Tranexamic acid
- Where
- 3 sites in France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Upper GI Bleeding
Detection of Blood in the GI Lumen With HemoPill Acute
The goal of this clinical trial is to learn if the HemoPill acute (trial device) can detect the presence of blood in participants suspected of having upper gastrointestinal bleeding.
- Trial name
- DIRECT (NCT07868068)
- Testing
- HemoPill acute
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stony Brook University
Acute Coronary Syndrome
Relationship of Helicobacter Pylori Eradication Therapy and Long-term Outcome in Acute Coronary Syndrome
Objective: To investigate the relationship between Helicobacter pylori (Hp) infection and the prognosis of acute coronary syndrome (ACS) in a Chinese population and to explore the significance of Hp eradication therapy in…
- Trial name
- NCT02317445
- Volunteers
- 472 people
- Sponsor
- Capital Medical University
Volatile Organic Compound, Gastrointestinal Hemorrhage
Rapid Diagnostic Technology for AUGIB Based on Analysis of VOCs in Exhaled Breath
This study aims to develop a non-invasive and rapid diagnostic technology for acute upper gastrointestinal bleeding (AUGIB) by analyzing volatile organic compounds (VOCs) in exhaled breath.
- Trial name
- VOCsAUGIB (NCT06877507)
- Testing
- Gastroscopy, Gas Chromatography - Mass Spectrometry
- Volunteers
- 200 people
- Sponsor
- Beijing 302 Hospital
Acute Non-variceal Upper Gastrointestinal Hemorrhage, Coronary Heart Disease
Timing of Endoscopy in Coronary Heart Disease Patients Taking Antiplatelet Drugs With Acute Non-variceal Upper Gastrointestinal Bleeding
This is a prospective randomized controlled trial (RCT) evaluating the optimal timing of endoscopy in patients with coronary heart disease who are taking antiplatelet drugs and present with acute non-variceal upper…
- Trial name
- PACT-UGIB (NCT07507162)
- Testing
- Urgent Endoscopy (Within 12 Hours of Admission), Early Endoscopy (12-24 Hours After Admission)
- Volunteers
- 212 people
- Sponsor
- Beijing Anzhen Hospital
Acute Upper Gastrointestinal Hemorrhage
Tranexamic Acid for Upper Gastrointestinal Bleeding
This study is to see whether the early intravenous administration of tranexamic acid improves the outcome of acute upper gastrointestinal bleeding.
- Trial name
- TAUGIB (NCT01713101)
- Testing
- Early intravenous tranexamic acid administration
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Seoul National University Hospital
Acute Upper Gastrointestinal Hemorrhage
Endoscopic Treatment of Recurrent Upper GI Bleeding: OTSC [Over the Scope Clip] Versus Standard Therapy
Prospective-randomized trial. Patients with recurrent bleeding from gastroduodenal ulcers are randomized into either endoscopic treatment with the OTSC [Over The Scope Clip] or endoscopic standard therapy.
- Trial name
- STING (NCT01836900)
- Testing
- Endoscopic hemostasis
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Upper Gastrointestinal Bleeding (UGIB)
Evaluation of ClearPlasma in Patients With Upper Gastrointestinal Bleeding.
Upper gastrointestinal hemorrhage (UGIH) is one of the most common gastrointestinal emergencies, and is associated with significant morbidity and mortality. Plas-Free aims to evaluate ClearPlasma safety in patients with UGIH.
- Trial name
- CLearPlasma (NCT06761430)
- Testing
- ClearPlasma
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- PlasFree Ltd.
Acute Upper Gastrointestinal Bleeding, Tumor Bleeding
Over-the-scope Clips and Standard Treatments in Endoscopic Control of Acute Bleeding From Non-variceal Upper GI Causes
In the management of patients with acute upper gastrointestinal bleeding from non-variceal causes, endoscopic treatment and acid suppression are now the standard of care.
- Trial name
- NCT03216395
- Testing
- Over-the-scope Clips, Hemo-clipping, thermo-coagulation
- Where
- 8 sites in Australia, China and 1 more
- Volunteers
- 191 people
- Sponsor
- Chinese University of Hong Kong
Cirrhosis, Liver, Acute Upper Gastrointestinal Hemorrhage
Risk Assessment After Acute Upper Gastrointestinal Haemorrhage in Cirrhosis
In previous studies, the investigators used retrospective analysis of cases of acute upper gastrointestinal bleeding in patients with liver cirrhosis from the Fifth Medical Center of the General Hospital of Beijing PLA, China…
- Trial name
- NCT04235166
- Testing
- Current risk scores, New risk scores
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Cirrhosis, Liver, Upper Gastrointestinal Bleeding
Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding
The investigators studied the renal function index level in terlipressin treated cirrhotic patients with upper-gastrointestinal bleeding at different time point.
- Trial name
- NCT04358016
- Testing
- Terlipressin, Somatostatin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Changhai Hospital
Acute Upper Gastrointestinal Hemorrhage, Cirrhosis
Timing of Endoscopic Intervention for Acute Variceal Hemorrhage: an RCT
Acute variceal upper gastrointestinal hemorrhage remains a hot potato in cirrhotic patients. The purpose of this study is to figure out whether urgent endoscopy (within 6h after gastroenterological consultation) is superior to…
- Conditions
- Acute Upper Gastrointestinal Hemorrhage, Cirrhosis, Varice Bleed, Gastroesophageal Varices
- Trial name
- TEACH (NCT04786743)
- Testing
- endoscopic intervention
- Where
- 4 sites in China
- Volunteers
- 412 people
- Sponsor
- Jinling Hospital, China
AUGIB, Gastrointestinal Bleeding
The First Acute Upper Gastrointestinal Bleeding (AUGIB) Audit in the Greater Bay Area (GBA) of China
Investigators aim to conduct a large-scale, prospective cohort study in the Greater Bay Area of South China. Investigators aim to identify consecutive patients with AUGIB in the area over a 2-month period in the second quarter of…
- Trial name
- AUGIB Audit (NCT06659783)
- Where
- 40 sites in China, Hong Kong
- Volunteers
- 4,534 people
- Sponsor
- Chinese University of Hong Kong
Liver Cirrhosis
Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis
The management of acute upper gastrointestinal bleeding (UGIB) is challenging in patients with cirrhosis, as it is responsible for severe complications and high mortality rates.
- Trial name
- NCT04489108
- Testing
- Tranexamic acid, Standard Medical Treatment
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Institute of Liver and Biliary Sciences, India