Clinical trials: Addiction
Substance Use, Harm Reduction
A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students
The primary goal of this study is to test the effectiveness of the iDECIDE (Drug Education Curriculum: Intervention, Diversion, and Empowerment) curriculum, a novel drug education and diversion program, in approximately 300…
- Conditions
- Substance Use, Harm Reduction, Adolescent Behavior
- Trial name
- NCT06115746
- Testing
- iDECIDE
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Tobacco Use Disorder
Effect of Orexin System on Nicotine Addiction and Its Neural Mechanism
The goal of this clinical trial is to reveal the role and mechanism of orexin in nicotine addicts, compared to healthy control. The main questions it aims to answer are: Whether nicotine addiction-related behaviors, including…
- Trial name
- NCT05947162
- Testing
- extinction training (nicotine cues), extinction training (neutral cues), Time-restricted smoking cessation
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shenzhen Kangning Hospital
Volunteers Repeated Drug Poisoning, Alcoholic
Repeated Voluntary Drug Intoxication (IMVr): Characterization of a New Addictive Behavior by Clinical Phenotyping and Functional Imaging
France is one of the European countries with the highest rate of death by suicide, more than 10 400 deaths each year, about 16 people out of 100 000.
- Conditions
- Volunteers Repeated Drug Poisoning, Alcoholic, Volunteers
- Trial name
- Phenot IMVr (NCT02889042)
- Testing
- MRI and biological assessment
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Alcohol Use Disorder, Alcoholism
Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD)
The study will compare alcohol use in two groups of subjects. One group will be assigned to the Deep TMS treatment and the other group will be assigned to the sham treatment.
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT07216872
- Testing
- Deep TMS (DTMS)
- Where
- 11 sites in United States, Israel and 1 more
- Volunteers
- 186 people
- Sponsor
- Brainsway
Urinary Incontinence, Pelvic Floor Disorders
Exercise and Pelvic Floor Health Education Program Effectiveness
The aim of the study is investigation of the effectiveness of Pelvic Floor Health Education and exercise program in women with Urinary Incontinence.
- Conditions
- Urinary Incontinence, Pelvic Floor Disorders, Exercise Addiction
- Trial name
- NCT05410899
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Harran University
Cocaine Use Disorder, Cocaine Dependence
Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction
The goal of this clinical trial is to learn about the effects of the combination of ketamine and realtime functional magnetic resonance imaging (fMRI) neurofeedback training in individuals with cocaine use disorder.
- Trial name
- Co-Boost (NCT06125054)
- Testing
- Ketamine, real-time fMRI neurofeedback training
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Dr. med. Marcus Herdener
Addiction Psychological, Addiction
The Turkish Version of the Parental Smartphone Use Management Scale (PSUMS)
Parental Smartphone Use Management Scale (PSUMS) was originally developed in English language to parents to educate adolescents and communicate with them about online behavior and safety, as well as to conduct plans to manage…
- Conditions
- Addiction Psychological, Addiction, Adolescent
- Trial name
- NCT04409106
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Alcohol Abuse, Alcohol Addiction
Guided and Unguided Internet Treatment for Problematic Alcohol Use
The purpose of this study was to determine whether a 10-week internet-based program based on cognitive behavioral therapy (CBT) is effective in the treatment of alcohol problems, and if having therapist guidance leads to greater…
- Trial name
- NCT02384304
- Testing
- Choice, Messages, Self help
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Alcohol Addiction
Repetitive Transcranial Magnetic Stimulation (rTMS) of the Insula for Treatment of Alcohol Addiction
The purpose of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) targeting the insula on alcohol use and neural responses in alcohol-dependent patients.
- Trial name
- NCT02643264
- Testing
- rTMS 10 Hz targeting the insula
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- Linkoeping University
Alcohol Drinking
Addiction Risk: The Influence of Mindset Induction on the Effect of a Brief Intervention to Reduce Alcohol Use
Brief Interventions (BI) based on Motivational Interviewing are effective to reduce alcohol use. In this study the investigators test the hypothesis that that an open Mindset increases the positive effects of BI.
- Trial name
- NCT03339687
- Testing
- Experimental Mindset Induction
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- University of Konstanz
Hyperalimentation and Obesity
Cognitive Processes Study in Obese Women With and Without Eating Disorders
The P300 is one of the cognitive wave of the Event-Related Potential (ERP) that is used to investigate the cognitive process. The P300 component are accepted as electro-physiological markers of neuropsychiatric disorders like…
- Trial name
- P300 (NCT01948414)
- Testing
- electroencephalography, Blood sampling, Questionnaires regarding eating habits (TFEQ, EDI) and anxiety/depression (HAD)
- Where
- France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
De Quervain Tenosynovitis, Smartphone Addiction
De Quervain Syndrome Among Medical Students with Smart Phone Addiction
To investigate the prevelance of the de quervain tenosynovitis among the Egyptian medical students with smartphone addiction
- Trial name
- NCT06731634
- Testing
- Hand grip strength dynamometer, pinch strength dynamometer, Finkelstein test
- Volunteers
- 103 people
- Sponsor
- Cairo University
Internet Addiction
Effectiveness of WeChat Public Account Intervention Based on the IMB Model for College Students With Internet Addiction
Objective: The investigators want to see if a WeChat program can help college students use the internet less and feel better. Methods: The investigators picked 226 students who use the internet too much.
- Trial name
- NCT06704984
- Testing
- Intervention Name: WeChat Intervention Based on the IMB Model
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Shihaiyan Shi
Alcohol Abuse, Alcohol Addiction
Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity?
This 26-week long, double-blinded randomized clinical trial aims to investigate the effects of the GLP-1 receptor agonist semaglutide s.c.
- Conditions
- Alcohol Abuse, Alcohol Addiction, Alcohol Dependence, Alcohol Use Disorder
- Trial name
- SEMALCO (NCT05895643)
- Testing
- Semaglutide Injectable Product
- Where
- Denmark
- Volunteers
- 108 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Depression, Opioid Dependence
Desvenlafaxine in Opioid-Dependent Patients
Background: Although substitution therapy has been shown to be highly effective to retain opioid-dependent patients in treatment and reduce drug use, this population is afflicted by numerous conditions including depression.
- Conditions
- Depression, Opioid Dependence, Methadone Treatment
- Trial name
- NCT02200406
- Testing
- Desvenlafaxine
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Internet Addiction
Prevalence of Internet Addiction and it's Effects on Psychological Well-being of Adults in Hong Kong
The goal of this quantitative study is to learn about the the prevalence of internet addiction and its effects on psychological well-being of adults in Hong Kong.
- Trial name
- NCT06205004
- Testing
- Questionnaires
- Where
- Hong Kong
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Opiate Addiction
The Effectiveness of Deep Brain Stimulation for Opioid Relapse Prevention
The nucleus accumbens (NAcc) has a significant role in the process of opiate addiction and the initiation of relapse after detoxification.
- Trial name
- NCT02440152
- Testing
- Suzhou Sceneray® DBS System
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- Ruijin Hospital
Healthy Subjects
The Critical Link Between Gut Microbiome Dysfunction, Cravings and Relapse: RECLAIM-GUT TRIAL
The human gut contains a vast community of microorganisms-including bacteria, viruses, and fungi-collectively known as the gut microbiota. This ecosystem co-evolves with humans and is shaped by diet, environment, and lifestyle.
- Trial name
- RECLAIM-GUT (NCT07350538)
- Testing
- Personalized prebiotic dietary Formulation 2, Personalized prebiotic dietary Formulation 3, Personalized prebiotic dietary Formulation 1
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Tobacco Smoking, Harm Reduction
Smoking Harm Reduction Using E-cigarettes and Cytisine
Smoking remains the leading cause of preventable death globally, with high prevalence in disadvantaged populations despite access to free nicotine replacement therapy (NRT) and counseling through Ontario's STOP Program.
- Conditions
- Tobacco Smoking, Harm Reduction, Nicotine
- Trial name
- SHRECC (NCT07274475)
- Testing
- E-cigarette e-liquid, Cytisine
- Volunteers
- 6,000 people
- Sponsor
- Centre for Addiction and Mental Health
Toxicomania
Pharmacokinetic Modeling of Methadone
The management of patients with opioid addiction is a challenge insofar as many distractors or variability factors can interfere with the control of the addiction, whether they are psychological, psychiatric, environmental…
- Trial name
- PKMETHAHOME (NCT05490732)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier