Clinical trials: Adjuvant Drug Therapy
Neoadjuvant Chemotherapy, Locally Advanced Cervical Cancer
NAC Followed by RH for the Treatment of LACC
This cohort study is to evaluate the role of neoadjuvant chemotherapy (NAC) in the treatment of locally advanced cervical cancer (LACC). Sixty patients with LACC (FIGO 2009 stage IB2 to IIB) will be enrolled.
- Conditions
- Neoadjuvant Chemotherapy, Locally Advanced Cervical Cancer, Radical Hysterectomy, Objective Response
- Trial name
- NCT03963882
- Testing
- Two cycles of neoadjuvant chemotherapy, First imaging evaluation, Second imaging evaluation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Lei Li
Breast Cancer
S9313B Study of Tumor Tissue Samples From Women With Early-Stage Breast Cancer Enrolled on Clinical Trial SWOG-9313
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00949013
- Testing
- immunohistochemistry staining method, laboratory biomarker analysis
- Volunteers
- 1,600 people
- Sponsor
- SWOG Cancer Research Network
LMS - Leiomyosarcoma, Uterine Leiomyosarcoma
CytoreductiveSurgery & HIPEC w/Gemcitabine+Chemotherapy w/Dacarbazine in Uterine Leiomyosarcoma
The purpose of this study is to find out if giving a dose of heated chemotherapy in the abdomen immediately after surgery that is done to remove uterine leiomyosarcoma type of cancer will help lower the risk of the cancer coming…
- Trial name
- NCT04727242
- Testing
- Gemcitabine, Dacarbazine, Cytoreductive Surgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Breast Cancer Stage II
Neoadjuvant and Adjuvant Ribociclib and ET for Clinically High-risk ER+ and HER2- Breast Cancer
This is an open-label, multicenter international trial in men and women with primary operable HR+/HER2-, ki67≥20%, grade 2 or 3 and stage II breast cancer to evaluate safety and long-term efficacy of a non-chemo treatment in…
- Trial name
- RIBOLARIS (NCT05296746)
- Testing
- Ribociclib (neoadjuvant), Chemotherapy (adjuvant), Ribociclib (adjuvant)
- Where
- 51 sites in France, Portugal and 1 more
- Volunteers
- 1,100 people
- Sponsor
- SOLTI Breast Cancer Research Group
Triple Negative Breast Cancer
Maintenance Treatment With Eribulin Mesylate Versus Observation in Triple Negative Breast Cancer Patients
This clinical trial is a multicenter, randomized, open-label, phase-II study to evaluate the efficacy and safety of maintenance treatment with eribulin mesylate following standard adjuvant chemotherapy in triple negative breast…
- Trial name
- EMBRAVE-001 (NCT04502680)
- Testing
- Eribulin Mesylate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Breast Cancer
Adding Adjuvant Cisplatin and Gemicitabine Versus Capecitabine in Triple-negative Breast Cancer Patients in Non pCR After Neoadjuvant Standard Chemotherapy
In our study; investigator aim To show efficacy and toxicity of Adjuvant cisplatin and gemcitabine in triple-negative breast cancer patients with non pathologically complete response after neoadjuvant chemotherapy To compare…
- Trial name
- NCT06268327
- Testing
- Cisplatin injection and gemcitabine, Capecitabine tablets
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Nasopharyngeal Carcinoma (NPC)
Dynamic Risk-adapted EBV-DNA and MRI-guided De-concurrent Chemotherapy in Nasopharyngeal Carcinoma
This study aims to explore the efficacy and safety of risk-adapted adjuvant therapy based on dynamic EBV-DNA changes and MRI in nasopharyngeal carcinoma patients.
- Trial name
- NCT07762976
- Testing
- Observation, Adjuvant therapy
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Fudan University
Non-Small Cell Lung Cancer
Trial of Perioperative Chemotherapy (Gemcitabine and Cisplatin) and Adjuvant Chemoradiotherapy (With Weekly Low Dose Gemcitabine) in Patients With Lung Cancer With Positive Nodes
The purpose of this study is to test feasibility, toxicity and efficacy of two different adjuvant treatment schedules in Stage II-IIIa Non-small cell lung cancer patients with positive lymph nodes.
- Trial name
- NCT00490659
- Testing
- gemcitabine, cisplatin, radical surgery
- Where
- Poland
- Volunteers
- 13 people
- Sponsor
- Eli Lilly and Company
Shoulder Pain, Injury of Shoulder Region
Plasma Glucose Levels With Dexamethasone as Adjuvant to Interscalene Block
The purpose of this study is to determine the Finger Blood Glucose (sugar) when dexamethasone is added to a local anesthetic for a shoulder nerve block procedure.
- Conditions
- Shoulder Pain, Injury of Shoulder Region, Disorder of Shoulder, Disorder of Rotator Cuff
- Trial name
- NCT01538459
- Testing
- Dexamethasone, Bupivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lifespan
Breast Cancer
'ADVANCE' (A Pilot Trial)
This study is being conducted to carefully study how chemotherapy is tolerated in group of patients age 70.
- Trial name
- NCT03858322
- Testing
- Paclitaxel, Cyclophosphamide, Carboplatin
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Dana-Farber Cancer Institute
Pancreatic Cancer
Fluorouracil Plus Radiation Therapy Following Surgery in Treating Patients With Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00010062
- Testing
- fluorouracil, radiation therapy
- Where
- 30 sites in France, Luxembourg
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
HER2-negative Breast Cancer, Neoadjuvant Therapy
Efficacy and Safety of Combinition of Camrelizumab in Second-line Neoadjuvant Chemotherapy and Adjuvant Therapy
The achievement of pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) is associated with improved outcome across all breast cancer (BC) subtypes.
- Conditions
- HER2-negative Breast Cancer, Neoadjuvant Therapy, Pathological Complete Response, Immunotherapy
- Trial name
- NCT04848454
- Testing
- Camrelizumab with vinorelbine and cisplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Esophageal Cancer
Endostatin Combined With Chemotherapy for Adjuvant Treatment of Esophageal Cancer
This is an open-label, randomized trial, it compares the efficacy and safety between apatinib combined chemotheray and chemotherapy for adjuvant treatment of esophageal cancer
- Trial name
- NCT03649945
- Testing
- Docetaxel, Nedaplatin, Endostar
- Volunteers
- 186 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Breast Cancer
Premenopausal Endocrine Responsive Chemotherapy Trial
The PERCHE trial evaluated the worth of adding adjuvant chemotherapy for premenopausal women with steroid hormone receptor positive early invasive breast cancer who receive ovarian function suppression plus either tamoxifen or…
- Trial name
- PERCHE (NCT00066807)
- Testing
- chemotherapy, exemestane, tamoxifen
- Where
- 6 sites in Hungary, Italy and 1 more
- Volunteers
- 29 people
- Sponsor
- ETOP IBCSG Partners Foundation
Small Cell Lung Cancer (SCLC)
Adjuvant Chemotherapy and Immunotherapy for Completely Resected Small Cell Lung Cancer
This is a phase II trial of adjuvant chemotherapy and immunotherapy for completely resected small cell lung cancer (SCLC).
- Trial name
- NCT07149363
- Testing
- Durvalumab 50 MG/ML
- Where
- 6 sites in United States
- Volunteers
- 65 people
- Sponsor
- Alliance Foundation Trials, LLC.
Breast Cancer
Outcome of Neo-adjuvant Chemotherapy Followed by Breast Conservative Surgery in Breast Cancer in Upper Egypt
Systemic chemotherapy along with radiotherapy has been successfully used to post-operatively manage patients following tumour resection in breast cancer.
- Trial name
- NCT03696004
- Testing
- FEC-100
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Biliary Tract Cancer
A Phase I Study of Adjuvant Chemotherapy With GS in Biliary Tract Cancer Undergoing Resection Without Major Hepatectomy
To decide maximum tolerated dose and recommended dose of treatment using gemcitabine plus S-1 combination therapy in patients with biliary tract cancer undergoing resection without major hepatectomy
- Trial name
- NCT01713387
- Testing
- Gemcitabine, S-1
- Where
- Japan
- Volunteers
- 38 people
- Sponsor
- Kansai Hepatobiliary Oncology Group
Oncology, Breast Cancer
Pantoprazole Prophylaxis Against Delayed CINV for Patients Receiving Breast Cancer Chemotherapy
This study explores whether a commonly used medication called Pantoprazole can help prevent delayed nausea and vomiting from chemotherapy for early breast cancer.
- Conditions
- Oncology, Breast Cancer, Chemotherapy-induced Nausea and Vomiting
- Trial name
- PantoCIN (NCT03948477)
- Testing
- Pantoprazole 40mg
- Where
- 10 sites in New Zealand
- Volunteers
- 160 people
- Sponsor
- University of Auckland, New Zealand
Incidental Gallbladder Carcinoma, Biliary Tract Cancer
Neoadjuvant Chemotherapy With Gemcitabine Plus Cisplatin Followed by Radical Liver Resection Versus Immediate Radical Liver Resection Alone With or Without Adjuvant Chemotherapy in Incidentally Detected Gallbladder Carcinoma After Simple Cholecystectomy or in Front of Radical Resection of BTC
Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma…
- Trial name
- GAIN (NCT03673072)
- Testing
- Gemcitabine, Cisplatin, Oncologically radical margin-free (R0) resection
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Krankenhaus Nordwest
Breast Cancer
Study Comparing EC-T Verses PCb in the Adjuvant Chemotherapy of Non-triple Negative Breast Cancer
This study is a randomized, single center, phase III clinical trial comparing the efficacy and safety of four cycles of epirubicin combined with cyclophosphamide followed by four cycles of docetaxel (EC*4-T*4) verses 6 cycles of…
- Trial name
- PANSY (NCT04193059)
- Testing
- Paclitaxel, Carboplatin, Epirubicin
- Where
- China
- Volunteers
- 1,560 people
- Sponsor
- Fudan University
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