Clinical trials: Adjuvant
Nasopharyngeal Carcinoma
Single-agent Capecitabine as Adjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
This is an randomized, controlled, multicenter phase 3 clinical trial. The purpose of this study is to evaluate the efficacy and safety of single-agent capecitabine as adjuvant chemotherapy in locoregionally advanced…
- Trial name
- CAN (NCT02958111)
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Sun Yat-sen University
COVID
Indirect Endovenous Systemic Ozone for New Coronavirus Disease (COVID19) in Non-intubated Patients
Systemic medical ozone has proved to help in several viral diseases, chronic obstructive pulmonary disease and chronic inflammation process.
- Trial name
- OzonoCOVID19 (NCT04359303)
- Testing
- Systemic indirect endovenous ozone therapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Javier Hidalgo Tallón
Oral Cavity Carcinoma, Flap
Flap Sparing in Postoperative Radiotherapy of Oral Cavity Cancers
Patients with oral cavity cancer treated by reconstructive surgery with a flap. Patients will be treated in the study for : Experimental arm: Post-operative radiotherapy with flap sparing Control arm: Standard post-operative…
- Conditions
- Oral Cavity Carcinoma, Flap, Radiotherapy, Adjuvant, Reconstruction Surgery
- Trial name
- OPTIFLAP (NCT06798922)
- Testing
- Standard post-operative radiotherapy without flap sparing (current practice), Post-operative radiotherapy with flap sparing
- Where
- 30 sites in France
- Volunteers
- 348 people
- Sponsor
- Centre Francois Baclesse
Stomach Neoplasm, GastroEsophageal Cancer
PREACT Study: Locally Advanced Gastric Cancer, Chemoradiotherapy vs. Chemotherapy Followed by D2 Surgery and Adjuvant Chemotherapy
Although the incidence of gastric cancer has been substantially declining for several decades, it is still the sixth most common cancer and the fourth most frequent cause of cancer death worldwide.
- Conditions
- Stomach Neoplasm, GastroEsophageal Cancer, Adenocarcinoma, Locally Advanced Cancer
- Trial name
- PREACT (NCT03013010)
- Testing
- Tegafur-Gimeracil-Oteracil Potassium, Chemoradiotherapy, Gastric resection
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Cancer Hospital, China
Breast Cancer
Oral Vinorelbine or Capecitabine Combined With Trastuzumab as Adjuvant Treatment for Patients With Lymph Node Negative, HER-2 Positive and Small Tumor Size Breast Cancer (ORCHID)
This is a prospective, open-lable Phase II clinical trial (ORCHID study) evaluating the effectiveness and safety of oral vinorelbine or capecitabine combined with trastuzumab as adjuvant treatment for patients with lymph node…
- Trial name
- ORCHID (NCT04296162)
- Testing
- Vinorelbine, Capecitabine, Trastuzumab
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Fudan University
Gastric Cancer
The Relationship Between Microsatellite Instability and Efficacy of Fluorouracil Based Adjuvant Chemotherapy in Gastric Cancer After Operation
The relationship between Microsatellite instability and efficacy of fluorouracil based adjuvant chemotherapy in gastric cancer after operation.
- Trial name
- NCT03485196
- Testing
- Microsatellite instability
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Affiliated Hospital of Qinghai University
Staged III Colorectal Cancer Receiving Adjuvant Chemotherapy
Oral Lactobacillus Rhamnosus TCELL-1 and Colorectal Cancer
Emerging evidences have shown that gut microbiota have played roles in the modulation of chemotherapy agents for cancer patients receiving chemotherapy. Probiotics are gut microbiota beneficial to human body.
- Trial name
- NCT05570942
- Testing
- Oral Lactobacillus rhamnosus TCELL-1
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Bier Block, Dexmedetomidine
A Sequential Allocation Study to Determine the ED50 of Dexmetedomidine as an Adjuvant to Lidocaine Intravenous Regional Anesthesia
Intravenous Regional Anesthesia (IVRA) is an easy and reliable anesthetic technique for hand and forearm surgery. Its use is however limited by the presence of tourniquet pain during the surgery and the absence of postoperative…
- Conditions
- Bier Block, Dexmedetomidine, Tourniquet Pain, Carpal Tunnel
- Trial name
- NCT05342870
- Testing
- Dexmedetomidine
- Volunteers
- 23 people
- Sponsor
- American University of Beirut Medical Center
Breast Cancer
Adjuvant Systemic Treatment for (ER)-Positive HER2-negative Breast Carcinoma in Women Over 70 According to Genomic Grade (GG): Chemotherapy + Endocrine Treatment Versus Endocrine Treatment
The purpose of the study is to evaluate the benefit of adjuvant chemotherapy on overall survival for elderly patients with breast cancer, in a sub group with a high risk of relapse according to Genomic Grade test.
- Trial name
- ASTER 70s (NCT01564056)
- Testing
- HORMONOTHERAPY, CHEMOTHERAPY then HORMONOTHERAPY
- Where
- 84 sites in Belgium, France
- Volunteers
- 1,989 people
- Sponsor
- UNICANCER
Brest Cancer, Abemaciclib
Retrospective Observational Study of the Safety and Toxicity Management of Abemaciclib in Combination with Adjuvant Hormone Therapy in Patients with RH+ ,HER2-nonoveramplified Breast Cancer, Real-life Data (MONARCHE29)
Overall survival at 8 years under treatment for localized hormone-dependent breast cancer is 93.3% (1). Adjuvant therapy, especially hormone therapy, helps reduce the risk of recurrence.
- Conditions
- Brest Cancer, Abemaciclib, Adjuvant Therapy, Antineoplastic Combined Chemotherapy Protocols
- Trial name
- MONARCHE29 (NCT06621459)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Erector Spinae Block, Dexmedetomidine
Systemic Versus Local Dexmedetomidine as An Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Block
The aim of this study is to investigate the analgesic effect of local versus systemic dexamedetomedine as adjuvant to bupivacaine in erector spinae block in kidney exploration surgeries.
- Trial name
- NCT06386770
- Testing
- Dexmedetomidine Injection [Precedex], Bupivacaine Hydrochloride, Dexmedetomidine in 0.9 % NaCl 200 Mcg/50 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Aswan University
Breast Cancer
Anastrozole and Fulvestrant Compared to Anastrozole as Adjuvant Treatment of Postmenopausal Patients With Breast Cancer
Purpose is to compare the frequency of events (presence of Disseminated Tumour Cells, clinical recurrence and/or death) after 1 and 2 years of adjuvant treatment with anastrozole and fulvestrant or anastrozole alone in patients…
- Trial name
- @FAME (NCT00357110)
- Testing
- Fulvestrant, Anastrozole
- Where
- 25 sites in Austria, Germany and 1 more
- Volunteers
- 13 people
- Sponsor
- AstraZeneca
HR+/HER2- Breast Cancer
Neoadjuvant Chemotherapy in Combination With Toripalimab for HR+/HER2- Breast Cancer (NEOTORCH-BREAST01)
This study is a prospective, single arm, multi-center phase II clinical trial. The primary study objective is to evaluate the pathologic complete response（PCR）and RCB0-1 ratio of neodjuvant treatment of HR+/HER2- breast cancer…
- Trial name
- NCT06611813
- Testing
- Neoadjuvant Chemotherapy in Combination with Toripalimab, HR+ HER2 breast cancer
- Where
- 11 sites in China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Melanoma (Skin)
Vaccine Therapy in Treating Patients With Stage IV Melanoma
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Vaccine therapy may be effective in treating stage IV melanoma.
- Trial name
- NCT00042783
- Testing
- D1/3-MAGE-3-His fusion protein, SB-AS02B adjuvant
- Where
- 7 sites in United States
- Sponsor
- SWOG Cancer Research Network
Melanoma (Skin)
Sorafenib, Tamoxifen, and Cisplatin in Treating Patients With High-Risk Stage III Melanoma
RATIONALE: Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00492505
- Testing
- cisplatin, sorafenib tosylate, tamoxifen citrate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- San Diego Pacific Oncology & Hematology Associates
Healthy Volunteer
Study to Assess Safety, Tolerability and Immune Response of Fimaporfin-induced Photochemical Internalisation of Antigen/Adjuvant
Fimaporfin (TPCS2a) is a photosensitiser drug being developed by PCI Biotech AS for use in novel Photochemical Internalisation (PCI) technology.
- Trial name
- NCT02947854
- Testing
- Fimaporfin (Photosensitizer), Hiltonol (Poly-ICLC), HPV E7 (Human Papilloma Virus E7) peptides
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- PCI Biotech AS
Cervical Cancer
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00980954
- Testing
- carboplatin, cisplatin, paclitaxel
- Where
- 125 sites in United States, Canada and 2 more
- Volunteers
- 236 people
- Sponsor
- Radiation Therapy Oncology Group
Covid19
Mesenchymal Stem Cells in Patients Diagnosed With COVID-19
The propose of this study is implement adjuvant therapy with adipose tissue derived-mesenchymal stem cells (MSCs) for critical COVID-19 patients admitted to the intensive care unit of the Regional Hospital Lic.
- Trial name
- NCT04611256
- Testing
- MSC, Control
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Reg. Lic. Adolfo Lopez Mateos
Breast Cancer, Quality of Life
Pharmacist's Influence on Breast Cancer Patient Quality of Life
The purpose of this study is to investigate the impact of pharmacist behavioral intervention's influence on breast cancer patients' quality of life. Croatian randomized controlled trial.
- Trial name
- PIBC (NCT02746666)
- Testing
- Pharmacist's behavioral intervention
- Volunteers
- 70 people
- Sponsor
- University Hospital Sestre Milosrdnice
Breast Cancer
Vaccine Therapy in Treating Patients With Breast Cancer
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells.
- Trial name
- NCT00004156
- Testing
- MUC1-KLH vaccine/QS21
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Memorial Sloan Kettering Cancer Center