Clinical trials: Adhesions
Thrombosis, Acute Coronary Syndrome
Safety, Pharmacokinetic and -Dynamic Study of PR-15, an Inhibitor of Platelet Adhesion
Primary objective: To evaluate safety and tolerability, adverse events (AEs), vital signs, ECG, bleeding time, evaluation of antibody titer and safety laboratory tests Secondary objectives: To evaluate the pharmacokinetics and…
- Conditions
- Thrombosis, Acute Coronary Syndrome, Myocardial Infarction, Stroke
- Trial name
- PR-15/01 (NCT01042964)
- Testing
- revacept (PR-15)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AdvanceCor GmbH
Post-surgery Adhesion Formation
Safety Study Investigating Local Tolerability and Pharmacokinetics of PXL01 in Healthy Volunteers
The main purpose of this study is to determine whether three different single doses of PXL01 are safe and well tolerated by healthy volunteers. The pharmacokinetic properties of PXL01 (same doses) will also be investigated.
- Trial name
- NCT00860080
- Testing
- PXL01
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- PharmaSurgics AB
Healthy
A Study to Evaluate Bioequivalence and Adhesion of a Transdermal Contraceptive Patch Manufactured With Newly Sourced Adhesive Components and Currently Marketed EVRA in Healthy Adult Women
The purpose of this study is to determine the bioequivalence of the hormones (ie, norelgestromin [NGMN] and ethinyl estradiol [EE]) from the transdermal contraceptive patch and to evaluate the adhesion of the transdermal…
- Trial name
- NCT03274297
- Testing
- EVRA patch (NGMN+EE) (Treatment A) (Reference), HMW PIB patch (NGMN+EE) (Treatment B) (Test)
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Nephrectomy, Prostatectomy
HYbrid RObotic Surgery MulTiCentric Study
The purpose of this clinical investigation, HYROS-MTC-I, is to confirm the effectiveness of the combined use of ROB-Bitrack System, its corresponding ElectroSurgical Endoscopic instruments and Non-ElectroSurgical Endoscopic…
- Trial name
- HYROS-MTC-I (NCT06849271)
- Testing
- Radical Nephrectomy (RN), Partial nephrectomy (PN), Radical Prostatectomy (RP)
- Where
- 5 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Rob Surgical Systems S.L.
Healthy
Pharmacokinetics and Adhesion of Lidocaine Topical System 1.8% Under Conditions of Heat and Exercise
The objectives of this study are to evaluate the pharmacokinetic and adhesion performance of ZTlido (lidocaine topical system) 1.8% during physical exercise, application of heat, and under normal conditions.
- Trial name
- NCT04150536
- Testing
- Lidocaine topical system 1.8%
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Scilex Pharmaceuticals, Inc.
Asherman Syndrome, Intrauterine Adhesion
PREvention of Intrauterine Adhesion After Adhesiolysis With Novel Tri-block deGradable Polymer Film.
PREG2 is a randomized controlled trial that aims to evaluate efficacy in preventing intrauterine adhesion recurrence after hysteroscopic adhesiolysis of a novel intrauterine barrier film named Womed Leaf
- Trial name
- PREG2 (NCT04963179)
- Testing
- Womed Leaf
- Where
- 15 sites in Belgium, China and 5 more
- Volunteers
- 160 people
- Sponsor
- Womed
Neuroendocrine Neoplasm, Neuroendocrine Carcinomas
Study of CTX-471 in Patients With Neural Cell Adhesion Molecule (NCAM) Positive Neuroendocrine Neoplasms
This study will enroll patients with central lab confirmed NCAM (CD56 IHC) positive metastatic neuroendocrine neoplasms that have progressed after standard of care treatment.
- Conditions
- Neuroendocrine Neoplasm, Neuroendocrine Carcinomas, Neuroendocrine Tumors
- Trial name
- NCT07684170
- Testing
- CTX-471
- Volunteers
- 58 people
- Sponsor
- Compass Therapeutics
Healthy
Evaluation of Adhesion Quality of a New Formulation of the Mylan Estradiol Transdermal System 0.025 mg/Day and Climara® Transdermal System 0.025 mg/Day
The primary objective of this study was to compare the adhesive quality of a new formulation of the Mylan Estradiol Transdermal System with that of Climara® Transdermal System following a single system application in 80 healthy…
- Trial name
- NCT00649896
- Testing
- Mylan Estradiol Transdermal System 0.025 mg/day, Climara® Transdermal System 0.025 mg/day
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Hysteroscopic Adhesiolysis
Usability of the CollaGUARD Adhesion Barrier Following Hysteroscopic Adhesiolysis
Assess the feasibility of CollaGUARD following Hysteroscopic Adhesiolysis.
- Trial name
- NCT02348541
- Testing
- CollaGUARD
- Where
- 2 sites in Netherlands
- Volunteers
- 9 people
- Sponsor
- Innocoll
Healthy
To Assess the Bioavailability of TK-254RX in Comparison with Oral Flurbiprofen Tablets and the Adhesion of TK-254RX in Healthy Subjects
This study is a single-center, open-label, multiple-dose trial performed in a 2-period, 2- sequence-cross-over design in healthy volunteers.
