Clinical trials: Addiction, Substance
Substance-Related Disorders, Drug Addiction
Home-Based Program to Help Parents of Drug Abusing Adolescents
This project is aimed at parents with a teenager who is already starting to use drugs. The study will test a new, innovative version of a brief intervention.
- Conditions
- Substance-Related Disorders, Drug Addiction, Substance Abuse
- Trial name
- NCT01591239
- Testing
- Home-Based Intervention, Educational Group
- Where
- United States
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Treatment Research Institute
Amphetamine Addiction
Robot-Assisted Intelligent Rehabilitation Treatment for Methamphetamine Use Disorders.
The purpose of this research is to evaluate the efficacy and safety of Robot-assisted rehabilitation intelligent system as a virtual stand-alone treatment, delivered with minimal clinical monitoring compared with treatment as…
- Trial name
- NCT04531384
- Testing
- robot-assisted rehabilitation intelligent treatment, standard psychotherapy treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Mental Health Center
Depression, Substance Dependence
Motivational Therapy for Substance Users With Depression
The primary objective of the study is to test the incremental efficacy and outcomes of an aftercare program of Cognitive Behavioral Therapy combined with motivational therapy (CBT-MT) relative to treatment as usual (TAU) in…
- Trial name
- Aftercare (NCT01189799)
- Testing
- Motivational therapy, Dual Recovery Anonymous/Tx as usual
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, Los Angeles
Psychiatry
NUTRItion-driven Detoxification of OPioid Addicted patiEnts
The NUTRIDOPE (NUTRItion-driven Detoxification of OPioid addicted patiEnts) study is a clinical trial that aims to investigate the role of pomegranate juice consumption by opioid-addicted patients under buprenorphine and…
- Trial name
- NUTRIDOPE (NCT05861544)
- Testing
- Pomegranate juice
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- Organization Against Drugs (ΟΚΑΝΑ)
Cocaine Dependence, Cocaine Abuse
A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence
The purpose of this study is to determine the effects of treatment with cabergoline, compared to treatment with placebo, on cocaine induced craving and subjective effects in cocaine-dependent human volunteers.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
- Trial name
- NCT01651364
- Testing
- Cabergoline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Nicotine Addiction, Vaping
Acute Effects of Vaping Nicotine on Cognition in Young Adults
To examine reward processing and cognitive control both with and without the influence of vaporized nicotine in young adults with no history of cigarette use using EEG and fMRI.
- Trial name
- NCT04901208
- Testing
- Nicotine pod
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Yale University
Addiction Disorders
Attachment and Substance Use Disorder: An Interventional Study in an Addictology Day Hospital
Introduction: Substance use disorders represent a major public health issue due to their high morbidity and mortality rates. Outpatient care, particularly short-term intensive programs integrating multidisciplinary support and…
- Trial name
- CRAV-ATT (NCT07831135)
- Testing
- attachment-focused therapeutic program, psychoeducation-based intervention (standard care)
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier de Cadillac
Stimulant Use Disorder, Substance-related Disorders
Treating Stimulant Addiction With Repetitive Transcranial Magnetic Stimulation
The purpose of this study is to establish a new treatment (repetitive transcranial stimulation (rTMS)) for Veterans with stimulant use disorder (SUD).
- Trial name
- VA-StARTS (NCT04228276)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Substance Use Disorders
Smartphone Addiction Recovery Coach for Young Adults (SARC-YA) Experiment
At discharge from outpatient treatment, researchers will recruit 300 young adults and randomly assign them to recovery support as usual control condition or the Smartphone Addiction Recovery Coach for Young Adults (SARC-YA)…
- Trial name
- SARC-YA (NCT03301012)
- Testing
- Recovery support as usual, Smartphone assisted relapse prevention
- Where
- 2 sites in United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Alcohol Use Disorder, Stress Reaction
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- A03 (NCT06105853)
- Testing
- Trier Social Stress Test, Barlab Cue-Exposure, Functional magnetic resonance imaging
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Opioid Dependence, Pain
Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintenance
Pain is very common in persons with a history of addiction, but few studies have examined the best treatment of pain in this population.
- Conditions
- Opioid Dependence, Pain, Addiction
- Trial name
- NCT01642030
- Testing
- Hydromorphone, Buprenorphine
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Clinical Neurobiology of Serotonin and Addiction
The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on…
- Trial name
- NCT00732901
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Tobacco Use Disorder
The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1
One of nicotine's effects on the body is at the level of the NMDA receptors in the brain. Memantine is a drug that also affects NMDA receptors, making it a candidate for the treatment of nicotine addiction.
- Trial name
- NCT00136747
- Testing
- Memantine, bupropion
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Use Disorder, Cocaine Dependence
Low-Intensity Focused Ultrasound for Cocaine Use Disorder
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
- Trial name
- NCT05857852
- Testing
- Low-Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Intoxication;Alcohol;Acute, Emergencies
Evaluation of the API-VIGIE Monitoring System: Program to Reduce Emergency Visits for Severe Paroxysmal Alcoholism
The study was designed to evaluate the APIVIGIE program use at CH d'Arras. The objective of this program is to reduce repeated visits by the same patient to the emergency room for Alcoholism Severe Paroxysmal
- Trial name
- EVAL-APIVIGIE (NCT05173116)
- Testing
- Medical Outcomes Study Short Form 36 (SF 36), observationnal study
- Where
- France
- Sponsor
- Centre Hospitalier Arras
Methamphetamine-dependence, Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation (tDCS) Combined With Computerized Cognitive Addiction Therapy(CCAT) and, Electronic Follow-up for Methamphetamine(MA) Dependent Patients
Transcranial direct current stimulation (tDCS) combined with computerized cognitive addiction therapy(CCAT) for methamphetamine(MA) dependent patients in voluntary drug rehabilitation center.
- Conditions
- Methamphetamine-dependence, Transcranial Direct Current Stimulation, Computerized Cognitive AddictionTherapy, Electronic Health Records
- Trial name
- NCT04139148
- Testing
- Ture Transcranial Direct Current Stimulation (tDCS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Mental Health Center
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute
Opiate Addiction, Pregnancy
Impact of Pregnancy on Buprenorphine Pharmacokinetics and Pharmacodynamics
The primary purpose of this study is to determine whether buprenorphine and metabolite exposure (reflected as the dose-adjusted plasma concentration x time curve [AUC]) differs during pregnancy and between pregnancy and the…
- Trial name
- NCT02863601
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Stress Disorders, Post-Traumatic, Opioid Use Disorder
MDMA for Co-occurring PTSD and OUD After Childbirth
This is an open-label study of the use of MDMA Assisted Therapy for postpartum people with co-occurring Post Traumatic Stress Disorder (PTSD) and Opioid Use Disorder (OUD).
- Trial name
- NCT05219175
- Testing
- MDMA Assisted Therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of New Mexico
Substance Use Disorder (SUD)
Fighting Addictions, Improving Lives: COmprehensive Drug Rehabilitation With Music
FALCO is a parallel pragmatic randomized control trial addressing long-term effects of music therapy (MT) on substance use disorder (SUD). 600 participants will be recruited from multiple European countries (see Locations).
- Trial name
- FALCO (NCT07028983)
- Testing
- Active Music Group (AMG), Music Listening Group (MLG), Treatment as Usual (TAU)
- Where
- 11 sites in Austria, Israel and 6 more
- Volunteers
- 600 people
- Sponsor
- NORCE Norwegian Research Centre AS