Clinical trials: Acute Wound
Acute Lung Injury, Acute Respiratory Distress Syndrome
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
sRAGE, the soluble form of the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, but is also involved in acute systemic inflammation.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Severe Sepsis, Septic Shock
- Trial name
- NCT00811629
- Testing
- sRAGE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
End Stage Renal Disease, Acute Kidney Injury
Immunomodulatory Biomimetic Device to Treat Myocardial Stunning in End-stage Renal Disease Patients
Hemodialysis is a therapy that filters waste, removes extra fluid and balances electrolytes. In hemodialysis, blood is removed from the body and filtered through a man-made membrane called a dialyzer, and then the filtered blood…
- Conditions
- End Stage Renal Disease, Acute Kidney Injury, Chronic Kidney Disease Stage 5
- Trial name
- ESRD (NCT03539861)
- Testing
- Hemodialysis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Ankle Sprain
Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain
To demonstrate the therapeutic efficacy of a generic diclofenac epolamine patch against Flector patch in the treatment of pain in subjects with minor ankle sprain
- Trial name
- NCT02324270
- Testing
- Diclofenac epolamine
- Where
- 31 sites in United States
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Fracture of Shaft of Humerus
Acute Management of Humeral Shaft Fractures: Sling vs. Splint
When people break their arm and arrive at Oregon Health and Science University's Emergency Department (OHSU ED), they are treated with a short-term means of immobilizing their broken arm.
- Trial name
- NCT01869322
- Testing
- Sling and Swathe, Coaptation Splint
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Aki After Ascending Aortic Surgeries
Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries
Acute kidney injury (AKI) is a frequent and serious complication after ascending aortic surgeries requiring cardiopulmonary bypass (CPB).
- Trial name
- NCT06958367
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Spinal Cord Injuries
Spinal Cord Stimulation for Autonomic Recovery in Inpatient Rehabilitation After Acute SCI
This study is a randomized, single-blind, two-arm sham-controlled clinical trial to evaluate the safety and efficacy of transcutaneous spinal cord stimulation (tSCS) over the lower thoracic and upper lumbar spinal cord segments…
- Trial name
- NCT06540859
- Testing
- Transcutaneous Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Washington
Chemical Injury, Chemicals; Intoxication
The Medical Management in Patients Exposed to Weapons of Mass Destruction
Observation study measuring medical response in contaminated environment.
- Conditions
- Chemical Injury, Chemicals; Intoxication, Acute Respiratory Distress Syndrome, Distress Respiratory Syndrome
- Trial name
- CBRNEObs (NCT05026645)
- Testing
- Clinical interventions performed in acute settings (contaminated environment), Protection (clinician and patient), Decontamination (clinician and patient)
- Where
- 15 sites in United States, Canada and 4 more
- Volunteers
- 1,000 people
- Sponsor
- St. Justine's Hospital
Goal-directed Fluid Therapy
Goal Directed Fluid Therapy Guided Fluid Management in Pneumoresection
Perioperative fluid management is a key component of anesthetic management during thoracic surgery. On one hand, fluid restriction could compromise perfusion of vital organs and surgical anastomosis.
- Trial name
- NCT03237351
- Testing
- Fluid therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ZhiHeng Liu
Acute Kidney Injury
Acute Kidney Injury Biomarkers: Diagnosis and Application in Pre-operative Period of Liver Transplantation
Acute kidney injury (AKI), is a common complication of patients undergoing liver transplantation. Timing and definition of AKI, usually based on serum creatinine, have been inaccurate and inconsistent.
- Trial name
- AKIB (NCT02095431)
- Where
- Brazil
- Volunteers
- 122 people
- Sponsor
- University of Sao Paulo
Acute Respiratory Distress Syndrome
Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)
Numerous trials support the efficacy and safety of volatile anesthetic agents, namely inhalation of sevoflurane through dedicated devices, for the sedation of ICU patients.
- Trial name
- SEGA (NCT02166853)
- Testing
- sevoflurane, midazolam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Kidney Injury
Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension
The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it
- Trial name
- NCT01554345
- Testing
- vitamin E +Selenium
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Pain, Acute, Rib Fractures
Mid-point to Pleura Transverse Process Block Versus Thoracic Intervertebral Foramen Block
The analgesic effect of continuous mid-point to pleura transverse process block compared to the analgesic effect of continuous thoracic intervertebral foramen block, in patients with multiple rib fractures.
- Conditions
- Pain, Acute, Rib Fractures, Polytrauma
- Trial name
- NCT05348330
- Testing
- Thoracic intervertebral foramen block, Mid-point to pleura transverse process block
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Acute Kidney Injury, Pediatric Cardiac Surgery
The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery
The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following…
- Trial name
- NCT06710353
- Testing
- Albumin solution, Crystalloid solutions
- Where
- South Korea
- Volunteers
- 190 people
- Sponsor
- Seoul National University Hospital
Whiplash Injuries
Manual Therapy Dosage Factorial Study
This study will determine biological responses to different dosages of neck mobilization intervention in patients, providing opportunities to identify the optimal dosage, predictors of response, outcome measures as well as the…
- Trial name
- NCT00560807
- Testing
- Mobilization
- Where
- Canada
- Sponsor
- McMaster University
Disorder of Consciousness
Hydrocephalus Treatment on Persistent Disorder of Consciousness
After acute brain injury or haemorrhagic stroke, hydrocephalus might participate to consciousness disorder. We plan to explore whether ventriculoperitoneal shunt insertion improves consciousness in patients with vegetative or…
- Trial name
- HYCO (NCT05219331)
- Testing
- Ventriculoperitoneal shunt
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Acute Renal Injury
Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans
Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.
- Trial name
- NCT05186636
- Testing
- KPI reports, Prescriber reports
- Where
- 15 sites in Canada
- Volunteers
- 9,348 people
- Sponsor
- University of Alberta
Strains
Acute Hamstring Strains in Danish Elite Soccer - Prevention and Rehabilitation
A common soft tissue injury in sports involving sprinting and jumping is the hamstring strain. Not much evidence-based research has been carried out on prevention of hamstring strains.
- Trial name
- NCT00557050
- Testing
- Training
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Amager Hospital
Diaphragm Injury, Pathology
Effects of Mechanical Ventilation on the Diaphragm in COVID-19 Intensive Care Patients. A Post-mortem Pathology Study
The diaphragm is the fundamental muscle of the respiratory system. The diaphragmatic dysfunction is present in 60% of critical patients at hospital admission and up to 80% after prolonged mechanical ventilation and difficult…
- Conditions
- Diaphragm Injury, Pathology, COVID-19 Acute Respiratory Distress Syndrome, Ventilation Therapy; Complications
- Trial name
- NCT05191433
- Where
- 2 sites in Italy
- Volunteers
- 41 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Acute Kidney Injury
Ultra-Low Contrast Angiography in AKI
The aim of this study is to evaluate the safety of ultra-low contrast coronary angiography in patients with pre-existing acute kidney injury.
- Trial name
- NCT05906758
- Testing
- Angiography
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Tulane University
Acute Kidney Injury
The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study
Acute kidney injury (AKI) in the intensive care unit is common, devastating and costly. However, minimal evidence exists to guide the prescription of optimal renal replacement therapy (RRT).
- Trial name
- OMAKI (NCT00675818)
- Testing
- Continuous venvenous hemofiltration (CVVH), Continuous venovenous hemodialysis (CVVHD)
- Where
- 5 sites in Canada
- Volunteers
- 78 people
- Sponsor
- Unity Health Toronto