Clinical trials: Adjuvant Drug Therapy
Missing Teeth, Implants
Outcome of Dental Implant Therapy in Patients Treated With Antiresorptive Medication
Aim of the study is to examine the feasibility of dental implant insertion in patients receiving high, adjuvant and low dose > 4 years.
- Conditions
- Missing Teeth, Implants, Cancer, Osteoporosis
- Trial name
- NCT04741906
- Testing
- Dental implant surgery, Prosthetic treatment
- Where
- Denmark
- Volunteers
- 225 people
- Sponsor
- Copenhagen University Hospital at Herlev
Prostatic Neoplasms, Locally Advanced
Leuprorelin Associated With Radiotherapy Versus Leuprorelin Alone in T3 - T4 or pT3 (on Biopsy) N0, M0 Prostate Cancer
The purpose of this study is to compare the efficacy and safety of combined radiotherapy and hormone therapy and hormone therapy alone in the treatment of clinically locally advanced prostate cancer (T3-T4 or pT3 on biopsy, N0…
- Trial name
- NCT01122121
- Testing
- Leuprorelin SR, Radiotherapy, Flutamide
- Where
- France
- Volunteers
- 273 people
- Sponsor
- Takeda
Breast Cancer, Chemotherapy, Adjuvant
Adjuvant FEC Versus EP in Breast Cancer (MIG5)
In this multicenter, randomized phase III trial, node positive early breast cancer patients are randomly assigned to receive either 6 cycles of FEC (5-fluorouracil 600 mg/m2, epirubicin 60 mg/m2 and cyclophosphamide 600 mg/m2, on…
- Trial name
- MIG5 (NCT02450058)
- Testing
- 5-fluorouracil, epirubicin, cyclophosphamide
- Where
- 8 sites in Italy
- Volunteers
- 1,055 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Breast Cancer
Simultaneous Versus Sequential Use of Adjuvant Chemotherapy and GnRHa in Treating ER+,Premenopausal Breast Cancer
The present study is a randomized open-label -phase III study that aims to compare the efficacy and safety of the adjuvant chemotherapy with simultaneous or sequential application of Zoladex up to 2-3 years for ≤ 45 year old…
- Trial name
- NCT01712893
- Testing
- Zoladex
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Fudan University
Colorectal Cancer
Fruquintinib Combined With Capecitabine as Adjuvant Extended Therapy After R0 Resection and Perioperative Chemotherapy in Patients With Liver-Only Metastatic Colorectal Cancer
Colorectal cancer (CRC) is among the most common malignancies in China, and approximately half of all patients develop liver metastases.
- Trial name
- NCT07885384
- Testing
- Fruquintinib Combined With Capecitabine, Follow-up observation
- Volunteers
- 140 people
- Sponsor
- West China Hospital
Thyroid Cancer, Differentiated Thyroid Carcinoma
Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer
This study will examine the safety and effectiveness of using lithium, which has been used to enhance the effectiveness of high-dose 131I, with a single low dose (30 mCi) of 131I for thyroid ablation in patients with recently…
- Trial name
- NCT00251316
- Testing
- Lithium Carbonate
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Early-stage Breast Cancer
Prospective Cohort Study of Traditional Chinese Medicine for Survival of Patients With Early Breast Cancer
This 2-year trial is intended to be used to study breast cancer patients through forward-looking generation design through collaboration between Chinese and Western medical teams.
- Trial name
- NCT03797248
- Testing
- Chinese herbal medicine
- Where
- Taiwan
- Volunteers
- 310 people
- Sponsor
- Chang Gung Memorial Hospital
Gastric Cancer
A Clinical Study of HLX10 Combined With Chemotherapy Versus Placebo Combined With Chemotherapy for Neoadjuvant/Adjuvant Treatment of Gastric Cancer
This is a two-arm, randomized, double-blinded, multicenter phase III clinical study to evaluate the efficacy of HLX10 combined with chemotherapy versus placebo combined with chemotherapy for neoadjuvant/adjuvant treatment of…
- Trial name
- NCT04139135
- Testing
- HLX10
- Where
- 15 sites in China
- Volunteers
- 642 people
- Sponsor
- Shanghai Henlius Biotech
Colorectal Neoplasms
Low-dose Capecitabine Adjuvant Chemotherapy for Elderly Patients With Stage II/III Colorectal Cancer
Approximately half of colorectal cancer (CRC) patients were first diagnosed after 70 years old. However, compared with younger patients, elderly patients were often undertreated in chemotherapy due to their impaired tolerance.
- Trial name
- LcACEC (NCT02316535)
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 710 people
- Sponsor
- West China Hospital
Non-Small Cell Lung Cancer
A Clinical Study to Assess the Efficacy of Adjuvant Immunotherapy With Cemiplimab in Patients With Surgically Removed Non-small Cell Lung Cancer Who Have Not Received Prior Chemotherapy
ARCH is a randomised, stratified, multicentre, phase III trial. Protocol treatment consists of cemiplimab, 350 mg i.v., every 3 weeks, for 4 cycles, followed by 700 mg i.v., every 6 weeks for 6 cycles or until relapse or…
- Trial name
- ARCH (NCT06931717)
- Testing
- Cemiplimab
- Where
- 35 sites in Austria, Estonia and 7 more
- Volunteers
- 390 people
- Sponsor
- ETOP IBCSG Partners Foundation
Endometrial Carcinoma
Combination Chemotherapy of Paclitaxel and Carboplatin With or Without Anthracycline as Aneo Adjuvant Treatment in Advanced Endometrial Carcinoma
Endometrial cancer, the most common gynecologic cancer worldwide, is steadily increasing in developed countries.The early-stage forms of endometrial cancer are usually highly curable by surgical treatment alone, whereas advanced…
- Trial name
- NCT06102252
- Testing
- Paclitaxel/epirubcin/carboplatin, Paclitaxel/carboplatin
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Brain and Central Nervous System Tumors
Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells, and may be an effective treatment for anaplastic oligodendroglioma. Combining combination chemotherapy with radiation therapy may kill more tumor cells.
- Trial name
- NCT00002840
- Testing
- lomustine, procarbazine hydrochloride, vincristine sulfate
- Where
- 40 sites in Austria, Belgium and 10 more
- Volunteers
- 350 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Cancer
Study Comparing 4 Cycles With 6 Cycles of TC (Docetaxel+Cyclophosphamide) Adjuvant Chemotherapy for 1-3 Lymph Node Positive ER+/HER2- Early Breast Cancer
This is a prospective, multisite, randomized, open-label Phase III clinical trial (CLOVER study) comparing 4 cycles with 6 cycles of TC (docetaxel+cyclophosphamide) adjuvant chemotherapy for 1-3 positive lymph node, ER+/HER2…
- Trial name
- CLOVER (NCT03926091)
- Testing
- Docetaxel, Cyclophosphamide
- Where
- 14 sites in China
- Volunteers
- 2,172 people
- Sponsor
- Fudan University
Breast Cancer
National Surgical Adjuvant Study of Breast Cancer(N-SAS BC) 07 [RESPECT]
To investigate clinical positioning between trastuzumab (Herceptin) monotherapy (H group) and combination therapy of trastuzumab and chemotherapy (H+CT group) based on a randomized controlled trial in women over 70 years with…
- Trial name
- RESPECT (NCT01104935)
- Testing
- trastuzumab monotherapy, trastuzumab and chemotherapy
- Where
- Japan
- Volunteers
- 275 people
- Sponsor
- Comprehensive Support Project for Oncology Research
Larynx Neoplasms
Concurrent Chemoradiation Versus Surgery With Adjuvant Therapy in Advanced Laryngopharyngeal Cancers
Surgery with post operative radiotherapy (PORT) had been the mainstay of treatment for advanced laryngeal-pharyngeal cancers (ALHC) until the eighth decade of the past century.
- Trial name
- NCT00128817
- Testing
- Concurrent Chemoradiation, Laryngectomy + adjuvant radiotherapy/chemoradiotherapy
- Where
- India
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Tata Memorial Hospital
Breast Cancer, Sentinel Lymph Node Biopsy
The Validation of Sentinel Lymph Node Biopsy After Neo-adjuvant Chemotherapy in Breast Cancer Patients
Neoadjuvant or primary systemic treatment is increasingly applied in the treatment of operable breast cancer. Down staging of the primary tumor is one of the important goals of neoadjuvant chemotherapy treatment (NCT), thereby…
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy, Neoadjuvant Therapy
- Trial name
- NCT04986306
- Testing
- SLNB + ALND
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Cheng-Kung University Hospital
Non-small Cell Lung Cancer
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)
This trial will evaluate the safety and efficacy of pembrolizumab (MK-3475) in combination with platinum doublet neoadjuvant chemotherapy (NAC) before surgery [neoadjuvant phase], followed by pembrolizumab alone after surgery…
- Trial name
- NCT03425643
- Testing
- Pembrolizumab, Cisplatin, Gemcitabine
- Where
- 227 sites in United States, Argentina and 23 more
- Volunteers
- 797 people
- Sponsor
- Merck Sharp & Dohme LLC
Carcinoma, Carcinoma, Hepatocellular
Hepatic Artery Infusion Chemotherapy Plus Donafenib in Patients With Hepatocellular Carcinoma After Surgery
This is an open-label，multi-center ，non-randomized ，single arm exploratory study . This clinical study is an investigator-initiated clinical trial（IIT ）.
- Conditions
- Carcinoma, Carcinoma, Hepatocellular, Liver Neoplasms, Digestive System Neoplasms
- Trial name
- NCT04962958
- Testing
- Hepatic arterial infusion chemotherapy, Folfox Protocol, Donafenib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
CIPN in Adjuvant Breast Cancer Patients
Prevention of CIPN Using Compressive Therapy
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of treatment with taxanes and platinum-based drugs, significantly impacting the quality of life of oncology patients.
- Trial name
- CIPN (NCT06823440)
- Testing
- Compression using surgical gloves and compression knee socks
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Martina Lojova
Malignant Bowel Obstruction, Ascites
Kinesio-Taping vs. Usual Care for Malignant Bowel Obstruction With Ascites
The goal of this clinical trial is to find out whether abdominal Kinesio-taping is a feasible and effective way to relieve symptoms in patients with malignant bowel obstruction and ascites who still have severe symptoms after…
- Conditions
- Malignant Bowel Obstruction, Ascites, Advanced Cancer
- Trial name
- KTMBO-RCT (NCT07023042)
- Testing
- Abdominal Kinesio taping, Standard Care Arm
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- National Taiwan University Hospital
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