Clinical trials: Adhesion
Postsurgical Adhesion
Effects of Soft Tissue Mobilization on Postsurgical Adhesions, Pain, Lumbopelvic Muscle Functions, Spinal Mobility, and Posture in Postpartum Women With Caesarean Section
Postpartum women with C-section receiving deep and superficial tissue mobilization would have better improvement on pain, lumbopelvic muscle functions, spinal mobility, and posture compare to the superficial tissue mobilization…
- Trial name
- NCT05008315
- Testing
- Myofascial abdominal diaphragm release, Direct focused scar release technique, Direct manipulations to visceral structures
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- YI-JU TSAI
Primary Graft Dysfunction
Quantifying Physical and Biochemical Factors That Contribute to Primary Graft Dysfunction After Lung Transplantation
Primary graft dysfunction (PGD or lung reperfusion edema) complicates 10 to 20% of lung transplantations and leads to severe early and late postoperative complications.
- Trial name
- NCT01151826
- Where
- 4 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Strasbourg, France
Pneumoperitoneum
CO2 Absorption During Laparoscopy
CO2 absorption from the pneumoperitoneum increases over time during laparoscopic procedures. Adding 4% of oxygen to the carbon dioxide was shown in rabbits to decrease CO2 resorbtion through prevention of mesothelial hypoxia.
- Trial name
- NCT01340989
- Testing
- alteration of the insufflation gas, full conditioning, standard pneumoperitoneum
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Breast Cancer, Radiation-Induced Vascular Disease
4D CT Scan Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy
To establish if the cardiac radiation dose assesment is well aproximated with routine 3D CT scan compared to 4D CT experimental scan with respiratory gating (breath motion monitoring).
- Conditions
- Breast Cancer, Radiation-Induced Vascular Disease, Left Anterior Descending Coronary Artery Stenosis, Radiotherapy Side Effect
- Trial name
- RD3D4 (NCT05726604)
- Testing
- Respiratory gating
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Central Hospital Saint Quentin
Benign Gynecological Disease, Uterine Fibroids
Prospective Perioperative Clinical Registry for Women Undergoing Benign Gynecological Surgery
This prospective observational registry aims to systematically collect preoperative, intraoperative, and postoperative clinical data from patients undergoing surgery for benign gynecological conditions.
- Conditions
- Benign Gynecological Disease, Uterine Fibroids, Endometriosis, Adenomyosis
- Trial name
- OPGYNBEN (NCT07772076)
- Testing
- Standard Surgical Procedures for Benign Gynecological Conditions
- Where
- Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS San Raffaele
Non Hematologic Cancers
Phase I Dose Escalation Study of VS-6063 in Japanese Subjects With Non-Hematologic Malignancies
This is a phase I, open-label, dose-escalation trial of defactinib (VS-6063), a focal adhesion kinase inhibitor, in Japanese patients with non-hematologic malignancies.
- Trial name
- NCT01943292
- Testing
- Defactinib
- Where
- Japan
- Volunteers
- 9 people
- Sponsor
- Verastem, Inc.
Intrauterine Adhesion
PREvention of Intrauterine Adhesion After Hysteroscopic Surgery With Novel deGradable Film
Intrauterine adhesions (IUA) are the major long-term complication of intrauterine procedures and are associated with pelvic pain, menstrual disorders, obstetrical complication and infertility.
- Trial name
- PREG1 (NCT04381728)
- Testing
- Womed Leaf
- Where
- 6 sites in Belgium, France and 1 more
- Volunteers
- 23 people
- Sponsor
- Womed
Adhesion of Flexor Tendon of Hand
Collagenase in the Treatment of Zone II Flexor Tendon Adhesions in the Hand
The purpose of this study is to dissolve flexor tendon adhesions associated with failed tendon repair surgery.
- Trial name
- NCT00261209
- Testing
- Collagenase, Collagenase injection
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stony Brook University
Pelvic Floor Muscle Electrophysiologic Therapy, Fast-Track Surgery
Effect of Pelvic Floor Muscle Electrophysiologic Therapy on Enhanced Recovery After Gynecologic Surgery
This study is to evaluate the effect of pelvic floor muscle electrophysiologic therapy on enhanced recovery after gynecologic surgery,to solve muscle soreness and retention of urine after laparoscopy, and endometrial repair after…
- Trial name
- NCT03524807
- Testing
- Electrophysiologic therapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hysteroscopic Adhesiolysis
Usability of the CollaGUARD Adhesion Barrier Following Hysteroscopic Adhesiolysis
Assess the feasibility of CollaGUARD following Hysteroscopic Adhesiolysis.
- Trial name
- NCT02348541
- Testing
- CollaGUARD
- Where
- 2 sites in Netherlands
- Volunteers
- 9 people
- Sponsor
- Innocoll
Tissue Adhesion, Surgery-Induced
Anti-adhesive Effect and Safety of MEDICURTAIN Applied to Undergoing Thyroid Surgery (Pivotal Study)
This study was designed to demonstrate the non-inferiority of MEDICURTAIN® (investigational device) compared to commercially available GUARDIX-SG® (control device) in treatment of subject who underwent total thyroidectomy for…
- Trial name
- NCT05058027
- Testing
- GUARDIX-SG®, Medicurtain®
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Infertility, Abortion, Spontaneous
Development of a Bioabsorbable Medical Device for the Prevention of Postoperative Intra-uterine Adhesions.
The main objective of this study is to describe the level of expression of the biological factors involved in the formation of adhesions (Transforming growth factor beta, Activin A, inhibin) at the time of a first diagnostic…
- Conditions
- Infertility, Abortion, Spontaneous, Embryo Implantation, Delayed
- Trial name
- PréSynUT-1 (NCT02328742)
- Testing
- Hysteroscopy + endometrial biopsy, Telephone call, Resection + endometrial biopsy
- Where
- 3 sites in France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Persistent Atrial Fibrillation
Irbesartan and Adhesion Molecules in AF
Experimental data suggest that angiotensin II-antagonists reduce the atrial expression of prothrombotic adhesion molecules and oxidative stress parameters.
- Trial name
- CREATIVE-AF (NCT00613496)
- Testing
- irbesartan
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Magdeburg
Ovarian Cancer
Phase I/Ib Study of Paclitaxel in Combination With VS-6063 in Patients With Advanced Ovarian Cancer
This is a Phase I/Ib, open-label, multicenter, dose-escalation trial of paclitaxel in combination with defactinib (VS-6063), a focal adhesion kinase inhibitor, in patients with advanced ovarian cancer.
- Trial name
- NCT01778803
- Testing
- defactinib, Paclitaxel
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Verastem, Inc.
Adhesion
A Randomized Control Study of Anti-Adhesion Agent After Colorectal Surgery
This project is to evaluate the difference of post-operation adhesion severity and adhesion area of patient received 4DryField after colorectal surgery.
- Trial name
- NCT05580471
- Testing
- Use 4DryField
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Uterine Septum
Intrauterine Balloon and Postoperative Estrogen Therapy in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
Patients who want to go TCRS will randomly divided 3 groups. In Group 1(100 patients), women received postoperative estrogen therapy.
- Trial name
- NCT02617108
- Testing
- Foley balloon
- Volunteers
- 310 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Orthodontics
Evaluation of the Contamination of Ligatures
This crossover, in-vivo study was carried out with 10 patients who have been started to be treated at Orthodontics Department. 3 elastomeric ligatures were examined in terms of microbiological and surface roughness.
- Trial name
- NCT04185987
- Testing
- Leone slide low friction elastomeric ligature, RMO tough - o energy elastomeric ligature, Dentsply sili tie elastomeric ligature
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- University of Gaziantep
Healthy Adult Participants
A Study to Assess the Bioavailability and Adhesion of Selegiline TDS in Healthy Subjects
The purpose of this research study is to compare the bioavailability and adhesion of a generic Selegiline transdermal system (TDS) against the marketed comparator (EMSAM®) in healthy volunteers.
- Trial name
- NCT07571824
- Testing
- Selegiline TDS 6 mg/24 hours, EMSAM® TDS 6 mg/24 hours
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Capsule Opacification, Tissue Adhesions
Evaluate Capsular Apposition to Intraocular Lens
In this study, the investigators examined the capsule-IOL interaction including anterior and posterior capsule adhesion, contact between posterior capsule and the posterior edge of intraocular lense (IOL), configuration of…
- Conditions
- Capsule Opacification, Tissue Adhesions, Aphakia - Lens Capsule Present, Opacification of Intraocular Lens
- Trial name
- NCT01605812
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Wenzhou Medical University
Adhesion
LEAFix Adhesion in Healthy Volunteers
This study compares the adhesiveness of the 3M material to be used in the final design.
- Trial name
- NCT05415059
- Testing
- Covatech Stoma bag material
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust