Clinical trials: Addiction, Substance
Nicotine Dependence, Transcranial Magnetic Stimulation
Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)
The goal of this clinical trial is to learn if a combination of varenicline and enhanced accelerated Transcranial Magnetic Stimulation (aTMS) works to help adults quit using nicotine products.
- Conditions
- Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation
- Trial name
- V-TMS (NCT07145866)
- Testing
- Varenicline, Transcranial Magnetic Stimulation, Nicotine Cessation Counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Stress Disorders, Post Traumatic, Substance-Related Disorders
Cognitive Therapy for PTSD in Addiction Treatment
The purpose of this phase of the study is to assess the feasibility of a cognitive behavioral therapy for post-traumatic stress disorder (PTSD) in persons receiving outpatient services at an addiction treatment program.
- Trial name
- NCT00685451
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- 3 sites in United States
- Volunteers
- 49 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cocaine Abuse, Cocaine-Related Disorders
The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3
Gamma-aminobutyric acid (GABA) is a type of neurotransmitter, which is a chemical that transmits information within and from the brain to all parts of the body.
- Trial name
- NCT00142883
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Yale University
Alcohol Dependence
ALK21-014: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) After Enforced Abstinence
VIVITROL is indicated for the treatment of alcohol dependence in patients who are able to abstain from alcohol in an outpatient setting prior to initiation of treatment with VIVITROL.
- Trial name
- NCT00501631
- Testing
- VIVITROL 380 mg
- Volunteers
- 300 people
- Sponsor
- Alkermes, Inc.
Opioid-Induced Hyperalgesia
Hyperalgesia in Methadone-Maintained Patients: Can it be Treated?
Utilizing a double-blind, placebo-controlled design, the proposed work will evaluate the ability of an adjuvant anticonvulsant analgesic to diminish or reverse the opioid-induced hyperalgesia complicating the pain states suffered…
- Trial name
- NCT01210079
- Testing
- Gabapentin;
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, Los Angeles
Substance Dependence, Executive Function Disorder
Brain Mechanism and Intervention of Executive-control Dysfunction Among Substance Dependents
The investigators assume that tACS could improve amphetamine and alcohol dependent patients' executive-control function by adjusting the synchronization patterns and enhancing the functional connectivity of the prefrontal-ventral…
- Conditions
- Substance Dependence, Executive Function Disorder, Transcranial Alternating Current Stimulation
- Trial name
- NCT05312359
- Testing
- Transcranial alternating current stimulation-true stimulus
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Nicotine Use Disorder
Behavioral Memory Modulation in Nicotine Addiction
The purpose of the study is to see if a behavioral intervention known as retrieval-extinction training (RET) might affect craving in response to nicotine cues (e.g., pictures, videos and objects) and smoking behavior in men and…
- Trial name
- NCT03744559
- Testing
- Retrieval Extinction Training (RET), Control Retrieval Extinction Training (RET)
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Methamphetamine Use Disorder
Psilocybin for Methamphetamine Addiction
The primary purpose of this study is to preliminarily determine if the use of psilocybin to promote abstinence from methamphetamine is feasible and well tolerated in populations such as those found in Northern Louisiana.
- Trial name
- NCT06899594
- Testing
- Psilocybin 25 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kevin Murnane
Cocaine Dependence, Alcohol Dependence
VIVITROL as a Treatment for Cocaine and Alcohol Dependence
To evaluate the efficacy of VIVITROL (naltrexone for extended-release injectable suspension) for the treatment of co-occurring cocaine and alcohol dependence
- Trial name
- NCT00777062
- Testing
- VIVITROL (Naltrexone extended-release injectable suspension)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Treatment for Nicotine Addiction in Women
The purpose of this study is to use a medication tolcapone and or placebo to test if the symptoms of nicotine withdrawal lessens , and or changes in smoking urges, and mental reasoning in female smokers over a 72 hour period.
- Trial name
- NCT02448654
- Testing
- Tolcapone, Sugar Pill
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Yale University
HIV, Substance Use Disorder (SUD)
Combining Social Network Strategies and Routine Substance Use Screening
This study aims to improve health care for people who may have HIV or substance use disorders by bringing two services to a large community health center in Chicago.
- Trial name
- SNSUS (NCT07414459)
- Testing
- Substance use disorder screening, Social network intervention
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of California, San Diego
Alcohol Use Disorder, Alcohol Use Disorder (AUD)
Optimizing Smart Technology for Addiction Recovery
The goal of this study is to develop a machine-learning guided recovery messaging system. The main question it aims to answer is can messages be used to: help people to improve their health make changes in people's lives to…
- Trial name
- STAR (NCT07573540)
- Testing
- STAR
- Where
- United States
- Volunteers
- 416 people
- Sponsor
- University of Wisconsin, Madison
Opioid Use Disorder (OUD), Chronic Pain
Addiction Treatment in Primary Care Expansion
The Veterans Health Administration (VA) is a national leader in addressing the twin epidemics of chronic pain and opioid use, misuse, and opioid use disorder (OUD); but important challenges remain.
- Trial name
- APEX (NCT03547882)
- Where
- 2 sites in United States
- Sponsor
- VA Office of Research and Development
Opioid-Related Disorders
Assessment of Tramadol as a Treatment for Opioid Addiction
Opioids are one of the most commonly abused drugs among individuals who seek treatment for drug abuse. Thus, it is necessary to develop new treatments for opioid addiction.
- Trial name
- NCT00301210
- Testing
- Tramadol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Johns Hopkins University
Poor Quality Sleep, Opiate Addiction
Insomnia and Drug Relapse Risk
The purposes of this study are: 1. to evaluate the relationship between subjective complaints of sleep and objective measures of sleep quality, as measured through polysomnography, and 2.
- Trial name
- NCT00253890
- Testing
- Trazodone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Butler Hospital
Cannabis Dependence
Social and Emotional Brain Function in Cannabis Users
The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a…
- Trial name
- NCT02711371
- Testing
- fMRI
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Smoking Cessation, Smoking, Cigarette
AXS-05 Phase II Trial on Smoking Behavior
This research study is designed with the purpose of evaluating a new drug, combination Dextromethorphan-Bupropion (AXS-05), for its effects on smoking behavior.
- Conditions
- Smoking Cessation, Smoking, Cigarette, Nicotine Dependence
- Trial name
- NCT03471767
- Testing
- AXS-05, Bupropion SR
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- James Davis
Alcohol Dependence, in Remission, Addiction, Alcohol
Virtual Reality-Assisted Cognitive Behavioral Therapy for Alcohol Dependence (CRAVR-Pilot)
The pilot study is a single-blinded, randomized, controlled, 2 months clinical trial. The objective is to investigate the feasibility, effects and side-effects of virtual reality-assisted cognitive behavioral therapy (VR-CBT) vs.
- Trial name
- NCT04990765
- Testing
- Virtual Reality Cognitive Behavioral Therapy (CRAVR), CBT
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Opioid Use Disorder, Chronic Pain
Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine
Chronic pain is common in individuals with opioid use disorder (OUD) and the first-line treatment, Medication for OUD (MOUD), does not address the considerable functional impairments associated with chronic pain.
- Trial name
- NCT07361432
- Testing
- Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT), Enhanced Treatment as Usual (ETAU)
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development
Tobacco Use Disorder, Nicotine Addiction
Effects of Semaglutide on Nicotine Intake
Tobacco use remains the foremost cause of preventable deaths in the U.S. and worldwide. Advancing new smoking cessation therapies, including those targeting novel biological mechanisms, is a critical public health priority.
- Trial name
- NCT05530577
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill