Clinical trials: Addiction, Substance
Addiction
Deep Brain Stimulation of Nucleus Accumbens for Opioid Relapse Prevention
Nucleus accumbens plays important roles in the process of opiate addiction and initial of relapse after detoxification.According to the single-centered preliminary open-labeled prospective trial results, the investigators…
- Trial name
- NCT03424616
- Testing
- Suzhou Sceneray® DBS System
- Where
- 5 sites in China
- Volunteers
- 60 people
- Sponsor
- Tang-Du Hospital
Opioid-Related Disorders, HIV Infections
Buprenorphine and Integrated HIV Care Evaluation
The purpose of this study is to assess the feasibility, cost and effectiveness of interventions designed to integrate buprenorphine treatment for opioid dependence into HIV primary care in ten HIV care centers in the U.S.
- Conditions
- Opioid-Related Disorders, HIV Infections, AIDS
- Trial name
- NCT00124358
- Testing
- Buprenorphine, Integrated HIV care and office-based opioid dependence treatment
- Where
- 10 sites in United States
- Volunteers
- 1,350 people
- Sponsor
- The New York Academy of Medicine
Substance Use Disorders
Enhancing Addiction Treatment Through Psychoeducation
Addiction is a brain disorder characterized by a broad range of both apparent and subtle cognitive impairments in attention, memory, executive functions, and decision-making.
- Trial name
- NCT07178158
- Testing
- Installing the Metacognium software app, Continue treatment as usual
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Opioid-use Disorder, Opioid-Related Disorders
Substance Use Treatment and Recovery Team (START)
Despite high prevalence, few hospitalized inpatients with opioid or alcohol use disorders (OAUDs) receive evidence-based treatments while in the hospital or get linked with appropriate follow-up care, leading to poor clinical…
- Conditions
- Opioid-use Disorder, Opioid-Related Disorders, Alcohol Use Disorder, Alcohol-Related Disorders
- Trial name
- START (NCT04314648)
- Testing
- Substance Use Treatment and Recovery Team (START)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- RAND
Alcohol Dependence
ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent Adults
This was a study of the effects of VIVITROL® on alcohol cue-induced craving and the associated brain activation patterns in alcohol-dependent adults who had recently completed alcohol detoxification and were seeking further…
- Trial name
- NCT00511836
- Testing
- VIVITROL 380 mg
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Alkermes, Inc.
Substance Abuse, Anxiety
Auricular Acupuncture in Substance Abuse: Effects on Anxiety, Sleep, Drug Use.
Background. A common alternative treatment for substance abuse is ear acupuncture. The aim of the study was to evaluate the short and long-term effect of auricular acupuncture on anxiety, sleep, drug use and addiction treatment…
- Conditions
- Substance Abuse, Anxiety, Sleep
- Trial name
- NCT02604706
- Testing
- NADA Acupuncture, LP acupuncture, Relaxation
- Where
- Sweden
- Volunteers
- 280 people
- Sponsor
- Örebro Läns Landsting
Substance Dependence
Memory Reconsolidation Blockade for Treating Drug Addiction
The treatment involves administering propranolol, a medication indicated for treating high blood pressure. Propranolol is hypothesized to reduce the strength of drug or alcohol cravings (an integral factor involved in relapse)…
- Trial name
- NCT01634347
- Testing
- Propranolol and memory reactivation
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- Douglas Mental Health University Institute
Opioid Use Disorder
Adaptive Decision Support for Addiction Treatment Master
This study refines and optimizes the EMBED* clinical decision support (CDS; see NCT03658642) to increase number of ED physicians following standard of care for the administration of buprenorphine to appropriate patients with…
- Trial name
- ADAPT (NCT06799117)
- Testing
- EMBED CDS, Nurse prompt to complete COWS, Provider Prompt
- Where
- 3 sites in United States
- Volunteers
- 1,912 people
- Sponsor
- Yale University
Smoking, Smoking Cessation
Biopsychosocial Predictors of Nicotine Relapse
This study aims to investigate the associations between emotion regulation ability, stress-induced neural activity changes, and susceptibility to relapse in smokers attempting to quit.
- Conditions
- Smoking, Smoking Cessation, Nicotine Addiction, Tobacco Smoking Behavior
- Trial name
- BioNic (NCT06470321)
- Testing
- Flexiquit Computerized Smoking Cessation Program
- Where
- Cyprus
- Volunteers
- 200 people
- Sponsor
- University of Cyprus
Nicotine Dependence, Smoking
Exercise Training for Smoking Students
Smoking can damage lung functions as a result of high carbon monoxide and low hemoglobin oxygen carrying capacity in the blood. Smoking between young people continues to increase, which can cause respiratory function problems and…
- Conditions
- Nicotine Dependence, Smoking, Physical Inactivity, Depression
- Trial name
- NCT06291558
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
HIV, Substance Use Disorder (SUD)
Combining Social Network Strategies and Routine Substance Use Screening
This study aims to improve health care for people who may have HIV or substance use disorders by bringing two services to a large community health center in Chicago.
