Clinical trials: Adenomyosis of Uterus
Adenomyosis
Evaluation of the Efficacy and Safety of Drospirenone in the Treatment of Adenomyosis
Adenomyosis is a common benign condition of fertile women and is characterized by dysmenorrhea, hypermenorrhea, abnormal uterine bleeding, infertility and chronic pelvic pain.
- Trial name
- NCT06174792
- Testing
- Drospirenone 4 MG
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Palermo
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Uterine Fibroids, Abnormal Uterine Bleeding
Does 3D Laparoscopy Improve Vaginal Cuff Suture Time?
The objective aim is to evaluate whether the use of 3D laparoscopy facilitates the vaginal cuff closure of the vaginal cuff during a total laparoscopic hysterectomy among novice laparoscopists (PGY 2-4, Fellow).
- Conditions
- Uterine Fibroids, Abnormal Uterine Bleeding, Pelvic Pain, Adenomyosis
- Trial name
- 3DRCT (NCT02192606)
- Testing
- Storz 3D Laparoscopy System, 2D Laparoscopy
- Where
- 2 sites in United States, Denmark
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Adenomyosis of Uterus, Implantation Failure
Linzagolix in Adenomyosis and Recurrent Implantation Failure
Adenomyosis is associated with impaired endometrial receptivity and reduced implantation rates in assisted reproduction, even when using high-quality embryos.
- Conditions
- Adenomyosis of Uterus, Implantation Failure, Infertility Female, Embryo Transfer
- Trial name
- LINZA-RIF (NCT07698561)
- Testing
- Linzagolix 200 mg (Yselty)
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Vida Fertility Institute
Metrorrhagia, Menorrhagia
Surgical Success After Laparoscopic vs Abdominal Hysterectomy
The purpose of the proposed pilot study is to investigate the effectiveness, cost, safety, and long-term impact on quality of life of laparoscopic hysterectomy (LH) in relation to abdominal hysterectomy (AH) for the treatment of…
- Conditions
- Metrorrhagia, Menorrhagia, Leiomyoma, Adenomyosis
- Trial name
- NCT01793584
- Testing
- Laparoscopic hysterectomy, Abdominal hysterectomy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Adenomyosis, Endometriosis
Risk Factors and Disorders Linked to Uterine Adenomyosis on MRI in Reproductive-Age Women
The goal of this observational case-control study is to identify risk factors and associated conditions related to adenomyosis in women of reproductive age.
- Conditions
- Adenomyosis, Endometriosis, Leiomyoma (Uterine Fibroids), Ovarian Cysts
- Trial name
- NCT06697444
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Mashhad University of Medical Sciences
Endometriosis, Adenomyosis
Psychotherapy in Patients With Endometriosis: Cognitive Behavioral Therapy Versus Acceptance and Commitment Therapy
The aim of the present study is to compare two types of psychotherapeutic interventions in women with endometriosis and/or adenomyosis: cognitive behavioral therapy (CBT) and acceptance and commitment therapy (ACT).
- Trial name
- T-ENDO (NCT07907848)
- Testing
- Cognitive Behavioral Therapy (CBT), Acceptance and Commitment Therapy (ACT)
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Fiammetta Cosci
Benign Gynecological Disease, Uterine Fibroids
Prospective Perioperative Clinical Registry for Women Undergoing Benign Gynecological Surgery
This prospective observational registry aims to systematically collect preoperative, intraoperative, and postoperative clinical data from patients undergoing surgery for benign gynecological conditions.
- Conditions
- Benign Gynecological Disease, Uterine Fibroids, Endometriosis, Adenomyosis
- Trial name
- OPGYNBEN (NCT07772076)
- Testing
- Standard Surgical Procedures for Benign Gynecological Conditions
- Where
- Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS San Raffaele
Adenomyosis, Heavy Uterine Bleeding
Effect of Ulipristal Acetate on Bleeding Patterns and Dysmenorrhea in Women With Adenomyosis
Adenomyosis affects approximately 21% of symptomatic women who present to gynecology clinics. The disease is characterized by heavy bleeding and pain during periods.
- Conditions
- Adenomyosis, Heavy Uterine Bleeding, Dysmenorrhea
- Trial name
- NCT03325868
- Testing
- Ulipristal Acetate
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Endometriosis
ENDOmetriosis Robotic Assisted Surgery
The purpose of this study is to compare the robot-assisted approach with the laparoscopic approach in terms of reducing the rates of intraoperative and postoperative complications in patients undergoing total hysterectomy for DIE…
- Trial name
- ENDO-RAS (NCT06445179)
- Testing
- Total Laparoscopic Hysterectomy, Ureterolysis
- Where
- 2 sites in France
- Volunteers
- 224 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Adenomyosis
Levonorgestrel Intrauterine System and Adenomyosis
Adenomyosis is defined when the endometrial tissue (gland and stroma) is present within the myometrium . The depth of endometrial penetration which uses in diagnosis of adenomyosis not yet agreed; opinions range from one high…
- Trial name
- NCT03104309
- Testing
- Levonorgestrel intrauterine system
- Volunteers
- 100 people
- Sponsor
- Assiut University
Adenomyosis
Ttt of Adenomyosis
to evaluate use of Dienogest versus uterine arteries embolization in treatment of Adenomyosis-associated symptoms as dysmenorrhea, heavy menstrual bleeding and bulk-related symptoms
- Trial name
- NCT06719934
- Testing
- Dienogest 2 mg orally, UAE
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Endometriosis, Adenomyosis
Comparison of the Operation and Medical Treatment of Endometriosis and Adenomyosis
Endometriosis (including adenomyosis) is one of the most common gynecological diseases among women of childbearing age. Common symptoms such as menstrual pain, excessive menstrual flow, infertility, chronic lower abdominal pain…
- Trial name
- NCT03778359
- Testing
- Leuprorelin, Levonorgestrel, Dienogest
- Where
- Taiwan
- Volunteers
- 5,000 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Adenomyosis of Uterus, Infertility Assisted Reproductive Technology
Does The Addition Of Letrozole To Ultra-Long GnRH Agonists Help Adenomyosis Patients in ART? The AURA Trial
The AURA Trial seeks to improve fertility treatment for women affected by a condition known as adenomyosis. Adenomyosis often leads to heavy menstrual bleeding, pelvic pain, dyspareunia and can make it more difficult to achieve…
- Trial name
- AURA (NCT06985186)
- Testing
- Ultra-Long GnRH Agonists + Letrozole, Ultra-Long GnRH Agonists
- Where
- Spain
- Volunteers
- 162 people
- Sponsor
- University of Palermo
Fibroid Uterus, Metrorrhagia
A Randomized Study Comparing Subtotal vs Total Hysterectomy Long Term Outcomes
The goal of this randomized clinical trial is to assess the outcomes of total laparoscopic hysterectomy vs subtotal laparoscopic hysterectomy + mini-laparotomy for uterine extraction for benign gynecological conditions in terms…
- Conditions
- Fibroid Uterus, Metrorrhagia, Adenomyosis, Benign Gynecologic Neoplasm
- Trial name
- STORY (NCT06802198)
- Testing
- total hysterectomy, subtotal hysterectomy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Adenomyosis
Norwegian Adenomyosis Study I
Adenomyosis is characterized by the appearance of endometrial cells in the muscular layer of the uterus. It affects about 15-20% of the female population.
- Trial name
- NAPPED I (NCT02201719)
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Adenomyosis, IVF
Ambispective Study to Assess the Effect of Pretreatment With a Levonorgestrel-Releasing Intrauterine System Versus Oral Progestin
The study participants' relevant medical records will be collected and reviewed for the retrospective subjects and after obtaining informed consent for the prospective subjects.
- Trial name
- NCT05152667
- Testing
- levonorgestrel-releasing intrauterine device (LNG-IUS)
- Where
- Egypt
- Volunteers
- 354 people
- Sponsor
- Wael Elbanna Clinic
Adenomyosis
FET in Adenomyosis
Purpose of the Study: To compare the effectiveness of GnRH agonist downregulation alone versus GnRH agonist combined with letrozole in improving pregnancy outcomes in women with adenomyosis undergoing frozen embryo transfer…
- Trial name
- ADY (NCT06913075)
- Testing
- GnRH agonist downregulation, GnRH agonist and Letrozole
- Where
- India
- Volunteers
- 700 people
- Sponsor
- Indira IVF Hospital Pvt Ltd
Cholecystitis, Cholecystolithiasis
Drainage or Not for Laparoscopic Cholecystetomy
Surgeons usually choosing drainage tube for laparoscopic cholecystectomy according to their experiences but not guidelines. The investigators design a RCT to evaluate the role of drainage in LC surgery and compare the clinical…
- Conditions
- Cholecystitis, Cholecystolithiasis, Polyps Gallbladder, Adenomyosis of Gallbladder
- Trial name
- NCT03909360
- Testing
- drainage tube
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Recurrent Miscarriage
3D Ultrasound to Assess in Recurrent Miscarriage
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
- Trial name
- 3D-ARM (NCT06164015)
- Testing
- 3D Ultrasound scan with power Doppler angiography
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust