Clinical trials: Addiction, Substance
Substance Use Disorders
E-health Implementation (Iowa)
This research will test a technology adoption framework to increase use of the A-CHESS smartphone app. The project, based in Iowa, will compare a control condition (using a typical product training approach to software…
- Trial name
- NCT03954184
- Testing
- NIATx-TI with Product Training/On-line Support
- Where
- 49 sites in United States
- Volunteers
- 23,659 people
- Sponsor
- University of Wisconsin, Madison
Craving, Depression, Anxiety
Non-invasive Brain Stimulation in Patients With Methamphetamine Use Disorder
The study aims to apply the intermittent theta burst transcranial magnetic stimulation (iTBS) treatment and evaluate the effect in improving craving, affective symptoms, and cognitive function for those participants in the…
- Conditions
- Craving, Depression, Anxiety, Amphetamine Addiction
- Trial name
- NCT05535101
- Testing
- Intermittent theta burst transcranial magnetic stimulation (iTBS)
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Cannabis Dependence
Social and Emotional Brain Function in Cannabis Users
The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a…
- Trial name
- NCT02711371
- Testing
- fMRI
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Opioid Use Disorder, Clinical Decision Support
Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2
This study is stage 2, round 2 of a larger study which refines and optimizes the EMBED clinical decision support (CDS); see NCT03658642 to increase number of ED physicians following standard of care for the administration of…
- Trial name
- NCT07602218
- Testing
- Refined EMBED CDS, Provider alert to order consultation with addiction counselor
- Where
- 3 sites in United States
- Volunteers
- 379 people
- Sponsor
- Yale University
Cannabis Use Disorder
RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative
The purpose of this sham-controlled pilot randomized controlled trial (RCT) is to evaluate the feasibility, safety, and preliminary efficacy of a one-month intervention consisting of 20 home-based active or sham RS-tDCS sessions…
- Trial name
- NCT07184983
- Testing
- Active Transcranial Direct Current Stimulation (tDCS), Mindfulness meditation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- NYU Langone Health
Opiate Addiction, Pregnancy
Pharmacologically-based Strategies for Opioid Substitution Therapy During Pregnancy
This study is a pharmacodynamic study in pregnant women evaluating the relationship between buprenorphine concentration and outcome such as opioid withdrawal symptoms , NAS scores, neurodevelopmental and neuroanatomic outcomes.
- Trial name
- NCT03831113
- Testing
- Magnitude Group, Frequency Group
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Steve N. Caritis, MD
Opioid Abuse and Addiction
Nalmefene Implant in Healthy Subjects
The goal of this clinical trial is to learn how safe either one or two nalmefene implants are after remaining implanted for 4 or 12 weeks.
- Trial name
- NCT07325279
- Testing
- 1 Nalmefene implant, 2 Nalmefene implants
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- ReacX Pharmaceuticals, Inc.
Hepatitis C, Substance Dependence
Initialization of Methadone in Primary Care, Randomized Intervention Research for Preventing HCV Transmission Practices
The rapid scale up of opioid substitution treatment (OST) for drug users mainly achieved through the possibility of prescribing buprenorphine in primary care has been successful in reducing HIV prevalence among drug users but…
- Conditions
- Hepatitis C, Substance Dependence, Methadone
- Trial name
- Methaville (NCT00657397)
- Testing
- Methadone
- Where
- France
- Volunteers
- 197 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Substance Use Disorders
Addiction-focused EMDR in Inpatients Who Use Non-opioid Drugs: a Multiple Baseline Study
Rationale: It is well established that Substance Use Disorders (SUD) have severe health consequences. Despite behavioral and pharmacological treatment options, relapse rates remain high.
- Trial name
- NCT05923697
- Testing
- AF-EMDR
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- IrisZorg
Cocaine Dependence, Opiate Dependence
A Drug Treatment for Cocaine Users Who Are Also on Methadone Maintenance Treatment
The main goal of this study is to evaluate the safety and tolerability of 40 or 80 mg atomoxetine as a treatment for cocaine dependence.
- Trial name
- NCT01802515
- Testing
- Atomoxetine, low dose, Atomoxetine, high dose
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Opioid Dependence, Substance Abuse Disorders
The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care
The goal of this pilot clinical trial is to learn if a community informed designed program of addiction counseling with coordinated community peer navigator for people with Opioid Use Disorder (OUD) and other medical conditions…
- Conditions
- Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
- Trial name
- MOUD+ (NCT06837662)
- Testing
- MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Oregon Health and Science University
Smoking, Cannabis
Imaging the Neurochemistry of Drug Addiction With PET
The investigators' project has two overarching goals. 1) The investigators will use newly developed positron emission tomography (PET) technology to investigate the dopaminergic neurochemistry of drugs of abuse including…
- Trial name
- NCT02817698
- Testing
- cannabis
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Substance Addiction
Maternal Acupuncture for Substance Abuse
To determine the efficacy of daily maternal acupuncture treatments in reducing the frequency and severity of neonatal abstinence syndrome among infants born to substance-using women..
- Trial name
- NCT00225316
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Opioid Dependence, Pain
Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintenance
Pain is very common in persons with a history of addiction, but few studies have examined the best treatment of pain in this population.
- Conditions
- Opioid Dependence, Pain, Addiction
- Trial name
- NCT01642030
- Testing
- Hydromorphone, Buprenorphine
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Johns Hopkins University
Alcoholism, fMRI
Neural Substrates of Approach-Avoidance Conflict
Background: People who are dependent on alcohol drink even when they know something bad might happen. Researchers want to learn more about why they do this.
- Conditions
- Alcoholism, fMRI, Rewarding Mediating System
- Trial name
- NCT02119624
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcoholism, Cocaine Addiction
The Effects of Theta Burst Stimulation on the Brain Response to Drug and Alcohol Cues
High relapse rates among substance dependent individuals are likely due to a combination of factors that involve limbic circuits in the brain involved in craving, including vulnerability to salient cues.
- Conditions
- Alcoholism, Cocaine Addiction, Drug Addiction
- Trial name
- addictionTBS (NCT02939352)
- Testing
- Real continuous Theta Burst Stimulation
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Medical University of South Carolina
Cocaine Addiction
Integrative Meditation (IM) for Cocaine Addiction
Cocaine addiction continues to be a major problem in the U.S. with no FDA-approved pharmaceutical therapy. Finding effective treatment for cocaine addiction has long been a challenge to scientists and clinicians.
- Trial name
- NCT01211418
- Testing
- Integrative Meditation, Supportive Counseling
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Maryland, Baltimore
Opioid-Related Disorders, Drug Addiction
Medication Treatment for Opioid Use Disorder in Expectant Mothers
The primary objective of this study is to evaluate the impact of treating opioid use disorder (OUD) in pregnant women with extended-release buprenorphine (BUP-XR), compared to sublingual buprenorphine (BUP-SL), on mother and…
- Conditions
- Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse
- Trial name
- MOMs (NCT03918850)
- Testing
- Buprenorphine Injection, Buprenorphine Sublingual Product
- Where
- 12 sites in United States
- Volunteers
- 140 people
- Sponsor
- T. John Winhusen, PhD
Cocaine Dependence
Pharmacologic MRI in Cocaine Addiction
In the proposed study, the investigators will assess the brain response to medication probes the investigators have previously studied with SPECT.
- Trial name
- phMRI (NCT01652378)
- Testing
- ondansetron, lidocaine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cocaine Related Disorders
Stress and Medication Effects on Cocaine Cue Reactivity
Stressful situations and cues associated with cocaine can lead to craving in cocaine dependent individuals. The purpose of this study is to determine whether guanfacine or modafinil are effective in reducing stress and cue…
- Trial name
- NCT00613015
- Testing
- Guanfacine, Modafinil
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Medical University of South Carolina