Clinical trials: Adolescents With Type 2 Diabetes
Obesity, Diabetes Mellitus, Type 2
Partners for Better Health in Adolescent Type 2 Diabetes: The Buddy Study
Background: Type 2 diabetes mellitus (T2DM) is becoming more common among youth, particularly in minority populations. Few drug treatments are approved for T2DM in adolescents, and behavioral and lifestyle factors may contribute…
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Abnormal Glucose Metabolism, Type 2 Diabetes
- Trial name
- NCT01007266
- Testing
- Assignment of a Lay Patient Partner
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Insulin Resistance
Endothelial Function in Hispanic Children/Adolescents at Risk for Type 2 Diabetes
Type 2 diabetes is now more frequent in children/adolescents, especially in those from minority populations, including Hispanic Americans (HA).
- Trial name
- NCT01926925
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Type 2 Diabetes, Prediabetes
A Mindfulness-based Intervention for Adolescents With Prediabetes or Type 2 Diabetes
The purpose of this study is to conduct a mindfulness-based intervention for adolescents referred for prediabetes or type 2 diabetes treatment to 1) evaluate feasibility and acceptability of the intervention for future research…
- Trial name
- L2BT2D (NCT07270900)
- Testing
- Mindfulness Based Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Type 2 Diabetes
SMART 2D: Study of Montelukast's Effects on Renal and Cardiovascular Health in Adolescents and Young Adults With Type 2 Diabetes
Adolescents and young adults (AYA) with type 2 diabetes (T2D) have a more severe phenotype than what is seen in youth-onset type 1 diabetes or adult-onset T2D including earlier kidney and cardiovascular disease complications; and…
- Trial name
- NCT07409714
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Type2 Diabetes, Diabetes Mellitus
A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both
The purpose of this study is to learn more about the safety and efficacy of tirzepatide compared to placebo in children or teenagers with type 2 diabetes taking metformin, or basal insulin, or both.
- Conditions
- Type2 Diabetes, Diabetes Mellitus, Diabetes Mellitus, Type 2, T2D
- Trial name
- SURPASS-PEDS (NCT05260021)
- Testing
- Tirzepatide Dose 1, Tirzepatide Dose 2
- Where
- 51 sites in United States, Australia and 7 more
- Volunteers
- 99 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 2
A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes
This study looks at how well a medicine called orforglipron works compared to another medicine called dulaglutide in pediatric participants aged 10 to less than 18 years with type 2 diabetes.
- Trial name
- ACHIEVE-PEDS (NCT07668336)
- Testing
- Orforglipron, Dulaglutide
- Where
- 71 sites in United States, Belgium and 9 more
- Volunteers
- 170 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes, Proteinuria
Improving Renal Complications in Adolescents With Type 2 Diabetes Through REsearch Cohort Study (National iCARE Study)
The overall aim of the project is to elucidate the primary bio-psycho-social (BPS) risk factors for albuminuria in youth with type 2 diabetes (T2D) and the mechanisms by which they cause renal injury. The Study aims include: 1.
- Conditions
- Type 2 Diabetes, Proteinuria, Stress, Nephropathy
- Trial name
- iCARE (NCT02818192)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Manitoba
Prediabetic State, Insulin Resistance
United for Health: Type 2 Diabetes Prevention in Latino Teens
This study pilots the feasibility and acceptability of a family-based lifestyle intervention for decreasing diabetes risk called "Salud sin Barreras" (meaning, "Health without Barriers") delivered in the community to Latino teens…
- Conditions
- Prediabetic State, Insulin Resistance, Type2 Diabetes, Stress
- Trial name
- UNITED (NCT03527641)
- Testing
- CookingMatters, Parent Education, Physical Activity
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Colorado State University
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Pediatric Atorvastatin in Diabetes Intervention Trial (PADIT)
The purpose of this study is to determine if Atorvastatin can improve blood vessel stiffness and blood vessel function in children 10-18 years old with Type 1 and Type 2 diabetes.
- Trial name
- NCT00130481
- Testing
- Atorvastatin 20 mg daily for 3 months
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Type 2 Diabetes
Title: Therapeutic Targets in African-American Youth With Type 2 Diabetes
Background: The pill metformin treats diabetes. But it does not work for all youth, especially African-Americans. The injectable Liraglutide treats type 2 diabetes in adults.
- Trial name
- NCT02960659
- Testing
- Liraglutide, Metformin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes
Implementation of Team Clinic for Type 2 Diabetes (TCT2)
The goal of this clinical trial is to learn if shared medical appointment is an acceptable way to deliver care to youth with type 2 diabetes.
- Trial name
- NCT06923046
- Testing
- Standard of Care, Shared Medical Appointments
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Children's Hospital Los Angeles
Diabetes Mellitus, Type 2
Adolescent-mediated Family Diabetes Intervention: American Samoa
The goal of this project is to test the feasibility, acceptability, and preliminary efficacy of an adolescent-mediated intervention designed to improve the glycemic control and self-care practices of a parent/grandparent.
- Trial name
- NCT05356884
- Testing
- Diabetes Intervention, Leadership & Life Skills
- Where
- American Samoa
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 2 Diabetes, Chronic Disease
Prevention Strategies for Adolescents at Risk of Diabetes
The primary aim of PRE-STARt Phase 1 is to pragmatically evaluate and refine a risk assessment tool to identify those children with chronic disease risk factors (including Type 2 Diabetes).
- Trial name
- PRE-STARt (NCT02545140)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Type 1 Diabetes
Avatar-based Social Physical Activity
This study is testing program where teens with type 1 diabetes play Meta Quest 2 virtual reality exercise games and talk, act, and paint about physical activity in virtual meetings with their peers and young adult role models.
- Trial name
- ASPA (NCT05662826)
- Testing
- Avatar-based Social Physical Activity
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Yale University
Type 2 Diabetes
TODAY Genetics Study
The TODAY study group has prepared a protocol with the primary objective of collecting blood and phenotypic information to be used to explore relationships between candidate genes and type 2 diabetes (T2D), as well as obesity…
- Trial name
- NCT00722397
- Where
- 25 sites in United States
- Volunteers
- 2,654 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Type 2 Diabetes
Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study
Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases.
- Trial name
- NCT06730113
- Where
- 2 sites in United States
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes Mellitus
Study of Saxagliptin, 5-Hydroxy Saxagliptin, and Metformin Concentrations/Levels in Pediatric Subjects With T2DM
The purpose of this study is to evaluate the pharmacokinetics of Saxagliptin, 5-hydroxy Saxagliptin, and Metformin in pediatric subjects with Type 2 diabetes mellitus (T2DM) following oral administration of Saxagliptin and…
- Trial name
- NCT01525225
- Testing
- Metformin immediate release (IR), Saxagliptin, Metformin IR
- Where
- 7 sites in United States
- Volunteers
- 4 people
- Sponsor
- AstraZeneca
Type 1 Diabetes
Automated Overnight Closed-loop Glucose Control in Young People With Type 1 Diabetes
Children and adolescents with type 1 diabetes need regular insulin injections or continuous insulin delivery with an insulin pump in order to keep blood sugar levels normal.
- Trial name
- APCam05 (NCT00989898)
- Testing
- Automated closed-loop insulin delivery
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Cambridge
Diabetes Mellitus Type 2, Childhood-Onset
iCARE 2.0: A Pilot Intervention of Dialectical Behavioural Therapy for Youth With Type 2 Diabetes.
In partnership with youth, parents, and community members the investigators have co-developed a program of research designed to address the substantial health disparities faced by First Nations children and families, and the…
- Trial name
- NCT05107154
- Testing
- Dialectical Behavioural Therapy
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Dr. Brandy Wicklow
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Evaluation of Updated Continuous Glucose Monitoring (CGM) Form Factor in Adults, Adolescents and Pediatrics
The purpose of this study is to demonstrate the performance of the Disposable Sensor (DS5) in subjects age 2 - 80 years, for the span of 170 hours (7 days).
- Trial name
- NCT04436822
- Testing
- Continuous Glucose Monitoring
- Where
- 18 sites in United States, China
- Volunteers
- 317 people
- Sponsor
- Medtronic MiniMed, Inc.