Clinical trials: Adolescent Substance Use
Alcohol Use Disorder
N-Acetylcysteine for Adolescent Alcohol Use Disorder
This is a 8-week randomized, placebo-controlled trial testing the effects of N-acetylcysteine (NAC), on a platform of weekly evidence-based brief alcohol intervention for 120 adolescents with alcohol use disorder (AUD).
- Trial name
- NCT03707951
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Medical University of South Carolina
Substance Use, Adolescent Behavior
Adolescents With Substance Use Disorders Transitioníng From Residential Treatment to the Community
Adolescents with substance use disorders (ASUD) in residential treatment have the most serious substance use disorders and the highest rates of psychological, motivational, behavioral, legal, environmental, and vocational…
- Trial name
- NCT03592186
- Testing
- Parenting Wisely+, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 122 people
- Sponsor
- Brown University
Adolescent Drinking, HIV/AIDS
Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents
The proposed study will test the impact of an economic empowerment intervention on reducing alcohol and drug use (ADU) among adolescents and youth living with HIV (AYLHIV) in poverty-impacted communities in Uganda.
- Conditions
- Adolescent Drinking, HIV/AIDS, Drug Use
- Trial name
- NCT05597865
- Testing
- Economic Empowerment Intervention, Alcohol and Drug Use Risk Reduction Sessions
- Where
- Uganda
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Substance Use
Individual and Family Motivational Interviews for Substance Using Truant Teens
This application will provide a test of one potential model for adding substance use assessment and brief intervention into a truancy court program.
- Trial name
- NCT01170026
- Testing
- Family Check-up/ Individual MI, Individual and family psychoeducation
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Brown University
Nicotine Dependence, Nicotine Use Disorder
Combined Pharmaco/Behavior Therapy in Adolescent Smokers
In the current proposal, we intend to study the efficacy of bupropion SR with or without combined contingency management (CM) among adolescent cigarette smokers.
- Trial name
- NCT00330187
- Testing
- Bupropion SR, Contingency Management
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Substance Use Disorders, Bipolar Disorder
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
This study proposes to use quetiapine as an adjunct treatment to treatment as usual to improve both substance use disorder (SUD) and mood symptoms in youth with SUD and severe mood dysregulation (SMD).
- Conditions
- Substance Use Disorders, Bipolar Disorder, Mood Disorders
- Trial name
- NCT02845453
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston Medical Center
Nicotine Dependence
Enhancing a High School Based Smoking Cessation Program
The purpose of this study is to examine the the efficacy of adjunctive nicotine replacement therapy when used in combination with the contingency management (CM) + cognitive behavioral therapy intervention.
- Trial name
- NCT01145001
- Testing
- Cognitive Behavioural Therapy, Contingency Management, Nicotine Transdermal Patch
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Yale University
Vaping, Nicotine Dependence
Varenicline for Nicotine Vaping Cessation in Adolescents
The study will test the hypothesis that varenicline, when added to behavioral and texting support for vaping cessation, will improve vaping abstinence rates in adolescents dependent on vaped nicotine over placebo plus behavioral…
- Trial name
- ViVA (NCT05367492)
- Testing
- Double Blind Varenicline, QuitVaping, This Is Quitting
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Nicotine Dependence, Cigarettes, Uncomplicated
Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco
Adolescents are an important vulnerable population to consider as the FDA moves toward a nicotine reduction policy. Such a policy, which would mandate a reduction of nicotine in all commercially available cigarettes, has the…
- Trial name
- SIREN (NCT03860077)
- Testing
- Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Brown University
Substance Use Disorders
Enhancing Adolescent Substance Abuse Treatment
The ultimate goal of this research is to facilitate rapid enhancement of youth substance abuse treatments by determining the key mechanisms of change (i.e., what to target more intensely to generate better outcomes).
- Trial name
- NCT03249350
- Testing
- Standard Contingency Management (CM), Enhanced Contingency Management (CM+)
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Oregon Social Learning Center
Vaping, Nicotine Dependence
Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents
The Investigators propose a randomized, placebo-controlled trial to test the hypothesis that varenicline added to group behavioral and texting support will be well tolerated and improve vaping cessation rates among nicotine…
- Trial name
- Pilot (NCT04602494)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Nicotine Dependence
Extended Cessation Treatment for Teen Smokers
This study is designed to test the efficacy of an extended smoking cessation program for teen smokers. We hypothesize that teen smokers randomized to extended treatment will have a higher abstinence rate at 52 week follow-up than…
- Trial name
- Nicoteens (NCT00459953)
- Testing
- Extended treatment
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Stanford University
Alcohol Drinking, Marijuana Smoking
Motivation and Skills for Delta-9-tetrahydrocannabinol/Ethanol (THC/ETOH+) Teens in Jail
This study will focus on treating substance abusing incarcerated teens using individually administered Motivational Interviewing (MI) followed by group Cognitive Behavior Therapy (CBT).
- Trial name
- SMART (NCT00506753)
- Testing
- MI/CBT, RT/SU
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Tobacco Use Cessation, Tobacco Use Disorder
Effectiveness of Bupropion for Treating Nicotine Dependence in Young People
Little is known about the best ways to help young people stop smoking. Bupropion (a medication marketed as Wellbutrin or Zyban) has proved helpful in treating adult smokers.
- Trial name
- NCT00129272
- Testing
- Bupropion-SR
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Diet Modification, Substance Use Disorders
The Impact of a Parenting Intervention on Latino Youth Health Behaviors
The purpose of this study is to test if a parenting program can be used to prevent substance use among Latino youth and at the same time promote healthy eating.
- Conditions
- Diet Modification, Substance Use Disorders, Diabetes Mellitus Risk, Cardiovascular Risk Factor
- Trial name
- FPNG+ (NCT03517111)
- Testing
- Nutrition/substance use prevention, Substance use prevention only, Academic success program
- Where
- United States
- Volunteers
- 844 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Attention Deficit Hyperactivity Disorder
Intervention for Teens With ADHD and Substance Use
Individuals with ADHD are at markedly high risk for increased substance use and Substance Use Disorder (SUD). Given the strong evidence for the negative trajectory of individuals with co-occurring ADHD and substance use…
- Trial name
- NCT02502799
- Testing
- Brief Early Intervention, Parent Training with Adolescent Cognitive Behavioral Therapy, Methylphenidate
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Florida International University
HIV/AIDS, Substance Use
Understanding and Reducing HIV Risk Behavior and Substance Use Among Self-identified Bisexual Adolescent Men
Young gay, bisexual, and other men who have sex with men (MSM) are disproportionately affected by HIV. Despite this burden, most HIV prevention interventions target adult MSM (most of whom identify as gay) and heterosexual youth…
- Conditions
- HIV/AIDS, Substance Use, Bisexuality
- Trial name
- NCT03409328
- Testing
- HIV and substance use prevention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rosalind Franklin University of Medicine and Science
ADHD, Substance Abuse
Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents With Substance Use Disorders (SUD)
The purpose of this study is to determine the efficacy of osmotic-release methylphenidate (OROS-MPH) versus placebo for the treatment of ADHD in adolescents with SUD.
- Trial name
- NCT00264797
- Testing
- Methylphenidate (OROS-MPH)
- Where
- 12 sites in United States
- Volunteers
- 303 people
- Sponsor
- University of Cincinnati
Attention Deficit Hyperactivity Disorder, Substance Abuse
Atomoxetine for Attention Deficit Hyperactivity Disorder in Adolescents With Substance Use Disorder
The purpose of this study is to find out whether atomoxetine (also called Strattera) helps teenagers (12-19) with Attention Deficit Hyperactivity Disorder (ADHD) and drug/alcohol problems.
- Trial name
- NCT00399763
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Anesthesia
Survey to Identify Substance Use in Teenagers and Adolescents
This is a prospective survey study of patients 12-21 years undergoing anesthetic care. The primary objective is to determine the incidence of illicit substance use and abuse prior to anesthetic care.
- Trial name
- NCT05353036
- Testing
- Survey
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Nationwide Children's Hospital