Clinical trials: Adenoma of Large Intestine
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Colorectal Neoplasms, Colorectal Cancer
Use of iFOBT in Patients Presenting With Alarm Symptoms of Colorectal Cancer
Background: Colorectal cancer (CRC) is one of the most common types of cancer in Denmark, and mortality among patients is high. Patients presenting with alarm symptoms of CRC are referred to colonoscopy in the cancer patient…
- Conditions
- Colorectal Neoplasms, Colorectal Cancer, Colorectal Carcinoma, Colorectal Adenoma
- Trial name
- NCT03367611
- Testing
- Immunochemical faecal occult blood test (iFOBT)
- Where
- Denmark
- Volunteers
- 1,258 people
- Sponsor
- University of Aarhus
Colorectal Adenoma, Stage 0 Colorectal Cancer AJCC v8
Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer
This phase II trial studies the how well linaclotide works in treating patients with stages 0-3 colorectal cancer. Linaclotide is a very small protein that binds to receptors on intestinal cells and makes them secrete water and…
- Conditions
- Colorectal Adenoma, Stage 0 Colorectal Cancer AJCC v8, Stage I Colorectal Cancer AJCC v8, Stage II Colorectal Cancer AJCC v8
- Trial name
- NCT03796884
- Testing
- Linaclotide
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Colorectal Adenomas
Antioxidant Supplement and Reduction of Metachronous Adenomas of the Large Bowel: a Double Blind Randomized Trial
The trial was aimed at evaluating the efficacy of a multiagent antioxidant compound (vitamin A, C, E, selenium and zinc) in reducing the incidence of metachronous adenomas of the large bowel after endoscopic polypectomy.
- Trial name
- NCT01437826
- Testing
- antioxidants
- Where
- Italy
- Volunteers
- 411 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Colorectal Adenoma, Probiotics
The Effect of Oral Clostridium Butyricum on the Recurrence After Colonoscopic Resection of Colorectal Adenoma
The prevention of recurrence after colorectal adenoma resection remains an urgent medical issue to be addressed. Previous studies have mainly focused on nonsteroidal anti-inflammatory drugs, calcium supplements, and vitamins.
- Trial name
- NCT07167342
- Testing
- Clostridium butyricum capsules, Live
- Where
- 2 sites in China
- Volunteers
- 294 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Colorectal Adenoma, Artificial Intelligence (AI)
Development and Demonstration of a Precision Prevention and Treatment System for Colorectal Tubular Adenomas Lesions
This study is a prospective,multi-center and observational clinical study.Investigators would like to innovatively construct a "trinity" database of colorectal tubular adenomas based on white light - magnifying chromo …
- Trial name
- NCT07073430
- Testing
- AI models with NBI
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Renmin Hospital of Wuhan University
Colorectal Cancer, Colorectal Adenoma
The Implementation of Genetic Risk for Colorectal Cancer Screening
The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp
- Trial name
- PRO-GENE-COLON (NCT07621757)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Colonic Polyps, Adenomatous Polyps
Linked-Color Imaging Versus Indigo Carmine Pump Spraying on the Colorectal Adenoma Detection Rate
Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigo carmine spraying up to the colonic mucosa could probably increase the adenoma detection rate, but considering the long…
- Conditions
- Colonic Polyps, Adenomatous Polyps, Adenoma Detection Rate, Chromoendoscopy
- Trial name
- NCT06961149
- Testing
- Chromoendoscopy with indigo carmine solution spray, Linked-color imaging endoscopy
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Shandong University
Inflammation, Prevention and Control
Effect of High-Legume Diet on Colorectal Cancer Risk
This study, sponsored by the National Cancer Institute and Penn State University, will examine how a diet high in legumes (dried beans) influences risk factors for colon cancer and polyps.
- Conditions
- Inflammation, Prevention and Control, Colonic Neoplasms, Diet
- Trial name
- NCT00339469
- Testing
- LIFE
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Polyp
Cold Snare Polypectomy of Non-pedunculated Colorectal Adenomas
A prospective randomised controlled trial of cold vs hot snare polypectomy of non-pedunculated colorectal adenomas.
