Clinical trials: Adolescent Substance Use
Substance Related Disorders
Screening and Brief Advice to Reduce Teen Substance Use
The purpose of this study is to test the effectiveness of a brief intervention for alcohol and drug use in adolescents that a primary care doctor can give in his/her office.
- Trial name
- NCT00227877
- Testing
- cSBA - New England, USA, cSBA - Prague, CZR
- Where
- 6 sites in United States, Czechia
- Volunteers
- 2,695 people
- Sponsor
- Boston Children's Hospital
Alcohol Use Disorder
Enhancing the Effects of Adolescent Alcohol Treatment With Atomoxetine
The primary objectives of this study are twofold. The first primary objective is to evaluate the feasibility, acceptability, and tolerability of atomoxetine (40 mg/day for 3 days then 80 mg/day thereafter) as compared to placebo…
- Trial name
- NCT04565288
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Brown University
Alcohol Use Disorder
Enhancing the Effects of Alcohol Treatment With Lamotrigine
This study will help determine the tolerability and efficacy of the mood-stabilizing anticonvulsant lamotrigine in youth with alcohol use disorder.
- Trial name
- NCT04770493
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Brown University
Adolescent Substance Use
The Rewire Study (Mindfulness Mobile App to Reduce Adolescent Substance Use)
The current proposal is aimed at developing a substance use cessation app (Rewire) for high risk adolescents who are involved in the juvenile justice system.
- Trial name
- NCT03533491
- Testing
- Rewire App
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
ADHD, Substance Use Disorders
Integrated Treatment for Adolescents With ADHD
Attention-Deficit/Hyperactivity Disorder (ADHD) exists in 20-50% of the 3 million adolescents annually enrolled in outpatient mental health and substance use treatment.
- Trial name
- CASALEAP IT2A (NCT02420990)
- Testing
- Medication Integration Protocol (MIP), Changing Academic Support in the Home for Adolescents with ADHD (CASH-AA)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Substance Use Disorder, Posttraumatic Stress Disorder
Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults
The purpose of the study is to determine the safety and efficacy of an integrated treatment for substance abuse and posttraumatic stress disorder for young adults.
- Trial name
- NCT02667119
- Testing
- Prolonged Exposure with Contingency Management, Standard Care
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- UConn Health
Delayed Sleep Phase
Delayed Sleep Timing in Teens Study
This study will (1) comprehensively characterize the substance use disorder (SUD) risk profile associated with adolescent Delayed Sleep Phase (DSP), and (2) probe whether SUD risk is diminished by altering sleep/circadian timing.
- Trial name
- NCT03806296
- Testing
- Increase morning bright light, Decrease evening blue light, Sleep scheduling
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cannabis Use Disorder
N-Acetylcysteine for Youth Cannabis Use Disorder
This is a 12-week randomized, placebo-controlled trial of N-acetylcysteine for cannabis use disorder (CUD) in youth (N=192). Participants will be randomized to double-blind NAC or PBO, yielding two equally-allocated treatment…
- Trial name
- NCT03055377
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute
Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration
The investigators are conducting a randomized controlled trial to assess the impact of Resiliency in Stressful Experiences (RISE) - a comprehensive trauma-based program for young men releasing from a southeastern state's prisons.
- Conditions
- Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute, Depressive Symptoms, Anxiety
- Trial name
- NCT04785677
- Testing
- Resiliency in Stressful Experiences (RISE) Program
- Where
- United States
- Volunteers
- 403 people
- Sponsor
- Florida State University
Cannabis Use
Feasibility and Acceptability of the Cannabis Awareness and Prevention Toolkit
The Stanford Smart Talk Cannabis Awareness and Prevention Curriculum includes 5 lessons, each providing activities, online quiz games, and worksheets in addition to presentations, resources, and other materials aimed at…
- Trial name
- NCT05521321
- Testing
- Stanford Smart Talk Cannabis Awareness and Prevention curriculum
- Where
- United States
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Stanford University
Substance Use Disorders
The Substance Use and Health Risk Intervention (SUHRI) for Justice-involved Youth
This investigation will adapt and pilot test an integrated health risk-reduction and motivational enhancement intervention for Juvenile Justice (JJ) youth that will ultimately be (after full testing through a subsequent…
- Trial name
- SUHRI (NCT06132282)
- Testing
- Substance Use and Health Risk Intervention (SUHRI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
Alcohol Use Disorder
Cannabidiol in Youth Alcohol Use Disorder
The goal of this study is to test cannabidiol (CBD) as a potentially effective candidate medication for youth alcohol use disorder (AUD).
- Trial name
- NCT05317546
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
Varenicline for Adolescent Smoking Cessation
This is a placebo-controlled smoking cessation treatment study for adolescents ages 14-21. After assessment and inclusion into the study, participants will be randomized to receive a 12-week double blind course of varenicline or…
- Trial name
- NCT01509547
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Medical University of South Carolina
Substance Use
A Social Network AOD Intervention for Homeless Youth Transitioning to Housing
This project will pilot test a computer-assisted social network intervention, using motivational interviewing techniques, that can help case managers work with formerly homeless young adults who recently transitioned to…
- Trial name
- NCT04637815
- Testing
- Motivational Network Intervention, Usual Care
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- RAND
Substance Use, Parenting
Feasibility Study of a Web-based Program to Help Parents of Middle School Students Effectively Communicate With Their Children About Substance Use
The goal of this study is to test the feasibility of a web-based program for parents of middle school aged students. 286 parents and their child in 6th, 7th, or 8th grade will be asked to each complete two online questionnaires…
- Conditions
- Substance Use, Parenting, Communication
- Trial name
- NCT05900115
- Testing
- Media Ready Parent, Active Control Program
- Where
- United States
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- Innovation Research & Training
Attention Deficit Hyperactivity Disorder
Pilot Study of Vyvanse™ In ADHD Adolescents at Risk for Substance Abuse
This is an open label pilot study to obtain information on the best way to study young adolescents with Attention Deficit Hyperactivity Disorder (ADHD)who may also be at risk of developing substance abuse, in part because of…
- Trial name
- NCT00573534
- Testing
- Vyvanse
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Bipolar Disorder, Cannabis-Related Disorder
Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania
The objectives of this study are to determine whether this treatment may be useful for reducing cannabis consumption; reducing symptoms of bipolar mania; and weight mitigation therapy for individuals on psychopharmacotherapy.
- Trial name
- NCT00393978
- Testing
- Quetiapine and Topiramate
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Cincinnati
Bipolar Disorder, Alcohol Abuse
Efficacy and Tolerability of Topiramate in Treatment of Bipolar Mania and Alcohol Use in Adolescents and Young Adults
The purpose of this research study is to study the effects (both good and bad) of combining quetiapine and topiramate for treating symptoms of bipolar mania (an illness with periods of elation, excessive excitement, irritability…
- Trial name
- NCT00550394
- Testing
- Quetiapine and Topiramate
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Cincinnati
Alcohol Use, Tobacco Use
Journey of Transformation Curriculum for Native American Adolescents
The investigators will conduct a waitlist control trial to test the efficacy of the Journey of Transformation-Native Youth Health Leadership Program (JOT) in terms of delaying or reducing tobacco and other substance use and…
- Conditions
- Alcohol Use, Tobacco Use, Substance Use, Sexual Health
- Trial name
- JOT (NCT05274217)
- Testing
- Journey of Transformation-Native Youth Health Leadership Program curriculum
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Washington
Substance Use Disorders
Behavioral Treatment of Adolescent Substance Use
This study will continue research designed to improve treatment outcomes for adolescent substance use disorders by integrating neuroscience- and behaviorally-based treatments.
- Trial name
- SMART (NCT02063984)
- Testing
- Intensive Outpatient Treatment (IOP) + Contingency Management (CM), Working Memory Training
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Dartmouth-Hitchcock Medical Center