Clinical trials: Adenomyosis of Uterus, open to volunteers
Adenomyosis
Validation and Optimisation of Ultrasound Diagnosis of Adenomyosis
Defining ultrasound criteria for normal uterine biometry and assessing the prevalence of repeat abortions in patients with abnormalities of the uterine cavity
- Trial name
- NCT06795711
- Where
- Italy
- Volunteers
- 465 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Adenomyosis, IVF
Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients
This randomized clinical trial aims to assess the comparative effectiveness of two distinct endometrial preparation protocols for frozen embryo transfer (FET) among women with adenomyosis undergoing IVF/ICSI.
- Conditions
- Adenomyosis, IVF, Frozen Embryo Transfer
- Trial name
- FET-ADE (NCT06239376)
- Testing
- GnRHa+AI - AC, Artificial cycle
- Where
- Vietnam
- Volunteers
- 222 people
- Sponsor
- Mỹ Đức Hospital
Adenomyosis of Uterus
Nintedanib for Improving Reproductive Outcomes in Adenomyosis
This study aims to evaluate the effectiveness and safety of nintedanib, an antifibrotic drug, in improving live birth rates for infertile women with adenomyosis who have frozen embryos.
- Trial name
- NCT07162961
- Testing
- Nintedanib, Progesterone
- Volunteers
- 328 people
- Sponsor
- Sun Yat-sen University
Adenomyosis, Endometriosis
Determination of Lipocalin Type-prostaglandin (L-PGDS) in Blood, Urine, Vaginal Samples and Endometrial Ablation by Enzyme-linked Immunosorbent Assay
Prostaglandin D2 (PGD2) has anti-inflammatory activity, particularly via Lipocalin type-prostaglandin (L-PGDS). L-PGDS has been studied in pathologies such as sleep apnea, rheumatoid arthritis, asthma and allergic phenomena, but…
- Trial name
- ADENO-L (NCT06864494)
- Testing
- Endometrial ablation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Elective Fertility Preservation
Study of the Prevalence of Endometriosis and Adenomyosis
Our study aims to assess the prevalence of adenomyosis and endometriosis in patients consulting for elective fertility preservation through the diagnosis of these pathologies by transvaginal pelvic ultrasound.
- Trial name
- PrevADEOSE (NCT06211569)
- Testing
- Usual follow-up
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Benign Gynecological Disease, Uterine Fibroids
Prospective Perioperative Clinical Registry for Women Undergoing Benign Gynecological Surgery
This prospective observational registry aims to systematically collect preoperative, intraoperative, and postoperative clinical data from patients undergoing surgery for benign gynecological conditions.
- Conditions
- Benign Gynecological Disease, Uterine Fibroids, Endometriosis, Adenomyosis
- Trial name
- OPGYNBEN (NCT07772076)
- Testing
- Standard Surgical Procedures for Benign Gynecological Conditions
- Where
- Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS San Raffaele
Endometriosis, Chronic Pelvic Pain
Pelvic Floor Muscle Function and Endometriosis-Related Pelvic Pain
Our study aims to investigate the associations between endometriosis-related pelvic pain and pelvic floor muscle strength, endurance, and relaxation ability, as well as quality of life, physical activity, and the presence of…
- Conditions
- Endometriosis, Chronic Pelvic Pain, Pelvic Pain Associated With Endometriosis or Adenomyosis
- Trial name
- NCT07713108
- Where
- Hungary
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Endometriosis, Adenomyosis of Uterus
Artificial Intelligence Into Ultrasound Diagnostics in Reproductive Medicine
The goal of this observational study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired…
- Conditions
- Endometriosis, Adenomyosis of Uterus, Leiomyoma (Uterine Fibroids), Uterine Neoplasms
- Trial name
- AUDRIE (NCT07810920)
- Where
- Hungary
- Volunteers
- 1,600 people
- Sponsor
- Semmelweis University
Adenomyosis of Uterus
Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical Symptoms
The goal of this study/research is to assess the relationship between ultrasound features of the myometrium suggestive of adenomyosis and clinical symptoms of adenomyosis and to establish a reporting system for adenomyosis…
- Trial name
- MUSA3 (NCT07397715)
- Where
- 5 sites in Belgium, Poland and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Swiss GO Trial Group
Adenomyosis of Uterus, Infertility Assisted Reproductive Technology
Does The Addition Of Letrozole To Ultra-Long GnRH Agonists Help Adenomyosis Patients in ART? The AURA Trial
The AURA Trial seeks to improve fertility treatment for women affected by a condition known as adenomyosis. Adenomyosis often leads to heavy menstrual bleeding, pelvic pain, dyspareunia and can make it more difficult to achieve…
- Trial name
- AURA (NCT06985186)
- Testing
- Ultra-Long GnRH Agonists + Letrozole, Ultra-Long GnRH Agonists
- Where
- Spain
- Volunteers
- 162 people
- Sponsor
- University of Palermo
Adenomyosis of Uterus, Implantation Failure
Linzagolix in Adenomyosis and Recurrent Implantation Failure
Adenomyosis is associated with impaired endometrial receptivity and reduced implantation rates in assisted reproduction, even when using high-quality embryos.
