Clinical trials: Addiction Opiate
Addiction
Safety and Tolerability of Cannabidiol Among Persons With Opioid Use Disorder Receiving Methadone or Buprenorphine
The overarching goal of this study is to evaluate the potential of Cannabidiol (CBD) as an adjunctive treatment for comorbid opioid use disorder (OUD) and chronic pain.
- Trial name
- NCT05076370
- Testing
- CBD Day 1, CBD Day 2, CBD Day 3
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Opioid Abuse, Opioid Dependence
Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers
Opioid drugs increase glial cell activation which may be related to the abuse liability of opioid drugs. Data supporting this hypothesis have demonstrated that glial cell attenuators decrease the positive rewarding aspect of…
- Trial name
- NCT01740414
- Testing
- MN-166 (50 mg) First
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York State Psychiatric Institute
Opiate Dependence, Sexually Transmitted Diseases
Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence
Before starting treatment with XR-NTX, a medication that blocks the positive effects of opioids and helps people stay off opioids, individuals who are dependent on opioids first have to endure a difficult withdrawal process.
- Conditions
- Opiate Dependence, Sexually Transmitted Diseases, HIV
- Trial name
- NCT02602795
- Testing
- Acceptance and Commitment Therapy, Information Motivation Behavioral Model
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rhode Island Hospital
Heroin Dependence, Opioid-Related Disorders
Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2 - 5
The purpose of this study is to assess the abuse liability and reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in heroin-dependent volunteers
- Trial name
- NCT00000330
- Testing
- Opioid-Related Disorders
- Where
- United States
- Sponsor
- University of Colorado, Denver
Opiate Dependence
Study of Buprenorphine-Naloxone Sublingual Spray and Suboxone® Sublingual Film in Healthy Volunteers
The primary objective of this study is to compare the bioavailability of a test formulation of Buprenorphine Naloxone Sublingual (SL) spray to that of a single dose of Suboxone® (buprenorphine and naloxone) sublingual film, under…
- Trial name
- NCT02477267
- Testing
- SL spray, SL film
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- INSYS Therapeutics Inc
Opioid Dependence, Parenting
Intervening With Opioid-Dependent MothersMothers and Infants
This study will assess the efficacy of the modified Attachment and Biobehavioral Catch-Up (mABC) Intervention, adapted for use with peripartum mothers receiving medication-assisted treatment for opioid use disorder.
- Conditions
- Opioid Dependence, Parenting, Infant Development
- Trial name
- mABC (NCT04454645)
- Testing
- mABC, mDEF
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Opioid Related Disorders, Opiate Addiction
Monitoring Patterns of Prescribing to Identify Changes in Access to ER/LA Opioid Analgesics
Changes in prescribing will be compared in prescribers from specialties whose prescribing is hypothesized to be relatively unaffected by the REMS (such as oncologists and hospice providers) versus those for whom the REMS could…
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02920775
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 360,000 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Chronic Pain, Opiate Dependence
Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment
This study involves the comparison of two treatment approaches for patients with chronic pain who are entering methadone maintenance treatment (MMT) for opioid addiction: (a) an integrated counseling that addresses both chronic…
- Trial name
- NCT01334580
- Testing
- Cognitive-Behavioral Therapy for Pain and Opioid Dependence, Methadone Drug Counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Opioid Dependence
Evaluation of BEMA® Buprenorphine NX for Buprenorphine Induction of Opioid Dependent Subjects
This is a randomized, double blind, placebo controlled study in opioid dependent subjects. Subjects meeting entry criteria will be treated with multiple doses of B-BNX or B-Placebo, with non-responders rescued within 6 hours.
- Trial name
- NCT01713803
- Testing
- Buprenorphine and naloxone
- Where
- United States
- Sponsor
- BioDelivery Sciences International
Drug Effect, Rib Fractures
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
Rib fractures represent a common injury pattern this is highly associated with patient morbidity and mortality, as pain control remains a challenge.
- Conditions
- Drug Effect, Rib Fractures, Rib Trauma, Surgical Procedure, Unspecified
- Trial name
- NCT03305666
- Testing
- Liposomal bupivacaine injection, Bupivacaine indwelling catheter
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Denver Health and Hospital Authority
Adult Opioid-Dependence
Applying Web Technology to Buprenorphine Treatment
The purpose of this clinical trial is to examine the efficacy and cost-effectiveness of an interactive, computer-based psychoeducational system when used by opioid-dependent patients in office-based buprenorphine treatment.
- Trial name
- NCT00182598
- Testing
- computer-based psychoeducational intervention, community-based substance abuse counseling
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Development and Research Institutes, Inc.
Opioid Use Disorder (OUD)
MethaLoad Dose-Finding Study
Methadone is an effective treatment for opioid use disorder (OUD), but starting it has become harder now that most people with OUD use fentanyl. Methadone is usually started at a low dose and increased slowly over several weeks.
- Trial name
- NCT06877858
- Testing
- Methadone hydrochloride
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ashish P Thakrar, MD MS
Opioid Withdrawal, Opioid Use Disorder (OUD)
Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder
This study is evaluating the Sparrow Link, a wearable device that delivers gentle electrical signals to nerves in the outer ear (a technique known as transcutaneous auricular neurostimulation, or tAN).
- Trial name
- NCT07079826
- Testing
- Sparrow Link (Active tAN)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Payel Roy
Opioid Dependence, Methadone Withdrawal Syndrome
Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients
The primary objective of this study is to assess QTc (an interval of the heart rhythm) interaction effects between lofexidine and methadone.
- Trial name
- NCT01650649
- Testing
- Lofexidine HCl, Lofexidine-matching sugar pill
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Opioid Dependence, Hepatitis
Computer-based Cognitive Behavioral Therapy for Risky Behaviors in Opioid Dependent Patients
The purpose of this study is to determine if a computerized version of Cognitive Behavioral Therapy (CBT) can improve high-risk sexual behaviors in patients attending an outpatient methadone treatment clinic.
- Conditions
- Opioid Dependence, Hepatitis, HIV
- Trial name
- NCT01645033
- Testing
- computerized Cognitive Behavioral Therapy (CBT), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Yale University
Opioid-Related Disorders, Substance-Related Disorders
Effects of Buprenorphine and Naloxone in Opiate Addicts - 4
The purpose of this study is to evaluate the behavioral and physiological effects of buprenorphine and naloxone, both alone and in combination.
- Trial name
- NCT00000355
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Dependence, HIV Seropositivity
Comparison of HIV Clinic-based Treatment With Buprenorphine Versus Referred Care in Heroin-dependent Participants
The purpose of this study is to compare the effectiveness of two approaches to treating HIV-infected patients who are addicted to opioid drugs (e.g., heroin) in an inner-city HIV clinic.
- Conditions
- Opiate Dependence, HIV Seropositivity, HIV Infections
- Trial name
- NCT00130819
- Testing
- Clinic-based substance abuse treatment with buprenorphine, Case management and referred substance abuse treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Johns Hopkins University
Opioid-Related Disorders
Buprenorphine as a Treatment for Individuals Dependent on Analgesic Opioids
Opioids used to treat chronic pain have a high abuse potential. The purpose of this study is to determine the effectiveness of buprenorphine in treating opioid dependent individuals who abuse opioids that are prescribed for…
- Trial name
- NCT00218101
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Opiate Dependence
Acceptance Therapy During Methadone Detoxification
The purpose of this study is to develop an opiate detoxification behavior therapy based on current Acceptance and Commitment Therapy (ACT) theory and method, and to test its feasibility and promise in the context of voluntary…
- Trial name
- NCT00439036
- Testing
- Behavior Therapy, Drug Counseling
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston