Clinical trials: Addictive Behaviors, open to volunteers
Alcohol Drinking, Cannabis Use
Cannabis' Impact on Alcohol Consumption
This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which…
- Conditions
- Alcohol Drinking, Cannabis Use, Cannabis, Alcohol Use Disorder
- Trial name
- NCT05389930
- Testing
- THC-dominant cannabis, CBD-dominant cannabis, Alcohol
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Brown University
Cocaine Use Disorder, Cocaine Dependence
Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction
The goal of this clinical trial is to learn about the effects of the combination of ketamine and realtime functional magnetic resonance imaging (fMRI) neurofeedback training in individuals with cocaine use disorder.
- Trial name
- Co-Boost (NCT06125054)
- Testing
- Ketamine, real-time fMRI neurofeedback training
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Dr. med. Marcus Herdener
Addiction, Substance, Alcohol Use Disorder
Validation of the French Version of the Prediction of the Alcohol Withdrawal Severity Scale (PAWSS)
The goal of this observational study is to validate the French version of the PAWSS scale in a population of patients with Alcohol Use Disorders.
- Conditions
- Addiction, Substance, Alcohol Use Disorder, Alcohol Dependence, Alcohol Withdrawal
- Trial name
- PAWSS-VF (NCT06675539)
- Testing
- French version PAWSS
- Where
- France
- Volunteers
- 545 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Addiction;Drug(S);LSD, Neuroprotective
Neuroprotective Effect of (Nano PSO), in Patients Who Used to Consume Psychoactive Substances
Addiction problems to psychoactive substances are becoming more frequent, which implies a serious health problem, with social, family and work repercussions.
- Trial name
- NCT06550167
- Testing
- Nano-PSO, Pomegranate seed oil (omega-5)
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Distribuidora Biolife SA de CV
Community Reinforcement And Family Training, Family Health
Phase II: Scalable Digital Delivery of CRAFT Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to demonstrate digital training efficacy at scale and commercial readiness. This pilot project will advance piloted digital training programs for CRAFT and maximize scalability.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT06685003
- Testing
- Digital Tutorial overview, Digital Tutorial plus training Materials, Digital Tutorial plus training Materials plus feedback and Coaching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Alcohol Drinking Related Problems, Alcohol Use Disorders
Co-occurence of Mental Illness and Problematic Alcohol Use: an Internet-based Cognitive Behavior Therapy Intervention
The goal of this clinical trial is to learn if internet-based cognitive behavior therapy (ICBT ) works to treat co-occurent of problematic alcohol use and mental illness including mild to moderate symptoms of either depression…
- Conditions
- Alcohol Drinking Related Problems, Alcohol Use Disorders, Depressive Disorders, Mental Illness
- Trial name
- CoMiT (NCT06789250)
- Testing
- Internet-based cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Linkoeping University
4-STEP-Training Program for Social Media Addiction
The Effectiveness of 4-STEP-Training Program for Social Media Addiction (4-STEP-TPS) and Psychological Problems Among Adolescence
This study evaluates the effectiveness of the 4-STEP Training Program in reducing social media addiction and improving psychological well-being among adolescents.
- Trial name
- 4-STEP-TPS (NCT07564115)
- Testing
- 4-STEP-Training Program for Social Media Addiction (4-STEP-TPS)
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Internet Gaming Disorder
Targeted TDCS Intervention for Internet Gaming Disorder
The aim of this project is to compare the effects of the newly discovered parietal cortex (Pz electrode point) with the dorsolateral prefrontal cortex (F3 electrode point), which has been commonly used in previous studies, and to…
- Trial name
- NCT06759051
- Testing
- tDCS
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Peking University
Smoking (Tobacco) Addiction, Smoking ( Cigarette)
Measuring Communal Coping in Dual-smoking Couples Making a Quit Attempt
Smoking is the leading preventable cause of death in the United States, and quitting is especially difficult for couples who both smoke.
- Conditions
- Smoking (Tobacco) Addiction, Smoking ( Cigarette), Tobacco, Tobacco Abstinence
- Trial name
- NCT07553962
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Smoking (Tobacco) Addiction
Impact of Exercise Associated With Cognitive-behavioral Therapy in Smokers
Smoking remains one of the leading causes of global morbidity and mortality, responsible for more than 8 million deaths annually, according to data from the World Health Organization.
- Trial name
- NCT07186049
- Testing
- Thesis Sessions, General Health Guidelines, Thesis and Exercises
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Agnaldo José Lopes
Cannabis Use Disorder
Lemborexant for Cannabis Use Disorder
The goal of this clinical trial is to investigate the use of Lemborexant as a treatment for moderate to severe Cannabis Use Disorder (CUD). The main questions it aims to answer are: 1.
- Trial name
- LemboCAN (NCT07802990)
- Testing
- Lemborexant 10mg, Brief Behavioural Intervention
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Calgary
Cannabis Use Disorder
Trial of Tirzepatide for the Treatment of Cannabis Use Disorder
The purpose of this randomized, double-blind, placebo-controlled, multi-site clinical trial is to evaluate the safety and efficacy of tirzepatide in a sample of 100 patients diagnosed with moderate or severe CUD by DSM-5 criteria.
- Trial name
- NCT07468552
- Testing
- Tirzepatide
- Volunteers
- 100 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Diabetes Mellitus, Type 2, Nicotine Addiction
Semaglutide for Smoking Cessation in Patients With Diabetes
To assess the feasibility of conducting a randomized controlled trial (RCT) to determine the effectiveness of semaglutide as an adjunct to combination NRT in supporting smoking cessation for patients with diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Nicotine Addiction, Tobacco Dependence
- Trial name
- GLP1-SC (NCT07059377)
- Testing
- Semaglutide, Nicotine replacement
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Smoking Cessation
Effects of Smoking Addiction on Lower Limb Speed and Coordination
This observational case-control study will investigate the impact of smoking addiction on lower extremity speed and coordination in young adults.
- Trial name
- NCT07061522
- Testing
- Behavioral/Physical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Substance-Related Disorders
The Road to Recovery Initiative (R2RI)
Despite substance use causing significant harms and cost to our health care system, British Columbia's (BC) current addiction treatment system remains under-resourced and fragmented.
- Trial name
- R2RI (NCT06639373)
- Testing
- Specialized clinical service access
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- BC Centre on Substance Use
Alcohol Use Disorder, Cannabis Use Disorder
Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment
This 2-arm study will recruit participants with 1) alcohol use disorder and 2) cannabis use disorder for a 12-week cognitive behavioral therapy, following a thorough baseline assessments on executive function, incentive salience…
- Trial name
- NCT05855668
- Testing
- CBT
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Centre for Addiction and Mental Health
Behavior, Addictive, College Student
The Experience of Short Video Addiction Among College Students
This qualitative study aims to explore the experience of short-video addiction among college students using a directed content analysis approach grounded in the integrated framework of the Stimulus-Organism-Response (S-O-R)…
- Trial name
- NCT07574021
- Testing
- Semistructured interview
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Stimulant Use (Diagnosis)
Implementing Contingency Management for Stimulant Use in Specialty Addiction Treatment Organizations
Stimulants constitute a new and deadly fourth wave of the opioid epidemic. Contingency management is the most effective intervention for stimulant use and is an evidence-based adjunct to medication for opioid use disorder.
- Trial name
- MIMIC2 (NCT05702021)
- Testing
- Science to Service Laboratory
- Where
- 9 sites in United States
- Volunteers
- 76 people
- Sponsor
- Northwestern University
Methamphetamine Abuse, Methamphetamine-dependence
Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder
Methamphetamine use disorder (MUD) is becoming an increasing public health concern in Canada. While the evidence on the efficacy and safety of prescription psychostimulants for the treatment of MUD is promising, the knowledge on…
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance Abuse
- Trial name
- NCT06788587
- Testing
- LDX-01 plus TAU
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Opioid Use Disorder, Methadone
Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy
This pilot study will evaluate the feasibility and safety of using 1:1 tetrahydrocannabinol (THC):Cannabidiol (CBD) cannabis oil as an adjunct therapy to methadone-based Opioid Agonist Therapy (OAT) for individuals with opioid…
- Conditions
- Opioid Use Disorder, Methadone, Cannabis, Fentanyl
- Trial name
- THC-MMT (NCT05985850)
- Testing
- Aurora 1:1 Drops (Indica)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- BC Centre on Substance Use