- Trial name
- NCT06823284
- Testing
- Esflurbiprofen Topical System, Flurbiprofen tablet
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Teikoku Seiyaku Co., Ltd.
Symptomatic Vitreomacular Adhesion
Ocriplasmin Research to Better Inform Treatment (ORBIT)
This is a multicenter, prospective, observational, Phase 4 study that will assess clinical outcomes and safety of JETREA® administered in a real-world setting for the treatment of symptomatic vitreomacular adhesion (VMA) by…
- Trial name
- ORBIT (NCT02079883)
- Where
- 110 sites in United States
- Volunteers
- 540 people
- Sponsor
- ThromboGenics
Schizophrenia
Switching From Oral Antipsychotics to Long-Acting Risperidone in Participants With Schizophrenia
The purpose of this study is to evaluate efficacy, safety and tolerance of long-acting risperidone when switching from oral antipsychotics in participants with schizophrenia (psychiatric disorder with symptoms of emotional…
- Trial name
- NCT01726335
- Testing
- Risperidone prolonged release
- Where
- 5 sites in Brazil
- Volunteers
- 53 people
- Sponsor
- Janssen-Cilag Ltd.
Adhesion, Thyroid Diseases
Evaluation of the Efficacy and Safety of a Hyaluronic Acid Gel in Adhesion Prevention After Open Thyroidectomy.
The aim of this study is to assess the safety and efficacy of HANBIO BarriGel to prevent thyroidectomy postoperative adhesions
- Trial name
- NCT05036525
- Testing
- HANBIO BarriGel
- Where
- 5 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- HAN Biomedical Inc
Adhesions, Colectomy
SurgiWrapTM to Reduce Soft Tissue Attachment & Incidence Early Post-Operative Bowel Obstruction in Colorectal Surgery
The purpose of this study is to determine if the use of SurgiWrapTM: (1) prevents/lowers the incidence of Grade 2 or higher soft tissue attachments under the incision made during abdominal surgery, (2) reduces post-operative…
- Trial name
- NCT00531739
- Testing
- Polylactic Acid Sheet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cytori Therapeutics
Herniation, Disc
Clinical Study to Evaluate the Anti-adhesion Efficacy and Safety of MegaShield®-SP in Comparison With Guardix-SP Plus After Spine Surgery
This study is Interventional, Parallel, Double-blinded, Randomized study. Subjects aged 20 to 70 years who had a Lumbar discectomy or laminectomy, MegaShield-SP® and Guardix-SP Plus will be applied.
- Trial name
- NCT06369233
- Testing
- MegaShield®-SP, Guardix-SP Plus
- Where
- 4 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- L&C Bio
Cardiac Patients, ECG Monitoring
BDx 7 Day ECG Patch: Electrode Adhesion Clinical Study
The purpose of this research study is to learn if a new 7 day patch ECG recording monitor can serve the same purpose as standard monitoring systems.
- Trial name
- NCT02133261
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Bardy Diagnostics, Inc.
Trigger Finger, Hyaluronic Acid
Evaluate the Effectiveness of Crosslinked HA on the Adhesion Preventing After Trigger Finger Release Surgery
To Evaluate the Effectiveness of the use of a Novel Crosslinking Hyaluronan Hydrogel on the Prevention of the Adhesion Occurrence After Trigger Finger Release Surgery
- Trial name
- NCT05082480
- Testing
- Hyaluronic acid (HA), Saline
- Where
- 2 sites in Taiwan
- Volunteers
- 5 people
- Sponsor
- SciVision Biotech Inc.
Pain
An Assessment of Buprenorphine Transdermal Delivery System (BTDS) Patch Adhesion
The purpose of this study is to assess the adhesion of BTDS patch 40 µg/h.
- Trial name
- NCT02431624
- Testing
- BTDS
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mundipharma Research Limited
Non Small Cell Lung Cancer, Lung Cancer
Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung Cancer
This is a Phase II, open-label, multicenter, multi cohort, study of VS-6063 (defactinib), a focal adhesion kinase inhibitor, in patients with KRAS mutant non-small cell lung cancer (NSCLC).
- Trial name
- NCT01951690
- Testing
- defactinib (VS-6063)
- Where
- 9 sites in United States
- Volunteers
- 55 people
- Sponsor
- Verastem, Inc.
Healthy Adult Participants
A Study to Assess the Bioavailability and Adhesion of Selegiline TDS in Healthy Subjects
The purpose of this research study is to compare the bioavailability and adhesion of a generic Selegiline transdermal system (TDS) against the marketed comparator (EMSAM®) in healthy volunteers.
- Trial name
- NCT07571824
- Testing
- Selegiline TDS 6 mg/24 hours, EMSAM® TDS 6 mg/24 hours
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.