Clinical trials: Addiction Opiate, open to volunteers
Chronic Pain, Opioid Use
Reducing Opioid Use for Chronic Pain Patients Following Surgery
Patients with chronic pain are often prescribed long-term opioid therapy, despite the serious risks and growing concerns related to opioid use.
- Conditions
- Chronic Pain, Opioid Use, Postoperative Pain, Opioid Dependence
- Trial name
- RECOUP (NCT03675386)
- Testing
- Interventional Group, Control Intervention
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
Opioid-use Disorder, Opioid Dependence
Young Houston Emergency Opioid Engagement System
The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opioid Overdose, Opioid Use
- Trial name
- YHEROES (NCT04811014)
- Testing
- Buprenorphine, Naloxone Drug Combination, Individual Counseling, Peer Recovery Support Services
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The University of Texas Health Science Center, Houston
Opioid-use Disorder
Smartphones for Opiate Addiction Recovery
Treatments for opioid addiction exist, but effectiveness is compromised when subjects use illicit opiates during treatment. Reuse rates during treatment can be high, and reducing illicit opiate use during treatment has thus…
- Trial name
- SOAR (NCT05033028)
- Testing
- Smartphone app
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- NYU Langone Health
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Opioid Use Disorder
Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons
This study will examine the safety and efficacy of the O'Neil Long Acting Naltrexone Implant (OLANI) in persons with opioid dependency who are seeking relapse-prevention treatment.
- Trial name
- GM0020 (NCT05382091)
- Testing
- naltrexone implant
- Volunteers
- 250 people
- Sponsor
- Go Medical Industries Pty Ltd
Subarachnoid Hemorrhage, Aneurysmal, Headache
Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage
The goal of this clinical trial is to learn if an infusion of lidocaine, with or without steroids, into the middle meningeal artery (MMA) helps relieve severe headaches in patients with spontaneous subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Headache, Opiate Dependence, Opioid Use
- Trial name
- NCT07294118
- Testing
- Lidocaine, Lidocaine and Dexamethasone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Opioid Dependence, Alcohol Dependence
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
- Conditions
- Opioid Dependence, Alcohol Dependence, Multiple Sclerosis
- Trial name
- NCT05620940
- Testing
- Vivitrol Injectable Product, IVL3004, IVL4002
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Inventage Lab., Inc.
Opioid Use Disorder, Opioid Dependence
Measuring Acute Drug Demand in Humans
This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.
- Trial name
- NCT05829655
- Testing
- Drug A (Blinded Drug), Drug B (Blinded Drug), Drug C (Blinded Drug)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Opioid Use Disorder, Opioid Abuse or Dependence
CEDRN: Opioid Registry
Unregulated opioids remain a leading driver of preventable mortality and potential years of life lost in Canada. Emergency departments (EDs)-open 24/7 and frequently accessed by people who use drugs-offer critical opportunities…
- Conditions
- Opioid Use Disorder, Opioid Abuse or Dependence, Opioid Withdrawal, Polysubstance Drug Use (Indiscriminate Drug Use)
- Trial name
- CEDRN OUD (NCT07466784)
- Where
- Canada
- Volunteers
- 7,200 people
- Sponsor
- University of British Columbia
Opioid Dependence, Chronic Pain
Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication
This is an open-label pilot trial to assess the safety and feasibility of a novel 8-week psilocybin-assisted psychotherapy intervention to facilitate successful tapering/discontinuation of opioid pain medication in adult patients…
- Trial name
- NCT05585229
- Testing
- Psilocybin-assisted Psychotherapy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Opioid Dependency
Treatment Education for Perinatal Women and Their Community Support
The study evaluates the feasibility and acceptability of a 50 minute treatment education session for perinatal women with opioid use disorder and a community support person.
- Trial name
- NCT06733649
- Testing
- substance abuse treatment education
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Drug Use Disorder, Opioid Dependence
fMRI and Opioid Abstinence
This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.
- Conditions
- Drug Use Disorder, Opioid Dependence, Opioid-Related Disorders, Opioid Use
- Trial name
- NCT06651333
- Testing
- fMRI
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Yale University
Opioid Withdrawal, Opioid Use Disorder (OUD)
Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder
This study is evaluating the Sparrow Link, a wearable device that delivers gentle electrical signals to nerves in the outer ear (a technique known as transcutaneous auricular neurostimulation, or tAN).
- Trial name
- NCT07079826
- Testing
- Sparrow Link (Active tAN)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Payel Roy
Opioid Use Disorder, Major Depressive Disorder (MDD)
Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation
This study will compare transcranial magnetic stimulation (TMS) with sham TMS in people with opioid use disorder who are taking buprenorphine and have major depressive disorder with ongoing depressive symptoms.
- Trial name
- NCT07842601
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Kentucky
Opioid Use Disorder
Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use
The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal.
- Trial name
- ROLDI (NCT06379984)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Chronic Pain, Opioid Use Disorder
Combined THC and CBD for OUD and Chronic Pain
The primary objective of this phase 2 study is to investigate the therapeutic potential of orally administered combined delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in relieving both pain and cue-induced opioid…
- Trial name
- NCT06544291
- Testing
- CBD 300mg, CBD 600mg
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Yale University
Opioid Use Disorder (OUD)
MethaLoad Dose-Finding Study
Methadone is an effective treatment for opioid use disorder (OUD), but starting it has become harder now that most people with OUD use fentanyl. Methadone is usually started at a low dose and increased slowly over several weeks.
- Trial name
- NCT06877858
- Testing
- Methadone hydrochloride
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ashish P Thakrar, MD MS
Toxicomania
Pharmacokinetic Modeling of Methadone
The management of patients with opioid addiction is a challenge insofar as many distractors or variability factors can interfere with the control of the addiction, whether they are psychological, psychiatric, environmental…
- Trial name
- PKMETHAHOME (NCT05490732)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Opioid Dependence
Assessing the Acceptability, Feasibility, Effectiveness and Cost-effectiveness of LADB
The goal of the proposed study is to generate evidence on the acceptability, feasibility, effectiveness, and cost-effectiveness of introducing long-acting depot buprenorphine (LADB) as an additional option for the treatment of…
- Trial name
- NCT06129916
- Testing
- long-acting depot buprenorphine (LADB)
- Volunteers
- 760 people
- Sponsor
- PATH
Pain, Postoperative, Ankle Fracture Surgery
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Addictive full-agonist opioids, like oxycodone and hydrocodone, are often used to treat pain after surgery. However, these full-agonist opioids can be very addictive.
- Conditions
- Pain, Postoperative, Ankle Fracture Surgery, Opioid Use Disorder, Opioid Dependence
- Trial name
- BAFA (NCT06949826)
- Testing
- Buprenorphine Transdermal System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jenna-Leigh Wilson