Clinical trials: Addiction, Substance
PTSD, Substance Addiction
Integrated vs Sequential Treatment for PTSD and Addiction
The investigators are examining different treatment strategies of helping patients with PTSD and addiction.
- Trial name
- NCT01211106
- Testing
- Prolonged Exposure, Motivational Enhancement Therapy
- Where
- 2 sites in United States
- Volunteers
- 183 people
- Sponsor
- VA Office of Research and Development
Opioid-Related Disorders, Opiate Addiction
A Survey to Eval the Relation Between Doctor/Pharmacy Shopping and Outcomes Suggestive of Misuse, Abuse and/or Diversion
To evaluate the reasons patients go to more than one prescriber or more than one pharmacy to obtain prescriptions opioids and assess whether the percentage of patients reporting misuse, abuse and/or diversion increases across…
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02667158
- Testing
- Survey to Eval Relation between Shopping and Misuse, Abuse
- Volunteers
- 1,085 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Substance Dependence
A Study To Assess The Effects Of A Single Dose Of GSK598809 In Modulating Nicotine Reward
GSK598809 is being developed as an innovative treatment for substance dependence and potentially other compulsive behavioral disorders.
- Trial name
- NCT00605241
- Testing
- GSK598809
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alcoholism
Sleep Disturbance and Relapse in Individuals With Alcohol Dependence: An Exploratory Mixed Methods Study
Despite research establishing the relationship between sleep disturbances and alcohol use, there is no clear understanding or model for what occurs once individuals who seek inpatient alcoholism treatment are discharged from…
- Trial name
- NCT02181569
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Addiction
Linking fMRI to Mobile Technologies in Addiction Research: Pathophysiology of Executive Deficits, Craving and Substance Use
120 individuals with alcohol, cannabis or nicotine dependence as well as healthy controls will be administered a whole-brain imaging exam.
- Trial name
- MobiCogIm (NCT02334956)
- Testing
- Brain MRI
- Where
- 2 sites in France
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Bipolar Disorder, Mania
Depakote ER Therapy for Mania Comorbid With Substance Abuse
The purpose of this study is to ascertain whether Depakote ER (Divalproex ER) has efficacy in the treatment of patients with bipolar disorder in the manic phase, who also have comorbid substance abuse diagnoses.
- Conditions
- Bipolar Disorder, Mania, Substance Abuse, Substance Dependence
- Trial name
- NCT00208195
- Testing
- Divalproex ER
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Creighton University
Opioid Related Disorders, Opiate Addiction
Evaluation of Drug Utilization Patterns for Extended Release/Long Acting Opioids and Comparator Products
A drug utilization study will be performed to describe trends in the number of prescriptions and patients for class REMS ER/LA opioids and comparator products.
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02925806
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 5,575,834 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Cocaine Addiction
Reducing Drug Craving Memories
The primary objective is to investigate the potential ability of Inderal (propranolol hydrochloride) to diminish the reconsolidation of motivationally potent drug-related cues in cocaine dependent participants.
- Trial name
- NCT01319214
- Testing
- Inderal
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Addiction, Alcohol Use Disorder
Semaglutide Therapy for Alcohol Reduction (STAR)
Background: Alcohol use disorder (AUD) is a problematic pattern of alcohol use accompanied by clinically significant medical consequences.
- Trial name
- NCT06015893
- Testing
- Take Control, Semaglutide
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder, Chronic Pain
Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine
Chronic pain is common in individuals with opioid use disorder (OUD) and the first-line treatment, Medication for OUD (MOUD), does not address the considerable functional impairments associated with chronic pain.
- Trial name
- NCT07361432
- Testing
- Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT), Enhanced Treatment as Usual (ETAU)
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development
Cannabis Use, Cannabis Dependence
Neuroimaging of Adolescent Cannabis Use Treatment
This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use.
- Conditions
- Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse
- Trial name
- ACT (NCT07340554)
- Testing
- Contingency Management, Elastic Net Regression
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Alcoholism
Alcohol Dependency Study: Combining Medication Treatment for Alcoholism
The purpose of this study is to learn whether ondansetron and topiramate either alone or in combination is safe and effective in the treatment of alcohol dependence.
- Trial name
- NCT00006205
- Testing
- ondansetron + cognitive behavioral therapy, topiramate + cognitive behavioral therapy, ondansetron + topiramate + cognitive behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Bankole Johnson
Nicotine Dependence
Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers
Previous results from the investigators' Center have shown that combination treatment with Chantix and Zyban is more successful in helping men quit smoking. The investigators hope to replicate these findings with this study.
- Trial name
- ConNic5 (NCT01806779)
- Testing
- Chantix, Zyban, Nicotine patches
- Where
- 4 sites in United States
- Volunteers
- 376 people
- Sponsor
- Duke University
Nicotine Dependence
Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation
The purpose of this study is to look at brain function in order to understand how different treatments work to help people quit smoking.
- Trial name
- ConNicBrain (NCT01406223)
- Testing
- Varenicline, Bupropion, Nicotine patches
- Where
- 2 sites in United States
- Volunteers
- 282 people
- Sponsor
- Duke University
Smoking Cessation
Interventions for Smoking Among Persons in Recovery
Examine the efficacy of a stepped-care smoking cessation intervention for current and former smokers in chemical dependency treatment programs.
- Trial name
- INSPIRE (NCT00714896)
- Testing
- Stepped-Care, Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Addiction, Substance Use Disorder
Group Version of CRAFT Compared to Self-Directed CRAFT Delivery and Non-intervention: a Three-armed RCT
The aim of this study is to determine whether a group format Community Reinforcement and Family Training (CRAFT) and Self-Directed CRAFT Delivery are more effective than non-intervention in terms of Concerned Significant Others…
- Conditions
- Addiction, Substance Use Disorder, Alcohol Use Disorder, Substance- Related Disorder
- Trial name
- NCT02510508
- Testing
- Group CRAFT, Self-Directed CRAFT Delivery, Non-intervention
- Where
- 6 sites in Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- IrisZorg
Alcohol Addiction
Effects of Frontopolar TMS in Alcohol Craving
The goal of this interventional study is to learn if continuous theta burst stimulation (cTBS) applied over the left frontopolar cortex can reduce psychological, physiological, and neurobiological markers of alcohol craving in…
- Trial name
- TMS-SUD (NCT07064590)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in Germany
- Volunteers
- 34 people
- Sponsor
- Goethe University
Tobacco Use Disorder
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the…
- Trial name
- NCT03713424
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Opioid Use Disorder
PRoducing Outcome Measures for OTP Quality Improvement
This study tests ways to help opioid treatment programs (OTPs) keep patients in care. Staying on methadone or buprenorphine is linked to better outcomes, yet many people leave treatment early.
- Trial name
- PROMOTE-QI (NCT07214389)
- Testing
- Quality Measures (Audit and Feedback), Quality Improvement (QI) Toolkit, External QI Facilitation
- Where
- United States
- Volunteers
- 4,500 people
- Sponsor
- RTI International
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic