Clinical trials: Addiction, Substance
Alcohol Addiction, Opiate Addiction
Effectiveness of a Hospital Addiction Service in Treating Opioid and Alcohol Addiction
Hypothesis: Patients who are addicted to opioids or alcohol will have reduced substance use, health care utilization if they have immediate and convenient access to pharmacotherapy and addiction counselling.
- Trial name
- H-SOAP (NCT01934751)
- Testing
- Delayed Intervention (DI), Rapid Intervention (RI)
- Where
- Canada
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Opioid-use Disorder
Deep Brain Stimulation Effects In Patients With Opioid Use Disorder
This is a pilot study to evaluate the safety and efficacy of deep brain stimulation (DBS) of the nucleus accumbens (NAc) as adjunctive treatment for treatment-refractory opioid use disorder.
- Trial name
- NCT04354077
- Testing
- DBS of the NAc
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Opioid Use Disorder, Cocaine Use Disorder
Cocaine Opioid Oxytocin Option - Limited
This is a pilot feasibility study assessing the tolerability of chronic administration of intranasal oxytocin to patients receiving methadone at an opioid replacement clinic who are actively using cocaine.
- Trial name
- COOOL (NCT02028533)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Alcoholism, Cocaine Addiction
The Effects of Theta Burst Stimulation on the Brain Response to Drug and Alcohol Cues
High relapse rates among substance dependent individuals are likely due to a combination of factors that involve limbic circuits in the brain involved in craving, including vulnerability to salient cues.
- Conditions
- Alcoholism, Cocaine Addiction, Drug Addiction
- Trial name
- addictionTBS (NCT02939352)
- Testing
- Real continuous Theta Burst Stimulation
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
Semaglutide Therapy for Alcohol Reduction - Tulsa
The purpose of this research study is to determine if semaglutide, when compared to placebo, is safe and may reduce alcohol drinking in individuals who endorse symptoms consistent with alcohol use disorder.
- Trial name
- STAR-T (NCT05891587)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oklahoma State University Center for Health Sciences
Substance Use Disorder
The Effectiveness of Mindfulness-based Relapse Prevention
This study developed a Mindfulness-based Relapse Prevention targeting craving. Based on the Randomized Controlled Trial design, 600 adult USD females and 600 adult USD males with methamphetamine, heroin, or ketamine in…
- Trial name
- NCT06739304
- Testing
- Mindfulness-based Relapse Prevention
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Opioid Use Disorder, Criminal Justice
Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews
This qualitative study investigates the potential benefits and challenges of using a once-a-month injectable medication, known as extended-release buprenorphine (XR-B), to treat individuals with opioid use disorder (OUD) within a…
- Conditions
- Opioid Use Disorder, Criminal Justice, Treatment Adherence and Compliance
- Trial name
- NCT06354465
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Lifespan
Cocaine Addiction
Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving
We propose that the systemic administration of lidocaine following the induction of cue-induced craving, relative to saline plus cue-induced craving or lidocaine without cue-induced craving, will block the reconsolidation of cue…
- Trial name
- LIDO (NCT01929343)
- Testing
- lidocaine following cue-induced craving, lidocaine following neutral stimulus, saline
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Bryon Adinoff
Substance Use Disorder (SUD), Addiction
NLP Analysis of Weekly Narratives for Dynamic Clinical Assessment in SUD
This prospective observational study follows adults undergoing residential rehabilitation for severe substance use disorders at a specialized treatment center in Mexico.
- Conditions
- Substance Use Disorder (SUD), Addiction, Anxiety, Emotional Dysregulation
- Trial name
- DYNA-NLP (NCT07595614)
- Testing
- Residential rehabilitation as usual
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Lauro Gutiérrez Castro
Opioid Use Disorders, Opioid-related Disorders
Prevalence and Predictors of Prolonged Post-surgical Opioid Use: a Prospective Observational Cohort Study
Post-surgical opioid prescribing intended for the short-term management of acute pain may lead to long-term opioid use, and its associated harms.
- Conditions
- Opioid Use Disorders, Opioid-related Disorders, Surgery, Pain, Postoperative
- Trial name
- NCT02571400
- Testing
- Continued use of opioid analgesics >90 days post-surgery
- Where
- Australia
- Volunteers
- 1,013 people
- Sponsor
- University of Notre Dame Australia
Tobacco Use Disorder
Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation
The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers.
- Trial name
- NCT05726045
- Testing
- Standard smoking cessation program (SCP), Cognitive remediation treatment (CRT), High-intensity interval training (HIIT evening)
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Opiate Addiction
Efficacy of Computer Delivered Community Reinforcement Approach (CRA) (Bup II)
This study is designed to examine the effects of combined buprenorphine and voucher incentives to promote abstinence from illicit opiate use, along with or without computer-delivered therapy, during treatment of opioid dependence.
- Trial name
- CAT (NCT00929253)
- Testing
- Suboxone, CRA, Therapy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Virginia Polytechnic Institute and State University
Alcoholism, Stress
Alcohol and Gender Effects on Stress Circuit Function
The purpose of this study is to look at the stress hormone response to medication-induced stress and a placebo (an inactive compound) in non-drinking, recovering male and female alcoholics, with a specific emphasis on the…
- Conditions
- Alcoholism, Stress, Alcohol Dependence
- Trial name
- NCT00226694
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Evaluation of Abuse Potential of Sativex
Abuse Potential of Sativex
This crossover study with six treatment sessions is to evaluate the abuse potential of three doses of Sativex as compared to Marinol and placebo, in subjects with a history of recreational marijuana use.
- Trial name
- NCT01323569
- Testing
- Sativex, Marinol
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals
Opiate Addiction
Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans
Despite the current available therapies for opioid-dependent patients, most patients relapse. This research project focuses on the development of a novel compound, cannabidiol, to modulate opioid craving in humans based on animal…
- Trial name
- NCT02539823
- Testing
- CBD 400 mg, CBD 800 mg
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Hurd,Yasmin, Ph.D.
Domestic Violence, Substance Abuse
Treatment of Intimate Partner Violence and Substance Abuse in a Substance Abuse Treatment Facility
Intimate partner violence is a significant societal problem. There is considerable evidence that a strong relationship between the use of alcohol and other drugs and intimate partner violence exists.
- Trial name
- NCT00847873
- Testing
- substance abuse/domestic violence treatment, Cognitive behavioral therapy addressing substance abuse
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- VU University of Amsterdam
Depression, Dual Diagnosis
A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users
Methamphetamine (MA) addiction is a public health concern that causes substantial harm to individual users, and imposes an economic burden in the U.S. totaling up to $48.3 billion annually.
- Conditions
- Depression, Dual Diagnosis, Drug Addiction
- Trial name
- NCT02192931
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Perry Renshaw
Opioid Use, Opioid-use Disorder
Evaluating The Efficacy Of A Mind-Body Intervention In Overcoming Opioid Addiction
This study demonstrates the feasibility, acceptability of SKY program as an adjuvant therapy for American population suffering with OUD through a pilot program in Columbus, Ohio.
- Conditions
- Opioid Use, Opioid-use Disorder, Substance Use Disorders
- Trial name
- SKY (NCT03791645)
- Testing
- Sky Intervention
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Ohio State University
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence
Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence
The primary aim of this study is to conduct a 60-patient feasibility, acceptability, and preliminary efficacy study of mSMART (Mobile App based Personalized Solutions and Tools for Medication Adherence of Rx Pill), a smartphone…
- Trial name
- mSMART-Ib (NCT02635919)
- Testing
- mSMART
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University