Clinical trials: Adolescent Bipolar Disorder
Bipolar Disorder
12-Month Extension Study of Dialectical Behavior Therapy for Youth With Bipolar Disorder
The overarching goal of this project is to evaluate the longer-term effects of implementing DBT for adolescents with BD in a subspecialty clinic.
- Trial name
- DB2 (NCT04283188)
- Testing
- Dialectical behavioral therapy
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pediatric Bipolar Disorder
Omega-3 Fatty Acid Adjunctive to Open-Label Aripiprazole for the Treatment of Bipolar Disorder in Children and Adolescents
This will be a 12 week, double blind study of omega-3 fatty acids vs. placebo adjunctive to open-label aripiprazole treatment in children and adolescents (ages 6-17) who meet DSM-IV criteria for bipolar disorder (BPD) (currently…
- Trial name
- NCT00592683
- Testing
- Aripiprazole, fish oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Bipolar I Disorder
Safety and Tolerability of Open-Labeled Iloperidone in Adolescents
To evaluate the safety and tolerability of iloperidone in adolescent patients with schizophrenia or bipolar I disorder for up to 52 weeks of treatment.
- Trial name
- NCT05648591
- Testing
- Iloperidone
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vanda Pharmaceuticals
Bipolar Disorder, Mood Disorders
Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study
This research protocol seeks to learn more about bipolar disorder in children and adolescents ages 6-17. Researchers will describe the moods and behaviors of children with bipolar disorder and use specialized testing and brain…
- Conditions
- Bipolar Disorder, Mood Disorders, Attention Deficit Hyerpactivity Disorder
- Trial name
- NCT00006177
- Where
- United States
- Volunteers
- 1,303 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Anxiety
Mechanism of Antidepressant-Related Dysfunctional Arousal in High-Risk Youth
A 16-week double blind, placebo-controlled investigation of escitalopram in adolescents with depression and/or anxiety with a family history of Bipolar Disorder.
- Conditions
- Depression, Anxiety, Bipolar Disorder
- Trial name
- NCT02553161
- Testing
- Escitalopram, Cognitive behavioral Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Bipolar Disorder, Youth
Prospective Metabolic Monitoring of Youth and Adults With Bipolar Disorder
Background: Most psychotropic medications that are effective in the treatment of Bipolar Disorder (BD) are associated with endocrine-metabolic changes (EMCs).
- Conditions
- Bipolar Disorder, Youth, Adults
- Trial name
- NCT01282281
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Dr. Ayal Schaffer
Bipolar Disorder, Mania
Ziprasidone for the Treatment of Mania in Children and Adolescents With Bipolar Disorder
The objective of this study is to compare the safety and effectiveness of Ziprasidone in the treatment of mania in children and adolescents with Bipolar disorder over 8 weeks.
- Trial name
- NCT00181922
- Testing
- ziprasidone (Geodon)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Bipolar I Depression
Lurasidone Pediatric Bipolar Study
A study to evaluate efficacy and safety of flexibly dosed Lurasidone in children and adolescents with bipolar I depression
- Trial name
- Illuminate (NCT02046369)
- Testing
- Lurasidone
- Where
- 66 sites in United States, Bulgaria and 9 more
- Volunteers
- 350 people
- Sponsor
- Sumitomo Pharma America, Inc.
Attention Deficit Hyperactivity Disorder
Neuroimaging Study of Risk Factors for Adolescent Bipolar Disorder
The main purpose of this study is to see the affects of the study medication called mixed amphetamine salts-extended release (MAS-XR) on brain function by taking brain pictures.
- Trial name
- NERF (NCT02478788)
- Testing
- mixed amphetamine salts-extended release (MAS-XR)
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Bipolar Disorder, Anxiety Disorders
Inositol for Comorbid Anxiety in Children and Adolescents With Bipolar Disorder
This is an open trial that seeks to determine the safety and tolerability of using inositol for children and adolescents with bipolar disorder and comorbid anxiety disorders with an exploration of efficacy and dose-response.
- Conditions
- Bipolar Disorder, Anxiety Disorders, Anxiety
- Trial name
- NCT02811133
- Testing
- Inositol
- Where
- United States
- Sponsor
- Ronald M. Glick, MD
Bipolar Disorder
The Treatment of Children and Adolescents With Treatment-Resistant Depression
This study seeks to learn about brain function in adolescents with depression and to determine whether adding lithium carbonate to antidepressant medication can reduce depression in children and adolescents.
