Clinical trials: Adnexal Tumor
Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma
Oregovomab With or Without Cyclophosphamide in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer That Responded to Second-Line Chemotherapy
This randomized clinical trial is studying the side effects of oregovomab and to see how well it works with or without cyclophosphamide in treating patients with stage III or stage IV ovarian epithelial cancer, fallopian tube…
- Conditions
- Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma, Recurrent Ovarian Carcinoma, Stage III Ovarian Cancer
- Trial name
- NCT00551265
- Testing
- Cyclophosphamide, Laboratory Biomarker Analysis, Oregovomab
- Where
- United States
- Sponsor
- Gynecologic Oncology Group
Polycystic Ovarian Syndrome, Obesity, Abdominal
Acupuncture in the Regulation of Dai Meridian for Polycystic Ovarian Syndrome Patients With Abdominal Obesity
The purpose of this study is to determine whether the use of electroacupuncture to dredge and regulate Dai Meridian combined with lifestyle modification are more effective than lifestyle modification only in the treatment of…
- Trial name
- NCT02785965
- Testing
- electroacupuncture, lifestyle modification
- Where
- 2 sites in China
- Volunteers
- 84 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Breast Cancer, Colon Cancer
CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors
Background: The p53 gene normally helps to stop cancer cells from growing. However, when the p53 gene is mutated or damaged, cancer cells may grow unchecked.
- Conditions
- Breast Cancer, Colon Cancer, Pancreatic Cancer, Sarcoma
- Trial name
- NCT01386502
- Testing
- p53: 264-272 peptide, CT-011
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Poly Cystic Ovary Syndrome
Inspiratory Muscle Training for the Management of Polyendocrine Metabolic Ovarian Syndrome
Inspiratory muscle training (IMT) is a relatively simple and accessible form of exercise that specifically targets the respiratory muscles and has been reported to improve inspiratory muscle strength, respiratory efficiency…
- Trial name
- NCT07871175
- Testing
- Exercise
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Biliary Tract Cancer, Breast Cancer
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2001 in patients with advanced solid tumors.
- Conditions
- Biliary Tract Cancer, Breast Cancer, Cervical Cancer, Colon Cancer
- Trial name
- NCT06239194
- Testing
- MDX2001
- Where
- 6 sites in United States
- Volunteers
- 330 people
- Sponsor
- ModeX Therapeutics, An OPKO Health Company
Polycystic Ovary Syndrome
OCP vs Metformin for Improvement in Clinical Symptoms and Metabolic Markers in Indian PCOS Women
Objective: To assess effectiveness of ISD (Insulin sensitizing drugs) Vs OCP (Combined E\&P cyproterone acetate) in improving clinical, hormonal and metabolic features of PCOS( polycystic ovary syndrome)women from India.
- Trial name
- OCP (NCT02744131)
- Testing
- Oral contraceptive pill combination of ethyl estradiol and Cyproterone acetate, Metformin 1500mgs per day
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Kar Clinic & Hospital Pvt. Ltd.
Fallopian Tube Cancer, Ovarian Cancer
Erlotinib, Docetaxel, and Carboplatin in Treating Patients With Newly Diagnosed Stage III or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as docetaxel and carboplatin, work in different ways to stop the growth of tumor…
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
- Trial name
- NCT00217529
- Testing
- pegfilgrastim, carboplatin, docetaxel
- Where
- 3 sites in United States
- Sponsor
- Fred Hutchinson Cancer Center
Recurrent Non-small Cell Lung Cancer, Recurrent Ovarian Epithelial Cancer
Erlotinib in Treating Patients With Advanced Non-Small Cell Lung Cancer, Ovarian Cancer, or Squamous Cell Carcinoma of the Head and Neck
This phase I/II trial is studying the side effects of erlotinib and to see how well it works in treating patients with metastatic or unresectable non-small cell lung cancer, ovarian cancer, or squamous cell carcinoma (cancer) of…
- Conditions
- Recurrent Non-small Cell Lung Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx, Recurrent Squamous Cell Carcinoma of the Larynx
- Trial name
- NCT00063895
- Testing
- erlotinib hydrochloride, pharmacological study, pharmacogenomic studies
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Ovarian Cancer, Breast Cancer
PARP Inhibition During Pre-surgical Window in Breast/Ovary Cancer
Study involves surgery for cytoreduction or laparoscopy to determine if you are a candidate for tumor debulking or a tissue biopsy. Following this surgery you will receive chemotherapy.
- Trial name
- NCT04041128
- Testing
- Lynparza
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Texas Southwestern Medical Center
Ovarian Neoplasms, Quality of Life
Improving Quality of Care for Patients With Recurrent Ovarian Cancer
Ovarian cancer is a major cause of cancer related death among women. The disease is usually advanced at diagnosis, because specialist referral is delayed due to vague nature of presenting symptoms.
- Trial name
- NCT02809339
- Testing
- Questionnaires
- Volunteers
- 360 people
- Sponsor
- Radboud University Medical Center
Ovarian Cancer
Vitamin D, Leptin, Vitamin D Receptor Polymorphism, and Treatment-Related Morbidity in Ovarian Cancer
This study will evaluate serum vitamin D (25(OH)D) and serum leptin levels at the time of diagnosis of ovarian, primary peritoneal, and/or fallopian tube cancer as well as vitamin D receptor mutation status (FokI SNP genotype).
- Trial name
- NCT03028519
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Oklahoma
Ovarian Cancer
Adjuvant Whole Abdominal Intensity Modulated Radiotherapy (IMRT) for High Risk Stage FIGO III Patients With Ovarian Cancer
The prognosis for patients with advanced epithelial ovarian cancer remains poor despite aggressive surgical resection and platinum-based chemotherapy.
- Trial name
- OVAR-IMRT-01 (NCT00527631)
- Testing
- whole abdomen irradiation using IMRT
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Heidelberg University
Epithelial Ovarian Cancer
Homologous Recombination Repair Deficiency (HRD) Testing in Newly Diagnosed Advanced-stage Epithelial Ovarian Cancer in Italy
The study aims to provide a comprehensive overview of HRD testing practices for epithelial ovarian cancer in Italy. In 2024, approximately 5,423 new cancer diagnoses were estimated in Italy.
- Trial name
- HRD-Italy (NCT07825181)
- Testing
- HRD test
- Where
- Italy
- Volunteers
- 1,125 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ovarian Cancer
A Study Evaluating Talazoparib in Relapsed Ovarian, Fallopian Tube, and Peritoneal Cancer
The purpose of this phase 2, multiple-cohort, randomized, open-label, international study of talazoparib (a poly (ADP-ribose) polymerase (PARP) inhibitor) is to compare the efficacy and safety of talazoparib monotherapy and…
- Trial name
- NCT02836028
- Testing
- Talazoparib, Temozolomide
- Sponsor
- Pfizer
Polycystic Ovary Syndrome
N-acetyl Cysteine and Clomiphene Citrate or Metformin and Clomiphene Citrate for Women With CC Resistant Polycystic Ovary Syndrome (PCOS).
The purpose of this study is to compare and determine the efficacy of combined N-acetyl cysteine and clomiphene citrate(CC)with combined metformin and CC in infertile women with Polycystic ovary syndrome(PCOS)not responding to…
- Trial name
- NCT01008046
- Testing
- combined N-acetyl cysteine -CC, combined metformin-CC
- Where
- Egypt
- Volunteers
- 192 people
- Sponsor
- Mansoura University
Polycystic Ovary Syndrome
AMH for the Identification of PCOM in PCOS Diagnosis
The purpose of this study is to validate the anti-müllerian hormone (AMH) cut-off established and validated in the APHRODITE study, for the determination of PCOM as part of the diagnosis of PCOS, using the Elecsys AMH Plus…
- Trial name
- HARMONIA (NCT05527353)
- Where
- Finland
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Cancer
Interleukin-12 in Treating Patients With Refractory Advanced-Stage Ovarian Cancer or Abdominal Cancer
Phase I trial to study the effectiveness of interleukin-12 in treating patients with refractory ovarian or abdominal cancers. Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a persons's…
- Trial name
- NCT00003439
- Testing
- recombinant interleukin-12
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Solid Tumors, Pancreatic Cancer
Study to Evaluate Safety, PK, PD, Immunogenicity & Antitumor Activity of MSC-1 in Patients With Adv Solid Tumors
This is a 2-part study to evaluate the safety and antitumor activity of MSC-1. MSC-1 is a first-in-class, humanized monoclonal antibody (IgG1) which binds to the immunosuppressive human cytokine Leukemia Inhibitory Factor (LIF)…
- Conditions
- Advanced Solid Tumors, Pancreatic Cancer, Non Small Cell Lung Cancer, Ovarian Cancer
- Trial name
- NCT03490669
- Testing
- MSC-1
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 41 people
- Sponsor
- AstraZeneca
Ovarian Cancer Recurrent
Trial of M4344 and Niraparib in Patients With Poly (ADP-ribose) Polymerase (PARP) Resistant Recurrent Ovarian Cancer
The purpose of this study is to find out if a new drug, M4344, is safe and has beneficial effects when given in combination with the PARP inhibitor, Niraparib, in women with recurrent ovarian cancer that has progressed while on a…
- Trial name
- PARP (NCT04149145)
- Testing
- M4344+Niraparib
- Sponsor
- University of Alabama at Birmingham
Ovarian Carcinoma, Stage 3 or 4, Epithelial Ovarian Carcinoma
N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer
RATIONAL FOR STUDYING IV NAC AS POTENTIAL CHEMOPROTECTANT: Cisplatin has shown efficacy in the treatment of subjects with epithelial ovarian cancer.
- Conditions
- Ovarian Carcinoma, Stage 3 or 4, Epithelial Ovarian Carcinoma, Primary Peritoneal Carcinoma
- Trial name
- NCT01138137
- Testing
- Paclitaxel, N-acetylcysteine, Cisplatin
- Where
- United States
- Sponsor
- OHSU Knight Cancer Institute
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