Clinical trials: Addiction, Substance
Alcohol Use Disorder (AUD)
The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study
A phase II randomized, double-blind, placebo-controlled clinical trial (RCT) to evaluate the ability of zonisamide (ZON) to decrease alcohol use among treatment-seeking adults with an alcohol use disorder (AUD).
- Trial name
- NCT05134857
- Testing
- Zonisamide
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Washington State University
Substance Use Disorders
Smartphone Addiction Recovery Coach for Young Adults (SARC-YA) Experiment
At discharge from outpatient treatment, researchers will recruit 300 young adults and randomly assign them to recovery support as usual control condition or the Smartphone Addiction Recovery Coach for Young Adults (SARC-YA)…
- Trial name
- SARC-YA (NCT03301012)
- Testing
- Recovery support as usual, Smartphone assisted relapse prevention
- Where
- 2 sites in United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Psychiatry
NUTRItion-driven Detoxification of OPioid Addicted patiEnts
The NUTRIDOPE (NUTRItion-driven Detoxification of OPioid addicted patiEnts) study is a clinical trial that aims to investigate the role of pomegranate juice consumption by opioid-addicted patients under buprenorphine and…
- Trial name
- NUTRIDOPE (NCT05861544)
- Testing
- Pomegranate juice
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- Organization Against Drugs (ΟΚΑΝΑ)
Opioid-use Disorder
Smartphones for Opiate Addiction Recovery
Treatments for opioid addiction exist, but effectiveness is compromised when subjects use illicit opiates during treatment. Reuse rates during treatment can be high, and reducing illicit opiate use during treatment has thus…
- Trial name
- SOAR (NCT05033028)
- Testing
- Smartphone app
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- NYU Langone Health
Post Traumatic Stress Disorders, Unsafe Sex
Cognitive Processing Intervention for Trauma, HIV/STI Risks, and Substance Use Among Native Women
Many American Indian (AI) women never receive services for serious mental health problems resulting from traumatic events, violence exposure and maltreatment.
- Conditions
- Post Traumatic Stress Disorders, Unsafe Sex, Substance Use Disorders
- Trial name
- NCT01849029
- Testing
- Cognitive Processing Therapy-Cognitive
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Alcohol Use Disorder
Psilocybin-assisted Therapy for Treatment of Alcohol Use Disorder
Note: The trial is only eligible for citizens of Denmark. The purpose of this project is to assess the treatment efficacy of a single high dose of psilocybin administered within a protocol of psychological support to patients…
- Trial name
- NCT05416229
- Testing
- Psilocybin, Maltodextrin
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Cocaine Dependence
Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
The proposed research program will investigate the changes in brain chemistry and circuitry that 're-wire' the brain during chronic cocaine use, promote relapse, and complicate treatment efforts.
- Trial name
- NCT03471182
- Testing
- Psychiatric and Cognitive Testing, Cocaine Self-adminstration, Positron Emission Tomography
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Yale University
Drug Addiction, HIV
The Cedar Project: Impact of mHealth for HIV Prevention Among Young Indigenous People Who Use Illicit Drugs
This study will examine the effect of a culturally-safe two-way supportive text message intervention to reduce HIV vulnerability among young Indigenous people who use illicit drugs in a community-based setting.
- Trial name
- NCT02437123
- Testing
- The Cedar Project mHealth intervention
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of British Columbia
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Intensive Care Unit Syndrome, Drug Abuse
Addiction in Intensive Cardiac Care Units
Background: Illicit drug use is a growing issue in Europe and leading cause of acute cardiac events in patients admitted to intensive cardiac care units.
- Conditions
- Intensive Care Unit Syndrome, Drug Abuse, Substance-Related Disorders, Cardiovascular Events
- Trial name
- ADDICT-CCU (NCT05063097)
- Testing
- urine test, Fagerström questionnaire, Exhaled carbon monoxide (CO) measurement
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hiv, Opioid-use Disorder
Integrating Addiction Treatment and HIV Services Into Primary Care Clinics in Ukraine
A randomized controlled trial to: 1. To compare both primary (composite quality health indicator (QHI) scores) and secondary (individual HIV/methadone maintenance treatment (MMT)/TB/primary care QHI scores, quality of life, and…
- Trial name
- IMPACT (NCT04927091)
- Testing
- Integration of HIV and PWID services
- Where
- Ukraine
- Volunteers
- 1,590 people
- Sponsor
- Yale University
Substance Use, Harm Reduction
A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students
The primary goal of this study is to test the effectiveness of the iDECIDE (Drug Education Curriculum: Intervention, Diversion, and Empowerment) curriculum, a novel drug education and diversion program, in approximately 300…
- Conditions
- Substance Use, Harm Reduction, Adolescent Behavior
- Trial name
- NCT06115746
- Testing
- iDECIDE
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Substance-Related Disorders
Effects of Repeated Memory Training on Memory Function and Addiction Related Processes
Prospective memory is the ability to implement an intention to the future (e.g. remember to take medication, attend a scheduled meeting), and has receive little attention in addiction.
- Trial name
- NCT03285256
- Testing
- Experimental memory training, Comparator memory training 1, Comparator memory training 2
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Addiction Chemical, Use, Substance
Substance Use Disorder in Chemsex Practice
The main aim of this descriptive cross-sectional study is to assess the prevalence of chemsex substance use disorder among chemsexers via an online self-questionnaire.
- Trial name
- TU CHEMSEX (NCT06476873)
- Testing
- Online self-questionnaire.
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Opioid Use Disorder, Addiction, Opioid
Leveraging Artificial Intelligence and Multi-Omics Data to Predict Opioid Addiction
The primary goal of this proposal is to validate a novel genomic and microbiome predictive model that may be used to assess a person's risk of developing opioid use disorder (OUD).
- Trial name
- NCT06540105
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, San Diego
Alcohol Dependence, Alcohol Drinking
Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
Background: People with alcoholism have differences in their brains compared with healthy people. People who are dependent on alcohol also perform differently on behavioral tasks.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Alcohol-Related Disorders, Alcoholism
- Trial name
- NCT02108080
- Where
- United States
- Volunteers
- 389 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Community Reinforcement And Family Training, Family Health
Phase II: Scalable Digital Delivery of CRAFT Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to demonstrate digital training efficacy at scale and commercial readiness. This pilot project will advance piloted digital training programs for CRAFT and maximize scalability.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT06685003
- Testing
- Digital Tutorial overview, Digital Tutorial plus training Materials, Digital Tutorial plus training Materials plus feedback and Coaching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Opioid-use Disorder
Treatment of Pregnant Women With OUD
The investigators are testing two models of support for pregnant women with an opioid use disorder (OUD)
- Trial name
- SMART (NCT04240392)
- Testing
- Collaborative Care (CC), Extension for Community Healthcare Outcomes (ECHO)
- Where
- 11 sites in United States
- Volunteers
- 230 people
- Sponsor
- Yale University
Alcohol Abuse, Arteriosclerosis
Clinical Study of Ligustrazine in Treating Alcohol Addiction
Alcohol consumption is one of the most important risk factors for chronic non-communicable diseases in the population, and it is also the main cause of death from cancer, cardiovascular disease and lung disease, causing serious…
- Trial name
- NCT05942352
- Testing
- Ligustrazine by intravenously administration, Ligustrazine by mouth
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shenzhen Kangning Hospital
Alcohol Dependence, in Remission, Addiction, Alcohol
Does Treatment With GLP-1 Reduce Alcohol Intake in Patients With Alcohol Dependence?
The study is a double-blinded, randomized, placebo-controlled, 26-weeks clinical trial. The objective of the trial is to investigate the effects of the GLP-1 receptor agonist Bydureon® (exenatide) vs.
- Trial name
- EXALT (NCT03232112)
- Testing
- Exenatide 2 MG Injection, BD PosiFlush (saline)
- Where
- Denmark
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Anders Fink-Jensen, MD, DMSci