Clinical trials: Adipose-Derived Mesenchymal Stem Cells
Spinal Cord Injuries
Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for Spinal Cord Injury
HBSCI02: This protocol is part of an FDA Individual Patient Non-emergency Expanded Access Request submitted on behalf of a 38-year-old father and husband who on August 4, 2017 at about 4:30pm, slipped off a boat head-first while…
- Trial name
- NCT04064957
- Testing
- HB-adMSCs
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
End Stage Renal Disease
AMSC for Reducing Anastomotic Stenosis in Primary Arteriovenous Anastomoses
Researchers are evaluating the safety of allogeneic Adipose Derived Mesenchymal Stem Cells (AMSC) use during hemodialysis arteriovenous fistula and arterial bypass creation and its efficacy on improving access maturation and…
- Trial name
- NCT04392206
- Testing
- Adipose Derived Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Houssam Farres, M.D.
Keratoconjunctivitis Sicca, in Sjogren's Syndrome
Mesenchymal Stem Cell Therapy of Dry Eye Disease in Patients With Sjögren's Syndrome
AMASS is a double-blinded randomized clinical trial with the purpose of investigating whether injection of allogeneic adipose-derived mesenchymal stem cells (ASCs) into the lacrimal gland (LG) results in increased ocular comfort…
- Trial name
- AMASS (NCT04615455)
- Testing
- ASCs, Cryostor CS10
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Drug-resistant
A Clinical Study of Mesenchymal Progenitor Cell Exosomes Nebulizer for the Treatment of Pulmonary Infection
Evaluate the efficacy and safety of haMPC-Exos treatment with pulmonary infection caused by gram-negative bacilli resistant to carbapenems.
- Trial name
- NCT04544215
- Testing
- Dosage 1 of MPCs-derived exosomes, Dosage 2 of MPCs-derived exosomes, No MPCs-derived exosomes
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Venous Leg Ulcer, Autologous Adipose Stromal Vascular Fraction
Open Label Single Arm Proof of Concept Trial to Evaluate the Efficacy and Safety of Cytori Celution System in Chronic Non-Healing Venous Leg Ulcers
To evaluate the efficacy and safety of Cytori Celution System in Hungarian patients with chronic non-healing venous leg ulcers.
- Conditions
- Venous Leg Ulcer, Autologous Adipose Stromal Vascular Fraction, Adipose-Derived Mesenchymal Stem Cells, Mesenchymal Stem Cells
- Trial name
- NCT05165459
- Testing
- Venous leg ulcer treatment with adipous SVF
- Where
- Hungary
- Volunteers
- 10 people
- Sponsor
- Szeged University
Alveolar Bone Loss
Effect of Buccal Fat Pad Derived Stem Cells in Maxillary Sinus Augmentation
In this study the buccal fat pad derived stem cells (BFPSCs) will be harvested from buccal fat pad tissue of patients receiving maxillary sinus augmentation.
- Trial name
- NCT02745379
- Testing
- BFPSCs+ DFDBA+ PRF, DFDBA + PRF
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Diabetes Mellitus, Type 2
Autologous SVF Therapy for Type 2 Diabetes
This prospective clinical study aims to evaluate the safety and efficacy of autologous adipose-derived stromal vascular fraction (SVF), enriched with mesenchymal stem cells (ADSCs), for the treatment of Type 2 Diabetes Mellitus…
- Trial name
- LASER-DM2 Tria (NCT07487467)
- Testing
- Autologous Adipose-Derived Stromal Vascular Fraction (SVF)
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Kaiser Clinic and Hospital
Knee Osteoarthritis, Hip Osteoarthritis
Adipose-derived Mesenchymal Stem Cells in Osteoarthritis
This phase I/II study will enroll 100 subjects with mild to moderate osteoarthritis of the hip/knee/glenohumeral joints will be enrolled according to strict inclusion and exclusion criteria.
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Glenohumeral Osteoarthritis, Osteoarthritis
- Trial name
- NCT03869229
- Testing
- Intra-articular injection of ADMSC
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Osteoarthritis
Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES)
The study is a multicenter trial conducted to compare the effectiveness of an injection of a corticosteroid control to mesenchymal stem cell (MSC) preparations from autologous bone marrow concentrate (BMAC), adipose derived stem…
- Trial name
- MILES (NCT03818737)
- Testing
- Bone Marrow Derived MSCs, Adipose-derived MSCs, Umbilical Cord Tissue (UCT) MSCs
- Where
- 5 sites in United States
- Volunteers
- 475 people
- Sponsor
- Emory University
Erectile Dysfunction
A Prospective Comparative Study of Autologous Bone Marrow-Derived and Adipose Tissue-Derived Mesenchymal Stem Cells Versus Platelet-Rich Plasma and Standard Therapy in Patients With Organic Erectile Dysfunction
Erectile dysfunction (ED) is a common condition characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual activity.
