Clinical trials: Adjuvant Drug Therapy
Anterior Urethral Cancer, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter
Gemcitabine Hydrochloride and Cisplatin or High-Dose Methotrexate, Vinblastine, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Urothelial Cancer
This study is about two chemotherapy study drug combinations (regimens) that are used for urothelial (bladder or upper urinary tract) cancer.
- Conditions
- Anterior Urethral Cancer, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter, Posterior Urethral Cancer, Recurrent Bladder Cancer
- Trial name
- NCT01639521
- Testing
- cisplatin, gemcitabine hydrochloride, methotrexate
- Sponsor
- University of Southern California
Colorectal Cancer Stage III, Adjuvant Chemotherapy
SOX Versus XELOX as Adjuvant Chemotherapy for Stage III Colorectal Cancer Patients
Fluorouracil combined with oxaliplatin are routinely recommended to patients with pathological stage III (p-stage III) colorectal cancer, leading to significant improvement of 5-year disease-free survival and overall survival…
- Trial name
- NCT03448549
- Testing
- Oxaliplatin, Tegafur，gimeracil and oteracil potassium, Xeloda
- Where
- China
- Volunteers
- 1,191 people
- Sponsor
- Peking University Cancer Hospital & Institute
Ovarian Cancer
Adjuvant Chemotherapy of Three-step Regimen in BRCA1/2 Wide Type Ovarian Cancer (ACTS-2)
Ovarian cancer was mostly diagnosed at late stage (III/IV) with high rate of recurrence after first line of therapy by optimal cytoreductive sugery and 6cycle of TP chemotherapy.
- Trial name
- NCT04520074
- Testing
- Etoposide, Cyclophosphamide, Carboplatin/Cisplatin
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Fudan University
Gastric Cancer
XELOX for 4 Months Versus 6 Months in Gastric Cancer (LOMAC)
Our study aims to compare 4 months versus 6 months of adjuvant capecitabine plus oxaliplatin after D2 gastrectomy in patients with gastric cancer.
- Trial name
- NCT03399110
- Testing
- Oxaliplatin, Capecitabine
- Where
- 10 sites in China
- Volunteers
- 1,024 people
- Sponsor
- Fudan University
Colorectal Carcinoma
ePRO for Adjuvant Therapy of Colorectal Adenocarcinoma
It is a multi-centric randomized controlled trial. The goal of this study is to observe the improvement of QoL using ePRO to manage patients with colorectal cancer who received Oxaliplatin-based adjuvant chemotherapy.The…
- Trial name
- NCT04069455
- Testing
- Electronic Patients Reported Outcomes
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Zhejiang University
Breast Cancer
Study to Determine Treatment Effects of Denosumab in Patients With Breast Cancer Receiving Aromatase Inhibitor Therapy
The purpose of this study is to determine whether denosumab compared to placebo, will reduce the rate of first clinical fracture in women with non-metastatic breast cancer receiving (non-steroidal) aromatase inhibitor therapy.
- Trial name
- NCT00556374
- Testing
- Denosumab, Non-steroidal aromatase inhibitor therapy, Zoledronic Acid
- Where
- 46 sites in Austria, Sweden
- Volunteers
- 3,420 people
- Sponsor
- Amgen
Breast Cancer
Genetic Testing or Clinical Assessment in Determining the Need for Chemotherapy in Women With Breast Cancer That Involves No More Than 3 Lymph Nodes
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- MINDACT (NCT00433589)
- Testing
- anthracycline-based, docetaxel and capecitabine, tamoxifen
- Where
- Netherlands
- Volunteers
- 6,600 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Nasopharyngeal Carcinoma
Induction Versus Adjuvant Gemcitabine/Cisplatin in Locally Advanced Non-metastatic Nasopharyngeal Carcinoma
The standard of care for locally advanced nasopharyngeal carcinoma is radical chemoradiation(CRT).Recent advances in radiation techniques and supportive measures resulted in improvemnent of locoregional control and quality of…
- Trial name
- NCT04898374
- Testing
- Gemcitabin/cisplatin
- Where
- Kuwait
- Volunteers
- 120 people
- Sponsor
- Kuwait Cancer Control Center
Bladder Cancer, Carcinoma, Transitional Cell
Adjuvant Versus Progression-Triggered Gemcitabine Monotherapy for Locally Advanced Bladder Cancer
Primary Objective: To analyse time to tumor progression in patients cystectomized for locally advanced transitional cell carcinoma (TCC) of the bladder, who are not suitable for cisplatin-based chemotherapy (i.e.
- Trial name
- NCT00146276
- Testing
- gemcitabine
- Where
- Germany
- Volunteers
- 178 people
- Sponsor
- Association of Urologic Oncology (AUO)
Nasopharyngeal Carcinoma (NPC)
Dynamic Risk-adapted EBV-DNA and MRI-guided De-concurrent Chemotherapy in Nasopharyngeal Carcinoma
This study aims to explore the efficacy and safety of risk-adapted adjuvant therapy based on dynamic EBV-DNA changes and MRI in nasopharyngeal carcinoma patients.
- Trial name
- NCT07762976
- Testing
- Observation, Adjuvant therapy
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Fudan University
Breast Cancer
Chemotherapy Plus Surgery in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining surgery with chemotherapy may kill more tumor cells.
- Trial name
- NCT00003013
- Testing
- CMF regimen, cyclophosphamide, doxorubicin hydrochloride
- Where
- 28 sites in Austria, Czechia and 9 more
- Volunteers
- 450 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer Female, Anxiety
The Effect of Virtual Reality on Anxiety and Fatigue in Women With Breast Cancer Receiving Adjuvant Chemotherapy
It was aimed to determine the effect of virtual reality glasses application on anxiety and fatigue in women with breast cancer receiving adjuvant chemotherapy.
- Conditions
- Breast Cancer Female, Anxiety, Fatigue
- Trial name
- NCT05168696
- Testing
- Virtual Reality Glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Carcinoma, Squamous Cell, Adenocarcinoma of the Esophagus and Gastric Cardia
Neoadjuvant Chemotherapy Versus Radiochemotherapy for Cancer of the Esophagus or Cardia
The purpose of this randomized study is to clarify if neoadjuvant radiochemotherapy gives a higher degree of complete histological response than neoadjuvant chemotherapy before surgery in patients undergoing treatment for cancer…
- Trial name
- NeoRes (NCT01362127)
- Testing
- Chemotherapy, Radiochemotherapy
- Where
- Sweden
- Volunteers
- 181 people
- Sponsor
- Karolinska University Hospital
Breast Cancer, Triple Negative Breast Cancer
Viscum Album for TNBC on Adjuvant Pembrolizumab
The goal of this clinical trial is to evaluate the efficacy and safety of Viscum album extract when used in combination with pembrolizumab as adjuvant chemotherapy in adult patients (aged 19 and older) who have been diagnosed…
- Trial name
- TNBNOBA (NCT06920810)
- Testing
- viscum album
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Ilsan Cha hospital
Colorectal Neoplasms, Peritoneal Neoplasms
Adjuvant HIPEC in High Risk Colon Cancer
This study aims to determine the oncological effectiveness of adjuvant HIPEC, using intraperitoneal oxaliplatin with concomitant i.v.
- Trial name
- COLOPEC (NCT02231086)
- Testing
- Adjuvant HIPEC (open/laparoscopic), Standard adjuvant systemic chemotherapy, Diagnostic laparoscopy
- Where
- 9 sites in Netherlands
- Volunteers
- 204 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Nasopharyngeal Carcinoma
Effect of Triple Combination of Induction, Concurrent and Adjuvant Chemotherapy in High Risk Nasopharyngeal Carcinoma
The investigators aim to evaluate the survival benefit from triple combination of induction, concurrent and aduvant chemotherapy versus concurrent chemotherapy alone for high risk locoregionally advanced nasopharyngeal carcinoma…
- Trial name
- NCT02621970
- Testing
- Cisplatin 1, Cisplatin 2, Docetaxel
- Where
- China
- Volunteers
- 534 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Fatigue
Physical Activity Intervention for Older Patients During Chemotherapy for Colorectal Cancer
This study will see if patient who undergo a physical activity intervention called Walk With Ease report experiencing less fatigue and a higher quality of life during chemotherapy for colorectal cancer than those who do not…
- Trial name
- NCT02191969
- Testing
- Walk With Ease
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Quality of Life
Pharmacist's Influence on Breast Cancer Patient Quality of Life
The purpose of this study is to investigate the impact of pharmacist behavioral intervention's influence on breast cancer patients' quality of life. Croatian randomized controlled trial.
- Trial name
- PIBC (NCT02746666)
- Testing
- Pharmacist's behavioral intervention
- Volunteers
- 70 people
- Sponsor
- University Hospital Sestre Milosrdnice
Breast Cancer
Investigation of Gene Mutations in Patients With Triple-negative and Patients With HER2+ Breast Cancer Adenocarcinoma
The present study is a transnational study in patients with high risk recurrent breast cancer who receive adjuvant chemotherapy with epirubicin and cyclophosphamide followed by docetaxel or paclitaxel.
- Trial name
- NCT04365790
- Where
- Greece
- Volunteers
- 500 people
- Sponsor
- Hellenic Cooperative Oncology Group
Stage IVA Pancreatic Cancer, Stage III Pancreatic Cancer
Combination Chemotherapy and Radiation Therapy Plus Surgery in Treating Patients With Advanced Cancer of the Pancreas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving the drugs in different ways, such as directly into the abdomen, and combining chemotherapy with…
- Conditions
- Stage IVA Pancreatic Cancer, Stage III Pancreatic Cancer, Adenocarcinoma of the Pancreas
- Trial name
- NCT00020345
- Testing
- fluorouracil, gemcitabine
- Where
- 2 sites in United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
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