Clinical trials: Adenomyosis
Adenomyosis
Evaluation of Therapeutic Effect and Safety of Mifepristone in the Treatment of Adenomyosis
This clinical trial is designed to study the effectiveness and safety of mifepristone in the treatment of symptomatic adenomyosis with multi center, random, double blind and controlled clinical trials.
- Trial name
- ETESRTA (NCT03520439)
- Testing
- Mifepristone
- Where
- China
- Volunteers
- 134 people
- Sponsor
- xinmei zhang
Adenomyosis, Quality of Life
Quality of Life After Hysterectomy (AdenoQOL)
Adenomyosis is a disease where ectopic endometrial-like glands affect the muscular wall of the uterus. About 70% of women affected by adenomyosis suffer from dysmenorrhea and menorrhagia.
- Trial name
- NCT04791033
- Testing
- Hysterectomy
- Where
- Norway
- Volunteers
- 218 people
- Sponsor
- Oslo University Hospital
Adenomyosis
Histopathological Diagnosis of Adenomyosis
The purpose of this study is to develop and evaluate a hysteroscopic endo-myometrial biopsy for diagnosing adenomyosis.
- Trial name
- NCT02340533
- Testing
- hysteroscopic endo-myometrial biopsy, ultrasound
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Endometriosis
Quinagolide Vaginal Ring on Lesion Reduction Assessed by MRI in Women With Endometriosis/Adenomyosis
This will be a randomized, double-blind, placebo-controlled, proof-of-mechanism phase 2 trial investigating the effect of quinagolide extended-release vaginal ring on reduction of lesions assessed by high-resolution magnetic…
- Trial name
- QLARITY (NCT03749109)
- Testing
- Quinagolide 1080 µg
- Where
- 11 sites in Denmark, Germany and 2 more
- Volunteers
- 67 people
- Sponsor
- Ferring Pharmaceuticals
Intrauterine Device Expulsion, Adenomyosis, Endometriosis
Clinical Observation of Hysteroscopy-Assisted Placement of Handmade Frameless GyneFix-LNG-IUS (Retrospective Cohort)
This is a retrospective self-controlled observational study. We evaluated the safety and efficacy of a handmade frameless levonorgestrel-releasing intrauterine system (GyneFix-LNG-IUS) in patients at high risk of IUD expulsion.
- Conditions
- Intrauterine Device Expulsion, Adenomyosis, Endometriosis, Menorrhagia, Dysmenorrhea, Abnormal Uterine Bleeding
- Trial name
- Gyne-LNG-IUS (NCT07518693)
- Testing
- Handmade Frameless GyneFix-LNG-IUS
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Yu Wang
Dysmenorrhea, Metrorrhagia
Cooperative Adenomyosis Network
To set up a Cooperative Network by enrolling 5000 patients with Adenomyosis(AM) from multiple centers.Based on the Network platform and Database,the investigators try to explore the diagnostic strategies for AM and carry out…
- Conditions
- Dysmenorrhea, Metrorrhagia, Infertility, Female, Pathology
- Trial name
- CAN (NCT03230994)
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Peking Union Medical College Hospital
Adenomyosis, Endometriosis
A Multi-omics Study of Adenomyosis
This study aims to analyze the multi-omics results between eutopic endometrium, adenomyosis and endometriosis of patients diagnosed of adenomyosis with and without endometriosis.
- Conditions
- Adenomyosis, Endometriosis, Ectopic Endometrium, Eutopic Endometrium
- Trial name
- NCT03742843
- Testing
- A multi-omics analysis
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Lei Li
Magnetic Resonance Imaging, Cesarean Section; Complications, Wound, Dehiscence
Association Between the Adenomyosis and the Clinical Outcomes of Vaginal Repair of CesareanSectionScar Defects
To examine the correlation between the occurrence of adenomyosis and the outcome of vaginal repair of cesarean section scar defects (CSD), women with CSD will be enrolled in this retrospective observational cohort study.
