Clinical trials: Administration, Topical
Plaque Type Psorisis
Study Comparing Tapinarof Cream 1% To VTAMA ® (Tapinarof Cream 1%) In the Treatment of Plaque Psoriasis
To compare the safety and efficacy of the test (Tapinarof Cream 1%), placebo (vehicle cream) and reference VTAMA® (Tapinarof Cream 1%) treatments to demonstrate clinical equivalence in patients with plaque psoriasis.
- Trial name
- NCT06742957
- Testing
- Tapinarof Cream 1%, VTAMA®
- Where
- 26 sites in United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Pediculosis Capitis
Efficacy and Safety of Topical 0.5% Ivermectin Lotion for the Treatment of Head Lice Infestation in Filipinos
This is a randomized, double-blind, placebo-controlled clinical study evaluating the efficacy and safety of a single application of 0.5% ivermectin lotion in Filipino subjects with head lice.
- Trial name
- NCT03286101
- Testing
- 0.5% Ivermectin lotion, Vehicle
- Where
- Philippines
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- United Laboratories
Moderate to Severe Papulopustular Rosacea
Open Label Phase 2 Feasibility Study of BPX-04 Topical Minocycline Gel in Rosacea
An open label feasibility study using BPX-04 topical minocycline gel in papulopustular rosacea.
- Trial name
- NCT03050086
- Testing
- BPX-04 1% minocycline topical gel, BPX-04 2% minocycline topical gel, BPX-04 vehicle topical gel
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- BioPharmX, Inc.
Alopecia Areata
A Study of ATI-50002 Topical Solution for the Treatment of Alopecia Areata
Primary: To assess safety, tolerability and efficacy of 2 dose strengths of ATI-50002 Topical Solution, compared to vehicle in subjects with alopecia areata (AA) Secondary: To evaluate key clinical outcome assessments
- Trial name
- NCT03354637
- Testing
- ATI-50002 high dose, ATI-50002 low dose
- Where
- 23 sites in United States
- Volunteers
- 129 people
- Sponsor
- Aclaris Therapeutics, Inc.
Recurrent Aphthous Stomatitis
Topical Hyaluronic Acid and Recurrent Aphthous Stomatitis.
This study was conducted to estimate the hypothesis that the topical hyaluronic acid mouthwash have no role in the treatment of recurrent aphthous stomatitis
- Trial name
- NCT04265001
- Testing
- Hyaluronic acid in the form of hyaluronan sodium 25 mg/100 ml as a mouthwash
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Psoriasis, Methotrexate
Topical Methotrexate Microemulsion in the Treatment of Plaque Psoriasis
Psoriasis is a chronic relapsing dermatological disease which often necessitates a long-term therapy and occurs in a significant percent of the population . It affects the skin and sometimes the nails and joints of patients .
- Trial name
- NCT04971239
- Testing
- topical methotrexate micoemulsion, Excimer light, Narrow band ultraviolet B
- Volunteers
- 30 people
- Sponsor
- Assiut University
Eczema
Alitretinoin in the Treatment of Chronic Hand Eczema
The purpose of the study is to investigate the safety and efficacy of alitretinoin in chronic hand eczema that is refractory to topical corticosteroids.
- Trial name
- NCT00519675
- Testing
- alitretinoin
- Where
- 4 sites in France, Germany
- Volunteers
- 150 people
- Sponsor
- Basilea Pharmaceutica
Hyperhidrosis, Excess Sweating
Non-prescription Versus Prescription Topical Treatments Versus no Treatment in the Control of Sweating
The purpose of this study is to assess the effectiveness of the prescription treatment compared to the non-prescription treatment.
- Trial name
- NCT00509886
- Testing
- Drysol, Drioff
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Oral Leukoplakia
Comparison of Topical Photodynamic Therapy With Topical Calcipotriol in Management of Oral Leukoplakia
(i)Rationale/ gaps in existing knowledge,: Oral cancer, one of the top three common cancers in India is usually preceded by Oral potentially malignant disorders in nearly two thirds of the cases like Oral leukoplakia.
- Trial name
- PDT CALCI HOL (NCT07453472)
- Testing
- Non-invasive Photo Dynamic Therapy using LED of wavelength ranging from 630-660nm( Fluence 15 J/cm2) as light source and 2.5% TB as photosensitizer, Topical application of Calcipotriol ointment 0.005% twice a day for 4 weeks along with preventive and conventional therapy, Conventional non-invasive management : All subjects in the two groups will receive the same standard conventional non- invasive management advised for OL as per current scientific evidence
- Where
- India
- Volunteers
- 166 people
- Sponsor
- Dr. Shalini Gupta
Vulvar Diseases, Vulvar Pain
Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis
To evaluate the use of topical application of Nifedipine cream for the treatment of Provoked localized Vulvodynia (vestibulitis, vestibulodynia).
- Conditions
- Vulvar Diseases, Vulvar Pain, Vestibulitis, Vestibulodynia
- Trial name
- NCT00496184
- Testing
- Nifedipine cream topical application
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Western Galilee Hospital-Nahariya
Tendinopathy, Achilles Tendon Pain
Topical Glyceryl Trinitrate (GTN) and Eccentric Exercises in the Treatment of Midportion Achilles Tendinopathy
The primary objective of this research is to determine if the addition of topical GTN over 24 weeks to a 12 week exercise programme improves clinical outcomes more than placebo GTN for people with Achilles Tendinopathy.
- Trial name
- NEAT (NCT02499484)
- Testing
- glyceryl trinitrate, Eccentric exercise program
- Where
- Ireland
- Volunteers
- 76 people
- Sponsor
- Royal College of Surgeons, Ireland
Onychomycosis
Optimizing the Treatment of Toenail Onychomycosis Using a New Transdermal Patch Combined With Terbinafine/Ketoconazole
This study is to explore the optimization of anti-onychomycosis patch with various formulation contents (three patch groups: 3%, 6% and 8% of terbinafine (contains 3-mg, 6-mg and 8-mg/patch terbinafine, respectively) combined…
- Trial name
- NCT01615913
- Testing
- 3 mg terbinafine and 2 mg ketoconazole containing patch, 6 mg terbinafine and 2 mg ketoconazole containing patch, 8 mg terbinafine and 2 mg ketoconazole containing patch
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Taiwan Biotech Co., Ltd.
Oral Lichen Planus
Effectiveness of a Sodium Hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash for the Treatment of Symptomatic Oral Lichen Planus
Annex 1. Patient Information and Informed Consent for the Study Study Title: Effectiveness of a sodium hyaluronate 0.01% and Sh-Oligopeptide-85 SP mouthwash for the treatment of symptomatic oral lichen planus: a randomized…
- Trial name
- NCT07280442
- Testing
- Sodium hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Complutense de Madrid
Psoriasis
Study of a New Dressing for Use With Topical Medications
The purpose of this study is to determine if a new dressing designed to be used with topical medications will enhance the effects of these topical medications.
- Trial name
- NCT00234728
- Testing
- Occlusive dressing
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Teikoku Pharma USA, Inc.
Diabetic Foot Ulcer, Surgical Wound
The Effect of Natrox® Oxygen Wound Therapy on the Healing Rate of Chronic Diabetic Foot Ulcers
A Multicentre Randomized Controlled Trial to Investigate the Effect of Natrox Topical Oxygen Wound Therapy on the Healing rates of Diabetic Foot Ulcers.
- Trial name
- NCT03905863
- Testing
- Natrox® Oxygen Wound Therapy
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 145 people
- Sponsor
- Inotec AMD Limited
Dry Eye Disease
Topical Statin Eye Drop in the Management of the Dry Eye
In the first stage, to evaluate the safety of the topical medication produced by Sina Pharmaceuticals, this medication is experimentally tested on 10 volunteer patients.
- Trial name
- NCT06208384
- Testing
- Statin eye drop
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Cervical Intraepithelial Neoplasia, Uterine Cervical Dysplasia
A Two-Stage Phase 2 Study Of A-007 Topical Gel in High-Grade Squamous Intraepithelial Lesions (HSIL)
A-007 is an investigational therapy which may be effective in the treatment of pre-cancerous cervical dysplasia (abnormal cell growth).
- Trial name
- TG-003 (NCT00596258)
- Testing
- A-007
- Where
- 5 sites in United States
- Volunteers
- 11 people
- Sponsor
- Tigris Pharmaceuticals
Actinic Keratoses, Skin Neoplasms
ALA-PDT Versus Vehicle PDT for Treatment of AK and Reduction of New NMSC in Solid Organ Transplant Recipients
The purpose of this study is to determine and compare the safety and efficacy of broad area photodynamic therapy with aminolevulinic acid (ALA-PDT) versus vehicle PDT (VEH-PDT) in the treatment of actinic keratoses (AK) and…
- Trial name
- NCT00865878
- Testing
- Aminolevulinic Acid, Vehicle
- Where
- 7 sites in United States
- Volunteers
- 6 people
- Sponsor
- DUSA Pharmaceuticals, Inc.
Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Uddevalla Skövde Transscleral Micropulse Study
Micro pulse transscleral laser treatment (MP-TLT) is a relatively new method to reduce the intraocular pressure (IOP) in glaucoma.
- Trial name
- USTMS (NCT05557721)
- Testing
- Topical lidocaine, MP-TLT
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Oral Chronic Graft-versus-host Disease
Topical Dexamethasone and Tacrolimus for the Treatment of Oral Chronic Graft-Versus-Host Disease
The purpose of this research study is to determine the effectiveness of topical steroid therapy (with a drug called dexamethasone) and topical tacrolimus therapy for the treatment of oral chronic Graft-Versus-Host Disease (cGVHD)
- Trial name
- NCT00686855
- Testing
- Tacrolimus, Dexamethasone
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- Brigham and Women's Hospital