Clinical trials: Adolescent Bipolar Disorder
Mania, Bipolar Disorder
Multimodal Neuroimaging of Treatment Effects in Adolescent Mania
Specific Aim 1: To determine the effects of treatment with quetiapine or lithium on brain activation in adolescents. The investigators will use functional magnetic resonance imaging (fMRI) to examine brain activation during an…
- Trial name
- NCT00893581
- Testing
- Healthy Controls
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Bipolar Disorder
Family Focused Therapy for Teens at Risk for Bipolar Disorder
The present study aims to examine the effects of a 4 month, family focused therapy (FFT) intervention on the 1 year course of mood symptoms in offspring of parents with bipolar disorder (BD).
- Trial name
- NCT02355366
- Testing
- Family-Focused Therapy, Brief Educational Treatment
- Where
- Canada
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Bipolar Disorder
Ziprasidone in Pediatric Bipolar Disorder
This is a 6 week, open-label, blinded-rater, randomized, controlled, pilot study designed to determine the dosing, safety and efficacy of ziprasidone in the treatment of pediatric bipolar disorder (PBD).
- Trial name
- NCT00622739
- Testing
- Ziprasidone
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Baylor College of Medicine
Bipolar Disorder, Suicidal Ideation
Mentalization-Based Therapy to Prevent Suicidal Behavior in Adolescents With Bipolar Disorder
Children and adolescents with early-onset bipolar disorder (BD) are at high risk for intentionally hurting themselves. Although there are therapies in existence for these youths with BD, they do not address suicide prevention…
- Trial name
- NCT02129790
- Testing
- Mentalization-Based Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Bipolar Disorder
Adjunctive Curcumin for Symptomatic Adolescents With Bipolar Disorder: Brain and Body Considerations
This study will enroll 30 adolescents with bipolar disorder (BD) who are suffering from symptoms of depression despite already taking a traditional mood-stabilizing medication.
- Trial name
- NCT01928043
- Testing
- Curcumin
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Sunnybrook Health Sciences Centre
Bipolar Disorder, Medication Adherence
Brief Motivational Intervention to Improve Medication Adherence for Adolescents With Bipolar Disorder
Adolescence is the peak onset period for serious and persistent psychiatric disorders. Treatment guidelines for management of major psychiatric disorders in youth include pharmacotherapy.
- Trial name
- BMI (NCT03203720)
- Testing
- Brief Motivational Intervention
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Pittsburgh
Bipolar Disorder
An Outpatient Study of the Effectiveness and Safety of Depakote ER in the Treatment of Mania/Bipolar Disorder in Children and Adolescents
The purpose of this study is to determine the safety and effectiveness of Depakote ER (Divalproex Sodium Extended-Release Tablets) compared to placebo in the treatment of bipolar disorder, manic or mixed type in children and…
- Trial name
- NCT00067262
- Testing
- Divalproex Sodium Extended-Release Tablets
- Where
- 16 sites in United States
- Volunteers
- 150 people
- Sponsor
- Abbott
Bipolar Disorder
Evaluation of Brain MRI and Clinical Characteristics of Adolescents With Bipolar Disorder and Children of Parents With Bipolar Disorder
Genetic transition is important in the etiology of bipolar disorder (BD). So, evaluation of children of BD parents and diagnosed with and BD children whether or not brain has affected zones.
- Trial name
- NCT01678989
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Turkish Psychiatry Association
Dialectical Behavior Therapy + Pharmacotherapy, Standard of Care Psychotherapy + Pharmacotherapy
Dialectical Behavior Therapy (DBT) for Adolescents With Bipolar Disorder
Of all psychiatric diagnoses, bipolar disorder imparts the greatest risk for completed suicide in adolescence, and is further associated with poor psychosocial functioning, substance abuse and legal difficulties, and exorbitant…
- Trial name
- DBT (NCT02003690)
- Testing
- Dialectical Behavior Therapy, Standard of Care Psychotherapy, Pharmacotherapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
ADHD, Bipolar Disorder
Concerta in the Treatment of ADHD in Youth and Adults With Bipolar Disorder
The objective of this study is to investigate the safety and effectiveness of Concerta in the treatment of children (ages 5 to 17 years old) and adults (ages 18 to 55 years old) with Bipolar I, Bipolar II and Bipolar Spectrum…
- Trial name
- NCT00181987
- Testing
- methylphenidate HCl (Concerta)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Mental Illness, Schizophrenia
Genetic Counselling in the Prevention of Mental Health Consequences of Cannabis Use
Severe mental illness (SMI) refers to the most burdensome psychiatric conditions. The need to pre-empt the onset of SMI is pressing because once SMI develops, quality of life is poor and available treatments have limited…
- Conditions
- Mental Illness, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- IMAGINE (NCT03601026)
- Testing
- Genetic counselling
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Nova Scotia Health Authority
Early Intervention, Child of Impaired Parents
VIA Family - Family Based Early Intervention Versus Treatment as Usual
This RCT aims to investigate the effect of an early family-based intervention (VIA Family) focusing on reducing risk and increasing resilience for children in families where at least one parent has a severe mental illness.The…
- Conditions
- Early Intervention, Child of Impaired Parents, Child, Adolescent
- Trial name
- NCT03497663
- Testing
- VIA Family intervention, Treatment As Usual
- Where
- Denmark
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Depression, Bipolar Disorder
Bupropion SR for Major Depression and Depression NOS in Children and Adolescents With Bipolar Disorder
This is an 8-week open label study of bupropion SR in the treatment of youth with bipolar depression with adequate mood stabilization.
- Trial name
- NCT00181896
- Testing
- bupropion SR
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Weight Gain
Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine
The primary objective of this study is to examine the efficacy of topiramate in combination with olanzapine for the prevention of weight gain in youth with bipolar disorder.
- Trial name
- NCT00394095
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Cincinnati
Schizophrenia, Schizoaffective Disorder
Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents
The overarching purpose of this pilot study is to collect preliminary data regarding the variability of weight gain associated with lurasidone (Latuda©) treatment of antipsychotic naive children and adolescents in order to inform…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Psychosis NOS
- Trial name
- NCT01731119
- Testing
- Latuda©
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of North Carolina, Chapel Hill
Bipolar I Disorder
A Double-Blind Randomized Placebo Controlled Study of Quetiapine for the Treatment of Depression in Adolescents With Bipolar Disorder
In this study, quetiapine is being tested for the possible treatment of bipolar I disorder with an acute depressive episode in children and adolescents.
- Trial name
- NCT00232414
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Schizophrenia, Bipolar Disorder
Skills for Wellness
Severe mental illness such as schizophrenia and mood disorders typically develops at a young age and can cause life-long disability. Currently available treatments cannot cure severe mental illness.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depression
- Trial name
- SWELL (NCT01980147)
- Testing
- maCBT
- Where
- 2 sites in Canada
- Volunteers
- 360 people
- Sponsor
- Nova Scotia Health Authority
Safety and Tolerability of Iloperidone
Tolerability and Pharmacokinetics of Iloperidone in Adolescent Patients
Tolerability, undertstanding of the action of the drug in the body, and understanding the effect of the drug in adolescent patients needing treatment with an antipsychotic medication
- Trial name
- NCT01495169
- Testing
- iloperidone (oral tablet)
- Where
- 10 sites in United States
- Volunteers
- 33 people
- Sponsor
- Vanda Pharmaceuticals
Bipolar Disorder, Mood Disorder
Mindfulness in Mood Dysregulated Youth
Mindfulness group therapy can help children with mood irregularities and family history of bipolar disorder.
- Conditions
- Bipolar Disorder, Mood Disorder, Emotional Disturbance
- Trial name
- NCT02120937
- Testing
- MBCT-C Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Bipolar Disorder
Study of Outcome and Safety of Lithium, Divalproex and Risperidone for Mania in Children and Adolescents
This study will evaluate the effectiveness of the medications, lithium (Eskalith®), valproate (Depakote®), and risperidone (Risperdal®) in treating children and adolescents with bipolar disorder or symptoms of mania.
- Trial name
- TEAM (NCT00057681)
- Testing
- Lithium carbonate, Valproate, Risperidone
- Where
- 5 sites in United States
- Volunteers
- 379 people
- Sponsor
- Washington University School of Medicine