- Conditions
- Adenomyosis of Uterus, Implantation Failure, Infertility Female, Embryo Transfer
- Trial name
- LINZA-RIF (NCT07698561)
- Testing
- Linzagolix 200 mg (Yselty)
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Vida Fertility Institute
Enlarged Uterus, Adenomyosis
Comparing the Efficacy of TU-LESS and vNOTES for Hysterectomy of Enlarged Uterus
Enlarged uterus is frequently encountered in clinical practice, and its incidence due to conditions such as adenomyosis, uterine fibroids, and other gynecological disorders has steadily increased over the years statistically.
- Conditions
- Enlarged Uterus, Adenomyosis, Uterine Fibroids (UF)
- Trial name
- NCT06663553
- Testing
- TU-LESS, vNOTES
- Where
- China
- Volunteers
- 210 people
- Sponsor
- West China Second University Hospital
Endometriosis, Adenomyosis
Pain in Endometriosis And the Relation to Lifestyle
The goal of this clinical trial is to investigate the effect of an anti-inflammatory diet and cognitive behavioral therapy (CBT) on pain symptoms, health related quality of life and the effect on inflammatory characteristics in…
- Trial name
- PEARL (NCT06332560)
- Testing
- Anti-inflammatory diet (DI), Cognitive behavioral therapy (CBT)
- Where
- 5 sites in Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Fibroid Uterus, Metrorrhagia
A Randomized Study Comparing Subtotal vs Total Hysterectomy Long Term Outcomes
The goal of this randomized clinical trial is to assess the outcomes of total laparoscopic hysterectomy vs subtotal laparoscopic hysterectomy + mini-laparotomy for uterine extraction for benign gynecological conditions in terms…
- Conditions
- Fibroid Uterus, Metrorrhagia, Adenomyosis, Benign Gynecologic Neoplasm
- Trial name
- STORY (NCT06802198)
- Testing
- total hysterectomy, subtotal hysterectomy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Endometriosis, Adenomatosis
The Influence of Central Sensitization in Endometriosis Disease
Endometriosis diseases include endometriosis and adenomyosis. Researchers will include 200 or more patients with endometriosis diseases; collect relevant clinical data such as age, BMI, educational level, history of other…
- Trial name
- NCT07014761
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Endometriosis, Fibroids
Impact of Educational Videos on Pre-operative Anxiety
The goal of this clinical trial is to learn if educational videos can reduce pre-operative anxiety in patients undergoing minimally invasive gynecologic surgery.
- Conditions
- Endometriosis, Fibroids, Adenomyosis, Pelvic Pain
- Trial name
- NCT07740759
- Testing
- educational video
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UConn Health
Abnormal Uterine Bleeding Due to Adenomyosis (Disorder)
Radiofrequency Endometrial Ablation or Uterine Artery Embolization for Treatment of Adenomyosis-related Abnormal Uterine Bleeding
The present study aims to compare the efficacy (menstrual blood loss, pain, quality of life) and the safety (complications, recovery) of each conservative intervention (RFA, UAE) versus hysterectomy for the treatment of…
- Trial name
- ADENOTREAT (NCT07195305)
- Testing
- Radiofrequency endometrial ablation, Uterine artery embolization, Hysterectomy
- Where
- 4 sites in France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Bordeaux
Minimally Invasive Surgical Procedures, Abnormal Uterine Bleeding, Unspecified
Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy
Typical postoperative pain control after minimally invasive hysterectomy includes ibuprofen, acetaminophen, and a short course of narcotics.
- Conditions
- Minimally Invasive Surgical Procedures, Abnormal Uterine Bleeding, Unspecified, Adenomyosis of Uterus, Fibroid Uterus
- Trial name
- NCT07664956
- Testing
- Cyclobenzaprine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Christiana Care Health Services
Adenomyosis
New Perspectives in Adenomyosis Pathogenesis With Epigenetic Analysis and miRNAs
Objectives: To identify differentially expressed miRNAs in the blood of adenomyosis patients in view to develop new diagnostic methods Hypotheses Circulating miRNAs may be abnormally expressed in patients suffering from…
- Trial name
- ADENO-MIRNA (NCT06373822)
- Testing
- Circulating-mirna
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain