Clinical trials: Adjuvant Drug Therapy
Cholangiocarcinoma, Gall Bladder Carcinoma
Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Biliary Tract Cancer
This is a multicenter, prospective, randomized, controlled phase III trial designed to assess the clinical performance of gemcitabine with cisplatin and observation vs.
- Trial name
- ACTICCA-1 (NCT02170090)
- Testing
- Gemcitabine, Cisplatin, Capecitabine
- Where
- 67 sites in Australia, Austria and 6 more
- Volunteers
- 789 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Combination Chemotherapy Following Surgery in Treating Patients With Urinary Tract Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00028860
- Testing
- filgrastim, carboplatin, gemcitabine hydrochloride
- Where
- United States
- Sponsor
- Tulane University Health Sciences Center
Hypovolemic Shock
A Study to Assess the Safety and Efficacy of Centhaquine in Hypovolemic Shock Patients
This is a prospective, multi-centric, open-labeled, phase-IV clinical study to evaluate the safety and efficacy of centhaquine citrate (LYFAQUIN™), a first-in-class drug for treating hypovolemic shock, a life-threatening…
- Trial name
- NCT05956418
- Testing
- Centhaquine
- Where
- 17 sites in India
- Volunteers
- 400 people
- Sponsor
- Pharmazz, Inc.
Breast Cancer
Premenopausal Endocrine Responsive Chemotherapy Trial
The PERCHE trial evaluated the worth of adding adjuvant chemotherapy for premenopausal women with steroid hormone receptor positive early invasive breast cancer who receive ovarian function suppression plus either tamoxifen or…
- Trial name
- PERCHE (NCT00066807)
- Testing
- chemotherapy, exemestane, tamoxifen
- Where
- 6 sites in Hungary, Italy and 1 more
- Volunteers
- 29 people
- Sponsor
- ETOP IBCSG Partners Foundation
Esophageal Cancer
Organ-Preserving Endoscopic Resection & Adjuvant RADIO-immuno-chemotherapy for Esophageal Cancer
The goal of this study is to assess the safety of delivering concurrent adjuvant chemoradiation or immuno-radiation therapy after EMR/ESD in pT1b/T2N0 esophageal cancer patients. The main objectives of the study are: 1.
- Trial name
- OPERARADIO (NCT05667298)
- Testing
- Adjuvant Immunoradiotherapy (ARM1) and Adjuvant Immunotherapy (ARM1B), Adjuvant chemoradiotherapy
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Manitoba
Colorectal Cancer
Combination Chemotherapy With or Without Cetuximab in Treating Patients With Stage III Colon Cancer That Was Completely Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, or fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00265811
- Testing
- Folfox, Cetuximab
- Where
- 8 sites in France
- Volunteers
- 2,559 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Breast Cancer
Prognostic and Predictive Impact of uPA/PAI-1
Chemo-N0 (1993-1998) is the first prospective randomized multicenter trial in N0 BC designed to prospectively evaluate the clinical utility of a biomarker.
- Trial name
- ChemoN0 (NCT01317108)
- Testing
- CMF Chemotherapy
- Volunteers
- 689 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
NSCLC
Adjuvant Erlotinib Intercalating Chemotherapy or Adjuvant Chemotherapy Alone in NSCLC With Common EGFR Mutation
This study will be performed as a local multicenter, randomized, phase III clinical study. It will compare the adjuvant chemotherapy in Stage IB-IIIA NSCLC with common EGFR mutation (Exon 19 deletion or L858R) who underwent total…
- Trial name
- NCT02795884
- Testing
- intercalation therapy using pemetrexed, cisplatin and erlotinib, Vinorelbine, cisplatin
- Sponsor
- Yonsei University
Colonic Neoplasms
Impact of Immunoscore Colon Test on Adjuvant Therapeutic Strategy in Non-Metastatic Colon Cancer
Immunoscore Colon Test (ICT) will be applied on tumor samples from curative surgery. In the Multidisciplinary Meeting (MM) evaluating the participant adjuvant strategy, a first decision will be taken, based on the participant…
- Trial name
- PROSCORE (NCT03946033)
- Testing
- Immunoscore Colon Test
- Where
- 21 sites in France
- Sponsor
- UNICANCER
Breast Cancer
A Pharmacogenomics Study for Breast Cancer Patients Undergoing Adjuvant Chemotherapy With Doxorubicin (A)/Cyclophosphamide ©) and/or Weekly Paclitaxel
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00131963
- Testing
- cyclophosphamide, doxorubicin, paclitaxel
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Duke University
Leiomyosarcoma, Uterine Neoplasm
Adjuvant Chemotherapy for High Risk Uterine Leiomyosarcoma
The purpose of this trial is to study the benefits of giving chemotherapy to women after they have had surgical resection of their primary disease and have no evidence of disease remaining(known as adjuvant therapy).
- Trial name
- NCT00282087
- Testing
- gemcitabine, docetaxel, doxorubicin
- Where
- 12 sites in United States
- Volunteers
- 47 people
- Sponsor
- Sarcoma Alliance for Research through Collaboration
Rectal Cancer
A Study Comparing Adjuvant Chemotherapy Versus Observation for Patients With Rectal Adenocarcinoma After Neoadjuvant Chemo-Radiotherapy Treatment.
Surgery is the most indicated curative treatment for rectal cancer when disease is diagnosed early, however local recurrence risk increases when the disease is diagnosed at advanced stage.T1-2 tumors have a recurrence rate lower…
- Trial name
- NCT01941979
- Testing
- 5-FU, Capecitabine, Oxaliplatin, Leucovorin.
- Where
- Brazil
- Volunteers
- 309 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Colon Cancer
The Relationship Between Relaxation or Wheat Germ Juice to the Immune Indices and Quality of Life (QoL) in Colorectal Cancer Patients on Adjuvant Chemotherapy
The immune system plays an important role in the fight against cancer. According to certain studies, Levels of cytokines secreted by the immune cells were found as predictors of prognosis and survival among cancer patients, as…
- Trial name
- NCT01991080
- Testing
- biofeedback, Wheatgerm juice
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Head and Neck Cancer
Adjuvant Cetuximab and Chemoradiation in Head and Neck Cancer
This multicenter, open-label, uncontrolled phase II trial evaluates safety and efficacy of post-operative chemoradiation in combination with cetuximab in squamous cell carcinoma of the head and neck.
- Trial name
- ACCRA-HN (NCT00791141)
- Testing
- Cetuximab
- Where
- 10 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Breast Cancer
'ADVANCE' (A Pilot Trial)
This study is being conducted to carefully study how chemotherapy is tolerated in group of patients age 70.
- Trial name
- NCT03858322
- Testing
- Paclitaxel, Cyclophosphamide, Carboplatin
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Dana-Farber Cancer Institute
HER2-positive Breast Cancer
Adjuvant Therapy Choice for Non-pCR HER2 Positive Early Breast Cancer After Neoadjuvant Therapy
Chemotherapy combined with trastuzumab and patuzumab is the standard neoadjuvant therapy for HER2 positive breast cancer patients.
- Trial name
- nonPHER (NCT06693037)
- Where
- China
- Volunteers
- 2,092 people
- Sponsor
- Shu Wang
Breast Neoplasms, Neoplastic Cells, Circulating
Evaluation of Treatment Efficacy by Circulating Tumor Cell Phenotype Surveillance in Breast Cancer Patients
The phenotype of circulating tumor cells (CTCs) is supposed to be significant indicator that is correlated the prognosis of breast cancer patients who have completed neoadjuvant chemotherapy, primary tumor surgery with/without…
- Conditions
- Breast Neoplasms, Neoplastic Cells, Circulating, Chemotherapy Effect
- Trial name
- NCT05326295
- Testing
- CTC detection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Hunan Cancer Hospital
Carcinoma, Non-Small-Cell-Lung Cancer
Neo-Adjuvant Gemcitabine and Cisplatin in Treating Patients With Early Stage of Non Small Cell Lung Cancer
Based on available data, the concept of neo-adjuvant chemotherapy seems to be promising for patients with resectable non-small cell lung cancer. The exploration of new drugs and regimens are warranted.
- Trial name
- NCT00191763
- Testing
- Gemcitabine, cisplatin
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Eli Lilly and Company
Resectable Pancreatic Cancer, Neoadjuvant Chemotherapy
NeoFOL-R Trial (Perioperative Versus Adjuvnat FOLFIRINOX in Resectable Pancreatic Cancer)
Rationale: Adjuvant chemotherapy after surgery significantly improved the survival of PC patients, but there is a problem that only about 50% of patients start adjuvant chemotherapy after pancreatectomy.
- Conditions
- Resectable Pancreatic Cancer, Neoadjuvant Chemotherapy, Effects of Chemotherapy
- Trial name
- NCT05529940
- Testing
- Folfirinox
- Where
- 2 sites in South Korea
- Volunteers
- 609 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
A Study of Pegylated Liposomal Doxorubicin and Cyclophosphamide in Her2-negative Stage I and II Breast Cancer Patients
Primary objective: To evaluate the disease-free survival (DFS) in the two randomized arms after therapy with LC vs. EC in chemo-naive Her2-patients with stage I or II breast cancer Secondary objectives: To assess the overall…
- Trial name
- NCT01210768
- Testing
- Epirubicin+Cyclophosphamide, liposomal-doxorubicin+Cyclophosphamide
- Where
- 9 sites in Taiwan
- Volunteers
- 254 people
- Sponsor
- TTY Biopharm
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