Clinical trials: Adipose Tissue, Brown
Obesity, Abdominal
Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue
A fully functional brown fat helps maintain a healthy weight and decreases the risk of metabolic diseases such as type II diabetes (T2DM).
- Trial name
- BATNAD (NCT06627868)
- Testing
- NAD+ precursor
- Where
- Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Turku
Obesity, Diabetes
A Role for Brown Adipose Tissue in Postprandial Thermogenesis?
Brown adipose (fat) tissue (BAT) is a type of fat tissue found in certain small rodents and human babies that is capable of extremely high rates of energy burning.
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT01974778
- Testing
- Meal
- Where
- Australia
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Obese, Metabolic Syndrome
Brown Fat Activation Study
This is an open lable, pilot study in which the investigator will research the effect of two FDA approved drugs, Mirabegron and Pioglitazone on fat tissue.
- Trial name
- NCT02919176
- Testing
- Mirabegron, Pioglitazone, Mirabegron and Pioglitazone
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Philip Kern
Pheochromocytoma, Adrenal Incidentaloma
Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue
To investigate the effect of catecholamine excess on brown fat. To evaluate the effect of brown fat on energy expenditure and lipid and glucose metabolism
- Trial name
- NCT01949714
- Testing
- Removal of adrenal tumor
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Obesity
Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation
In this study the investigators aim to quantitate the extent of cervical and upper thoracic brown adipose tissue (BAT) activation in lean and obese humans via positron emission tomography-computed tomography (PET-CT) in response…
- Trial name
- NCT01015794
- Testing
- ephedrine hydrochloride
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Obesity
Exenatide and Brown Adipose Tissue
The obesity epidemic has led to a enormous increase in the prevalence of type 2 diabetes mellitus (T2D), dyslipidemia and cardiovascular events.
- Trial name
- exe01 (NCT03002675)
- Testing
- Bydureon
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Obesity, Type 2 Diabetes
Cold Stress Stimulate the Browing of Subcutaneous White Adipose in Healthy Adults
Adipose tissues, which include white adipose tissue (WAT) and brown adipose tissue (BAT), play an essential role in regulating whole-body energy homeostasis.
- Trial name
- NCT02159144
- Testing
- cold stress
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Nonshivering Thermogenisis
Human Neck Brown Adipose Tissue mRNA Profile, a Seasonal Variation Study.
The primary objective in this study is to examine the seasonal variation in genetic markers in the deep neck adipose tissue in humans.
- Trial name
- NCT02486419
- Testing
- Outdoor weather
- Where
- Denmark
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Energy Expenditure, Obesity
BRown Fat Activity Measurement With Infrared imaginG tHermography andThermogenesis - the BRIGHT Study
The whole body calorimeter is sensitive enough to reliably measure cold-induced thermogenesis as a surrogate marker of brown adipose tissue (BAT) activation.
- Conditions
- Energy Expenditure, Obesity, Adipose Tissue, Brown
- Trial name
- BRIGHT (NCT02790255)
- Testing
- Cold air, Cold water
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Type1diabetes
Brown Adipose Tissue in Type 1 Diabetes
Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type…
- Trial name
- NCT02984514
- Testing
- Positron emission tomography with tracer 18F-deoxy glucose
- Where
- Sweden
- Volunteers
- 11 people
- Sponsor
- Per-Ola Carlsson
Pheochromocytoma, Paraganglioma
The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue (aBAT) in Patients With Pheochromocytoma or Paraganglioma (PPGLs)
White adipose tissue (WAT) and brown adipose tissue (BAT) form the main adipose tissue subtypes in humans and several animals. BAT, owing to its unique metabolic function, has been of increased focus and interest in metabolic…
- Trial name
- NCT06440122
- Testing
- FDG-PET Scan
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- King's College Hospital NHS Trust
Cachexia, Neoplasms
Brown Adipose Tissue Activity and Energy Metabolism in Cachexia
To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.
- Conditions
- Cachexia, Neoplasms, Pulmonary Disease, Chronic Obstructive, Pancreatic Neoplasms
- Trial name
- BAT-Cachexia (NCT02500004)
- Testing
- 18F-FDG PET-MRI-imaging, DXA scanning, Abdominal subcutaneous adipose tissue biopsy
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cardiometabolic Diseases
Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women
Type of Study: Clinical Trial Goal: The goal of this clinical trial is to investigate specific brown and beige fat cells in the dorsocervical area of young, lean adult women.
- Trial name
- DEBATE (NCT06426082)
- Testing
- Thermoneutral condition, Cold condition, Aerobic exercise condition
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Diabetes, Brown Adipose Tissue
Brown Fat as Therapeutic Strategy for Obesity and Associated Metabolic Diseases Via Functional Food/Nutraceutical Approach - Molecular Mechanisms of Pentacyclic Triterpenes (BRACE)
To examine MA (Maslinic Acid) safety and efficacy in ameliorating insulin resistance and the cardinal features of metabolic syndrome.
- Trial name
- NCT06484543
- Testing
- Maslinic Acid
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Obesity
Mirabegron and Brown Adipose Tissue
Obesity and type 2 diabetes (T2D) are emerging problems worldwide. In particular South Asian individuals (representing 20% of the world population) have an increased risk of obesity and related disorders.
- Trial name
- Mirab (NCT03012113)
- Testing
- Mirabegron, Short term mild cooling
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Metabolic Diseases
Brown Adipose Tissue as a Therapeutic for the Metabolic and Cardiac Dysfunction With Senescence (BATSR)
The goal of this study is to define the effect of aging on brown adipose tissue mass in a cohort of older sedentary and older athlete adults.
- Trial name
- BATSR (NCT04168580)
- Testing
- Exercise Training Intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity
Cold Acclimation as a Modulator of Brown Adipose Tissue Function in Adults With Obesity
This study will investigate the effects of at least 12 weeks of weekly cold water immersions (water temperature 18ºC) on BAT perfusion in individuals with obesity.
- Trial name
- MOTORBAT (NCT05468151)
- Testing
- Cold acclimation, Intervention Control group - volunteers with obesity, Acute cold exposure
- Where
- Finland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Adipose Tissue, Brown, Insulin Resistance
Effect of Fluvastatin on Brown Fat Activity
The purpose of this study is to elucidate the effects of Fluvastatin on brown adipose tissue activity in humans.
- Conditions
- Adipose Tissue, Brown, Insulin Resistance, Clinical Trial
- Trial name
- FluvaBAT (NCT03189511)
- Testing
- Fluvastatin
- Where
- 2 sites in Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obesity
Effects of b3-Adrenergic Receptor Agonists on Brown Adipose Tissue
This study will test the hypothesis that human brown adipose tissue (BAT) can be activated using a β3-adrenergic receptor (AR) agonist.
- Trial name
- NCT01783470
- Testing
- beta3-adrenergic receptor agonist
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aaron Cypess
Obesity, Diabetes
Studying the Effect of Capsinoids on Brown Fat Using Infrared Thermal Imaging.
The primary hypothesis of this study is that consumption of capsinoids increases brown adipose tissue activity, detectable by infrared thermal imaging.
- Conditions
- Obesity, Diabetes, Impaired Glucose Tolerance
- Trial name
- NCT01961674
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation