Clinical trials: Adhesions
Intrauterine Adhesion
Efficacy of Estrogen-intrauterine Stent System After Intrauterine Adhesiolysis
This is a prospective, randomized, single-blinded,multi-center trial to compare the efficacy of an Estrogen-intrauterine stent system with foley balloon combined with intrauterine cross-linked sodium hyaluronate gel in the…
- Trial name
- NCT04972032
- Testing
- Estrogen Intrauterine Stent System, Foley balloon combined with self-cross-link sodium hyaluronate gel
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Limin Feng
Herniation, Disc
Clinical Study to Evaluate the Anti-adhesion Efficacy and Safety of MegaShield®-SP in Comparison With Guardix-SP Plus After Spine Surgery
This study is Interventional, Parallel, Double-blinded, Randomized study. Subjects aged 20 to 70 years who had a Lumbar discectomy or laminectomy, MegaShield-SP® and Guardix-SP Plus will be applied.
- Trial name
- NCT06369233
- Testing
- MegaShield®-SP, Guardix-SP Plus
- Where
- 4 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- L&C Bio
Parkinson Disease
Clinical Trial to Investigate Patch Adhesion of Rotigotine Containing Patches in Patients With Parkinson's Disease
The investigational medicinal product (IMP) to be tested in the clinical trial (Rotigotine (ROT)-Transdermal System (TDS) (8 mg/24 h)), which is subject to this submission, was designed as a generic of Neupro® 8 mg/24 h, which is…
- Trial name
- NCT06247410
- Testing
- Rotigotine 8Mg/24Hrs Patch
- Where
- 8 sites in Germany
- Volunteers
- 38 people
- Sponsor
- SocraTec R&D GmbH
Intrauterine Adhesions
The Efficacy and Safety of the Dried Biological Amnion Graft in Patients With Intrauterine Adhesions
To estimate the efficacy and safety of dried biological amnion graft after hysteroscopic lysis of intrauterine adhesions.
- Trial name
- NCT02496052
- Testing
- dried biological amnion graft, Foley balloon, estradiol valerate tablets+dydrogesterone Tablets
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Menorrhagia
Hyaluronic Acid Gel in Prevention of Intrauterine Adhesions After Endometrial Ablation
The aim of the study is to evaluate if hyaluronic acid gel prevents intrauterine adhesion formation after endometrial thermal ablation.
- Trial name
- NCT01829451
- Testing
- Hyaluronic acid gel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Cardiac Patients, ECG Monitoring
BDx 7 Day ECG Patch: Electrode Adhesion Clinical Study
The purpose of this research study is to learn if a new 7 day patch ECG recording monitor can serve the same purpose as standard monitoring systems.
- Trial name
- NCT02133261
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Bardy Diagnostics, Inc.
Age Related Macular Degeneration, AMD
Study of Efalizumab Combined With Intravitreal Ranibizumab in the Treatment of Age-Related Macular Degeneration
Efalizumab is an immunosuppressive recombinant humanized IgG1 monocolonal antibody (150 Kd) that binds to human CD11a (1) and is used for the treatment of plaque psoriasis.
- Conditions
- Age Related Macular Degeneration, AMD, CNV
- Trial name
- SEIRA (NCT00726466)
- Testing
- Efalizumab, Ranibizumab
- Where
- United States
- Sponsor
- Vitreous -Retina- Macula Consultants of New York
Trigger Finger, Hyaluronic Acid
Evaluate the Effectiveness of Crosslinked HA on the Adhesion Preventing After Trigger Finger Release Surgery
To Evaluate the Effectiveness of the use of a Novel Crosslinking Hyaluronan Hydrogel on the Prevention of the Adhesion Occurrence After Trigger Finger Release Surgery
- Trial name
- NCT05082480
- Testing
- Hyaluronic acid (HA), Saline
- Where
- 2 sites in Taiwan
- Volunteers
- 5 people
- Sponsor
- SciVision Biotech Inc.
Pain
An Assessment of Buprenorphine Transdermal Delivery System (BTDS) Patch Adhesion
The purpose of this study is to assess the adhesion of BTDS patch 40 µg/h.
- Trial name
- NCT02431624
- Testing
- BTDS
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mundipharma Research Limited
Intrauterine Adhesion
Safety and Efficacy of Intrauterine Biological Barrier on Postoperative Adhesion After Hysteroscopic Adhesiolysis
To evaluate the safety and efficacy of Intrauterine Biological Barrier developed and produced by Chengdu TopRegMed Medical Technology Co., Ltd on postoperative adhesion after Hysteroscopic Adhesiolysis.
- Trial name
- NCT05475756
- Testing
- Intrauterine Biological Barrier, Intrauterine Adhesion Barrier Gel
- Where
- 6 sites in China
- Volunteers
- 264 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic White Matter Lesions (WMIL), Cerebral Small Vessel Disease
Atorvastatin Mitigates WMH-Related Cognitive Impairment by Reducing VCAM-1
This prospective study will enroll patients younger than 60 years with ischemic white matter lesions (WMIL) and age-matched healthy controls.
