Clinical trials: Adherence to HIV Treatment and Medication
mHealth, PMTCT
Mobile Strategies for Women's and Children's Health: Optimizing Adherence and Efficacy of PMTCT/ART
The investigators are conducting a 3-arm randomized trial comparing the effects of unidirectional SMS (ie: "push" messaging to participant) vs. bidirectional SMS dialogue between participant and provider vs.
- Conditions
- mHealth, PMTCT, Adherence, Medication, SMS
- Trial name
- Mobile WAChx (NCT02400671)
- Testing
- SMS messaging
- Where
- 6 sites in Kenya
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- University of Washington
Adherence, Medication, Risk Behavior
DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence
The researchers are working with a technology company, AiCure, to develop a smartphone app, DOT Diary, which combines two drug adherence strategies.
- Conditions
- Adherence, Medication, Risk Behavior, Pre-Exposure Prophylaxis, HIV Prevention
- Trial name
- NCT03387462
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet, DOT Diary mobile app
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Tuberculosis, Pulmonary, HIV Coinfection
Pharmacist-Led Intervention to Improve TB Treatment Adherence
The goal of this clinical trial is to compare the adherence of co-morbid patients in control and experimental group The main question[s]it aims to answer are: 1.
- Trial name
- RA-15041995 (NCT06608069)
- Testing
- Educational counselling
- Where
- 2 sites in Malaysia
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Acquired Immunodeficiency Syndrome, HIV Infections
A Pilot Study of Adherence to Oral Medication and Health Beliefs of Adolescents With HIV and Their Mothers
The proposed study has two specific aims 1) to gather data about treatment adherence levels among adolescents (11-21 years) with HIV and 2) to obtain information about the adolescents and mothers' health beliefs and examine their…
- Trial name
- NCT00001699
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
HIV/AIDS, Medication Adherence
INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)
Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission.
- Conditions
- HIV/AIDS, Medication Adherence, Habits
- Trial name
- INMIND (NCT06949774)
- Testing
- Daily Text Messages, Incentivization based on timely ART adherence
- Where
- Uganda
- Volunteers
- 550 people
- Sponsor
- RAND
HIV
Incentives to Promote Medication Adherence Among HIV-Infected Youth
Medication adherence is one of the most salient predictors of patient outcomes in the era following development of effective treatment for HIV infection.
- Trial name
- NCT02206906
- Testing
- Incentive intervention model
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- St. Jude Children's Research Hospital
Suicide, Suicidal Ideation
Telehealth to Reduce Suicidality and Improve HIV Care Engagement in Tanzania
The overall objectives of the proposed research are to develop a brief telehealth counseling intervention to provide support for people living with HIV and experiencing suicidal ideation, and to support HIV care engagement.
- Conditions
- Suicide, Suicidal Ideation, HIV Infections, Adherence, Medication
- Trial name
- NCT04696861
- Testing
- IDEAS for Hope, Enhanced Standard of Care (Safety Planning)
- Where
- 2 sites in Tanzania
- Volunteers
- 60 people
- Sponsor
- Duke University
HIV, HIV Antiretroviral Therapy (ART) Adherence
Selection of Resistant Mutations to Dolutegravir in PLWH Treated in Mozambique
The HIV infection not fully controlled, despite being under antiretroviral treatment, could make virus resistance against the antiretroviral treatments, making hardest the well control of HIV infection.
- Trial name
- REDOCH (NCT06607588)
- Testing
- Not applicable- observational study
- Where
- Mozambique
- Volunteers
- 200 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Human Immunodeficiency Virus, Medication Adherence
Medication Adherence and Outcomes Among Patients in United States With HIV
With support from the NIH, this pilot study will assess the feasibility of using wireless devices and financial incentives to motivate medication adherence among HIV-positive adults in the U.S., focusing on those with…
- Trial name
- CHANGE (NCT03995745)
- Testing
- Medication adherence and financial incentives
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Depression, Posttraumatic Stress Disorder
Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
Pregnant women in South Africa (SA) are at high risk of HIV acquisition. Pre-exposure prophylaxis (PrEP) use during pregnancy is both safe and effective in preventing HIV.
- Conditions
- Depression, Posttraumatic Stress Disorder, Pregnancy Related, Medication Adherence
- Trial name
- NCT05624931
- Testing
- Brief CBT-Based Intervention, Enhanced Treatment as Usual
- Where
- 2 sites in United States, South Africa
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Partner Abuse, Depression
Addressing Intimate Partner Violence, Mental Health, and HIV in Antenatal Care
This quasi-experimental feasibility study recruit n=40 participants from each of two public antenatal clinics in Johannesburg, South Africa. Using the Bowen et al.
- Conditions
- Partner Abuse, Depression, Adherence, Medication
- Trial name
- NCT05389358
- Testing
- Asiphephe health worker training, Asiphephe therapeutic sessions, IPV assessment
- Where
- 2 sites in South Africa
- Volunteers
- 80 people
- Sponsor
- University of Witwatersrand, South Africa
HIV Infections
Managing Medications
The primary aim of this study is to compare the effect of an individualized adherence intervention (TI) and a structured adherence intervention (TS) to usual care on adherence to antiretroviral therapy in persons infected with…
- Trial name
- MM2 (NCT00222716)
- Testing
- Problem solving counseling
- Where
- United States
- Volunteers
- 349 people
- Sponsor
- University of Pittsburgh
HIV Infections
Evaluation of an Intervention on Adherence to Highly Active Antiretroviral Therapy (HAART) in HIV Infected Adults
It is known successful HIV therapy depends on the patients' ability to take their medicine regularly. This study is designed to find out if an intervention designed to help patients remember to take their medication is effective.
- Trial name
- NCT00203853
- Testing
- pillbox, wristwatch
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Hiv
Tenofovir Adherence to Rapidly Guide and Evaluate PrEP and HIV Therapy
Adherence to antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are critical to the success of HIV treatment and therapeutic prevention.
- Trial name
- TARGET (NCT03012607)
- Testing
- Truvada
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections
Triggered Escalating Real-time Adherence (TERA) Intervention
Youth Living with HIV (YLWH) often face unique challenges achieving high and sustained rates of adherence to their antiretroviral therapy (ART).
- Trial name
- TERA (NCT03292432)
- Testing
- TERA Intervention (TERA), Standard of Care (SOC)
- Where
- 8 sites in United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus Infection (HIV), HIV-1 Infection in Adults
Long-Term Real-World Evidence Study to Evaluate Effectiveness, Persistence, Adherence, Safety and Tolerability of Long-acting Cabotegravir Plus Rilpivirine.
The RELATIVITY study is a nationwide, multicenter, ambispective observational cohort evaluating the long-term effectiveness, safety, persistence, and tolerability of long-acting injectable cabotegravir plus rilpivirine (CAB+RPV…
- Trial name
- NCT07703748
- Where
- Spain
- Volunteers
- 3,346 people
- Sponsor
- FUNDACIÓN HOSPITAL UNIVERSITARIO INFANTA LEONOR Y DEL HOSPITAL UNIVERSITARIO DEL SURESTE
HIV/AIDS, Medication Adherence
Adherence Through Home Education and Nursing Assessment, Indonesia
Adherence to antiretroviral therapy (ART) drops sharply after prison release. Effective medication adherence training immediately before and after prison release may improve health outcomes and limit transmission of Human…
- Conditions
- HIV/AIDS, Medication Adherence, Substance Use
- Trial name
- ATHENA-I (NCT03397576)
- Testing
- ATHENA
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
HIV Infections
Integrating Supports to Promote PrEP for Black Adolescents Working With Apps- Atlanta
This study applies Social Cognitive Theory to develop behavioral interventions promoting PrEP adherence. It seeks to adapt and test the enhanced HMP app for feasibility and acceptability among Black adolescents and young adults…
- Trial name
- NCT07535346
- Testing
- Health MPowerment App
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emory University
Medication Adherence
Establishing Novel Antiretroviral Imaging for Hair to Elucidate Non-Adherence (ENLIGHTEN)
This is a pilot study to assess the feasibility, acceptability and appropriateness of delivery of the investigational "MedViewer" intervention in adult patients living with HIV who have been prescribed antiretroviral (ARV)…
- Trial name
- ENLIGHTEN (NCT04232540)
- Testing
- MedViewer report
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of North Carolina, Chapel Hill
Medication Adherence, Retention in Care
An Avatar-based Mobile Phone Intervention to Promote Health in African American MSM
The investigators propose to determine the efficacy of "My Personal Health Guide," a theory-based innovative talking relational human Avatar mobile phone application to engage HIV-positive AAMSM in adherence and retention in…
- Trial name
- NCT04217174
- Testing
- My Personal Health Guide, My Personal Food Guide
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- University of Illinois Chicago