- Trial name
- NCT03859479
- Testing
- Cold snare polypectomy, Hot snare polypectomy
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Vaginal Cancer, Cervical Cancer
T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers
Background: The National Cancer Institute (NCI) Surgery Branch has developed an experimental therapy for treating patients with cancer that involves taking white blood cells from the patient, growing them in the laboratory in…
- Conditions
- Vaginal Cancer, Cervical Cancer, Anal Cancer, Penile Cancer
- Trial name
- NCT02280811
- Testing
- Fludarabine, Cyclophosphamide, E6 TCR
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Adenoma and Carcinoma
Recurrence Mechanisms of Colorectal Adenoma After Resection and a Multi-Omics Research Protocol
We aim to establish a single-cell atlas of primary adenomas, recurrent adenomas, and paired normal mucosa, identify recurrence-associated cell subpopulations and transcriptional pathways, and construct a risk prediction model for…
- Trial name
- RM-CAR-MRP (NCT07683312)
- Volunteers
- 30 people
- Sponsor
- Zhongshan Hospital Xiamen University
Colorectal Adenoma
Transparent Cap-Assisted Colonoscopy Combined With Computer-Aided Detection in Improving the Detection Rate of Colorectal Adenomas
A prospective, single-center, single-blind, randomized controlled study to compare the effectiveness of transparent cap-assisted colonoscopy combined with computer-aided detection and computer-aided detection alone in improvement…
- Trial name
- NCT07097350
- Testing
- computer-aided detection alone, transparent cap-assisted colonoscopy combined with computer-aided detection
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Fudan University
Colorectal Adenoma, Polyp
Early Diagnosis Model of Colorectal Adenoma Using Laboratory Examinations
Colorectal cancer has the third highest incidence and second highest mortality rate of all malignant tumors worldwide. Distinct from most other cancers, colorectal cancer can be prevented; colonoscopy-based identification and…
- Trial name
- NCT07793110
- Testing
- No active intervention
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Colorectal Adenoma, Colorectal Polyp
Examining Techniques on Adenoma Miss Rate in Proximal Colon
The primary aim of this study is to explore the usefulness of re-examination and retroflexion on adenoma miss rate (AMR) in the proximal colon.
- Trial name
- SINOCOLO2017 (NCT03355443)
- Testing
- Retroflexion, Re-examination
- Where
- 3 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Carcinoma, Polyp
New bioMarkers tO straTIfy cOlorectal caNcer Referrals
The goal of this observational study is to evaluate if a blood test for circulating progastrin (hPG80) and transposable elements (TEs) can accurately predict colorectal cancer (CRC) or polyps in adult patients referred to the…
- Conditions
- Colorectal Carcinoma, Polyp, Colorectal Adenoma
- Trial name
- MOTION (NCT07035691)
- Where
- United Kingdom
- Volunteers
- 582 people
- Sponsor
- Queen Mary University of London
Colorectal Cancer, Colorectal Adenoma
To Investigate Risk of Colorectal Neoplasms in First-degree Relatives of Patients With Non-advanced Adenomas
The risk of CRC in families of patients with CRC is well established, but it is less well-defined for families of patients with adenomas.
- Trial name
- NonAA (NCT02521727)
- Where
- 2 sites in Hong Kong
- Volunteers
- 828 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colorectal Adenoma
Study of Calcium Plus Vitamin D Supplementation in Prevention of Colorectal Adenomas Recurrence
Calcium plus vitamin D may be effective in the prevention of colorectal adenoma recurrence. The aim of this study is to investigate the effect of supplementation with calcium plus vitamin D on the recurrence of colorectal…
- Trial name
- NCT02143505
- Testing
- Ca plus vit D
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Colorectal Adenoma, Sessile Serrated Lesion
Evaluation of 'WAYMED Endo CL CS' for Automated Detection and Diagnosis of Colorectal Adenoma and Non-Adenoma Lesions
The purpose of this clinical trial is to evaluate the effectiveness of the computer-aided diagnosis (CADx) software, 'WAYMED endo CL CS', which assists medical specialists by automatically analyzing colorectal endoscopic images…
- Conditions
- Colorectal Adenoma, Sessile Serrated Lesion, Hyperplastic Polyp, Carcinoma
- Trial name
- NCT07470827
- Testing
- WAYMED endo CL CS, Reference standard review
- Where
- South Korea
- Volunteers
- 1,178 people
- Sponsor
- WAYCEN Inc
Colonic Polyp, Colorectal Adenoma
Clinical Trial Evaluating External Evaluation and Training on the Incomplete Resection (POLIPEVA Study)
Introduction It has been shown that some quality indicators in endoscopy can be improved through educational interventions. There are marked differences in the proportion of incomplete polypectomies among endoscopists.
- Conditions
- Colonic Polyp, Colorectal Adenoma, Colorectal Cancer
- Trial name
- POLIPEVA (NCT04636619)
- Testing
- Colonic polypectomy, Online training course
- Where
- Spain
- Volunteers
- 1,920 people
- Sponsor
- Hospital del Rio Hortega