- Conditions
- Ischemic White Matter Lesions (WMIL), Cerebral Small Vessel Disease, Vascular Cell Adhesion Molecule-1, VCAM-1
- Trial name
- NCT07128212
- Testing
- Atorvastatin 10 mg daily
- Where
- China
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- Suzhou Municipal Hospital of Anhui Province
Endometriosis
Post-operative Ovarian Adhesion Study in Women With Endometriosis
Endometriosis is a common gynaecological condition which typically present with pelvic pain and fertility problems. It is caused by tissues which are similar to the lining of the womb growing inside the women's pelvis.
- Trial name
- NCT01989260
- Testing
- Anti-adhesive gel
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College London Hospitals
Non Small Cell Lung Cancer, Lung Cancer
Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung Cancer
This is a Phase II, open-label, multicenter, multi cohort, study of VS-6063 (defactinib), a focal adhesion kinase inhibitor, in patients with KRAS mutant non-small cell lung cancer (NSCLC).
- Trial name
- NCT01951690
- Testing
- defactinib (VS-6063)
- Where
- 9 sites in United States
- Volunteers
- 55 people
- Sponsor
- Verastem, Inc.
Primary Sclerosing Cholangitis
A Trial of BTT1023 in Patients With Primary Sclerosing Cholangitis
This is a phase II study to determine the safety and preliminary efficacy of a human monoclonal antibody (BTT1023) which targets the vascular adhesion protein (VAP-1) and its use in the treatment of patients with primary…
- Trial name
- BUTEO (NCT02239211)
- Testing
- BTT1023
- Where
- 6 sites in United Kingdom
- Volunteers
- 23 people
- Sponsor
- University of Birmingham
Ventral Hernia, Adhesions
Comparative Effectiveness Multicenter Trial for Adhesion Characteristics of Ventral Hernia Repair Mesh
The proposed study will compare the benefits, harms, and comparative effectiveness of intraperitoneal barrier-coated and non-barrier coated ventral hernia repair (VHR) mesh in reducing adhesions, adhesion-related complications…
- Trial name
- NCT01355939
- Testing
- Clinically-Indicated Abdominal Re-Exploration Surgery
- Where
- 6 sites in United States
- Volunteers
- 173 people
- Sponsor
- Washington University School of Medicine
Hereditary Cancer Syndrome, Hereditary Breast and Ovarian Cancer
Evaluation of the Adhesion to the GENEPY Network
In order to best meet the needs of all those affected by the genetic risk of cancer in our region, it is important to identify the factors likely to influence the course leading to the GENEPY surveillance network.
- Conditions
- Hereditary Cancer Syndrome, Hereditary Breast and Ovarian Cancer, Hereditary Colorectal Endometrial Cancer Syndrome
- Trial name
- GENEPY (NCT03979612)
- Testing
- inclusion of subjects in the GENEPY network
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Institut Claudius Regaud
Adhesion
Dentin Treatments for Restorations of Cervical Lesions Non-Carious
The surface of non-carious cervical lesions (LCNC) is a challenge to adhesive systems, it presents a dentin layer sclera hypermineralized, presence of bacteria and lack of mechanical retention, so this study aimed to evaluate the…
- Trial name
- NCT02434601
- Testing
- Treatment of Dentin Surface, Dentin Surface, Treatment
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Molar Incisor Hypomineralization
Clinical Evaluation of Giomer and Resin-based Fissure Sealants
The objective of this research was to evaluate the clinical success of giomer and resin-based sealants applied in the first permanent molars (FPMs) affected by MIH.
- Trial name
- NCT04929782
- Testing
- Resin-based sealant, Giomer sealants
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Hacettepe University
Premature Ovarian Insufficiency, Intrauterine Adhesion
Application of Platelet-rich Plasma (PRP) in Reproductive Medicine
Female fertility is affected by many factors, such as ovarian function, fallopian tube patency, uterine environment, and mental state, among which the ovaries and endometrium are more important.
- Conditions
- Premature Ovarian Insufficiency, Intrauterine Adhesion, Poor Ovarian Response, Repeated Implantation Failure
- Trial name
- NCT06645379
- Testing
- Platelet-Rich Plasma (PRP) Injections
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Healthy Adult Participants
A Study to Assess the Bioavailability and Adhesion of Selegiline TDS in Healthy Subjects
The purpose of this research study is to compare the bioavailability and adhesion of a generic Selegiline transdermal system (TDS) against the marketed comparator (EMSAM®) in healthy volunteers.
- Trial name
- NCT07571824
- Testing
- Selegiline TDS 6 mg/24 hours, EMSAM® TDS 6 mg/24 hours
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.