Clinical trials: Adjuvant Drug Therapy
Breast Neoplasms
A Study of Genetic Based Chemotherapy Dosing for Breast Cancer Patients
Epirubicin is a common chemotherapy medication used in the treatment of breast cancer. However, chemotherapy dosing is calculated based on people's height and weight, which may not be the most accurate way.
- Trial name
- NCT01740271
- Testing
- Epirubicin
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- AHS Cancer Control Alberta
Solid Tumors
A Single-arm, Open-label Study of GK01 in Combination With or Without Chemotherapy for the Adjuvant Treatment of Solid Tumors
This study is an open-label, single-arm clinical trial to evaluate the safety, pharmacokinetics, and preliminary efficacy of GK01 in patients with advanced solid tumors.
- Trial name
- GUARDIAN-02 (NCT07351903)
- Testing
- GK01 Injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Nasopharyngeal Carcinoma
Effect of Triple Combination of Induction, Concurrent and Adjuvant Chemotherapy in High Risk Nasopharyngeal Carcinoma
The investigators aim to evaluate the survival benefit from triple combination of induction, concurrent and aduvant chemotherapy versus concurrent chemotherapy alone for high risk locoregionally advanced nasopharyngeal carcinoma…
- Trial name
- NCT02621970
- Testing
- Cisplatin 1, Cisplatin 2, Docetaxel
- Where
- China
- Volunteers
- 534 people
- Sponsor
- Sun Yat-sen University
Ovarian Carcinoma
HE4 as a Relapse Biomarker in Ovarian Cancers
HE4 is a more sensitive marker than CA-125 in patients with ovarian cancers. The interest of serum HE4 before surgery has been demonstrated to predict overall survival and its interest has also been shown in combination with…
- Trial name
- PRONOV4IR (NCT02595281)
- Testing
- Experimental arm
- Where
- 7 sites in France
- Volunteers
- 90 people
- Sponsor
- Institut de Cancérologie de Lorraine
Breast Cancer
Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation
The aim of the study is to perform a French multicenter prospective interventional study in order to assess the feasibility and safety of ovarian hyperstimulation for oocyte / embryo cryopreservation in young women with breast…
- Trial name
- CHACRY (NCT02871167)
- Testing
- Controlled ovarian hyperstimulation (COH), Oocyte/embryo freezing
- Where
- 28 sites in France
- Volunteers
- 140 people
- Sponsor
- Centre Oscar Lambret
Breast Neoplasms, Neoplastic Cells, Circulating
Evaluation of Treatment Efficacy by Circulating Tumor Cell Phenotype Surveillance in Breast Cancer Patients
The phenotype of circulating tumor cells (CTCs) is supposed to be significant indicator that is correlated the prognosis of breast cancer patients who have completed neoadjuvant chemotherapy, primary tumor surgery with/without…
- Conditions
- Breast Neoplasms, Neoplastic Cells, Circulating, Chemotherapy Effect
- Trial name
- NCT05326295
- Testing
- CTC detection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Hunan Cancer Hospital
Breast Carcinoma, BRCA Mutation
Intensive Adjuvant Therapy for TNBC with BRCA Gene Mutation
Evaluation of the efficacy and safety of different adjuvant intensification regimens in early-stage BRCA1/2 mutant triple-negative breast cancer.
- Conditions
- Breast Carcinoma, BRCA Mutation, Adjuvant Drug Therapy
- Trial name
- NCT06405295
- Testing
- no intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Gastric Cancer
Intraperitoneal Chemotherapy Guided by the Detection of DNA in Peritoneal Lavage Fluid in Patients With Gastric Cancer
Peritoneal metastasis is a major pattern of gastric cancer recurrence and predicts poor prognosis. In our previous study, we developed a next-generation sequencing technology to detect minimal residual cancer cells in peritoneal…
- Trial name
- NCT05497739
- Testing
- Intraperitoneal chemotherapy, Adjuvant systemic chemotherapy
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Breast Cancer
Studying Tumor Samples From Women Who Have Undergone Chemotherapy for Breast Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897845
- Testing
- RNA analysis, microarray analysis, immunohistochemistry staining method
- Volunteers
- 2,541 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
HER2-positive Breast Cancer
Randomized Trial of Neo-adjuvant Chemotherapy With or Without Metformin for HER2 Positive Operable Breast Cancer
The primary objective of this study is to determine the efficacy of metformin as a repurposed agent in human epidermal growth factor receptor 2 (HER2) positive breast cancer when added to standard neo-adjuvant chemotherapy.
- Trial name
- HERMET (NCT03238495)
- Testing
- Taxotere, Carboplatin, Herceptin + Pertuzumab, Metformin
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Qamar Khan
Stomach Neoplasms
Acupuncture for QoL and Symptoms in Gastric Cancer During Adjuvant Chemotherapy
In the investigator's pilot study(NCT 03753399), a trend of improvement of quality of life, as well as release of symptoms, in gastric patients in acupuncture groups was indicated.
- Trial name
- NCT04360577
- Testing
- acupuncture
- Where
- 11 sites in China
- Volunteers
- 240 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
NSCLC, Adjuvant Treatment
A Study to Assess the Efficacy and Safety of Firmonertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB - IIIB NSCLC With Uncommon Epidermal Growth Factor Receptor (EGFR) Mutations, Following Complete Surgical Resection With or Without Adjuvant Chemotherapy（FIRMOST）
This is a Phase 3, global, double-blind, randomized, controlled multicenter clinical study to assess the efficacy and safety of adjuvant treatment with firmonertinib versus placebo in participants with Stage IB-IIIB NSCLC with…
- Trial name
- FIRMOST (NCT07010419)
- Testing
- Firmonertinib
- Where
- 2 sites in China
- Volunteers
- 338 people
- Sponsor
- Allist Pharmaceuticals, Inc.
Endometrial Cancer
Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features
RAINBO MMRd-GREEN is an international, multicenter, phase III randomised trial wherein adjuvant pelvic external beam radiotherapy combined with and followed by durvalumab for one year is compared to adjuvant pelvic external beam…
- Trial name
- RAINBO-GREEN (NCT05255653)
- Testing
- Pelvic external beam radiotherapy, Chemotherapy, Durvalumab
- Where
- 60 sites in Belgium, Canada and 5 more
- Volunteers
- 316 people
- Sponsor
- Leiden University Medical Center
Leiomyosarcoma Uterus
Interest of Post-operative Chemotherapy in Patients With Localised Uterine Leiomyosarcoma Suspected of Having a High Risk of Recurrence Based on a Biological Test Performed on the Tumour
Addition of postoperative chemotherapy to prevent or delay recurrence in patients newly diagnosed with localized uterine leiomyosarcoma and who have undergone complete tumor surgery.
- Trial name
- L-UteCIN (NCT06524583)
- Testing
- Doxorubicin, Trabectedin
- Where
- 25 sites in France
- Volunteers
- 198 people
- Sponsor
- UNICANCER
Breast Cancer, Invasive Breast Cancer
Neo-adjuvant Chemotherapy With Letrozole in Patients With Estrogen Receptor Positive/HER-2 Negative Breast Cancer
This is an exploratory interventional study that initiates chemotherapy with letrozole in patients with estrogen receptor positive/HER2-negative breast cancer preoperably.
- Trial name
- NeoChAI (NCT03497702)
- Testing
- Doxorubicin, Cyclophosphamide, Docetaxel
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- National Cancer Center, Korea
Fatigue
Impact of Baduanjin Qigong Exercise on Fatigue in Patients With NSCLC Undergoing Adjuvant Chemotherapy
Baduanjin，a type of Qigong which belongs to aerobic exercise, is very popular in China. There is increasing evidence to support its positive effects on health outcomes in various groups of people with physical and mental…
- Trial name
- NCT05159167
- Testing
- Baduanjin, a type of Qigong
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Hubei Cancer Hospital
Colorectal Cancer With a Resected Minimal Synchronous PC, Ovarian Metastases
Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients
Multicentric randomised trial. Patients with a high risk of developing colorectal Peritoneal Carcinomatosis (PC) after resection of their primary will be informed, will sign the consent and will be pre-registered.
- Conditions
- Colorectal Cancer With a Resected Minimal Synchronous PC, Ovarian Metastases, Tumour Rupture in the Abdominal Cavity
- Trial name
- ProphyloCHIP (NCT01226394)
- Testing
- laparotomy plus HIPEC
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Pancreas Cancer
Biomarker Directed Adjuvant Chemotherapy for Resected Pancreas Cancer
Chemotherapy is given after curative surgery for pancreas cancer to try to improve cure rates. There are two choices of chemotherapy which are currently considered equal treatments: gemcitabine or 5-fluorouracil (5FU).
- Trial name
- NCT01411072
- Testing
- gemcitabine, 5-fluorouracil
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- AHS Cancer Control Alberta
Fallopian Tube Cancer, Ovarian Cancer
Two Different Schedules of Carboplatin, Paclitaxel, Gemcitabine, and Surgery in Treating Patients With Newly Diagnosed Stage IIIC or Stage IV Primary Epithelial Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy, such as carboplatin, gemcitabine, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00838656
- Testing
- carboplatin, gemcitabine hydrochloride, paclitaxel
- Where
- 4 sites in United Kingdom
- Volunteers
- 88 people
- Sponsor
- Warwick Medical School
Premenopausal Breast Cancer, Breast Cancer
Ovarian Reserve in Premenopausal Breast Cancer
This is a translational, mutlicentre study. The aim of this study is to determine whether pre-treatment levels of hormones predict ovarian follicular reserve post adjuvant or neoadjuvant chemotherapy for breast cancer and…
- Trial name
- NCT01726322
- Where
- 10 sites in Ireland
- Volunteers
- 216 people
- Sponsor
- Cancer Trials Ireland
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