Clinical trials: Acute-graft-versus-host Disease
Breathing Rate
Coherence Breathing Before Cardiopulmonary Exercise Testing
This randomized crossover trial will examine the acute effects of pre-exercise coherence breathing on cardiopulmonary exercise responses in recreationally active adults.
- Trial name
- NCT07650279
- Testing
- Coherence Breathing, Spontaneous Breathing
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Human Performance Lab of Monmouth University
Breast Cancer
Acute Exercise Cardioprotection From Doxorubicin
In rodents, a single bout of exercise prior to injection of a chemotherapy agent used to treat breast cancer prevents or attenuates a number of markers of cardiac injury.
- Trial name
- NCT02006979
- Testing
- exercise
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Gastrointestinal Hemorrhage
Bipolar Hemostatic Forceps Versus Standard Therapy in Acute Non-variceal Upper GI Bleeding
Bipolar hemostatic forceps will be tested against standard therapy in active, non-variceal, upper gastrointestinal bleeding by a prospective, randomized trial
- Trial name
- BeBop (NCT05353062)
- Testing
- Hemostatic therapy, Endoscopic therapy with hemoclip +/- injection of epinephrine solution
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Sepsis, Acute Kidney Injury Due to Sepsis
Urinary Actin, as a Potential Marker of Sepsis-related Acute Kidney Injury
In our study, 17 septic, 43 sepsis-related acute kidney injury and 24 control patients were enrolled. Blood and urine samples were collected at the intensive care unit from acutely diagnosed septic and sepsis-related acute kidney…
- Trial name
- NCT04968262
- Testing
- Sepsis therapy, Sepsis-related acute kidney injury therapy
- Where
- Hungary
- Volunteers
- 84 people
- Sponsor
- University of Pecs
Allogeneic Stem Cell Transplant, Acute Graft Versus Host Disease
Pharmacokinetics of Posaconazole (Noxafil®) as Prophylaxis for Invasive Fungal Infections
This study evaluates the the pharmacokinetics of posaconazole (new solid oral and IV) given as prophylaxis to patients who are at risk for developing fungal infections after receiving conditioning therapy (except strictly…
- Conditions
- Allogeneic Stem Cell Transplant, Acute Graft Versus Host Disease, Acute Myeloid Leucaemia, Myelo Dysplastic Syndrome
- Trial name
- PIRAÑA (NCT02805946)
- Testing
- posaconazole
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 21 people
- Sponsor
- Radboud University Medical Center
Leukemia
Long-term Safety of Dasatinib in Patients With Chronic Myelogenous Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
This study assesses the long-term safety and tolerability of dasatinib administered to patients with chronic myelogenous leukemia or Philadelphia chromosome positive acute lymphoblastic leukemia and experienced clinical benefit…
- Trial name
- START rollover (NCT00982488)
- Testing
- Dasatinib, Imatinib
- Where
- 72 sites in United States, Argentina and 22 more
- Volunteers
- 238 people
- Sponsor
- Bristol-Myers Squibb
Cirrhosis and Chronic Liver Disease
Predictors of Decompensation, Acute-on-chronic Liver Failure and Mortality in Liver Cirrhosis
The purpose of this study is to identify factors that predict the development of decompensation, acute-on-chronic liver failure (ACLF) and death in patients with liver cirrhosis.
- Trial name
- SoLiDaRity (NCT07438288)
- Testing
- Observation
- Where
- 3 sites in Singapore
- Volunteers
- 2,200 people
- Sponsor
- Singapore General Hospital
Acute Kidney Injury
Dialysis Weaning in Intensive Care Units (Dialysis STOP)
Evaluation of daily urinary urea excretion, to guide Renal Replacement Therapy weaning, in Intensive Care Units. The objective is to show that remove the dialysis catheter, once daily urinary urea excretion is greater than 1.35…
- Trial name
- D-STOP (NCT03763188)
- Testing
- Use of daily urinary urea excretion
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Dr Alexandre Gros
Acute Ischemic Stroke
Effect of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation in Patients With Intravenous Thrombolysis (SRICDCA-IVT)
The purpose of this study is to determine the effect of serial remote ischemic conditioning on dynamic cerebral autoregulation in patients with intravenous thrombolysis with alteplase.
- Trial name
- SRICDCA-IVT (NCT05550103)
- Testing
- Remote ischemic conditioning, Standard medical treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yi Yang
Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
JNJ-40346527 in Treating Participants With Relapsed or Refractory Acute Myeloid Leukemia
This phase II trial studies how well edicotinib (JNJ-40346527) works in treating participants with acute myeloid leukemia that has come back or does not respond to treatment.
- Trial name
- NCT03557970
- Testing
- Edicotinib, Pharmacokinetic Study
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- OHSU Knight Cancer Institute
Acute Heart Failure, Diuretic Resistance
Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance
The P-VALUE-AHF trial is a multicenter, randomized, open-label, parallel-group trial on the diuretic and decongestive effects of different diuretic escalation strategies in patients with acute heart failure and diuretic…
- Trial name
- P-Value-AHF (NCT05986773)
- Testing
- Furosemide, Metolazone, Acetazolamide
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- Stadtspital Zürich
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Methods of T Cell Depletion Trial (MoTD)
A multi-centre phase II trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin vs. Calcineurin inhibitor or Sirolimus-based post-transplant cyclophosphamide.
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes
- Trial name
- MoTD (NCT04888741)
- Testing
- Thymoglobulin, Cyclophosphamide, Cyclosporine
- Where
- 17 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- University of Birmingham
Acute Mountain Sickness
Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide
The primary objective of the study will be to determine whether rapid remote limb ischemic preconditioning (RIPC) combined with acetazolamide can further reduce the incidence of acute mountain sickness (AMS) during the 6-hour…
- Trial name
- NCT05023941
- Testing
- Acetazolamide, Doctormate® (twice daily for 6 days), Doctormate® (forth daily for 3 days)
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Ji Xunming,MD,PhD
Pulmonary Complications
Hemodynamic Responses to Ventilator Hyperinflation Technique
The purpose of this study is to explore acute hemodynamic responses to VHI technique in critical traumatic patients with pulmonary complications in the intensive care unit.
- Trial name
- NCT02739841
- Testing
- Ventilator hyperinflation, Chest physical therapy
- Where
- Thailand
- Volunteers
- 15 people
- Sponsor
- Khon Kaen University
Central Sensitisation, Low Back Pain
Nociplastic Pain Symptoms and Sensory Profiles in Low Back Pain
Assessing associations between Sensory profiles and nociplastic pain symptoms, and assessing the prognostic value of sensory profiles in the development of nociplastic pain symptoms in a low back pain population.
- Trial name
- NCT05592405
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Vrije Universiteit Brussel
ARDS
Impact of Immune Status on Secondary Infections in Patients With Acute Respiratory Failure
This is a retrospective observational study over the period 1/2019 - 02/2024 with the aim of identifying patients with a predisposition to secondary infections.
- Trial name
- NCT06511622
- Where
- Germany
- Volunteers
- 686 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Depression
Poststroke Depression of Clinical Trial Registration
The investigators aim to explore the relationship between gut microbiota composition and earlier poststroke depression via 16S rRNA sequencing.
- Trial name
- IFEPSDAIS (NCT03863951)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Healthy
Rice Anthocyanin Bioavailability in Humans
Aims of the project 1. To determine the rice anthocyanin content via high-performance liquid chromatographycoupled to mass spectrometry, HPLC-MS 2.
- Trial name
- NCT03935022
- Testing
- Rice
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Milan
Anterior Cruciate Ligament Tear
IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions
Injury to the knee during sports participation often involves partial or full detachment of the anterior cruciate ligament (abbreviated as ACL). ACL tears cause pain, swelling and inflammation.
- Trial name
- EASI ACL (NCT02930122)
- Testing
- anakinra (150mg), Saline intraarticularly
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cale Jacobs, PhD
Asthma
Adequacy of Management of Patients With Asthma Exacerbation in Martinique
Asthma is a chronic respiratory disease whose goal of therapeutic, educational and preventive care is to prevent the onset of acute crisis, the most serious of which are life threatening.
- Trial name
- APEXA (NCT05253391)
- Testing
- Routine care
- Where
- 7 sites in Martinique
- Volunteers
- 339 people
- Sponsor
- University Hospital Center of Martinique
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.