- Trial name
- NCT07544537
- Testing
- Autologous Bone marrow-derived Mesenchymal Stem Cells (BMSC), Autologous Platelet-Rich Plasma (4 mL), Autologous Platelet-Rich Plasma (6 mL)
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- National Scientific Medical Center, Kazakhstan
Degenerative Arthritis, Knee Osteoarthritis
A Phase 3 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis
The purpose of this study is to investigate the efficacy and safety of autologous Adipose Tissue derived Mesenchymal stem cells (JOINTSTEM®) in patient with severe Knee Osteoarthritis.
- Trial name
- NCT03990805
- Testing
- JOINTSTEM, saline
- Where
- 13 sites in South Korea
- Volunteers
- 260 people
- Sponsor
- R-Bio
Osteoarthritis
Autologous Adipose-Derived Stromal Cells Delivered Intra-articularly in Patients With Osteoarthritis.
This will be an open-label, non-randomized, multi-center, patient sponsored study of Adipose-Derived Stromal Vascular Fraction (AD-SVF) implantation performed intra-articularly to affected joints.
- Trial name
- NCT01739504
- Testing
- Liposuction with Local Anesthesia, Intra articular infusion of AD-SVF
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ageless Regenerative Institute
Hormone Deficiency
Outcomes of Adipose Derived Mesenchymal Stem Cells on Sexual Hormone Deficiency
The purpose of this study is to evaluate the safety and effectiveness of adipose derived mesenchymal stem cells (AD-MSCs) therapy on sexual hormone deficiency in the middle-aged patients
- Trial name
- MSCSHD (NCT03346967)
- Testing
- adipose-derived mesenchymal stem cells
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Premature Ovarian Failure
Autologous Adipose Derived Mesenchymal Stromal Cells Transplantation in Women With Premature Ovarian Failure (POF)
The goal of this study is to determine safety and tolerability and of intra-ovarian injection of adipose derived stromal cell in women with premature ovarian failure and to study the preliminary efficacy ADSCs intra ovarian…
- Trial name
- NCT02603744
- Testing
- Intraovarian injection of Adipose derived Stromal cells (ADSCs)
- Where
- Iran
- Volunteers
- 9 people
- Sponsor
- Royan Institute
Alzheimer Disease
A Study to Evaluate the Safety and Efficacy of AstroStem in Treatment of Alzheimer's Disease
This is a randomized, double-blind, placebo-controlled, parallel-group comparison study in subjects with Alzheimer's Disease. Following first screening period, subjects will be randomly assigned into one of the following arms…
- Trial name
- NCT03117738
- Testing
- AstroStem
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Nature Cell Co. Ltd.
Rotator Cuff Tear
Treatment of Tendon Injury Using Allogenic Adipose-derived Mesenchymal Stem Cells (Rotator Cuff Tear)
Main purpose of this study is to evaluate efficacy of allogenic adipose-derived mesenchymal stem cells in treatment of tendon injury.
- Trial name
- NCT02298023
- Testing
- allogenic adipose stem cell injection, fibrin glue/normal saline injection, normal saline injection
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Seoul National University Hospital
End Stage Renal Disease (ESRD), Vascular Access Complication
Autologous Adipose Derived Mesenchymal Stem Cells (AMSC) in Reducing Hemodialysis Arteriovenous Fistula Failure
The aim of this phase 1 study is to determine the role of autologous adipose derived mesenchymal stem cells in the reduction of hemodialysis arteriovenous fistula failure when applied during the time of surgical creation.
- Trial name
- NCT02808208
- Testing
- Single Application of Adipose Derived Mesenchymal Stem Cells (AMSC), Two Applications of Adipose Derived Mesenchymal Stem Cells (AMSC)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes
Evaluate Safety of Adipose Derived Mesenchymal Stem Cell Transplantation for Type 1 Diabetes Treatment
The purpose of this study is to evaluate the safety of intravenously (IV) administered adipose-derived mesenchymal stem cell (AD-MSC) in patients with type 1 diabetes mellitus (T1D)
- Trial name
- NCT05308836
- Testing
- adipose-derived messenchymal stem cell
- Where
- Vietnam
- Volunteers
- 10 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Perianal Fistula, Adipose Tissue
Adipose Derived Mesenchymal Stem Cell Characteristics in Anal Fistulas
This study investigated the cellular and molecular characteristics of AT-MSCs obtained from autologous AT therapy in patients with high transphincteric perianal fistulas of crytoglandular origin.
- Conditions
- Perianal Fistula, Adipose Tissue, Tissue Transplantation
- Trial name
- NCT04834609
- Testing
- Injection of autologous adipose tissue in anal fistula
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Traumatic Brain Injury
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure…
- Trial name
- NCT05951777
- Testing
- Autologous HB-adMSCs, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Hope Biosciences LLC