- Trial name
- NCT00029640
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder
Quetiapine Fumarate (SEROQUEL) Compared to Placebo in the Treatment of Children & Adolescents With Bipolar I Mania
The purpose of this study is to demonstrate efficacy and safety of quetiapine fumarate (SEROQUEL) compared with placebo in the treatment of children and adolescent patients with Bipolar I mania.
- Trial name
- ANCHOR 149 (NCT00090311)
- Testing
- quetiapine fumarate
- Where
- 32 sites in United States
- Volunteers
- 220 people
- Sponsor
- AstraZeneca
Bipolar I Disorder, Manic or Mixed
Evaluate the Safety of Depakote Extended Release Tablets in the Treatment of Mania Associated With Bipolar Disorder in Children and Adolescents
To determine if long-term treatment, up to 6 months, with Depakote ER is safe and effective in the treatment of bipolar I disorder in children and adolescents.
- Trial name
- NCT00195767
- Testing
- divalproex sodium
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Abbott
Bipolar Disorder
Improving Adherence in Adolescents and Young Adults With Bipolar Disorder
Although poor medication adherence occurs in more than 65% of adolescent and young adults (AYA) with bipolar disorder (BD) and is associated with poor recovery, high rates of relapse, and a 5.2 fold increased suicide risk, there…
- Trial name
- IGNITE (NCT04348604)
- Testing
- Customized Adherence Enhancement for Adolescents and Young Adults (CAE-AYA), Enhanced Treatment as Usual (ETAU)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Case Western Reserve University
Bipolar Disorder
Efficacy and Safety Trial of Flexible Doses of Oral Ziprasidone in Children and Adolescents With Bipolar I Disorder
The purpose of this study is to determine if ziprasidone is safe and effective for the treatment of children and adolescents (ages 10-17) with bipolar I disorder (manic or mixed).
- Trial name
- NCT02075047
- Testing
- ziprasidone oral capsules
- Where
- 50 sites in United States, Ukraine
- Volunteers
- 171 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Bipolar Disorder
Early Family-Focused Treatment for Youth at Risk for Bipolar Disorder
This study will test a family-based therapy aimed at preventing or reducing the symptoms of bipolar disorder in at-risk children.
- Trial name
- NCT00943085
- Testing
- Family-focused therapy, Brief educational treatment
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of California, Los Angeles
Omega-3 Fatty Acids, Pediatric Bipolar Disorder
Omega 3 Fatty Acid Trial
This study is being done to detect the metabolic changes that Omega 3 fatty acid treatment has on the brain and to find out whether magnetic resonance spectroscopy (MRS) scan can detect metabolic differences between bipolar…
- Conditions
- Omega-3 Fatty Acids, Pediatric Bipolar Disorder, Adolescent Bipolar Disorder, Magnetic Resonance Spectroscopy Imaging
- Trial name
- NCT00586222
- Testing
- Omega-3 Fatty Acid
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Bipolar Disorder
Omega-3 Fatty Acids in Children and Adolescents With Bipolar Disorder
The purpose of this study is to test the hypothesis that flax oil, as an omega-3 fatty acid, will be superior to placebo in the maintenance treatment of bipolar disorder in children and adolescents.
- Trial name
- NCT00252486
- Testing
- Flax oil
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Rochester
Bipolar Disorder
Three-level Model of DBT-informed Care for Youth With and/or at Familial Risk for Bipolar Disorder (DB3)
This study seeks to bridge the knowledge-to-action gap regarding psychosocial treatment "dosing" for youth with and/or at familial risk for bipolar disorder (BD).
- Trial name
- DB3 (NCT05153369)
- Testing
- Enhanced Care, DBT Skills Training, Dialectical Behavior Therapy Full Intervention
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia, Bipolar Disorder
Olanzapine Treated Adolescents With Schizophrenia or Bipolar I Disorder
The purpose of this study is to characterize olanzapine pharmacokinetics: the inter- and intra- subject variabilities of olanzapine pharmacokinetics; and the potential influence of patient factors such as age, weight, gender…
- Trial name
- NCT00113594
- Testing
- Olanzapine
- Where
- 17 sites in United States, Puerto Rico and 1 more
- Volunteers
- 100 people
- Sponsor
- Eli Lilly and Company