- Trial name
- NCT05187728
- Testing
- No Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Adenomyosis
Role of Dienogest in the Treatment of Patient With Symptomatic Adenomyosis
Adenomyosis was first described as endometrial glands in the myometrium of the uterus. The current definition of adenomyosis is provided in 1972 'the benign invasion of endometrium into the myometrium, producing a diffusely…
- Trial name
- NCT03654144
- Testing
- Dienogest, Combined Oral Contraceptive
- Volunteers
- 100 people
- Sponsor
- Assiut University
Adenomyosis of Uterus
Aspirin in the Treatment of Pregnant Women With Adenomyosis on Reducing Preterm Delivery
Objective: This study intends to carry out a randomized double-blind clinical trial study of aspirin in the treatment of pregnancy with adenomyosis to reduce the incidence of preterm delivery, and provide a new therapeutic target…
- Trial name
- NCT04535804
- Volunteers
- 550 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Endometriosis, Adenomyosis
Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis
Endometriosis and adenomyosis can impact on the quality of life including the physical, psychological and social aspects. It is important to include quality of life measurements in evaluating the disease severity and response to…
- Trial name
- NCT03302468
- Where
- Hong Kong
- Volunteers
- 448 people
- Sponsor
- Chinese University of Hong Kong
Endometriosis, Adenomyosis
Diagnosis of Adenomyosis Using Ultrasound, Elastography and MRI
comparison of transvaginal ultrasound, transvaginal ultrasound elastography and MRI for the diagnosis of adenomyosis in patients receiving hysterectomy afterwards
- Trial name
- NCT04665414
- Testing
- MRI, transvaginal ultrasound, transvaginal ultrasound elastography
- Where
- Germany
- Volunteers
- 103 people
- Sponsor
- University Hospital Muenster
Endometriosis, Adenomyosis of Uterus
Artificial Intelligence Into Ultrasound Diagnostics in Reproductive Medicine
The goal of this observational study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired…
- Conditions
- Endometriosis, Adenomyosis of Uterus, Leiomyoma (Uterine Fibroids), Uterine Neoplasms
- Trial name
- AUDRIE (NCT07810920)
- Where
- Hungary
- Volunteers
- 1,600 people
- Sponsor
- Semmelweis University
Endometriosis
ENDOmetriosis Robotic Assisted Surgery
The purpose of this study is to compare the robot-assisted approach with the laparoscopic approach in terms of reducing the rates of intraoperative and postoperative complications in patients undergoing total hysterectomy for DIE…
- Trial name
- ENDO-RAS (NCT06445179)
- Testing
- Total Laparoscopic Hysterectomy, Ureterolysis
- Where
- 2 sites in France
- Volunteers
- 224 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Adenomyosis, Endometriosis
Determination of Lipocalin Type-prostaglandin (L-PGDS) in Blood, Urine, Vaginal Samples and Endometrial Ablation by Enzyme-linked Immunosorbent Assay
Prostaglandin D2 (PGD2) has anti-inflammatory activity, particularly via Lipocalin type-prostaglandin (L-PGDS). L-PGDS has been studied in pathologies such as sleep apnea, rheumatoid arthritis, asthma and allergic phenomena, but…
- Trial name
- ADENO-L (NCT06864494)
- Testing
- Endometrial ablation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Adenomyosis
Adenomyosis and Pregnancy: Levonorgestrel vs. GnRH for Blastocyst Transfer
Adenomyosis is a condition where endometrial tissue grows into the uterine muscle, causing symptoms like pelvic pain, heavy bleeding, and infertility.
- Trial name
- NCT06581679
- Testing
- Triptorelin, levonorgestrel-releasing intrauterine system, frozen embryo transfer
- Where
- Egypt
- Volunteers
- 184 people
- Sponsor
- Zagazig University
Endometriosis
Efficacy of Trace Elements in the Treatment of Endometriosis: a Pilot Study
The primary objective of this pilot study is to evaluate the efficacy of trace elements, versus placebo, on the reduction of pain in endometriosis of an American Fertility Society (AFSr) score of 2 to 4, combined or not to an…
- Trial name
- NCT02437175
- Testing
- ENDO 1/ENDO 2
- Where
- Belgium
- Volunteers
- 99 people
- Sponsor
- Laboratoires Pronutri
Uterine Myoma, Adenomyosis
Use of Dexamethasone in Uterine Artery Embolization
The primary purpose of this study is to investigate the effects of dexamethasone on inflammatory reactions after uterine artery embolization.
- Trial name
- NCT02056717
- Testing
- Dexamethasone, Normal saline
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Severance Hospital
Adenomyosis
Radiofrequency Ablation of Adenomyosis
To observe the effects of radiofrequency ablation on adenomyosis through the pathological analysis of treated tissue that has been removed during planned hysterectomy.
- Trial name
- NCT05130190
- Testing
- RF Treatment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Texas Southwestern Medical Center
Endometriosis
Proliferation of Endometrial Stromal Cells in Adenomyosis
Adenomyosis refers to the presence of endometrial glands and stroma that is haphazardly deep within the myometrium. However, the etiology and pathologic mechanism responsible for adenomyosis are not yet very well known.
- Trial name
- NCT00173212
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital