Clinical trials: Addiction, Substance
Substance Abuse
Methylphenidate Studies for Drug Abuse Vulnerability Molecular Genentics
Background: Research has shown that several human genes have been associated with vulnerability to substance abuse and dependence.
- Trial name
- NCT00247689
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
PTSD, Depression
Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care
The most common reasons Veterans seek VA addiction and mental health care is for help with opioid and alcohol misuse, depression and PTSD.
- Conditions
- PTSD, Depression, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- NCT04356274
- Testing
- Participatory System Dynamics (PSD), Audit and Feedback (AF)
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Addiction, Addiction Disorders
Can Selfcompassion Training Reduce Alcohol Consumption in Patients With Alcohol Use Disosrder ?
The objective of this interventional study is to evaluate the effectiveness of the Mindful Self-Compassion (MSC) program in reducing alcohol consumption in a population of individuals with Alcohol Use Disorder (AUD), six months…
- Conditions
- Addiction, Addiction Disorders, Alcohol Use Disorders, Alcohol Dependence
- Trial name
- COMPAL (NCT07131124)
- Testing
- Mindful Self-Compassion program, Treatment As Usual (TAU) program
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Substance Use Disorders, Drug Use Disorder
Brief Contextual-Behavioral vs Twelve-Step Intervention for Emotion Regulation in Substance Use: Pilot Study
This study evaluated the effectiveness of a brief behavioral-contextual intervention delivered through 11 weekly individual sessions (45 minutes each) to improve emotion regulation, distress tolerance, and psychological…
- Conditions
- Substance Use Disorders, Drug Use Disorder, Alcohol Use Disorder, Emotional Dysregulation
- Trial name
- MEX-BERA (NCT07337733)
- Testing
- Behavioral-Contextual Emotion Regulation Program (BCERP)
- Where
- Mexico
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Lauro Gutiérrez Castro
Substance Use Disorders
Life-Skills Training Program: Its Effect on Self-efficacy Among Patients With Substance Use Disorders
The goal of this clinical trial is to evaluate the effect of life-skills training program on self-efficacy among patients with substance in purposive sample male participants diagnosed with substance use disorders, aged from 20…
- Trial name
- NCT07174960
- Testing
- Life-Skills Training Program
- Where
- 2 sites in Egypt
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Opioid-Related Disorders
Tramadol to Reduce Opioid Withdrawal Symptoms
Individuals with opioid addiction often experience serious withdrawal symptoms that may make relapse unavoidable. Tramadol, a medication that is currently used to treat pain caused by chronic conditions such as cancer or joint…
- Trial name
- NCT00142896
- Testing
- Tramadol, Naloxone, Morphine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction
The purpose of this study is to investigate the effect of gemfibrozil on nicotine reinforcement and cue-elicited craving. Other objectives of this study include screening for the ability of gemfibrozil to aid smoking abstinence…
- Trial name
- NCT01876810
- Testing
- Gemfibrozil
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Use, Substance Use
Tobacco-Concurrent Addictions in At-Risk Youth in Ottawa
According to the 2015 Ontario Student Drug Use and Health Survey (OSDUHS), there has been a significant increase in the number of secondary school youth who use poly-substances.
- Conditions
- Tobacco Use, Substance Use, Cannabis Use
- Trial name
- TCAY-Ottawa (NCT04812613)
- Where
- Canada
- Volunteers
- 520 people
- Sponsor
- Ottawa Hospital Research Institute
Hepatitis C, Substance Dependence
Initialization of Methadone in Primary Care, Randomized Intervention Research for Preventing HCV Transmission Practices
The rapid scale up of opioid substitution treatment (OST) for drug users mainly achieved through the possibility of prescribing buprenorphine in primary care has been successful in reducing HIV prevalence among drug users but…
- Conditions
- Hepatitis C, Substance Dependence, Methadone
- Trial name
- Methaville (NCT00657397)
- Testing
- Methadone
- Where
- France
- Volunteers
- 197 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Cannabis Use Disorder
Lemborexant for Cannabis Use Disorder
The goal of this clinical trial is to investigate the use of Lemborexant as a treatment for moderate to severe Cannabis Use Disorder (CUD). The main questions it aims to answer are: 1.
