Clinical trials: Adjuvant Treatment
COVID-19
Eucalyptus Oil as Adjuvant Therapy for Coronavirus Disease 19 (COVID-19)
Background : Based on several clinical trials, eucalyptus oil can suppress edema formation and reduce inflammation, where the effect of 1,8-cineole is due to the inhibition of cytokine secretion by T lymphocytes.
- Trial name
- NCT05398965
- Testing
- Eucalyptus Oil, Standard COVID medication
- Where
- Indonesia
- Volunteers
- 54 people
- Sponsor
- Hasanuddin University
Gastric Cancer Stage III
Using ctDNA to Guide Treatment Decisions for Stage III Gastric Cancer
The goal of this randomized, controlled phase III clinical trial is to evaluate whether combining Tislelizumab with standard SOX chemotherapy improves disease-free survival (DFS) compared to chemotherapy alone in patients with…
- Trial name
- NCT06939439
- Testing
- Tislelizumab + SOX Chemotherapy, SOX Chemotherapy
- Where
- China
- Volunteers
- 416 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Esophagus Squamous Cell Carcinoma
Raltitrexed Concurrent With Radiotherapy for Elderly Chinese Patients With Squamous Cell Carcinoma of Esophagus
Concurrent chemoradiotherapy is one of the curative options for esophageal squamous cell carcinoma. We evaluated the efficacy and toxicity of raltitrexed with concurrent radiotherapy in elderly patients with esophageal cancer.
- Trial name
- NCT03585530
- Testing
- raltitrexed
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Huai'an First People's Hospital
Biliary Tract Cancer
Durvalumab Combined With S-1 as Adjuvant Therapy of Resectable BTC
The aim of this study is to assess the efficacy and safety of durvalumab combined with S-1 as adjuvant therapy of resectable Biliary Tract Cancer(BTC) with high risk of recurrence
- Trial name
- NCT06490107
- Testing
- Durvalumab combined with S-1
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Irritable Bowel Syndrome
Effect of Oral Combined Berberine and Curcumin Pharmacological Therapy on IBS
Irritable bowel syndrome (IBS) is a prevalent, chronic functional gastrointestinal (GI) disorder, characterized by recurrent abdominal discomfort (pain) associated with altered bowel movements.
- Trial name
- NCT06187298
- Testing
- A combined supplement of Berberine and Curcumin (Enterophytol® PLUS) alongside standard of care
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- Liaquat University of Medical & Health Sciences
HR+/HER2-breast Cancer
A Randomized, Controlled, Open-label Clinical Trial of Adjuvant Intensive Therapy for HR+/ HER2-SNF4 Early Breast Cancer
This is a randomized, controlled, open, phase III trial of adjuvant intensive therapy for early breast cancer with HR+/ HER2-SNF4 based on SNF molecular typing.
- Trial name
- NCT05889871
- Testing
- Standard endocrine therapy plus Apatinib
- Volunteers
- 916 people
- Sponsor
- Fudan University
Colon Cancer
Post-surgical Liquid Biopsy-guided Treatment of Stage III and High-risk Stage II Colon Cancer Patients: the PEGASUS Trial
PEGASUS is a prospective multi-centric study designed to prove the feasibility of using liquid biopsy to guide the post-surgical and post-adjuvant clinical management in 140 microsatellite stable Stage-III and T4N0 Stage-II colon…
- Trial name
- NCT04259944
- Testing
- CAPOX, Capecitabine, FOLFIRI
- Where
- 11 sites in Italy, Spain
- Volunteers
- 140 people
- Sponsor
- IFOM ETS - The AIRC Institute of Molecular Oncology
Breast Cancer
AX Versus AC as Adjuvant Treatment for Node-Negative Breast Cancer
Capecitabine has shown high efficacy in metastatic and adjuvant settings. This is a prospective, randomised trial, to compare the efficacy and safety profiles of capecitabine-containing regimen with non- capecitabine-containing…
- Trial name
- NCT01415336
- Testing
- Doxorubicin, Cyclophosphamide, doxorubicin, Capecitabine
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Early Breast Cancer
Nab-paclitaxel in Combination With Pyrotinib in Postoperative Adjuvant Therapy for HER2-positive Breast Cancer
This is a multicenter, open-label, single-arm, prospective, phase II study. conducted to evaluate the efficacy, safety and tolerability of nab-paclitaxel plus pyrotinib in patients with lymph node-negative and tumor size ≤3 cm…
- Trial name
- NCT04659499
- Testing
- Nab-paclitaxel in combination with pyrotinib
- Volunteers
- 261 people
- Sponsor
- Peking Union Medical College Hospital
Ovarian Cancer
Immunotherapy With Neo-adjuvant Chemotherapy for OVarian Cancer
This is a randomized, open, comparative, multi-centre study which will recruit up to 66 patients. The objective is mainly to explore the safety and feasibility in neo-adjuvant first-line ovarian cancer (including patients with…
- Trial name
- INeOV (NCT03249142)
- Testing
- ARM A Durvalumab/chemotherapy association, ARM B Durvalumab/Tremelimumab/chemotherapy association
- Where
- 11 sites in France
- Volunteers
- 69 people
- Sponsor
- ARCAGY/ GINECO GROUP
Tubular Breast Cancer Stage II, Mucinous Breast Cancer Stage II
Addition of Carboplatin to Neoadjuvant Therapy for Triple-negative and HER2-positive Early Breast Cancer
Study participants with primary breast cancer will receive a standard chemotherapy with an anthracycline and a taxane as well as trastuzumab in case of HER2-positive tumors at doses and duration in concordance to current…
- Conditions
- Tubular Breast Cancer Stage II, Mucinous Breast Cancer Stage II, Breast Cancer Female NOS, Invasive Ductal Breast Cancer
- Trial name
- GeparSixto (NCT01426880)
- Testing
- Carboplatin, background treatment
- Where
- 3 sites in Germany
- Volunteers
- 595 people
- Sponsor
- GBG Forschungs GmbH
Hepatocarcinoma
HAIC Combined With Anlotinib and TQB2450 as Adjuvant Therapy in HCC Patients With High Risk of Recurrence After Resection
This is a single center, non-randomized, open, multi-cohort clinical, exploratory Phase II study, to evaluate the efficacy and safety of HAIC combined with TQB2450 and anlotinib as adjuvant therapy in hepatocellular carcinoma…
- Trial name
- NCT05311319
- Testing
- HAIC+TQB2450+Anlotinib
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Fudan University
Head and Neck Squamous Cell Carcinoma
Postoperative Radiotherapy With Nimotuzumab ± Benmelstobart in Intermediate-Risk Head and Neck Squamous Cell Carcinoma
A multicenter, randomized, controlled, open-label, Phase II/III clinical trial designed to evaluate the efficacy and safety of postoperative radiotherapy combined with Nimotuzumab,with or without Bemcentinib, in postoperative…
- Trial name
- NimoBenSeq (NCT07535567)
- Testing
- Nimotuzumab, Nimotuzumab, Benmelstobart, Postoperative Radiotherapy
- Volunteers
- 386 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Hepatocellular Carcinoma
Research on Effectiveness and Safety of the Treatment, Hyperthermic Intraperitoneal Chemotherapy Combined With Tislelizumab and Targeted Therapy, That is Used for High-risk Hepatocellular Carcinoma After R0 Resection
There are limited treatment options for HCC with high recurrence risk, and there is no consistent plan for adjuvant therapy after surgery. Hence an unmet clinical need.
- Trial name
- NCT05546619
- Testing
- HIPEC+tislelizumab + targeted therapy
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sulai Liu
Brain and Central Nervous System Tumors
Radiation Therapy in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Grade II or Grade III Meningioma
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving high-dose radiation therapy after surgery may kill any tumor cells that remain after surgery.
- Trial name
- NCT00626730
- Testing
- adjuvant therapy, radiation therapy
- Where
- Switzerland
- Volunteers
- 78 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Chemotherapy-Induced Neutropenia
Use of Biosimilar Nivestim® to Prevent Chemo-induced Neutropenia. Real Life Study
The aim of this study is to describe in real-life conditions the determinants of use of GCSF (Granulocyte Colony-Stimulating Factor) Nivestim® in primary or secondary prophylaxis and in patients receiving chemotherapy for solid…
- Trial name
- VISTA (NCT02454530)
- Testing
- Nivestim®
- Where
- 92 sites in France
- Volunteers
- 1,160 people
- Sponsor
- Pfizer
Renal Cell Carcinoma
Multimodal Recurrence Scoring System for Stratifying Stage III Clear Cell Renal Cell Carcinoma of Receiving Adjuvant Treatment
Whether patients with stage III clear cell renal cell carcinoma (ccRCC) should receive adjuvant targeted therapy or not is still on debate.
- Trial name
- NCT06032728
- Testing
- Sunitinib
- Volunteers
- 488 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Endometriosis, Dysmenorrhea
Effect of Propolis Administration for Dysmenorrhea in Endometriosis Patient With Levonorgestrel Implant Therapy
The goal of this clinical trial is to investigate the effect of propolis administration on dysmenorrhea in endometriosis patient.
- Trial name
- NCT05770297
- Testing
- Propolis
- Where
- Indonesia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Colorectal Cancer
Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug, giving the drugs in different ways, and combining radiation therapy and surgery…
- Trial name
- NCT00002523
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 35 sites in Belgium, France and 8 more
- Volunteers
- 1,011 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Abscess
Antibiotic Therapy After Incision and Drainage for Abscess
Background: Skin abscesses are a growing problem in the general pediatric population around the world. While the standard treatment for an abscess/boil is incision and drainage, many physicians also prescribe antibiotics, despite…
- Trial name
- NCT00900510
- Testing
- Incision and drainage, Trimethoprim/Sulfamethoxazole (Bactrim)
- Where
- United States
- Sponsor
- Wake Forest University
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