- Trial name
- SNSUS (NCT07414459)
- Testing
- Substance use disorder screening, Social network intervention
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of California, San Diego
Heroin Addiction
Observational Study to Assess the Efficacy and Tolerability of Eptadone®, in Heroin Addicted Patients in a MMT
The efficacy and tolerability of Eptadone® in the context of a maintenance program will be evaluated in an observational prospective, multicenter study, in heroin addicted patients.
- Trial name
- METHODE (NCT02062723)
- Where
- 22 sites in Germany
- Volunteers
- 515 people
- Sponsor
- L.Molteni & C. dei F.lli Alitti-Soc. di Esercizio S.p.A.
Alcohol Use Disorder, Addiction
Tdcs And cogNitive traininG cOmbined for AUD (TANGO)
The overarching goal of this project is to expand the traditional expertise in non-invasive neuromodulation at the University of Minnesota towards developing novel paired-neuromodulation approaches using transcranial direct…
- Trial name
- NCT05062369
- Testing
- TaskFlow Transcranial Electrical Stimulation device, Executive Function Focused Cognitive Training
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Alcoholism
To Evaluate the Influence of the A118G Polymorphism in the mu Opioid Receptor Gene (OPRM1) on Effects of GSK1521498 and Naltrexone on Physiological and Behavioural Markers of Brain Function in Healthy Social Drinkers
A total of at least 48 healthy subjects with a history of social drinking will be recruited into this single-centre, randomized, double-blind, cross-over study.
- Trial name
- NCT01738867
- Testing
- GSK1521498, Naltrexone (NTX)
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alcohol Addiction, Opiate Addiction
Effectiveness of a Hospital Addiction Service in Treating Opioid and Alcohol Addiction
Hypothesis: Patients who are addicted to opioids or alcohol will have reduced substance use, health care utilization if they have immediate and convenient access to pharmacotherapy and addiction counselling.
- Trial name
- H-SOAP (NCT01934751)
- Testing
- Delayed Intervention (DI), Rapid Intervention (RI)
- Where
- Canada
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Substance Abuse
Computer-assisted Delivery of Cognitive Behavioral Therapy for Mental Health and Addictions in Canada
Computer-based Training for Cognitive Behavioural Therapy (CBT4CBT) is a new on-line addiction treatment developed by Dr Kathleen Carroll at the Yale School of Medicine in New Haven, Connecticut.
- Trial name
- NCT03230669
- Testing
- cbt4cbt
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Prince Edward Island
Opioid-Related Disorders, Opioid Dependence
An Innovative Intervention for OUD Treatment
The Bridge Device (BD) is a neuromodulator medical device that has been cleared by the FDA for Opioid Use Disorder (OUD) treatment.
- Conditions
- Opioid-Related Disorders, Opioid Dependence, Opioid Addiction, Opioid Withdrawal
- Trial name
- Bridge (NCT04325659)
- Testing
- Bridge Device, Lofexidine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Schizophrenia, Mood Disorders
Behavioral Treatment of Drug Abuse in Severe and Persistent Mental Illness (SPMI) Patients
The main purpose of this study is to determine if the multifaceted treatment for substance abuse in dual disordered patients is more effective in reducing drug use than a supportive control treatment.
- Conditions
- Schizophrenia, Mood Disorders, Substance Dependence
- Trial name
- NCT00295139
- Testing
- Behavioral Treatment for Substance Abuse in SPMI (BTSAS), Supportive Treatment in Addiction Recovery (STAR), Critical Time Intervention (CTI)
- Where
- 4 sites in United States
- Volunteers
- 293 people
- Sponsor
- University of Maryland, Baltimore
PTSD
Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence
Pharmacotherapy has demonstrated efficacy in a number of controlled trials in the treatment of PTSD. The selective serotonin reuptake inhibitors have proven particularly useful in treating this disorder.
- Trial name
- NCT00330239
- Testing
- Paroxetine CR
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical University of South Carolina
Addiction, Cocaine
Attention Training for Opioid-maintained Cocaine Users
The purpose of this study is to determine the feasibility and preliminary efficacy of attention training using a portable electronic device for opioid-dependent cocaine-users stabilized on methadone.
- Conditions
- Addiction, Cocaine, Methadone, Opiates
- Trial name
- NCT01870882
- Testing
- Attentional retraining, Control condition
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University