- Trial name
- LemboCAN (NCT07802990)
- Testing
- Lemborexant 10mg, Brief Behavioural Intervention
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Calgary
Intensive Care Unit Syndrome, Drug Abuse
Addiction in Intensive Cardiac Care Units
Background: Illicit drug use is a growing issue in Europe and leading cause of acute cardiac events in patients admitted to intensive cardiac care units.
- Conditions
- Intensive Care Unit Syndrome, Drug Abuse, Substance-Related Disorders, Cardiovascular Events
- Trial name
- ADDICT-CCU (NCT05063097)
- Testing
- urine test, Fagerström questionnaire, Exhaled carbon monoxide (CO) measurement
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Anxiety
Microcurrent Neurofeedback as an Adjunct to Standard Care for Substance Use Disorders
The goal of this clinical trial is to learn whether adding Microcurrent Neurofeedback (MCN) to standard residential treatment helps adults with substance use disorder more than standard treatment alone.
- Conditions
- Depression, Anxiety, Substance Use Disorder (SUD), Post Traumatic Stress Disorder
- Trial name
- NCT07737652
- Testing
- Microcurrent Neurofeedback (MCN), Standard Care for Substance Use Disorder
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Alabama, Tuscaloosa
Cocaine-Related Disorders, Cocaine Addiction
Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence
This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups.
- Conditions
- Cocaine-Related Disorders, Cocaine Addiction, Substance-Related Disorders
- Trial name
- NCT01984177
- Testing
- Corticotropin-Releasing Hormone
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Addiction, Substance, COVID-19
Evolution of Psychoactive Substances Consumption in Connection With COVID-19 Containment
The current containment linked to COVID-19 will have consequences for people suffering from addiction and there is a risk of overdoses when the containment ends.
- Trial name
- EPILOGUE (NCT04343339)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Addiction, Alcohol, Urinary Tract Disease
Does Homebrewing Beer Affect Urinary Tract Symptoms and Bladder Cancer
In this study, investigators aim to reveal the harmful effects of increasing consumption of homemade beer in recent years on the urinary tract.
- Trial name
- NCT05134675
- Testing
- Homemade beer
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Drug Addiction
Project on tDCS Intervention to Enhance Advanced Social Cognitive Functions in Drug Rehabilitation Individuals
This project aims to explore key brain functional and biochemical indicators associated with impaired advanced social cognition through an integrated approach encompassing unconscious control, conscious control, cognitive…
- Trial name
- NCT06888700
- Testing
- Transcranial direct current stimulation
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Shaanxi Normal University
Drug Addiction, Stimulant Dependence
CRAFT Behavior Therapy: Treatment Entry Component
This research compares the benefits of the original treatment, Community Reinforcement and Family Training (CRAFT), with the Treatment Entry Training (TEnT) component of CRAFT to determine if TEnt alone can produce the primary…
- Conditions
- Drug Addiction, Stimulant Dependence, Opiate Dependence, Alcohol Dependence
- Trial name
- NCT00842036
- Testing
- Community Reinforcement and Family Training, Treatment Entry Training, 12- step Al/Nar- Anon Facilitation
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Treatment Research Institute
Cocaine Addiction, Opiate Addiction
Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292136
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance-related Disorders
Working With HIV Clinics to Adopt Addiction Treatments Using Implementation Facilitation
Tobacco, alcohol and opioid use disorders threaten the health of HIV-infected patients. What if evidence-based counseling and medication treatments for tobacco, alcohol and opioid use disorders (herein refered to as addiction…
- Trial name
- WHAT-IF? (NCT02907944)
- Testing
- Implementation Facilitation
- Where
- 4 sites in United States
- Volunteers
- 3,838 people
- Sponsor
- Yale University
Smoking, Smoking Cessation
Biopsychosocial Predictors of Nicotine Relapse
This study aims to investigate the associations between emotion regulation ability, stress-induced neural activity changes, and susceptibility to relapse in smokers attempting to quit.
- Conditions
- Smoking, Smoking Cessation, Nicotine Addiction, Tobacco Smoking Behavior
- Trial name
- BioNic (NCT06470321)
- Testing
- Flexiquit Computerized Smoking Cessation Program
- Where
- Cyprus
- Volunteers
- 200 people
- Sponsor
- University of Cyprus