Clinical trials: Adjuvant Chemotherapy
Breast Cancer
Evaluate Trastuzumab Plus Standard Chemotherapy Given Before Surgery in Breast Cancer Patients With Low HER 2 Expression
The purpose of this study is to find out if there is a benefit of adding Herceptin (trastuzumab) to standard chemotherapy in this type of breast cancer.
- Trial name
- NCT00944047
- Testing
- nab-paclitaxel, trastuzumab, Doxorubicin
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Kansas Medical Center
Breastcancer, Invasive Breast Carcinoma by Gene Expression Profile
The Symphony Triple A Study: Using Symphony in Treatment Decisions Concerning Adjuvant Systemic Therapy
Rationale: Prediction of prognosis in patients with breast cancer is important to determine the indication for adjuvant chemo-, endocrine- and immunotherapy.
- Trial name
- Symphony (NCT02209857)
- Where
- 34 sites in Netherlands
- Volunteers
- 660 people
- Sponsor
- Diakonessenhuis, Utrecht
Breast Cancers, Triple Negative Breast Cancer (TNBC)
Personalizing the Use of Pembrolizumab for Patients Who Have a Strong Response in Early Triple Negative Breast Cancer
OPT-PEMBRO trial is a pragmatic, multicentre, international, prospective, non-inferiority, two-arms, randomised (1:1), open-label, Phase III clinical study.
- Trial name
- OPT-PEMBRO (NCT06606730)
- Testing
- Pembrolizumab, Deescalation
- Where
- 2 sites in Belgium, France
- Volunteers
- 2,454 people
- Sponsor
- UNICANCER
Uterine Cervical Neoplasms, Cervical Cancer
Clinical Efficacy of Adjuvant Chemotherapy in Patients With Locally Advanced Cervical Cancer Who Did Not Meet the NCCN Guidelines for Adjuvant Treatment After NACT Combined With Surgery
This is a prospective, phase 3 randomized controlled clinical trial. Cervical cancer patients with FIGO stage IB3, Ⅱ A2 or IIB with tumor size> 4 cm will be enrolled.
- Trial name
- NCT04733820
- Testing
- Adjuvant chemotherapy
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Huazhong University of Science and Technology
Colorectal Cancer
Identifying Prognostic Factors in Patients Receiving Tegafur-Uracil for Stage II Colon Cancer That Was Completely Removed By Surgery
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00898846
- Testing
- UFT adjuvant chemotherapy
- Where
- 152 sites in Japan
- Volunteers
- 1,111 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Quality of Life
Immediate or Delayed Naturopathic Medicine in Combination With Neo-Adjuvant Chemotherapy for Breast Cancer
This study is examine the effect of the addition of naturopathic on immunologic and/or inflammatory parameters and/or quality of life in women receiving neoadjuvant chemotherapy for breast cancer.
- Trial name
- NCT02486796
- Testing
- Reishi mushroom extract, Coenzyme Q10, Melatonin
- Volunteers
- 5 people
- Sponsor
- Midwestern Regional Medical Center
Triple Negative Breast Cancer
Investigate the Contribution of Ipatasertib to Neoadjuvant Chemotherapy Plus Atezolizumab in TNBC
International, randomised, open label, neo-adjuvant phase II trial in women with newly diagnosed, non-metastatic, high-risk (node positive and/or tumour size ≥ 2cm), triple negative breast cancer.
- Trial name
- BARBICAN (NCT05498896)
- Testing
- Atezolizumab, Ipatasertib, Paclitaxel
- Where
- United Kingdom
- Volunteers
- 146 people
- Sponsor
- Queen Mary University of London
Esophageal Cancer, Surgery
Neo-adjuvant Immunochemotheray Versus Neo-adjuvant Chemotherapy for Resectable Esophageal Carcinoma
The effect of neo-adjuvant immunochemotherapy on survival of patients with thoracic esophageal squamous cell carcinomas remains unknown.
- Conditions
- Esophageal Cancer, Surgery, Neoadjuvant Treatment, Survival
- Trial name
- NCT04280822
- Testing
- Neoadjuvant immunochemotherapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Henan Cancer Hospital
Colonic Diseases, Adenocarcinoma
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer
Based on the astonishing high response rate in metastatic colorectal cancer in weekly high dose 5-FU and leucovorin, we will conduct a clinical trial to clarify the activity of this regimen in the adjuvant setting.
- Trial name
- NCT00201331
- Testing
- leucovorin+5-FU
- Where
- Taiwan
- Volunteers
- 162 people
- Sponsor
- National Health Research Institutes, Taiwan
Nasopharyngeal Carcinoma
Phase Ⅲ Trial of Adjuvant Chemotherapy in Patients With N2-3 Nasopharyngeal Carcinoma
To see the effect if a combination of concurrent chemoradiotherapy followed by different adjuvant chemotherapy in treating patients with N2-3 nasopharyngeal carcinoma(NPC).
- Trial name
- NCT03321539
- Testing
- CCRT+GP, CCRT+PF
- Where
- 4 sites in China
- Volunteers
- 216 people
- Sponsor
- Sun Yat-sen University
Oropharyngeal Cancer
Comparative Effectiveness Trial of Transoral Head and Neck Surgery Followed by Adjuvant Radio(Chemo)Therapy Versus Primary Radiochemotherapy for Oropharyngeal Cancer
Comparative Effectiveness Trial of Transoral Head and Neck Surgery followed by adjuvant Radio(chemo)therapy versus primary Radiochemotherapy for Oropharyngeal Cancer
- Trial name
- NCT03691441
- Testing
- Resection, Radiotherapy, Chemotherapy
- Where
- 20 sites in Germany
- Volunteers
- 280 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Esophageal Squamous Cell Carcinoma
Study Compare Adjuvant Chemotherapy, Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma
A multi-center prospective randomized controlled study was conducted to compare the effects of adjuvant chemotherapy, chemoradiotherapy and surgery alone for the patients with esophageal cancer.
- Trial name
- NCT04009265
- Testing
- adjuvant treatment
- Where
- China
- Volunteers
- 819 people
- Sponsor
- Fujian Medical University Union Hospital
Breast Cancer
Nail Changes Associated With Chemotherapy and Prevention of Nail Pigmentation by Ice Water Immersion
Anthracyclines combined with cyclophosphamide or taxane-containing regimens may cause nail pigmentation which reduces quality of life in breast cancer patients.
- Trial name
- NIPPER (NCT04215744)
- Testing
- Ice water immersion
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Schizophrenia, Schizoaffective Disorder
Israel Multicenter D-Serine Study (IMSER) for the Treatment of Schizophrenia
The goal of the present study is to evaluate the effect of D-serine, added to antipsychotic treatment, on negative and cognitive symptoms in schizophrenia.
- Trial name
- NCT00138775
- Testing
- D-serine
- Where
- 14 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Uterine Carcinoma
Uterine Serous Carcinoma and Adjuvant Combined Intraperitoneal Chemotherapy and Radiation
Uterine serous carcinoma (USC) is an uncommon, but aggressive variant of endometrial carcinoma that has poor response to standard therapy.
- Trial name
- NCT04030000
- Testing
- Paclitaxel/Carboplatin, Pelvic radiation therapy
- Where
- United States
- Sponsor
- Northwell Health
Cervical Cancer, Cervix Cancer
Adjuvant Chemotherapy in cfHPV-DNA Plasma Positive Patients: A Biomarker In Locally Advanced Cervical Cancer
This study hypothesizes that patients who persist with cell-free human papillomavirus deoxyribonucleic acid (cfHPV-DNA) plasma expression at the end of standard treatment, can derive the benefit of using adjuvant chemotherapy in…
- Conditions
- Cervical Cancer, Cervix Cancer, Cervix Neoplasm
- Trial name
- AddChemo (NCT05764044)
- Testing
- cisplatin, gemcitabine, Follow-up
- Where
- 26 sites in Brazil
- Volunteers
- 365 people
- Sponsor
- Hospital do Coracao
Breast Cancer, Cardiac Toxicity
SWOG-9342 Chemotherapy in Treating Women Enrolled in the SWOG-8897 Clinical Trial
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This clinical trial is studying the effect of chemotherapy on heart function in treating women who…
- Trial name
- NCT00002900
- Testing
- management of therapy complications
- Where
- 105 sites in United States
- Volunteers
- 180 people
- Sponsor
- SWOG Cancer Research Network
Esophageal Cancer
Sutent Following Chemotherapy, Radiation and Surgery For Resectable Esophageal Cancer
The purpose of this study is to see whether or not the combination of cisplatin, irinotecan and radiation, followed by surgery, followed by oral Sutent, is effective and safe for patients with resectable esophageal cancer.
- Trial name
- NCT00400114
- Testing
- Irinotecan, Cisplatin, Radiation
- Where
- 2 sites in Canada
- Volunteers
- 36 people
- Sponsor
- University Health Network, Toronto
Gastric Cancer Stage III
A Randomized Phase III Study Comparing POF With SOX/CAPOX/FOLFOX as a Postoperative Adjuvant Chemotherapy for Curatively Resected Stage III Gastric Cancer
FNF-014 is a randomised, open-label, multicentre, parallel-group, phase 3 study in China to prove superiority of POF over S-1/docetaxel in postoperative adjuvant setting for pStage III gastric adenocarcinoma (including…
- Trial name
- NCT03788226
- Testing
- POF, CAPOX/SOX/FOLFOX
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Fujian Cancer Hospital
Colorectal Cancer
DC-CIK Immunotherapy Plus Chemotherapy vs Chemotherapy Alone in the Adjuvant Treatment of Stage III Colorectal Cancer
Stage III colorectal cancer constitutes more than half of the colorectal patients, and the prognosis does not improve much recently although varies of adjuvant drugs have been tried.
- Trial name
- NCT02415699
- Testing
- Fluorouracil, Oxaliplatin, Leucovorin
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University