Clinical trials: Acute-on-Chronic Liver Failure (ACLF)
Liver Failure, Hepatitis B
A Study Evaluating the Efficacy of Glucocorticoids in Patients With Pre-ACLF-HBV
This is a randomized, open label study evaluating the efficacy and safety of glucocorticoids in patients with HBV associated pre-ACLF. Sponsor: Department of infectious diseases, Southwest Hospital.
- Trial name
- preACLF (NCT01344174)
- Testing
- 5 days dexamethasone therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Military Medical University
Acute Liver Failure
ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF
The artificial liver support system (ALSS) in patients with acute on chronic liver failure - the use of combined molecular adsorption system with double plasma (DPMAS) and therapeutic plasma exchange (TPE), its effect on primary…
- Trial name
- NCT07329036
- Testing
- The artificial liver support system (ALSS) - DPMAS/TPE
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Acute-On-Chronic Liver Failure
Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%
This is a Phase 3, multicenter, randomized, controlled, parallel-group, open-label study to evaluate the effects of plasma exchange using human serum albumin 5% (PE-A 5%) in acute-on-chronic liver failure (ACLF) subjects.
- Trial name
- APACHE (NCT03702920)
- Testing
- SMT + PE-A 5%, Standard Medical Treatment
- Where
- 30 sites in United States, Austria and 7 more
- Volunteers
- 274 people
- Sponsor
- Instituto Grifols, S.A.
Acute-On-Chronic Liver Failure
Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections.
Acute on chronic liver failure patients are at high risk for nosocomial infections due to liver dysfunction, which impairs immune responses and increases vulnerability to infections.
- Trial name
- NCT06818565
- Testing
- Meropenem Injection, Ceftazidime-avibactam, Teicoplanin
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute-On-Chronic Liver Failure
Bowel Colonization With Multi-drug Resistant Bacterial Species in Hospitalized Patients With acute-on Chronic Liver Failure (ACLF), and Its Relationship With Extra-intestinal Infectious Events and Short-term Outcomes.
Bowel colonization with anti-microbial resistant bacteria increases the risk of clinical infections. Infections caused by anti-microbial resistant bacteria have been associated with increased mortality, prolonged hospital stay…
- Trial name
- NCT04383106
- Testing
- no intervention
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure
Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed
Acute portal hypertension, as measured by rapid rise in hepatic venous pressure gradient (HVPG) can lead to further dreaded complications, including acute variceal bleeding (AVB) AVB: 6-week mortality rates of around 15-20% in…
- Trial name
- NCT06815770
- Testing
- Terlipressin Injectable Product
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure (ACLF)
Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF
Clinical trial The goal of this clinical trial is to learn if a liver support protocol works to treat Liver failure in adults. The main questions it aims to answer are: Does hemoadsorption plus half-dose plasma exchange provide…
- Trial name
- Phoenix (NCT07593638)
- Testing
- DPMAS plus plasma exchange
- Where
- Portugal
- Volunteers
- 240 people
- Sponsor
- Unidade Local de Saude do Nordeste
Hepatitis B, Chronic, Acute-On-Chronic Liver Failure
Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
This study is to investigate investigate the safety and efficacy of Double plasma molecular adsorption system with sequential low-dose plasma exchange in treating hepatitis B virus-related acute-on-chronic liver failure.
- Trial name
- NCT04597164
- Testing
- Artificial liver support system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute on Chronic Hepatic Failure, Acute Liver Failure
Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF
The study will evaluate the pharmacokinetics, pharmacodynamics, safety and preliminary efficacy of IDN-6556 in subjects with cirrhosis of the liver who are hospitalized for more than 24 hours due to acute deterioration of liver…
- Conditions
- Acute on Chronic Hepatic Failure, Acute Liver Failure, Liver Cirrhosis, Acute Alcoholic Hepatitis
- Trial name
- NCT01937130
- Testing
- IDN-6556
- Where
- 26 sites in United States, United Kingdom
- Volunteers
- 23 people
- Sponsor
- Conatus Pharmaceuticals Inc.
Acute-On-Chronic Liver Failure
Phase II Safety Study of 2 Dose Regimens of HepaStem in Patients With ACLF
The study will assess the safety of different dose regimens of HepaStem in cirrhotic Patients with ACLF or with acute decompensation at risk of developing ACLF up to Day 28 of the active study period.
- Trial name
- HEP101 (NCT02946554)
- Testing
- HepaStem
- Where
- 10 sites in Belgium, France
- Volunteers
- 24 people
- Sponsor
- Cellaion SA
Acute-On-Chronic Liver Failure
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF)
Liver disease deaths are rising, but transplants remain scarce in India. With over 100,000 needed annually and only ~2,500 performed, non-transplant options are urgently needed.
- Trial name
- NC-CHRM (NCT07131540)
- Testing
- umbilical cord Mesenchymal Stem Cell
- Volunteers
- 10 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Diseases, Liver Cirrhosis
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial.
- Conditions
- Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
- Trial name
- CHANCE (NCT04613921)
- Testing
- Observational Protocol
- Where
- 106 sites in United States, Argentina and 25 more
- Volunteers
- 3,000 people
- Sponsor
- European Foundation for Study of Chronic Liver Failure
Acute on Chronic Liver Failure
Lactate Kinetics as a Predictor of Survival in ACLF With Septic Shock
Shock is a clinical state of tissue hypoxia. This hypoxia may be brought about by either decreased perfusion or the inability of the cell to extract oxygen in the presence of adequate perfusion. This causes cellular dysfunction.
- Trial name
- NCT06116305
- Testing
- No intervention
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure
To Study the Role of Plasma Von Willebrand Factor Antigen (vWF) to A Disintegrin-like and Metalloproteinase With Thrombospondin Type-1 Motifs 13 (ADAMTS-13) Activity Ratio as a Predictor of Development of Extrahepatic Organ Failure in Acute on Chronic Liver Failure (ACLF) Patients.
Acute on chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of chronic liver disease associated with organ failures and high short- term mortality.
- Trial name
- NCT06066814
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE)
RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure
This is a Phase 1/2, first-in-human (FIH) safety, proof-of-concept, two-part study of the genetically-engineered EGEN-5784 liver in combination with the metra® extra-corporeal liver cross-circulation (ELC) system in participants…
- Trial name
- NCT07429838
- Testing
- metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- eGenesis, INC
Acute on Chronic Liver Failure(ACLF)
Intravenous NAC Use in ACLF Patients
Primary Objective To evaluate the efficacy and safety of 72 hour NAC treatment regimen in the management of ACLF Secondary Objective To evaluate the six weeks mortality and length of hospital stay in ACLF patients treated with…
- Trial name
- NCT05089981
- Testing
- N acetyl cysteine
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University
Cirrhosis, Acute Liver Failure
Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure
After successful screening diagnosis of cirrhosis and/or acute or chronic liver failure will be made. These patients will undergo detail clinical, biochemical and microbiological examination at baseline.
- Conditions
- Cirrhosis, Acute Liver Failure, Chronic Liver Failure
- Trial name
- NCT01872767
- Where
- India
- Volunteers
- 522 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Severe Viral Hepatitis, Acute on Chronic Liver Failure
Evaluation of Role of Transient Elastography (Fibroscan) in Differentiating Patients of Acute Severe Viral Hepatitis and Acute on Chronic Liver Failure
Transient elastography is novel non-invasive method for assessment of hepatic fibrosis in patients with chronic liver disease, by measuring liver stiffness.
- Trial name
- ACLF (NCT01866072)
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Sir Ganga Ram Hospital
Acute on Chronic Liver Failure, HBV
A Study of AARC Standards on Diagnosis and Treatment of Patients With HBV-ACLF in China (AARC China Study)
The AARC China Study is to establish a widely recognized and harmonized standard of patients with HBV-ACLF in the Asia Pacific region.
- Trial name
- NCT04054037
- Testing
- No intervention
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Qin Ning
Septic Shock and Acute Kidney Injury
Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI
Consecutive patients with ACLF (Acute on Chronic Liver Failure) and septic shock with AKI (Acute Kidney Injury) who give written informed consent will be included in this prospective trial at ILBS.
- Trial name
- NCT03343340
- Testing
- Early CRRT, Late CRRT, Standard Medical Therapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India