Clinical trials: Adjuvant Treatment
Locally Advanced Nasopharyngeal Carcinoma
TPF Induction Chemotherapy vs PF Adjuvant Chemotherapy Combined With Concurrent Chemoradiotherapy in the Treatment of Locally Advanced NPC
Through randomized controlled phase III multicenter clinical trials, TPF induction chemotherapy vs. PF regimen adjuvant chemotherapy concurrently Radiotherapy and chemotherapy for the treatment of locally advanced nasopharyngeal…
- Trial name
- NCT03574324
- Testing
- TPF+CCRT, CCRT+PF
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Guiyang Medical University
Squamous Cell Carcinoma of Head and Neck
HYPORT: A Phase I/II Study of Hypofractionated Post-operative Radiation Therapy for Head and Neck Cancer
There is a strong radiobiological and economic rationale for hypofractionated radiation therapy in head and neck cancer. Phase 1 of the trial aims to assess the acute toxicity and tolerability of hypofractionated radiation…
- Trial name
- NCT04403620
- Testing
- Intensity-modulated Radiation Therapy (IMRT)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer
Quality of Life and Sexuality of Patients Over 65 Years Undergoing Adjuvant Treatment for Breast Cancer
The purpose of this study is to assess the quality of life and sexuality during adjuvant chemotherapy in over 65 years old patients with breast cancer
- Trial name
- QUALITY-AGE (NCT03946579)
- Testing
- self questionnaires
- Where
- 3 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Henri Becquerel
Breast Cancer
Liposomal Doxorubicin Compared With Observation or Cyclophosphamide and Methotrexate in Treating Older Women Who Have Undergone Surgery for Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as methotrexate, cyclophosphamide, and liposomal doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- CASA (NCT00296010)
- Testing
- cyclophosphamide, methotrexate, pegylated liposomal doxorubicin hydrochloride
- Where
- 33 sites in Australia, Belgium and 7 more
- Volunteers
- 77 people
- Sponsor
- ETOP IBCSG Partners Foundation
Colorectal Cancer Metastatic, Liver Metastases
Efficacy of FOLFOX Versus FOLFOX Plus Aflibercept in K-ras Mutant Patients With Resectable Liver Metastases
Patients presenting with multiple innumerable liver metastases will probably never come to resection, however, for all others, including patients with numerous multiple metastases or large metastases, resection should be…
- Conditions
- Colorectal Cancer Metastatic, Liver Metastases, KRAS Mutated Colorectal Cancer
- Trial name
- BOS3 (NCT01646554)
- Testing
- Modified FOLFOX6, Aflibercept, Surgery
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Pancreatic Tubular Adenocarcinoma
Influence of Gemcitabine Treatment on Immunological and Serological Profile in Patients With Pancreatic Cancer
Observational study of influence of gemcitabine treatment on serological and immunological status and gene expression profile in patients with pancreatic tubular carcinoma after tumor resection.
- Trial name
- GEMSTHER (NCT00947102)
- Testing
- Observation
- Where
- Slovenia
- Sponsor
- Blood Transfusion Centre of Slovenia
Alzheimer's Disease
Tolerability and Safety of Subcutaneous Administration of AFFITOPE AD02 in Mild to Moderate Alzheimer's Disease
The purpose of this study is to assess the tolerability and safety of repeated subcutaneous injection of a single dose of AFFITOPE AD02 in patients with mild to moderate Alzheimer's Disease.
- Trial name
- NCT00633841
- Testing
- AFFITOPE AD02
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Affiris AG
Nasopharyngeal Carcinoma
Effect of Triple Combination of Induction, Concurrent and Adjuvant Chemotherapy in High Risk Nasopharyngeal Carcinoma
The investigators aim to evaluate the survival benefit from triple combination of induction, concurrent and aduvant chemotherapy versus concurrent chemotherapy alone for high risk locoregionally advanced nasopharyngeal carcinoma…
- Trial name
- NCT02621970
- Testing
- Cisplatin 1, Cisplatin 2, Docetaxel
- Where
- China
- Volunteers
- 534 people
- Sponsor
- Sun Yat-sen University
Tratment of Multinodular Goitre
Three-Year Follow-up of Radioiodine Therapy for Goitre
Background: Preadministration of recombinant human thyrotropin (rhTSH) increases the amount and homogeneity of thyroid radioiodine uptake, and when used as an adjuvant can augment the efficiency of 131I therapy by allowing…
- Trial name
- NCT00509483
- Testing
- Radioactive iodine
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Melanoma
Neoadjuvant SHR-1701 Plus Famitinib With Response-guided Adjuvant Therapy in Resectable Mucosal Melanoma
This study aims to investigate the efficacy and safety of SHR-1701 in combination with famitinib in the perioperative treatment of mucosal melanoma
- Trial name
- NCT07517653
- Testing
- SHR-1701, Famitinib
- Volunteers
- 70 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Cancer
Therapeutic Education Intervention in Breast Cancer: PEPs Hormonotherapy
The purpose of this study is to evaluate the feasibility and the effectiveness of a patient education program on patients' adherence to adjuvant hormone therapy (anti-estrogen or aromatase inhibitors) for breast cancer, in…
- Trial name
- PEPs HORMONO (NCT02300675)
- Testing
- therapeutic education program
- Where
- 3 sites in France
- Volunteers
- 352 people
- Sponsor
- Institut de Cancérologie de la Loire
Malignant Melanoma
Observational Study for Melanoma Adjuvant Treatment With Tafinlar® + Mekinist® (Dabrafenib + Trametinib)
The primary objective for this non-interventional study was to assess the quality of life of melanoma patients under adjuvant treatment with dabrafenib and trametinib in real world setting in Portugal through disease specific…
- Trial name
- NCT04547946
- Testing
- dabrafenib + trametinib
- Where
- 2 sites in Portugal
- Volunteers
- 3 people
- Sponsor
- Novartis Pharmaceuticals
Trismus, Head and Neck Cancer
Feasibility Study of Dynasplint to Prevent Trismus in Head and Neck Cancer
The purpose of this study is to see if use of a device called the Jaw Dynasplint® System can be used during and immediately after cancer treatment.
- Trial name
- NCT01649583
- Testing
- Jaw Dynasplint System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Breast Neoplasm
Adjuvant Treatment of EC Followed by Taxane +/- Carboplatin in Triple-Negative Breast Cancer
To compare disease-free survival (DFS) rate of adjuvant chemotherapy epirubicin-cyclophosphamide followed by weekly paclitaxel or docetaxel (EC-T), or weekly paclitaxel or docetaxel-carboplatin (EC-TCb) in triple-negative breast…
- Trial name
- TCTN (NCT02455141)
- Testing
- Epirubicin plus Cyclophosphamide, Taxanes, Taxanes plus Carboplatin
- Where
- 27 sites in China
- Volunteers
- 786 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Lung Cancer
Combination Chemotherapy Compared With No Treatment Following Surgery in Treating Patients With Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if combination chemotherapy given after surgery is more effective than surgery alone for…
- Trial name
- NCT00002823
- Testing
- cisplatin, etoposide, vinblastine sulfate
- Where
- 123 sites in United States, Argentina and 27 more
- Volunteers
- 3,300 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Breast Neoplasm
Application Of Epirubicin Within A Neo-/Adjuvant Chemotherapy In Patients With Primary Breast Cancer
Evaluation of efficacy of treatment with epirubicin (5 years follow-up). Evaluation of frequency of dose reduction. Evaluation of frequency of neoadjuvant treatment with E(120mg) / C(600mg).
- Trial name
- NCT01061359
- Testing
- Epirubicin: Observational Study
- Volunteers
- 1,981 people
- Sponsor
- Pfizer
Lung Cancer Stage II, Lung Cancer Stage III
Use of High Dose Radiation Followed by Chemotherapy and Radiation to Treat Locally Advanced NSCLC
This is a single-arm, single-stage Phase II study designed to evaluate the 1-year PFS rate in subjects with locally-advanced NSCLC (stage II/III) and treated with Stereotactic Body Radiation Therapy (SBRT) followed by concurrent…
- Conditions
- Lung Cancer Stage II, Lung Cancer Stage III, Non Small Cell Lung Cancer
- Trial name
- NCT03141359
- Testing
- SBRT, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Wake Forest University Health Sciences
HPV Related Oropharyngeal Squamous Cell Carcinoma
Surgery Followed by Risk-Directed Post-Operative Adjuvant Therapy for HPV-Related Oropharynx Squamous Cell Carcinoma: "The Minimalist Trial (MINT)"
The overarching goal of the MINT trial is to reduce treatment-related toxicity while maintaining efficacy. Patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC) will undergo resection of the primary tumor site…
- Trial name
- MINT (NCT03621696)
- Testing
- Cisplatin, Intensity modulated radiation therapy, Intensity modulated proton therapy
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Washington University School of Medicine
Breast Cancer
Randomized Phase III Trial Comparing Sequential Administration of FE75C Followed by Docetaxel Versus Paclitaxel as Adjuvant Chemotherapy in Axillary Lymph Node (+) Breast Cancer
Anthracycline-containing regimens are recommended as adjuvant treatment for women with node positive breast cancer. In at least three large randomized clinical trials the addition or sequential administration of a taxane…
- Trial name
- NCT00431080
- Testing
- Docetaxel, Paclitaxel, Epirubicin
- Where
- 10 sites in Greece
- Volunteers
- 478 people
- Sponsor
- Hellenic Oncology Research Group
Breast Cancer Female
Real-time Tele-monitoring Versus Routine Monitoring of Breast Cancer Patients Receiving Adjuvant Systemic Therapy
Patients with breast cancer receiving systemic therapy have a variety of symptoms. In cancer patients receiving chemotherapy and targeted therapy, it is common to report symptoms to physicians before each cycle of systemic…
- Trial name
- NCT05401942
- Testing
- Tele-monitoring through mobile application
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
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