Clinical trials: Addiction, Substance
Tobacco Use Disorder, Addiction Nicotine
Accelerated dTMS Smoking Cessation
The goal of this clinical trial is to examine whether a 5-day course of bilateral accelerated deep transcranial magnetic stimulation (aTMS) is a feasible treatment to help adults (18-65) with Tobacco Use Disorder to quit smoking.
- Trial name
- NCT07292883
- Testing
- Bilateral deep accelerated repetitive transcranial magnetic stimulation
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Waypoint Centre for Mental Health Care
Alcohol Dependence, Alcohol Drinking
Behavioral and Functional Task Development, Implementation, and Testing
Background: Scientists know that alcohol use disorders affect brain structure. They want to know more about the effects of alcohol use disorders on a person s behavior.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Alcoholism, Alcohol Use Disorder
- Trial name
- NCT02108054
- Testing
- 7T MRI
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Cocaine-Related Disorders
Venlafaxine to Reduce Cocaine Dependence in Depressed Individuals
Preliminary research has shown that venlafaxine, a medication currently used for treating depression, may also discourage cocaine use in depressed individuals.
- Trial name
- NCT00249483
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Use Disorder
RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative
The purpose of this sham-controlled pilot randomized controlled trial (RCT) is to evaluate the feasibility, safety, and preliminary efficacy of a one-month intervention consisting of 20 home-based active or sham RS-tDCS sessions…
- Trial name
- NCT07184983
- Testing
- Active Transcranial Direct Current Stimulation (tDCS), Mindfulness meditation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- NYU Langone Health
Alcohol Use Disorder, Insomnia
Online Cognitive Behavior Therapy for Comorbid Sleep Problems in Alcohol Use Disorder
The main goal is to study the effects of internet-delivered cognitive behavioural therapy with minimum guidance for comorbid sleep problems in alcohol use disorder, in routine addiction care.
- Conditions
- Alcohol Use Disorder, Insomnia, Sleep Disorder, Dyssomnias
- Trial name
- NCT04402619
- Testing
- Cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Cocaine Addiction
Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction
This study aims at testing for the impact of glutamatergic changes on drug craving in cocaine addiction, and to evaluate the effects of n-acetylcysteine (n-AC) on both glutamate homeostasis and craving using a randomized…
- Trial name
- CoGlu (NCT02626494)
- Testing
- N-Acetylcystein
- Where
- Switzerland
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Substance-related Disorders, Behavior, Addictive
A Study of the Correlation Between the Severity of Substance Use Disorder and the Intensity of Dependence on Generative Artificial Intelligence
This bicentric, cross-sectional observational study conducted in France evaluates the relationship between substance use disorder (SUD) severity and generative artificial intelligence dependency among outpatients treated in…
- Conditions
- Substance-related Disorders, Behavior, Addictive, Artificial Intelligence (AI)
- Trial name
- ADDICT-IA (NCT07819851)
- Testing
- Questionnaire assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Depression, Dual Diagnosis
A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users
Methamphetamine (MA) addiction is a public health concern that causes substantial harm to individual users, and imposes an economic burden in the U.S. totaling up to $48.3 billion annually.
- Conditions
- Depression, Dual Diagnosis, Drug Addiction
- Trial name
- NCT02192931
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Perry Renshaw
Tobacco Use Disorder
A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.
Dopamine (DA) plays a critical role in nicotine (and other) addiction and this drug is known to release DA in brain areas mediating reward and motivational processes.
- Trial name
- NCT00396669
- Testing
- Bupropion
- Where
- Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Opiate Addiction, Borderline Personality Disorder
Evaluation of DBT Compared to Drug Counseling for Opiate Addicts
The purpose of this study is to compare a one year treatment program of Dialectical Behavior Therapy (DBT) + suboxone for opiate addicted individuals meeting criteria for borderline personality disorder (BPD) to a one year…
- Trial name
- NCT00117741
- Testing
- Dialectical Behavior Therapy, Drug Counseling
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Washington
Opioid Use Disorder (OUD)
HEALing Communities Study
This study will test the impact of implementing the Communities That Helping to End Addiction Long-term (HEAL) intervention on opioid overdose deaths within 67 highly affected communities with the goal of reducing opioid overdose…
- Trial name
- NCT04111939
- Testing
- Communities That HEAL, Wait-list control
- Where
- 4 sites in United States
- Volunteers
- 67 people
- Sponsor
- RTI International
Nicotine Vaping, Nicotine Dependence
Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency
Electronic nicotine delivery systems (ENDS) heat and vaporize a nicotine-containing liquid to produce an aerosol that can deliver nicotine to the blood and the brain.
- Conditions
- Nicotine Vaping, Nicotine Dependence, Nicotine Addiction
- Trial name
- NCT05430334
- Testing
- e-liquid 1, e-liquid 2, e-liquid 3
- Where
- Lebanon
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Drug Dependency
Clinician-patient Interaction During Addiction Consultation
Accurately predicting the risk factors of patients' suffering a drug overdose plays a crucial role in effective prevention of drug overdose.
- Trial name
- CLiPID (NCT01769651)
- Testing
- methadone replacement therapy
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of St Andrews
Nicotine Addiction
Nicotine Reinforcement and Aversion in Young Adult Light Smokers
The proposed study will examine the threshold for nicotine self-administration (NSA) using five different nicotine doses in young adult male and female non-dependent smokers (light and intermittent smokers or LITS).
- Trial name
- NCT01495819
- Testing
- Saline, Nicotine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention
A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents
This study will examine E-Invite Only VR, a novel school-based universal e-cigarette prevention intervention that uses virtual reality (VR) to deliver prevention and emotion regulation skills-building content to middle school…
- Conditions
- E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
- Trial name
- NCT07460622
- Testing
- Virtual Reality E-Cigarette Prevention Program
- Where
- United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use Disorder, Stimulant Use Disorder
Contingency Management for Opioid and Stimulant Use Disorders in Primary Care
Contingency management (CM) is a behavioral intervention that involves incentivizing participants for target behaviors in a clinical setting.
- Trial name
- NCT05288751
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Minnesota
Depression, Anxiety
Microcurrent Neurofeedback as an Adjunct to Standard Care for Substance Use Disorders
The goal of this clinical trial is to learn whether adding Microcurrent Neurofeedback (MCN) to standard residential treatment helps adults with substance use disorder more than standard treatment alone.
- Conditions
- Depression, Anxiety, Substance Use Disorder (SUD), Post Traumatic Stress Disorder
- Trial name
- NCT07737652
- Testing
- Microcurrent Neurofeedback (MCN), Standard Care for Substance Use Disorder
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Alabama, Tuscaloosa
Opioid Use Disorder, Opioid Abuse and Addiction
GLP-1R Agonist Treatment for Opioid Use Disorder
The goal of this clinical trial is to learn if semaglutide can reduce illicit opioid use in adults in outpatient treatment for opioid use disorder, and who are receiving either buprenorphine or methadone maintenance treatment.
- Conditions
- Opioid Use Disorder, Opioid Abuse and Addiction, Narcotic-Related Disorders, Substance-Related Disorders
- Trial name
- NCT06548490
- Testing
- Semaglutide Pen Injector
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Milton S. Hershey Medical Center
Stress Disorder, Post-Traumatic, Substance-Related Disorders
Integrated Cognitive Behavioral Therapy (ICBT) for Posttraumatic Stress Disorder (PTSD) and Substance Use Disorders
The purpose of this study is to assess the safety and practicality, feasibility and efficacy of ICBT for co-occurring PTSD and substance use disorders within the OEF/OIF/OND Veterans population, as delivered by routine clinicians…
- Trial name
- NCT01457404
- Testing
- Integrated Cognitive Behavioral Therapy, Treatment-as-usual
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Amphetamine-Related Disorders
A Cognitive Behavioral Therapy-Based Text Message Intervention for Methamphetamine Dependence
This Phase I behavior therapy development study seeks to improve treatment outcomes for methamphetamine (MA)-dependent subjects by developing a novel cognitive behavioral therapy- (CBT-) based short message service (SMS) text…
- Trial name
- NCT01899313
- Testing
- CBT- based SMS text messaging intervention, CBT group therapy
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- California Pacific Medical Center Research Institute