Clinical trials: Acute-Phase Reaction
Acute Phase Response
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery
The purpose of the proposed study is to test these hypotheses through the following aims: 1. To determine if early plasmin activation following severe injury correlates with SIRS, TIC and complications throughout convalescence in…
- Trial name
- NCT03741023
- Testing
- Blood draw (venipuncture or fingerstick)
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Periodontal Diseases, Obesity
Acute-phase Response & Periodontal Treatment in Obese Patients
The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in terms of acute-phase responses following no surgical periodontal treatment in obese patients affected by…
- Trial name
- PERIO-OBESE (NCT03122977)
- Testing
- FM-SRP, Q-SRP
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Pisa
Ketosis, Acute-Phase Response
Metabolic Effects of Whey Protein Supplementation After Fasting in Volunteers
This study aims to investigate the early metabolic effects and acute phase response of an oral clear supplement containing whey protein plus carbohydrates in young healthy volunteers during fasting-induced organic response
- Conditions
- Ketosis, Acute-Phase Response, Insulin Resistance
- Trial name
- NCT05656339
- Testing
- CHO+WP, CHO, Fast
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Mato Grosso
Infective Endocarditis, Response, Acute Phase
Personalized Medicine in Patients With Infective Endocarditis
The hypothesis underlying this work is the identification of different sub phenotypes of patients with infective endocarditis through the study of the host's response to infection.
- Conditions
- Infective Endocarditis, Response, Acute Phase, Treatment
- Trial name
- NCT04838938
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Kidney Failure, Chronic
Isoflavones and Acute-phase Response in Chronic Renal Failure
This is a randomized, double-blinded dietary intervention in hemodialysis patients to determine the clinical and metabolic effects of soy isoflavones on disease activity, including improvement of blood markers of acute-phase…
- Trial name
- NCT00029796
- Testing
- soy isoflavones
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Acute Malaria
Phase IIa Proof of Concept Study of M5717-Pyronaridine in Adults and Adolescents With Acute Uncomplicated Plasmodium Falciparum Malaria (CAPTURE 1)
The purpose of this study was to evaluate the safety, efficacy, and pharmacokinetic of the combination M5717 plus pyronaridine in participants with acute uncomplicated Plasmodium falciparum malaria.
- Trial name
- NCT05689047
- Testing
- M5717 330 mg, M5717 500 mg, M5717 660 mg
- Where
- 5 sites in Burkina Faso, Gabon and 2 more
- Volunteers
- 38 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Drug Reaction to Analgesic Nos
Phase I Pharmacokinetic Study of RX0041-2
This Phase I study is to examine the systemic pharmacokinetics of RX0041-002 following acute, topical, intranasal administration to healthy male and female volunteers.
- Trial name
- NCT02667106
- Testing
- RX0041-2
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharmaceutical Project Solutions, Inc.
COVID-19, Vaccine Reaction
Evaluation of Inactivated Vaccine in Healthy Adults Against Coronavirus Disease of 2019 (COVID-19)
In this phase 1 study, the inactivated virus vaccine National Research Centre (NRC) Vaccine-101 (VACC-101) will be investigated for its safety and immunogenicity in healthy volunteers with the aim of providing effective and safe…
- Conditions
- COVID-19, Vaccine Reaction, Vaccine Adverse Reaction
- Trial name
- NCT05128721
- Testing
- Covi Vax
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Covid19, BCG Vaccination Reaction
Clinical Trial Evaluating the Effect of BCG Vaccination on the Incidence and Severity of SARS-CoV-2 Infections Among Healthcare Professionals During the COVID-19 Pandemic in Poland
Countries that have not carried out universal mass vaccination against tuberculosis (BCG) have been shown to have higher incidence and death rates due to COVID-19 than countries with mass, long-term BCG immunization programmes.
- Conditions
- Covid19, BCG Vaccination Reaction, SARS-CoV Infection
- Trial name
- NCT04648800
- Testing
- BCG-10 vaccine, 0.9% saline
- Where
- 6 sites in Poland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hanna Czajka
Endotoxemia, Sepsis
Low-Dose Endotoxemia and the Acute Phase Response
The purpuse of this study is to examine the acute phase respons when different doses of E. Coli Endotoxin is injected in healty volunters.
- Trial name
- NCT00197899
- Testing
- E. Coli endotoxin
- Where
- Denmark
- Sponsor
- Herlev Hospital
Covid19, SARS-CoV Infection
Immunogenicity, Efficacy and Safety of QazCovid-in® COVID-19 Vaccine
Multicenter, randomized, blind, placebo-controlled clinical study of III phases on the assessment of preventive efficiency, safety and immunogenicity QazCovid-in®-vaccine against COVID-19 in healthy adult volunteers
- Conditions
- Covid19, SARS-CoV Infection, Vaccine Adverse Reaction
- Trial name
- NCT04691908
- Testing
- QazCovid-in®-vaccine against COVID-19
- Where
- Kazakhstan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Research Institute for Biological Safety Problems
Infections, Respiratory, Virus Diseases
A Trial Investigating the Safety and Effects of Four BNT162 Vaccines Against COVID-19 in Healthy and Immunocompromised Adults
Originally, the study was planned to include two parts, i.e., Part A and Part B, however Part B was cancelled due to changes in the overall clinical development plan.
- Conditions
- Infections, Respiratory, Virus Diseases, Infection Viral, Vaccine Adverse Reaction
- Trial name
- NCT04380701
- Testing
- BNT162a1, BNT162b1, BNT162b2
- Where
- 5 sites in Germany
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Acute Graft Versus Host Disease
Multicenter Study Of Natalizumab Plus Standard Steroid Treatment For High Risk Acute Graft-Versus-Host Disease
This research trial is designed to study the safety and effectiveness of combining the study drug, Natalizumab (Tysabri®) with the standard treatment, the use of steroids, as a new treatment for acute graft versus host disease…
- Trial name
- NCT02133924
- Testing
- natalizumab, steroids
- Where
- 12 sites in United States
- Volunteers
- 76 people
- Sponsor
- John Levine
Acute Allergic Reaction, Anaphylaxis
Phase 1 Crossover Study Evaluating the Safety, Tolerability, and Pharmacokinetics of KP001 in Healthy Adult Volunteers
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of several KP001 dose regimens to identify a treatment regimen with a PK profile that safely meets or exceeds the PK profile of…
- Trial name
- NCT06963411
- Testing
- KP001
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kokua Pharma Inc.
Acute Phase Response
Defining the Temporal Changes in the Acute Phase Response During Graded Exercise: A Prospective Study
The purpose of this study is to detail the precise temporal changes in the APR that occur in response to exercise in order to determine the types of exercise that confer maximal reparative fibrinolysis.
- Trial name
- NCT03398304
- Testing
- Graded Exercise, Marathon participation
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Periodontitis, Diabetes
Acute-phase Response & Periodontal Treatment in Diabetes Affected Patients
Thirty-eight periodontitis- and diabetes-affected subjects will be randomly allocated to non surgical periodontal treatment with either Full-Mouth Approach (FM-SRP) or Quadrant approach (Q-SRP).
- Trial name
- PERIO-DIA (NCT03087266)
- Testing
- FM-SRP, Q-SRP
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Pisa
Laparotomy, Laparoscopy
Remote Ischemic Conditioning in Abdominal Surgery
This phase II randomized (1:1) controlled trial will examine the effects of remote ischemic conditioning (RIC) on the outcomes of major abdominal surgery.
- Conditions
- Laparotomy, Laparoscopy, Retroperitoneal Disease, Pelvis Disease
- Trial name
- NCT03234543
- Testing
- Remote ischemic conditioning, No Remote ischemic conditioning
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rutgers, The State University of New Jersey
Confusion, Inflammation
Confusion in the Elderly After Colon Surgery
A study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.
- Conditions
- Confusion, Inflammation, Acute Phase Reaction, Surgery
- Trial name
- NCT01623297
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- New York Hospital Queens
Coronavirus Infection, Endothelial Dysfunction
Microvascular Flow and Reactivity in Patients Presenting in the Acute Phase of COVID-19.
Considering that the intensity of systemic microvascular changes in patients in the acute phase of COVID-19 could be related to disease progression and prognosis, the present cross-sectional and observational study aims to…
- Conditions
- Coronavirus Infection, Endothelial Dysfunction, Microvascular Rarefaction
- Trial name
- NCT04406545
- Testing
- evaluation of skin microvascular flow and reactivity
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Cancer, Diagnosis
Assessing Cancer Treatment Response to Therapy Using 18F-FSPG PET
Prospective single centre non-randomised exploratory observational study to measure changes in tumour cellular redox status with 18F-FSPG PET in stage 3 non-small cell lung cancer (NSCLC) and stage 3 and 4 head and neck squamous…
- Conditions
- Cancer, Diagnosis, Resistant Cancer, Response, Acute Phase
- Trial name
- NCT05889312
- Testing
- 18F-FSPG PET/CT in NSCLC, 18F-FSPG PET/CT in HNSCC
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust