Clinical trials: Addiction, Substance
Nicotine Addiction, Nicotine Use Disorder
Nicotine Virtual Reality Conditioned Place Preference
In this between-subjects, placebo controlled, double-blind study, the investigators will examine the effects of low oral doses of nicotine on the learning and extinction of a conditioned place preference acquired in a virtual…
- Trial name
- NEVE (NCT06259630)
- Testing
- Nicotine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Cocaine-Related Disorders
Treatment With Transcranial Magnetic Stimulation for Cocaine Addiction: Clinical Response and Functional Connectivity.
The purpose of this study is to investigate the short and long term clinical and cognitive effects of repetitive Transcranial Magnetic Stimulation (rTMS) at 5 Hz and/or 10 Hz frequencies on the left dorsolateral prefrontal cortex…
- Trial name
- TMS_COC_CONN (NCT02986438)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Substance Abuse, Substance Dependence
Adolescent Outpatient and Continuing Care Study
The purpose of this study was to evaluate the effectiveness and cost-effectiveness of two types of outpatient treatment with and without Assertive Continuing Care (ACC) for 320 adolescents with substance use disorders.
- Trial name
- AOCCS (NCT01381133)
- Testing
- Chestnut Bloomington Outpatient (CBOP), Motivational Enhancement Therapy/Cognitive Behavior Treatment (MET/CBT 7), Assertive Continuing Care (ACC)
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Chestnut Health Systems
Opioid Use Disorder, Pregnancy Related
Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD
The primary objective of this study is to evaluate the ability of TOME to increase Medication for Opioid Use Disorder (MOUD) and opioid-overdose knowledge in pregnant and postpartum persons.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse
- Trial name
- TOME (NCT06262347)
- Testing
- Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
- Where
- 6 sites in United States
- Volunteers
- 131 people
- Sponsor
- T. John Winhusen, PhD
Opioid-Related Disorders
Effectiveness of Lofexidine to Prevent Stress-Related Opiate Relapse During Naltrexone Treatment - 1
Lofexidine is an experimental medication that may be beneficial in reducing opiate withdrawal symptoms, such as sleep difficulty, anxiety, and tension.
- Trial name
- NCT00142909
- Testing
- Lofexidine
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Yale University
Heroin Addiction
Decision Making Deficit and DNA Methylation in Opioid Receptor Genes Among Community Heroin Addicts
Heroin addiction has emerged as a serious problem with tremendous impacts on the addicts and the society. Since the introduction of opioids substitutive treatment in 2006, more than 30,000 heroin addicts had received treatment…
- Trial name
- NCT01668732
- Volunteers
- 1 people
- Sponsor
- National Health Research Institutes, Taiwan
Opiate Addiction
NAOMI: A Study to Compare Medically-prescribed Heroin With Oral Methadone in Chronic Opiate Addiction
The objective of this study is to determine whether the closely supervised provision of injectable, pharmaceutical-grade heroin (in combination with oral methadone) is more effective than methadone therapy alone in recruiting…
- Trial name
- NCT00175357
- Testing
- Methadone, Diamorphine hydrochloride
- Where
- 2 sites in Canada
- Volunteers
- 192 people
- Sponsor
- University of British Columbia
Nicotine Dependence
Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity
Background: Smoking is a difficult habit to quit, and some people find it more difficult to quit than others do. Nicotine is the substance in cigarettes that makes smoking so addictive.
- Trial name
- NCT01867411
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Repetitive Transcranial Magnetic Stimulation (rTMS) for Nicotine Addiction
Cigarette smoking remains a significant public health concern. A magnetic field applied to the outside of the skull can produce electrical activity in the brain without significant pain or the need for anesthesia.
- Trial name
- rTMS (NCT02401672)
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Opioid-Related Disorders, Opioid-use Disorder
RETAIN: Retaining Opioid Users Entering Medication Assisted Treatment and Encouraging HCV/HIV Testing
The purpose of this research study is to: 1. assess how well individuals entering medication assisted treatment like the RETAIN e-health application as measured by their feedback on the intervention. 2.
- Conditions
- Opioid-Related Disorders, Opioid-use Disorder, Drug Addiction, Substance Use Disorders
- Trial name
- RETAIN (NCT03411265)
- Testing
- self-administered, e-health application
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Hepatitis C, Medication Adherence
Intensive Models of HCV Care for Injection Drug Users
Injection drug users (IDUs) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). HCV treatment leading to sustained viral response (SVR) is associated with increased survival.
- Trial name
- NCT01857245
- Testing
- Intensive Models (mDOT and CGT) of HCV Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Prisma Health-Upstate
Marijuana Abuse
Efficacy and Safety of the Hcoil Deep TMS for the Treatment of Cannabis Addiction
Evaluation of efficacy and safety of H-coil deep transcranial magnetic stimulation 9 week treatment trial for cannabis addiction as assessed by measures of drug intake and craving.
- Trial name
- NCT00543036
- Testing
- H-Coil deep TMS
- Where
- Israel
- Sponsor
- Shalvata Mental Health Center
Addiction, Substance Abuse Drug Chronic
Stage III Community-based Efficacy Trial for Mothering From the Inside Out
This is a Stage III community-based randomized clinical efficacy trial testing Mothering from the Inside Out (MIO), the first evidence-based parenting intervention designed to be delivered by addiction counselors in addiction…
- Conditions
- Addiction, Substance Abuse Drug Chronic, Child Neglect, Child Neglect Emotional
- Trial name
- NCT02955199
- Testing
- Mothering From the Inside Out (MIO), Parent Education
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Yale University
End Stage Liver Disease, End Stage Renal Disease
Transplant and Addiction Project (TAP) - 1
The purpose of this study is to test a novel distance-based (telephone) intervention to help transplant candidates with current or recent substance abuse to stay "clean and sober" both prior and following transplant surgery.
- Conditions
- End Stage Liver Disease, End Stage Renal Disease, Substance-Related Disorders
- Trial name
- NCT00249652
- Testing
- TAP, TAU
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Cocaine Dependence
Therapeutic Cocaine Vaccine: Human Laboratory Study
Clinical data demonstrate that a cocaine vaccine (TA-CD: Celtic Pharmaceutical) produces selective anti-cocaine antibodies, yet the impact of these antibodies on cocaine's direct effects is unknown.
- Trial name
- NCT00965263
- Testing
- Cocaine vaccine (TA-CD)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cigarette Addiction, Tobacco Use Disorder
Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability
This randomized, double-blind, crossover human laboratory study compares the abuse liability of cigarettes containing menthol and non-menthol cigarette variants, using the participant's usual brand menthol cigarette as a…
- Trial name
- NCT07564648
- Testing
- Biospecimen Collection, Questionnaire Administration, Cigarette Purchase Task
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Nicotine Addiction
tDCS Effects on Resisting Smoking: Dose Ranging Study
Behaviors such as tobacco use, unhealthy diet, and sedentary behavior have far-reaching health implications. These modifiable behaviors account for a substantial proportion of deaths from cancer, cardiovascular disease and…
- Trial name
- RDR (NCT02624284)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Smoking, Electronic Cigarette Use
Dual Use Approach Bias Training for Nicotine Addiction
The present project will evaluate the initial efficacy of approach bias retraining among dual combustible cigarette (CC) and electronic cigarette (ECIG) users.
- Conditions
- Tobacco Smoking, Electronic Cigarette Use, Substance Use
- Trial name
- NCT05306158
- Testing
- CC+ECIG Condition, CC Condition
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Houston
Opioid-related Disorders, Opioid Addiction
Surveillance Monitoring of Opioid Abuse in Poison and Drug Treatment Centers
To conduct surveillance for abuse, misuse, overdose, addiction, and death and to evaluate if the REMS meets its surveillance goals, and if it does not, to modify it appropriately based on the metrics.
- Conditions
- Opioid-related Disorders, Opioid Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02871232
- Testing
- Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS) System of post-marketing surveillance of prescription medication abuse, misuse, and diversion
- Volunteers
- 26,500 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute